Articles
Page 4 of 13
-
Citation: Biological Research 2022 55:6
-
Neuronal GRK2 regulates microglial activation and contributes to electroacupuncture analgesia on inflammatory pain in mice
G protein coupled receptor kinase 2 (GRK2) has been demonstrated to play a crucial role in the development of chronic pain. Acupuncture is an alternative therapy widely used for pain management. In this study,...
Citation: Biological Research 2022 55:5 -
Molecular structures and functional exploration of NDA family genes respond tolerant to alkaline stress in Gossypium hirsutum L.
The internal NAD(P)H dehydrogenase (NDA) gene family was a member of the NAD(P)H dehydrogenase (ND) gene family, mainly involved in the non-phosphorylated respiratory pathways in mitochondria and played crucia...
Citation: Biological Research 2022 55:4 -
Correction to: Effects of enriched-potassium diet on cardiorespiratory outcomes in experimental non-ischemic chronic heart failure
Citation: Biological Research 2022 55:3 -
Knockout of caspase-7 gene improves the expression of recombinant protein in CHO cell line through the cell cycle arrest in G2/M phase
Chinese hamster ovary cell line has been used routinely as a bioproduction factory of numerous biopharmaceuticals. So far, various engineering strategies have been recruited to improve the production efficienc...
Citation: Biological Research 2022 55:2 -
Genome-wide analysis of metallothionein gene family in maize to reveal its role in development and stress resistance to heavy metal
Maize (Zea mays L.) is a widely cultivated cereal and has been used as an optimum heavy metal phytoremediation crop. Metallothionein (MT) proteins are small, cysteine-rich, proteins that play important roles in p...
Citation: Biological Research 2022 55:1 -
Dual effects of entomopathogenic fungi on control of the pest Lobesia botrana and the pathogenic fungus Eutypella microtheca on grapevine
Entomopathogenic fungi (EPF) are the natural enemies of insect pests. Nevertheless, research on the use of EPF for simultaneous prevention of pest and disease agents on the same crop is limited. In this study,...
Citation: Biological Research 2021 54:44 -
Effects of enriched-potassium diet on cardiorespiratory outcomes in experimental non-ischemic chronic heart failure
Chronic heart failure (CHF) is a global health problem. Increased sympathetic outflow, cardiac arrhythmogenesis and irregular breathing patterns have all been associated with poor outcomes in CHF. Several stud...
Citation: Biological Research 2021 54:43 -
The therapeutic potential of mesenchymal stem cells in treating osteoporosis
Osteoporosis (OP), a common systemic metabolic bone disease, is characterized by low bone mass, increasing bone fragility and a high risk of fracture. At present, the clinical treatment of OP mainly involves a...
Citation: Biological Research 2021 54:42 -
Non-coding RNAs and chromatin: key epigenetic factors from spermatogenesis to transgenerational inheritance
Cellular fate and gene expression patterns are modulated by different epigenetic factors including non-coding RNAs (ncRNAs) and chromatin organization. Both factors are dynamic throughout male germ cell differ...
Citation: Biological Research 2021 54:41 -
Diosmetin inhibits cell proliferation and promotes apoptosis through STAT3/c-Myc signaling pathway in human osteosarcoma cells
Diosmetin is a bioflavonoid compound naturally abundant in citrus fruits. It is found to perform a variety of activities, while its antitumor property in osteosarcoma, a malignant tumor with unmet clinical tre...
Citation: Biological Research 2021 54:40 -
Mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortex
The aim of the study was to investigate the effect of mild cerebral hypoxia on haemoglobin oxygenation (HbO2), cerebrospinal fluid dynamics and cardiovascular physiology. To achieve this goal, four signals were r...
Citation: Biological Research 2021 54:39 -
Increased susceptibility of cystic fibrosis airway epithelial cells to ferroptosis
Defective chloride transport in airway epithelial cells (AECs) and the associated lung disease are the main causes of morbidity and early mortality in cystic fibrosis (CF). Abnormal airway iron homeostasis and...
