Berberine (BBR), a compound extracted from a variety of medicinal herbs, has been shown multiple pharmacological effects against cancer cells of different origins. Cisplatin (DDP) is known as an effective chem...
Authors: Li Liu, Jingyan Fan, Guihai Ai, Jie Liu, Ning Luo, Caixia Li and Zhongping Cheng
Recent evidences indicated that some local anaesthetic agents played a role in inhibiting the proliferation of cancer cells; Whether ropivacaine is able to promote apoptosis of hepatocellular carcinoma (HCC) c...
Authors: Wenting Wang, Mingyue Zhu, Zhixin Xu, Wei Li, Xu Dong, Yi Chen, Bo Lin and Mengsen Li
Non-small cell lung cancer (NSCLC) is one of the leading causes of death in the world. NSCLC diagnosed at an early stage can be highly curable with a positive prognosis, but biomarker limitations make it diffi...
Authors: Hyunhee Do, Dain Kim, JiHoon Kang, Beomseok Son, Danbi Seo, HyeSook Youn, BuHyun Youn and Wanyeon Kim
Psoralen is a coumarin-like and coumarin-related benzofuran glycoside, which is a commonly used traditional Chinese medicine to treat patients with kidney and spleen-yang deficiency symptom. Psoralen has been ...
Authors: Xiaomin Wang, Peike Peng, Zhiqiang Pan, Zhaoqin Fang, Wenli Lu and Xiaomei Liu
Studies have shown that cancer susceptibility candidate 11 (CASC11), a newly discovered long non-coding RNA (lncRNA), was aberrantly overexpressed in hepatic carcinoma, gastric cancer and colorectal cancer. Howev...
Long non-coding RNA H19 (H19) plays an important role by regulating protein expression in different tissues and organs of the body. However, whether H19 induces hypoxia/reoxygenation (h/R) injury via increase ...
The purpose of the present study was to investigate the role of the methylation status of the DACT1 gene on the invasion and metastasis of nasopharyngeal carcinoma cells.
Chronic prostatitis has been supposed to be associated with preneoplastic lesions and cancer development. The objective of this study was to examine how chronic inflammation results in a prostatic microenviron...
Acute kidney injury (AKI), which is mainly caused by sepsis, has high morbidity and mortality rates. CXCL8(3–72) K11R/G31P (G31P) can exert therapeutic effect on inflammatory diseases and malignancies. We aimed t...
Hypoxic-ischemic encephalopathy (HIE) is a common disease that occurs during the perinatal period. The primary cause of neonatal HIE is related to fetal intrauterine anoxia. Carbamylated erythropoietin (CEPO),...
Authors: Min Diao, Yi Qu, Hui Liu, Yushan Ma and Xuemei Lin
To assess the expression of T-box transcription factor 4 (TBX4) during the anorectal development in normal and ethylenethiourea (ETU)-induced anorectal malformations (ARM) rat embryos.
Authors: Meng Li, Hailan Zhang, Huiying Liu, Hongzhong Tian, Xiaobing Tang, Yuzuo Bai and Weilin Wang
Acute myeloid leukemia (AML) is an aggressive and mostly incurable hematological malignancy with frequent relapses after an initial response to standard chemotherapy. Therefore, novel therapies are urgently re...
Authors: Yubin Feng, Xiaoxiao Hua, Ruowen Niu, Yan Du, Congjian Shi, Renpeng Zhou and Fei-Hu Chen
The morphological diversity of flower organs is closely related to functional divergence within the MADS-box gene family. Bryophytes and seedless vascular plants have MADS-box genes but do not have ABCDE or AGAMO...
Authors: Gangxu Shen, Chih-Hui Yang, Chi-Yen Shen and Keng-Shiang Huang
Conjunctival filtering bleb scar formation is the main reason for the failure of glaucoma filtration surgery. Cytoglobin (Cygb) has been reported to play an important role in extracellular matrix (ECM) remodel...
Authors: Haiying Wei, Lili Lin, Xiaomei Zhang, Zhuolei Feng, Yeqing Wang, Yan You, Xiaodan Wang and Yongsheng Hou
Tumor microenvironment (TME) plays a vital role in determining the outcomes of radiotherapy. As an important component of TME, vascular endothelial cells are involved in the perivascular resistance niche (PVRN...
Authors: Qianwen Li, Yan Zong, Ke Li, Xiaohua Jie, Jiaxin Hong, Xiaoshu Zhou, Bian Wu, Zhenyu Li, Sheng Zhang, Gang Wu and Rui Meng
Defects in DNA methylation have been shown to be associated with metabolic diseases such as obesity, dyslipidemia, and hypercholesterolemia. To analyze the methylation profile of the ADRB3 gene and correlate it w...
