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  1. Content type: Research article

    Heavy metals can cause great harm to Siberian tigers in the natural environment. Cadmium (Cd2+) is an environmental contaminant that affects multiple cellular processes, including cell proliferation, differentiat...

    Authors: Hui Wang, Zheng Liu, Wenxiu Zhang, Ziao Yuan, Hongyi Yuan, Xueting Liu, Chunwen Yang and Weijun Guan

    Citation: Biological Research 2016 49:42

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  2. Content type: Research article

    Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. Here, the effects of 80 % ethanol extracts of Salvia plebeia R. Br. (SE) on an induced inflam...

    Authors: Hwan-Hee Jang, Su-Yeon Cho, Mi-Ju Kim, Jung-Bong Kim, Sung-Hyen Lee, Mee-Young Lee and Young-Min Lee

    Citation: Biological Research 2016 49:41

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  3. Content type: Research article

    New sequencing technologies have opened the way to the discovery and the characterization of pathogenic viruses in clinical samples. However, the use of these new methods can require an amplification of viral ...

    Authors: Nicolas Berthet, Stéphane Descorps-Declère, Andriniaina Andy Nkili-Meyong, Emmanuel Nakouné, Antoine Gessain, Jean-Claude Manuguerra and Mirdad Kazanji

    Citation: Biological Research 2016 49:39

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  4. Content type: Research article

    From ancient times, marine algae have emerged as alternative medicine and foods, contains the rich source of natural products like proteins, vitamins, and secondary metabolites, especially Chlorella vulgaris (C. ...

    Authors: Soundharrajan Ilavenil, Da Hye Kim, Mayakrishnan Vijayakumar, Srisesharam Srigopalram, Sang Gun Roh, Mariadhas Valan Arasu, Jong Suk Lee and Ki Choon Choi

    Citation: Biological Research 2016 49:38

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  5. Content type: Research article

    Several evidences indicate that hormones and neuropeptides function as immunomodulators. Among these, growth hormone (GH) is known to act on the thymic microenvironment, supporting its role in thymocyte differ...

    Authors: Marvin Paulo Lins, Larissa Fernanda de Araújo Vieira, Alfredo Aurélio Marinho Rosa and Salete Smaniotto

    Citation: Biological Research 2016 49:37

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  6. Content type: Research article

    Long non-coding RNAs can regulate tumorigenesis of various cancers. Dys-regulation of lncRNA-AFAP1-AS1 has not been studied in colorectal carcinoma (CRC). This study was to examine the function involvement of ...

    Authors: Xu Han, Lingling Wang, Yu Ning, Shuang Li and Zhenjun Wang

    Citation: Biological Research 2016 49:36

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  7. Content type: Erratum

    Authors: Carlos Fernández, Eloísa Ferreira, Eduardo San Miguel and Almudena Fernández-Briera

    Citation: Biological Research 2016 49:35

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    The Erratum to this article has been published in Biological Research 2016 49:35

    The original article was published in Biological Research 2016 49:35

  8. Content type: Research article

    Cellular senescence is induced either internally, for example by replication exhaustion and cell division, or externally, for example by irradiation. In both cases, cellular damages accumulate which, if not su...

    Authors: Shiva Marthandan, Uwe Menzel, Steffen Priebe, Marco Groth, Reinhard Guthke, Matthias Platzer, Peter Hemmerich, Christoph Kaether and Stephan Diekmann

    Citation: Biological Research 2016 49:34

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  9. Content type: Research article

    Glioblastoma is one of the most aggressive cancers of the brain. Malignant traits of glioblastoma cells include elevated migration, proliferation and survival capabilities. Galectins are unconventionally secre...

    Authors: Claudia Metz, Remziye Döger, Elizabeth Riquelme, Priscilla Cortés, Christopher Holmes, Ronan Shaughnessy, Claudia Oyanadel, Catalina Grabowski, Alfonso González and Andrea Soza

    Citation: Biological Research 2016 49:33

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  10. Content type: Research article

    Chitosan, the N-deacetylated derivative of chitin, is a cationic polyelectrolyte due to the presence of amino groups, one of the few occurring in nature. The use of chitosan in protein and drug delivery system...

    Authors: Xuebing Cao, Dongzhi Hou, Lei Wang, Sai Li, Shengang Sun, Qineng Ping and Yan Xu

    Citation: Biological Research 2016 49:32

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  11. Content type: Research article

    Physicochemical properties are frequently analyzed to characterize protein-sequences of known and unknown function. Especially the hydrophobicity of amino acids is often used for structural prediction or for t...