Citation: Biological Research 2021 54:38 -
The role of vulpinic acid as a natural compound in the regulation of breast cancer-associated miRNAs
Breast cancer is the most frequently diagnosed cancer, and no effective treatment solution has yet been found. The number of studies based on the research of novel natural compounds in the treatment of breast ...
Citation: Biological Research 2021 54:37 -
Genome-wide identification and characteristic analysis of the downstream melatonin metabolism gene GhM2H in Gossypium hirsutum L.
Melatonin 2-hydroxylase (M2H) is the first enzyme in the catabolism pathway of melatonin, which catalyzes the production of 2-hydroxymelatonin (2-OHM) from melatonin. The content of 2-hydroxymelatonin in plant...
Citation: Biological Research 2021 54:36 -
Allergens of the urushiol family promote mitochondrial dysfunction by inhibiting the electron transport at the level of cytochromes b and chemically modify cytochrome c1
Urushiols are pro-electrophilic haptens that cause severe contact dermatitis mediated by CD8+ effector T-cells and downregulated by CD4+ T-cells. However, the molecular mechanism by which urushiols stimulate inna...
Citation: Biological Research 2021 54:35 -
The SREBP (Sterol Regulatory Element-Binding Protein) pathway: a regulatory bridge between carotenogenesis and sterol biosynthesis in the carotenogenic yeast Xanthophyllomyces dendrorhous
Xanthophyllomyces dendrorhous is a basidiomycete yeast that naturally produces the red–orange carotenoid astaxanthin, which has remarkable antioxidant properties. The biosynthesis of carotenoids and sterols share...
Citation: Biological Research 2021 54:34 -
Antisense noncoding mitochondrial RNA-2 gives rise to miR-4485-3p by Dicer processing in vitro
The antisense noncoding mitochondrial RNAs (ASncmtRNAs) derive from the mitochondrial 16S gene. Knockdown of these transcripts with chemically-modified antisense oligonucleotides induces proliferative arrest, ...
Citation: Biological Research 2021 54:33 -
Heart rate and cardiac autonomic responses to concomitant deep breathing, hand grip exercise, and circulatory occlusion in healthy young adult men and women
Deep breathing (DB) and handgrip (HG) exercise -with and without circulatory occlusion (OC) in muscle-, have been shown to have beneficial effects on cardiovascular function; however, the combination of these ...
Citation: Biological Research 2021 54:32 -
Structural and functional alterations in heart and skeletal muscle following severe TAC in mice: impact of moderate exercise training
Heart failure (HF) is the leading cause of death in western countries. Cardiac dysfunction is accompanied by skeletal alterations resulting in muscle weakness and fatigue. Exercise is an accepted interventiona...
Citation: Biological Research 2021 54:31 -
miR-146a-5p-mediated suppression on trophoblast cell progression and epithelial-mesenchymal transition in preeclampsia
This study aims to identify the effect of miR-146a-5p on trophoblast cell invasion as well as the mechanism in preeclampsia (PE).
Citation: Biological Research 2021 54:30 -
Retraction Note to: LncRNA HCG11 regulates proliferation and apoptosis of vascular smooth muscle cell through targeting miR‑144‑3p/FOXF1 axis in atherosclerosis
Citation: Biological Research 2021 54:29 -
Effects of foliar spray of agricultural grade mineral oil in springtime, in combination with potassium and calcium sulfates on the phenological and biophysical indices of clusters, and foliar nutritional levels in grapevine (Vitis vinifera L.) cv. Sultana (Id. Thompson seedless, Sultanina)
Improving the nutritional condition of grapevine in spring to regulate bloom, fruit set, and yield is among the management goals of vineyards.
Citation: Biological Research 2021 54:28 -
Demethylzeylasteral (T-96) initiates extrinsic apoptosis against prostate cancer cells by inducing ROS-mediated ER stress and suppressing autophagic flux
Demethylzeylasteral (T-96) is a pharmacologically active triterpenoid monomer extracted from Tripterygium wilfordii Hook F (TWHF) that has been reported to exhibit anti-neoplastic effects against several types of...
