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  1. Content type: Research article

    Despite manifold benefits of nanoparticles (NPs), less information on the risks of NPs to human health and environment has been studied. Cobalt oxide nanoparticles (Co3O4-NPs) have been reported to cause toxicity...

    Authors: Mohammad Faisal, Quaiser Saquib, Abdulrahman A. Alatar, Abdulaziz A. Al-Khedhairy, Mukhtar Ahmed, Sabiha M. Ansari, Hend A. Alwathnani, Sourabh Dwivedi, Javed Musarrat and Shelly Praveen

    Citation: Biological Research 2016 49:20

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  2. Content type: Research article

    Cancer, being the foremost challenge of the modern era and the focus of world-class investigators, gargantuan research is in progress worldwide to explore novel therapeutic for its management. The exploitation...

    Authors: Sajjad Ahmad, Farhat Ullah, Muhammad Ayaz, Anwar Zeb, Farman Ullah and Abdul Sadiq

    Citation: Biological Research 2016 49:18

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  3. Content type: Research article

    In China, mesangial proliferative glomerulonephritis (MsPGN) is one of the most common kidney diseases. In this study, we treated a rat model of chronic anti-Thy-1 MsPGN with Shenhua Tablet and evaluated wheth...

    Authors: Wenjia Geng, Ribao Wei, Shuwen Liu, Li Tang, Hanyu Zhu, Pu Chen, Jie Wu, Xueguang Zhang, Fei Zhu, Zhong Yin and Xiangmei Chen

    Citation: Biological Research 2016 49:17

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  4. Content type: Review

    Schizophrenia is a severe psychiatric disorder that results in a significant disability for the patient. The disorder is characterized by impairment of the adaptive orchestration of actions, a cognitive functi...

    Authors: Ignacio Negrón-Oyarzo, Ariel Lara-Vásquez, Ismael Palacios-García, Pablo Fuentealba and Francisco Aboitiz

    Citation: Biological Research 2016 49:16

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  5. Content type: Research article

    It has been proposed that the γ-aminobutyric acid (GABA) plays a key role in the regulation of food intake and body weight by controlling the excitability, plasticity and the synchronization of neuronal activi...

    Authors: Cuauhtemoc Sandoval-Salazar, Joel Ramírez-Emiliano, Aurora Trejo-Bahena, Cecilia I. Oviedo-Solís and Martha Silvia Solís-Ortiz

    Citation: Biological Research 2016 49:15

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  6. Content type: Review

    The use of transgenic models for the study of neurodegenerative diseases has made valuable contributions to the field. However, some important limitations, including protein overexpression and general systemic...

    Authors: Claudia Salazar, Gonzalo Valdivia, Álvaro O. Ardiles, John Ewer and Adrián G. Palacios

    Citation: Biological Research 2016 49:14

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  7. Content type: Review

    The carotid body (CB) is the main peripheral chemoreceptor that senses the arterial PO2, PCO2 and pH. In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory discharge elicits reflex respiratory,...

    Authors: Rodrigo Iturriaga, Rodrigo Del Rio, Juan Idiaquez and Virend K. Somers

    Citation: Biological Research 2016 49:13

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  8. Content type: Research article

    Prunella vulgaris L. is a medical plant cultivated in sloping, sun-shaded areas in China. Recently, owing to air-environmental stress, especially drought stress strongly inhibits plant...

    Authors: Yuhang Chen, Li Liu, Qiaosheng Guo, Zaibiao Zhu and Lixia Zhang

    Citation: Biological Research 2016 49:12

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  9. Content type: Review

    Cognitive ecologist posits that the more efficiently an animal uses information from the biotic and abiotic environment, the more adaptive are its cognitive abilities. Nevertheless, this approach does not test...

    Authors: Daniela S. Rivera, Nibaldo C. Inestrosa and Francisco Bozinovic

    Citation: Biological Research 2016 49:10

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  10. Content type: Research article

    The radiation-induced lung injury is a common complication from radiotherapy in lung cancer. CpG ODN is TLR9 activator with potential immune modulatory effects and sensitization of radiotherapy in lung cancer....

    Authors: Xuan Li, Guoxiong Xu, Tiankui Qiao, Sujuan Yuan and Xibing Zhuang

    Citation: Biological Research 2016 49:8

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  11. Content type: Research Article

    Aged garlic extract (AGE) and its main constituent S-allylcysteine (SAC) are natural antioxidants with protective effects against cerebral ischemia or cancer, events that involve hypoxia stress. Cobalt chlorid...