    Authors: Stefan Simm, Jens Einloft, Oliver Mirus and Enrico Schleiff

    Citation: Biological Research 2016 49:31

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  12. Content type: Research article

    α-Farnesene is a volatile sesquiterpene synthesized by the plant mevalonate (MVA) pathway through the action of α-farnesene synthase. The α-farnesene synthase 1 (MdAFS1) gene was isolated from apple peel (var. wh...

    Authors: Yu Liu, Lu Wang, Heng Liu, Rongrong Zhao, Bin Liu, Quanjuan Fu and Yuanhu Zhang

    Citation: Biological Research 2016 49:30

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  13. Content type: Research article

    Tear desiccation on a glass surface followed by transmitted-light microscopy has served as diagnostic test for dry eye. Four distinctive morphological domains (zones I, II, III and transition band) have been r...

    Authors: Felipe Traipe-Salas, Leonidas Traipe-Castro, Daniela Salinas-Toro, Daniela López, Felipe Valenzuela, Christian Cartes, Héctor Toledo-Araya, Claudio Pérez and Remigio López Solís

    Citation: Biological Research 2016 49:28

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  14. Content type: Research article

    Transient receptor potential melastatin 3 (TRPM3) cation channels are ubiquitously expressed by multiple cells and have an important regulatory role in calcium-dependent cell signalling to help maintain cellul...

    Authors: T. Nguyen, D. Staines, B. Nilius, P. Smith and S. Marshall-Gradisnik

    Citation: Biological Research 2016 49:27

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  15. Content type: Research article

    Zinc finger RNA binding protein (ZFR) is involved in the regulation of growth and cancer development. However, little is known about ZFR function in pancreatic cancer.

    Authors: Xiaolan Zhao, Man Chen and Jishan Tan

    Citation: Biological Research 2016 49:26

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    The Correction to this article has been published in Biological Research 2018 51:20

  16. Content type: Research article

    Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute inflammatory lung injury as well as a major cause of acute respiratory failure. Although researchers have made significant ...

    Authors: Min Wang, Jingjun Yan, Xingxing He, Qiang Zhong, Chengye Zhan and Shusheng Li

    Citation: Biological Research 2016 49:25

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  17. Content type: Research article

    This study was undertaken to determine the effects of varied salinity regimes on the morphological traits (plant height, number of leaves, number of flowers, fresh and dry weight) and major mineral composition...

    Authors: Md. Amirul Alam, Abdul Shukor Juraimi, M. Y. Rafii, Azizah Abdul Hamid, Farzad Aslani and M. A. Hakim

    Citation: Biological Research 2016 49:24

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  18. Content type: Research article

    Disturbance of the equilibrium between reactive oxygen species (ROS) and anti-oxidants (AOX) has been implicated in various diseases, including atherosclerosis, the most common pathologic process underlying co...

    Authors: Yosra Souiden, Hela Mallouli, Salah Meskhi, Yassine Chaabouni, Ahmed Rebai, Foued Chéour and Kacem Mahdouani

    Citation: Biological Research 2016 49:22

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  19. Content type: Research article

    Trichosanthin produced in the root tube of Trichosanthes kirilowii shows anti-tumor activity on a series of cancer cells including Hela, MCF-7, HL-60. But there is little information about its effect on the carci...

    Authors: JinLong Li, Hui Li, ZhaoLi Zhang, NianYue Wang and YongChen Zhang

    Citation: Biological Research 2016 49:21

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  20. Content type: Research article

    Despite manifold benefits of nanoparticles (NPs), less information on the risks of NPs to human health and environment has been studied. Cobalt oxide nanoparticles (Co3O4-NPs) have been reported to cause toxicity...

    Authors: Mohammad Faisal, Quaiser Saquib, Abdulrahman A. Alatar, Abdulaziz A. Al-Khedhairy, Mukhtar Ahmed, Sabiha M. Ansari, Hend A. Alwathnani, Sourabh Dwivedi, Javed Musarrat and Shelly Praveen

    Citation: Biological Research 2016 49:20

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  21. Content type: Research article

    Cancer, being the foremost challenge of the modern era and the focus of world-class investigators, gargantuan research is in progress worldwide to explore novel therapeutic for its management. The exploitation...