Citation: Biological Research 2021 54:27 -
Association between single-nucleotide polymorphisms in miRNA and breast cancer risk: an updated review
Breast cancer (BC), a heterogeneous, aggressive illness with high mortality, is essentially a genomic disease. While the high-penetrance genes BRCA1 and BRCA2 play important roles in tumorigenesis, moderate- and ...
Citation: Biological Research 2021 54:26 -
DNMT1-mediated PPARα methylation aggravates damage of retinal tissues in diabetic retinopathy mice
Peroxisome proliferator-activated receptor alpha (PPARα) is associated with diabetic retinopathy (DR), and the underlying mechanism is still unclear. Aim of this work was to investigate the mechanism of PPARα ...
Citation: Biological Research 2021 54:25 -
Electroacupuncture suppresses glucose metabolism and GLUT-3 expression in medial prefrontal cortical in rats with neuropathic pain
Accumulating evidence has demonstrated that the electroacupuncture (EA) stimulation could effectively alleviate neuropathic pain. The medial prefrontal cortex (mPFC) is a vital part of the cortical representat...
Citation: Biological Research 2021 54:24 -
Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies
The Ras family of small Guanosine Triphosphate (GTP)-binding proteins (G proteins) represents one of the main components of intracellular signal transduction required for normal cardiac growth, but is also cri...
Citation: Biological Research 2021 54:23 -
Cisplatin-induced hydroxyl radicals mediate pro-survival autophagy in human lung cancer H460 cells
Accumulated evidence demonstrates cisplatin, a recommended chemotherapy, modulating pro-survival autophagic response that contributes to treatment failure in lung cancer patients. However, distinct mechanisms ...
Citation: Biological Research 2021 54:22 -
Circulating miR-146a as a possible candidate biomarker in the indeterminate phase of Chagas disease
Chagas disease is considered important and presents intense inflammatory and fibrotic processes induced by the perpetuation of the parasite in the affected tissues and organs. Therefore, it is necessary to inq...
Citation: Biological Research 2021 54:21 -
OUTBREAK: a user-friendly georeferencing online tool for disease surveillance
The current COVID-19 pandemic has already claimed more than 3.7 million victims and it will cause more deaths in the coming months. Tools that track the number and locations of cases are critical for surveilla...
Citation: Biological Research 2021 54:20 -
Exploration of silicon functions to integrate with biotic stress tolerance and crop improvement
In the era of climate change, due to increased incidences of a wide range of various environmental stresses, especially biotic and abiotic stresses around the globe, the performance of plants can be affected b...
Citation: Biological Research 2021 54:19 -
Identification of 5-methylcytosine-related signature for predicting prognosis in ovarian cancer
Ovarian cancer is one of the most common malignancies often resulting in a poor prognosis. 5-methylcytosine (m5C) is a common epigenetic modification with roles in eukaryotes. However, the expression and funct...
Citation: Biological Research 2021 54:18 -
Mvda is required for zebrafish early development
The MVD gene mutations are identified in porokeratosis, which is considered a skin-specific autoinflammatory keratinization disease. However, the biological function of MVD gene remains largely unknown. Therefore...
Citation: Biological Research 2021 54:17 -
Manuka honey enhanced sensitivity of HepG2, hepatocellular carcinoma cells, for Doxorubicin and induced apoptosis through inhibition of Wnt/β-catenin and ERK1/2
Recently, there is increasing awareness focused on the identification of naturally occurring anticancer agents derived from natural products. Manuka honey (MH) has been recognized for its biological properties...
Citation: Biological Research 2021 54:16 -
Functional relationship between photosynthetic leaf gas exchange in response to silicon application and water stress mitigation in sugarcane
Water stress is one of the serious abiotic stresses that negatively influences the growth, development and production of sugarcane in arid and semi-arid regions. However, silicon (Si) has been applied as an al...
Citation: Biological Research 2021 54:15 -
The role of circular RNA circ_0008285 in gestational diabetes mellitus by regulating the biological functions of trophoblasts
Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM).
Citation: Biological Research 2021 54:14 -
NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI-positive H. pylori
Helicobacter pylori is detected by pathogen recognition receptors including toll-like receptors (TLR) and nucleotide-binding oligomerization domain (NOD)-like receptors, eliciting an innate immune response agains...