    Authors: Marisol Orozco-Ibarra, Jorge Muñoz-Sánchez, Martín E. Zavala-Medina, Benjamín Pineda, Roxana Magaña-Maldonado, Edgar Vázquez-Contreras, Perla D. Maldonado, José Pedraza-Chaverri and María Elena Chánez-Cárdenas

    Citation: Biological Research 2016 49:7

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  12. Content type: Short report

    Cryptogamic vegetation dominates the ice-free areas along the Antarctic Peninsula. The two mosses Sanionia uncinata and Polytrichastrum alpinum inhabit soils with contrasting water availability. Sanionia uncinata

    Authors: Paz Zúñiga-González, Gustavo E. Zúñiga, Marisol Pizarro and Angélica Casanova-Katny

    Citation: Biological Research 2016 49:6

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  13. Content type: Research article

    Reprimo (RPRM), a highly glycosylated protein, is a new downstream effector of p53-induced cell cycle arrest at the G2/M checkpoint, and a putative tumor suppressor gene frequently sil...

    Authors: Kurt Buchegger, Carmen Ili, Ismael Riquelme, Pablo Letelier, Alejandro H. Corvalán, Priscilla Brebi, Tim Hui-Ming Huang and Juan Carlos Roa

    Citation: Biological Research 2016 49:5

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  14. Content type: Research Article

    Coenzyme Q10 (CoQ10 or ubiquinone) deficiency can be due either to mutations in genes involved in CoQ10 biosynthesis pathway, or to mutations in genes unrelated to CoQ10 biosynthesis. CoQ10 defect is the only oxi...

    Authors: Konstantina Fragaki, Annabelle Chaussenot, Jean-François Benoist, Samira Ait-El-Mkadem, Sylvie Bannwarth, Cécile Rouzier, Charlotte Cochaud and Véronique Paquis-Flucklinger

    Citation: Biological Research 2016 49:4

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  15. Content type: Research Article

    Vibrio parahaemolyticus (V. parahaemolyticus) is a Gram-negative, halophilic bacterium recognized as one of the most important foodborne pathogen. When ingested, V. parahaemolyticus ca...

    Authors: Sebastian Beltran, Cristian A. Munoz-Bergmann, Ana Elola-Lopez, Javiera Quintana, Cristopher Segovia and Annette N. Trombert

    Citation: Biological Research 2016 49:2

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  16. Content type: Research article

    Mammary cell cultures are convenient tools for in vitro studies of mammary gland biology. However, the heterogeneity of mammary cell types, e.g., glandular milk secretory epithelial or myoepithelial cells, oft...

    Authors: Edgar Corneille Ontsouka, Janique Sabina Bertschi, Xiao Huang, Michael Lüthi, Stefan Müller and Christiane Albrecht

    Citation: Biological Research 2016 49:1

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  17. Content type: Research article

    Human amnion mesenchymal cells (hAMCs), isolated from the amniotic membrane of human placenta, are a unique population of mesenchymal stem cells. Recent studies demonstrated that hAMCs could inhibit the activi...

    Authors: Jun Shu, Xiaojuan He, Lan Zhang, Hong Li, Ping Wang and Xiaojie Huang

    Citation: Biological Research 2015 48:69

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  18. Content type: Review

    The advent of in vitro fertilization (IVF) in animals and humans implies an extraordinary change in the environment where the beginning of a new organism takes place. In mammals fertilization occurs in the mat...

    Authors: Patricio Ventura-Juncá, Isabel Irarrázaval, Augusto J. Rolle, Juan I. Gutiérrez, Ricardo D. Moreno and Manuel J. Santos

    Citation: Biological Research 2015 48:68

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  19. Content type: Short report

    In the recent studies, it is suggested that the analysis of transcriptomic change of functional modules instead of individual genes would be more effective for system-wide identification of cellular functions....

    Authors: Kimin Oh, Taeho Hwang, Kihoon Cha and Gwan-Su Yi

    Citation: Biological Research 2015 48:67

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  20. Content type: Research article

    Changed temperature not only threaten agricultural production, but they also affect individual biological behavior, population and community of many insects, and consequently reduce the stability of our ecosys...

    Authors: Yuhong Zhang, Hongsheng Wu, Jiaqin Xie, Ruixin Jiang, Congshuang Deng and Hong Pang

    Citation: Biological Research 2015 48:66

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  21. Content type: Research article

    Tridax procumbens flavonoids (TPFs) are well known for their medicinal properties among local natives. Besides traditionally used for dropsy, anemia, arthritis, gout, asthma, ulcer, pi...

    Authors: Md. Abdullah Al Mamun, Mohammad Jakir Hosen, Kamrul Islam, Amina Khatun, M. Masihul Alam and Md. Abdul Alim Al-Bari

    Citation: Biological Research 2015 48:65

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  22. Content type: Research article

    Salinity is a serious factor limiting the productivity of agricultural plants. One of the potential problems for plants growing under saline conditions is the inability to up take enough K+. The addition of K+ m...