    Authors: Sajjad Ahmad, Farhat Ullah, Muhammad Ayaz, Anwar Zeb, Farman Ullah and Abdul Sadiq

    Citation: Biological Research 2016 49:18

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  22. Content type: Research article

    In China, mesangial proliferative glomerulonephritis (MsPGN) is one of the most common kidney diseases. In this study, we treated a rat model of chronic anti-Thy-1 MsPGN with Shenhua Tablet and evaluated wheth...

    Authors: Wenjia Geng, Ribao Wei, Shuwen Liu, Li Tang, Hanyu Zhu, Pu Chen, Jie Wu, Xueguang Zhang, Fei Zhu, Zhong Yin and Xiangmei Chen

    Citation: Biological Research 2016 49:17

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  23. Content type: Review

    Schizophrenia is a severe psychiatric disorder that results in a significant disability for the patient. The disorder is characterized by impairment of the adaptive orchestration of actions, a cognitive functi...

    Authors: Ignacio Negrón-Oyarzo, Ariel Lara-Vásquez, Ismael Palacios-García, Pablo Fuentealba and Francisco Aboitiz

    Citation: Biological Research 2016 49:16

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  24. Content type: Research article

    It has been proposed that the γ-aminobutyric acid (GABA) plays a key role in the regulation of food intake and body weight by controlling the excitability, plasticity and the synchronization of neuronal activi...

    Authors: Cuauhtemoc Sandoval-Salazar, Joel Ramírez-Emiliano, Aurora Trejo-Bahena, Cecilia I. Oviedo-Solís and Martha Silvia Solís-Ortiz

    Citation: Biological Research 2016 49:15

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  25. Content type: Review

    The use of transgenic models for the study of neurodegenerative diseases has made valuable contributions to the field. However, some important limitations, including protein overexpression and general systemic...

    Authors: Claudia Salazar, Gonzalo Valdivia, Álvaro O. Ardiles, John Ewer and Adrián G. Palacios

    Citation: Biological Research 2016 49:14

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  26. Content type: Review

    The carotid body (CB) is the main peripheral chemoreceptor that senses the arterial PO2, PCO2 and pH. In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory discharge elicits reflex respiratory,...

    Authors: Rodrigo Iturriaga, Rodrigo Del Rio, Juan Idiaquez and Virend K. Somers

    Citation: Biological Research 2016 49:13

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  27. Content type: Research article

    Prunella vulgaris L. is a medical plant cultivated in sloping, sun-shaded areas in China. Recently, owing to air-environmental stress, especially drought stress strongly inhibits plant...

    Authors: Yuhang Chen, Li Liu, Qiaosheng Guo, Zaibiao Zhu and Lixia Zhang

    Citation: Biological Research 2016 49:12

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  28. Content type: Review

    Cognitive ecologist posits that the more efficiently an animal uses information from the biotic and abiotic environment, the more adaptive are its cognitive abilities. Nevertheless, this approach does not test...

    Authors: Daniela S. Rivera, Nibaldo C. Inestrosa and Francisco Bozinovic

    Citation: Biological Research 2016 49:10

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  29. Content type: Research article

    The radiation-induced lung injury is a common complication from radiotherapy in lung cancer. CpG ODN is TLR9 activator with potential immune modulatory effects and sensitization of radiotherapy in lung cancer....

    Authors: Xuan Li, Guoxiong Xu, Tiankui Qiao, Sujuan Yuan and Xibing Zhuang

    Citation: Biological Research 2016 49:8

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  30. Content type: Research Article

    Aged garlic extract (AGE) and its main constituent S-allylcysteine (SAC) are natural antioxidants with protective effects against cerebral ischemia or cancer, events that involve hypoxia stress. Cobalt chlorid...

    Authors: Marisol Orozco-Ibarra, Jorge Muñoz-Sánchez, Martín E. Zavala-Medina, Benjamín Pineda, Roxana Magaña-Maldonado, Edgar Vázquez-Contreras, Perla D. Maldonado, José Pedraza-Chaverri and María Elena Chánez-Cárdenas

    Citation: Biological Research 2016 49:7

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  31. Content type: Short report

    Cryptogamic vegetation dominates the ice-free areas along the Antarctic Peninsula. The two mosses Sanionia uncinata and Polytrichastrum alpinum inhabit soils with contrasting water availability. Sanionia uncinata

    Authors: Paz Zúñiga-González, Gustavo E. Zúñiga, Marisol Pizarro and Angélica Casanova-Katny

    Citation: Biological Research 2016 49:6

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  32. Content type: Research article

    Reprimo (RPRM), a highly glycosylated protein, is a new downstream effector of p53-induced cell cycle arrest at the G2/M checkpoint, and a putative tumor suppressor gene frequently sil...