Citation: Biological Research 2021 54:13 -
Identification of blood-derived candidate gene markers and a new 7-gene diagnostic model for multiple sclerosis
Multiple sclerosis (MS) is a central nervous system disease with a high disability rate. Modern molecular biology techniques have identified a number of key genes and diagnostic markers to MS, but the etiology...
Citation: Biological Research 2021 54:12 -
CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis
Atherosclerosis (AS) is the most common type in cardiovascular disease. Due to its complex pathogenesis, the exact etiology of AS is unclear. circRNA has been shown to play an essential role in most diseases. ...
Citation: Biological Research 2021 54:11 -
Long non‐coding RNA MALAT1 regulates cell proliferation and apoptosis via miR-135b-5p/GPNMB axis in Parkinson’s disease cell model
Parkinson’s disease (PD) is a common age-related neurodegenerative disorder worldwide. This research aimed to investigate the effects and mechanism underlying long non-coding RNA metastasis-associated lung ade...
Citation: Biological Research 2021 54:10 -
Deciphering the functional role of EGR1 in Prostaglandin F2 alpha induced luteal regression applying CRISPR in corpus luteum of buffalo
PGF2α is essential for the induction of the corpus luteum regression which in turn reduces progesterone production. Early growth response (EGR) proteins are Cys2-His2-type zinc-finger transcription factor that...
Citation: Biological Research 2021 54:9 -
LncRNA MALAT1 aggravates oxygen‐glucose deprivation/reoxygenation-induced neuronal endoplasmic reticulum stress and apoptosis via the miR-195a-5p/HMGA1 axis
This study aimed to investigate the potential role and molecular mechanism of lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in cerebral ischemia/reperfusion injury.
Citation: Biological Research 2021 54:8 -
Lotus leaf flavonoids induce apoptosis of human lung cancer A549 cells through the ROS/p38 MAPK pathway
Leaves of the natural plant lotus are used in traditional Chinese medicine and tea production. They are rich in flavonoids.
Citation: Biological Research 2021 54:7 -
Degradation of mitochondrial structure and deficiency of complex I were associated with the transgenic CMS of rice
Mitochondria play a significant role in plant cytoplasmic male sterility (CMS). In our previous study, mitochondrial complex I genes, nad4, nad5, and nad7 showed polymorphisms between the transgenic CMS line M2BS...
Citation: Biological Research 2021 54:6 -
Exo70 intracellular redistribution after repeated mild traumatic brain injury
Exo70 is a subunit of the greater exocyst complex, a collection of proteins that oversees cellular membrane addition and polarized exocytosis by acting as a tethering intermediate between the plasma membrane a...
Citation: Biological Research 2021 54:5 -
Proteome profiling of different rat brain regions reveals the modulatory effect of prolonged maternal separation on proteins involved in cell death-related processes
Early-life stress in the form of maternal separation can be associated with alterations in offspring neurodevelopment and brain functioning. Here, we aimed to investigate the potential impact of prolonged mate...
Citation: Biological Research 2021 54:4 -
Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy
Testosterone regulates nutrient and energy balance to maintain protein synthesis and metabolism in cardiomyocytes, but supraphysiological concentrations induce cardiac hypertrophy. Previously, we determined th...
Citation: Biological Research 2021 54:3 -
Low-temperature extracts of Purple blossoms of basil (Ocimum basilicum L.) intervened mitochondrial translocation contributes prompted apoptosis in human breast cancer cells
The preventive and therapeutic medical utilization of this plant is an age-long practice across the globe. This study aimed to validate the impact of dark purple blossoms of basil (Ocimum basilicum L.) aqueous ex...
Citation: Biological Research 2021 54:2 -
Influence of kaolin application on most important fruit and leaf characteristics of two apple cultivars under sustained deficit irrigation
Apple is one of the oldest and most valuable fruits. Water restriction is one of the major problems in the production of this fruit in some planting areas.
Citation: Biological Research 2021 54:1
Follow
- ISSN: 0717-6287 (electronic)