    Authors: Suliman A. Alkhateeb, Abdullatif A. Alkhateeb and Mohei EL-Din Solliman

    Citation: Biological Research 2015 48:63

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  23. Content type: Research article

    Recently, a continuous growth of interest has been observed in antimicrobial peptides (AMPs) in the light of an alarming increase in resistance of bacteria and fungi against antibiotics. AMPs are used as bioma...

    Authors: Anna Jurczak, Dorota Kościelniak, Monika Papież, Palina Vyhouskaya and Wirginia Krzyściak

    Citation: Biological Research 2015 48:61

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  24. Content type: Research article

    Theoretically human embryonic stem cells (hESCs) have the capacity to self-renew and differentiate into all human cell types. Therefore, the greatest promise of hESCs-based therapy is to replace the damaged ti...

    Authors: Haide Chen, Yang Li, Xijuan Lin, Di Cui, Chun Cui, Hui Li and Lei Xiao

    Citation: Biological Research 2015 48:59

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  25. Content type: Research article

    Limonoids are highly oxygenated compounds with a prototypical structure. Their occurrence in the plant kingdom is mainly confined to plant families of Meliaceae and Rutaceae. Owing to their wide range of phar...

    Authors: Jean P. Dzoyem, Armelle T. Tsamo, Raduis Melong, Pierre Mkounga, Augustin E. Nkengfack, Lyndy J. McGaw and Jacobus N. Eloff

    Citation: Biological Research 2015 48:57

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  26. Content type: Research article

    Endometriosis, pro-inflammatory and invasive benign disease estrogen dependent, abnormally express in endometria the enzyme P450Arom, positively regulated by steroid factor-1 (SF-1). Our objective was to study th...

    Authors: Jazmin Castro, Germán Araya, Pamela Inostroza, Paulina Hidalgo, Reinaldo González-Ramos, Hugo Sovino, M. Angélica Boric, Ariel Fuentes and M. Cecilia Johnson

    Citation: Biological Research 2015 48:56

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  27. Content type: Research article

    In the central nervous system, interleukin-10 (IL-10) provides trophic and survival effects directly on neurons, modulates neurite plasticity, and has a pivotal importance in the neuronal regeneration in neuro...

    Authors: S. Koriauli, N. Natsvlishvili, T. Barbakadze and D. Mikeladze

    Citation: Biological Research 2015 48:55

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  28. Content type: Research article

    Impaired wound healing is a complication of diabetes and a serious problem in clinical practice. We previously found that whey protein (WP) was able to regulate wound healing normally in streptozotocin (STZ)-d...

    Authors: Rasha R. Ahmed, Ayman Mahmoud, Osama M. Ahmed, Ali Metwalli and Hossam Ebaid

    Citation: Biological Research 2015 48:54

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  29. Content type: Research article

    Metabolic syndrome is a growing worldwide health problem. We evaluated the effects of wine grape powder (WGP), rich in antioxidants and fiber, in a rat model of metabolic syndrome induced by a high fructose di...

    Authors: Romina Hernández-Salinas, Valerie Decap, Alberto Leguina, Patricio Cáceres, Druso Perez, Ines Urquiaga, Rodrigo Iturriaga and Victoria Velarde

    Citation: Biological Research 2015 48:53

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  30. Content type: Research article

    Glycoproteins play a critical role in the cellular activities of eukaryotes. Sialic acid is typically the outermost monosaccharide of glycolipids and glycoproteins, and is necessary for normal development.

    Authors: Yangui Liang, Qiang Hua, Pengwei Pan, Jie Yang and Qi Zhang

    Citation: Biological Research 2015 48:52

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  31. Content type: Research article

    The Tridax procumbens flavonoids (TPF), are well known for their medicinal properties among local natives. The TPF are traditionally used for dropsy, anaemia, arthritis, gout, asthma, ulcer, piles, and urinary pr...

    Authors: Md. Abdullah Al Mamun, Kamrul Islam, Md. Jahangir Alam, Amina Khatun, M. Masihul Alam, Md. Abdul Alim Al-Bari and Md. Jahangir Alam

    Citation: Biological Research 2015 48:51

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  32. Content type: Research article

    DNA methylation is commonly linked with the silencing of the gene expression for many tumor suppressor genes. As such, determining DNA methylation patterns should aid, in times to come, in the diagnosis and pe...