    Authors: Kurt Buchegger, Carmen Ili, Ismael Riquelme, Pablo Letelier, Alejandro H. Corvalán, Priscilla Brebi, Tim Hui-Ming Huang and Juan Carlos Roa

    Citation: Biological Research 2016 49:5

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  33. Content type: Research Article

    Coenzyme Q10 (CoQ10 or ubiquinone) deficiency can be due either to mutations in genes involved in CoQ10 biosynthesis pathway, or to mutations in genes unrelated to CoQ10 biosynthesis. CoQ10 defect is the only oxi...

    Authors: Konstantina Fragaki, Annabelle Chaussenot, Jean-François Benoist, Samira Ait-El-Mkadem, Sylvie Bannwarth, Cécile Rouzier, Charlotte Cochaud and Véronique Paquis-Flucklinger

    Citation: Biological Research 2016 49:4

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  34. Content type: Research Article

    Vibrio parahaemolyticus (V. parahaemolyticus) is a Gram-negative, halophilic bacterium recognized as one of the most important foodborne pathogen. When ingested, V. parahaemolyticus ca...

    Authors: Sebastian Beltran, Cristian A. Munoz-Bergmann, Ana Elola-Lopez, Javiera Quintana, Cristopher Segovia and Annette N. Trombert

    Citation: Biological Research 2016 49:2

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  35. Content type: Research article

    Mammary cell cultures are convenient tools for in vitro studies of mammary gland biology. However, the heterogeneity of mammary cell types, e.g., glandular milk secretory epithelial or myoepithelial cells, oft...

    Authors: Edgar Corneille Ontsouka, Janique Sabina Bertschi, Xiao Huang, Michael Lüthi, Stefan Müller and Christiane Albrecht

    Citation: Biological Research 2016 49:1

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  36. Content type: Research article

    Human amnion mesenchymal cells (hAMCs), isolated from the amniotic membrane of human placenta, are a unique population of mesenchymal stem cells. Recent studies demonstrated that hAMCs could inhibit the activi...

    Authors: Jun Shu, Xiaojuan He, Lan Zhang, Hong Li, Ping Wang and Xiaojie Huang

    Citation: Biological Research 2015 48:69

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  37. Content type: Review

    The advent of in vitro fertilization (IVF) in animals and humans implies an extraordinary change in the environment where the beginning of a new organism takes place. In mammals fertilization occurs in the mat...

    Authors: Patricio Ventura-Juncá, Isabel Irarrázaval, Augusto J. Rolle, Juan I. Gutiérrez, Ricardo D. Moreno and Manuel J. Santos

    Citation: Biological Research 2015 48:68

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  38. Content type: Short report

    In the recent studies, it is suggested that the analysis of transcriptomic change of functional modules instead of individual genes would be more effective for system-wide identification of cellular functions....

    Authors: Kimin Oh, Taeho Hwang, Kihoon Cha and Gwan-Su Yi

    Citation: Biological Research 2015 48:67

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  39. Content type: Research article

    Changed temperature not only threaten agricultural production, but they also affect individual biological behavior, population and community of many insects, and consequently reduce the stability of our ecosys...

    Authors: Yuhong Zhang, Hongsheng Wu, Jiaqin Xie, Ruixin Jiang, Congshuang Deng and Hong Pang

    Citation: Biological Research 2015 48:66

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  40. Content type: Research article

    Tridax procumbens flavonoids (TPFs) are well known for their medicinal properties among local natives. Besides traditionally used for dropsy, anemia, arthritis, gout, asthma, ulcer, pi...

    Authors: Md. Abdullah Al Mamun, Mohammad Jakir Hosen, Kamrul Islam, Amina Khatun, M. Masihul Alam and Md. Abdul Alim Al-Bari

    Citation: Biological Research 2015 48:65

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  41. Content type: Research article

    Salinity is a serious factor limiting the productivity of agricultural plants. One of the potential problems for plants growing under saline conditions is the inability to up take enough K+. The addition of K+ m...

    Authors: Suliman A. Alkhateeb, Abdullatif A. Alkhateeb and Mohei EL-Din Solliman

    Citation: Biological Research 2015 48:63

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