    Authors: Fabiana Greyce Oliveira Almeida, Priscila Ferreira de Aquino, Afonso Duarte Leão de Souza, Antonia Queiroz Lima de Souza, Sonia do Carmo Vinhote, Thaís Messias Mac-Cormick, Marcelo Soares da Mota Silva, Sidney Raimundo Silva Chalub, Juliana de Saldanha da Gama Fischer, Paulo Costa Carvalho and Maria da Gloria da Costa Carvalho

    Citation: Biological Research 2015 48:50

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  33. Content type: Research article

    The Mediterranean diet is a healthy diet with positive scientific evidence of preventing chronic diseases. Bioactive components support the healthy properties of the Mediterranean diet. Antioxidants and fiber,...

    Authors: Inés Urquiaga, Sonia D’Acuña, Druso Pérez, Sara Dicenta, Guadalupe Echeverría, Attilio Rigotti and Federico Leighton

    Citation: Biological Research 2015 48:49

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  34. Content type: Research article

    The collective cell migration of stratified epithelial cells is considered to be an important phenomenon in wound healing, development, and cancer invasion; however, little is known about the mechanisms involv...

    Authors: Taro Mikami, Keiichiro Yoshida, Hajime Sawada, Michiyo Esaki, Kazunori Yasumura and Michio Ono

    Citation: Biological Research 2015 48:48

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  35. Content type: Research article

    Although numerous efforts have been made, the pathogenesis underlying lung squamous-cell carcinoma (SCC) remains unclear. This study aimed to identify the CNV-driven genes by an integrated analysis of both the...

    Authors: Zhao Yang, Bing Zhuan, Ying Yan, Simin Jiang and Tao Wang

    Citation: Biological Research 2015 48:47

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  36. Content type: Research article

    Clinical use of chemotherapeutic drug, cisplatin is limited by its toxicity and drug resistance. Therefore, efforts continue for the discovery of novel combination therapies with cisplatin, to increase efficac...

    Authors: Thangjam Davis Singh, Heikrujam Thoihen Meitei, Adhikarimayum Lakhikumar Sharma, Asem Robinson, Lisam Shanjukumar Singh and Thiyam Ramsing Singh

    Citation: Biological Research 2015 48:46

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  37. Content type: Research article

    Low survival rate of transplanted cells compromises the efficacy of cell therapy. Hexokinase II (HKII) is known to have anti-apoptotic activity through its interaction with mitochondria. The objective was to i...

    Authors: Seahyoung Lee, Ina Yun, Onju Ham, Se-Yeon Lee, Chang Yeon Lee, Jun-Hee Park, Jiyun Lee, Hyang-Hee Seo, Eunhyun Choi and Ki-Chul Hwang

    Citation: Biological Research 2015 48:45

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  38. Content type: Research article

    The fetus is surrounded by the amniotic fluid (AF) contained by the amniotic sac of the pregnant female. The AF is directly conveyed to the fetus during pregnancy. Although AF has recently been reported as an ...

    Authors: Yongwoo Jang, Eun-Kyung Kim, Won-Sik Shim, Ki-Min Song and Sung Min Kim

    Citation: Biological Research 2015 48:44

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  39. Content type: Research article

    Gossypol is a chemical present in the seeds of cotton plants (Gossypium sp.) that reduces fertility in farm animals. Vitamin E is an antioxidant and may help to protect cells and tissues against the deleterious e...

    Authors: Andréia T Santana, Marieli Guelfi, Hyllana C D Medeiros, Marco A Tavares, Paulo F V Bizerra and Fábio E Mingatto

    Citation: Biological Research 2015 48:43

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  40. Content type: Research article

    Previous reports have described a decrease in retinal temperature and clinical improvement of wet age-related macular degeneration (AMD) after vitrectomy. We hypothesized that the retinal temperature decrease ...

    Authors: Masayuki Takeyama, Masahiko Yoneda, Masahiko Gosho, Masayoshi Iwaki and Masahiro Zako

    Citation: Biological Research 2015 48:42

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  41. Content type: Research article

    CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disea...

    Authors: Hiroshi Takahashi, Kazuhiko Ikeda, Kazuei Ogawa, Syunnichi Saito, Alain M Ngoma, Yumiko Mashimo, Koki Ueda, Miki Furukawa, Akiko Shichishima-Nakamura, Hiroshi Ohkawara, Kenneth E Nollet, Hitoshi Ohto and Yasuchika Takeishi

    Citation: Biological Research 2015 48:41

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  42. Content type: Research article

    We have investigated the potential anticancer effects of karanjin, a principal furanoflavonol constituent of the Chinese medicine Fordia cauliflora, using cytotoxic assay, cell cycle arrest, and induction of apop...

    Authors: Jian-Ru Guo, Qian-Qian Chen, Christopher Wai-Kei Lam and Wei Zhang

    Citation: Biological Research 2015 48:40

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