Authors: Raquel Patrícia Ataíde Lima, Marina Ramalho Ribeiro, Keylha Querino de Farias Lima, Elisama Araújo de Sena, Diego de Oliveira Costa, Rafaella Cristhine Pordeus Luna, Rayner Anderson Ferreira do Nascimento, Maria da Conceição Rodrigues Gonçalves, Rodrigo Pinheiro de Toledo Vianna, Ronei Marcos de Moraes, Naila Francis Paulo de Oliveira, Aléssio Tony Cavalcanti de Almeida and Maria José de Carvalho Costa
Histone acetylation is an important epigenetic modification that regulates gene activity in response to stress. Histone acetylation levels are reversibly regulated by histone acetyltransferases (HATs) and histone...
Authors: Fan Wei, Danfeng Tang, Zengqiang Li, Muhammad Haneef Kashif, Aziz Khan, Hai Lu, Ruixing Jia and Peng Chen
Recent studies indicate that circular RNAs (circRNAs) may play important roles in the regulation of plant growth and development. Plant roots are the main organs of nutrient and water uptake. However, whether ...
Authors: Yanhua Xu, Yongzhe Ren, Tongbao Lin and Dangqun Cui
Prunella vulgaris L. has been an important medicinal plant for the treatment of thyroid gland malfunction and mastitis in China for over 2000 years. There is an urgent need to select effective wavelengths for gre...
Authors: Yuhang Chen, Xuerong Zhang, Qiaosheng Guo, Liping Cao, Qin Qin, Chen Li, Miao Zhao and Wenming Wang
Sperm production is one of the most complex biological processes in the body. In vitro production of sperm is one of the most important goals of researches in the field of male infertility treatment, which is ...
Authors: Mahdi Mohaqiq, Mansoureh Movahedin, Zohreh Mazaheri and Naser Amirjannati
Tumourigenic cells modify metabolic pathways in order to facilitate increased proliferation and cell survival resulting in glucose- and glutamine addiction. Previous research indicated that glutamine deprivati...
Authors: Mokgadi Violet Gwangwa, Anna Margaretha Joubert and Michelle Helen Visagie
Drought is a major abiotic stress affecting global wheat (Triticum aestivum L.) production. Exploration of drought-tolerant genes is essential for the genetic improvement of drought tolerance in wheat. Previous s...
Authors: Xinbo Wang, Yongzhe Ren, Jingjing Li, Zhiqiang Wang, Zeyu Xin and Tongbao Lin
Ovarian cancer is a significant cancer-related cause of death in women worldwide. The most used chemotherapeutic regimen is based on carboplatin (CBDCA). However, CBDCA resistance is the main obstacle to a bet...
Authors: Tamara Viscarra, Kurt Buchegger, Ignacio Jofre, Ismael Riquelme, Louise Zanella, Michel Abanto, Alyssa C. Parker, Stephen R. Piccolo, Juan Carlos Roa, Carmen Ili and Priscilla Brebi
Hypoxia microenvironment plays a crucial role during tumor progression and it tends to exhibit poor prognosis and make resistant to various conventional therapies. HIF-1α acts as an important transcriptional r...
Authors: Nishant Kumar Rana, Priya Singh and Biplob Koch
The present study aimed to investigate the underlying role of interferon-regulatory factor 2 (IRF2)–inositol polyphosphate-4-phosphatase, type-II (INPP4B) axis in the regulation of autophagy in acute myeloid l...
Authors: Feng Zhang, Jiajia Li, Junfeng Zhu, Lin Liu, Kai Zhu, Shuang Cheng, RuDi Lv and Pingping Zhang
Non-canonical Wnt pathways play important roles in liver fibrosis. Notum is a newly discovered inhibitor to Wnt proteins. This study was to investigate anti-fibrotic effects of Notum.
Authors: Wenting Li, Xiaolan Yu, Chuanlong Zhu, Zheng Wang, Zonghao Zhao, Yi Li and Yonghong Zhang
Fava beans (FBs) have long been used as food, and their principal disadvantage is derived from their haemotoxicity. We hypothesized that FB ingestion alters the intestinal gene expression pattern, thereby indu...
Authors: Guankui Du, Man Xiao, Qiwei Zhu, Chen Zhou, Ao Wang and Wangwei Cai
Cervical cancer (CC) ranks third in the morbidity and mortality of female cancer around the world. Derlin1 has been found to be overexpressed in several human cancers. However, it is still unclear about its ro...
Authors: Ling Li, Ming Liu, Zhihu Zhang, Wei Zhang, Naifu Liu, Xiugui Sheng and Ping Wei
Currently, the prognosis of patients with non-small cell lung cancer (NSCLC) remains dismal; hence, it is critical to identify effective anti-NSCLC agents with limited side effects. This study aimed to evaluat...
Authors: Xiaoli Liu, Qingfeng Jiang, Huaimin Liu and Suxia Luo
Pollen development is an energy-consuming process that particularly occurs during meiosis. Low levels of adenosine triphosphate (ATP) may cause cell death, resulting in CMS (cytoplasmic male sterility). DNA se...
Authors: Xiangjun Kong, Dongmei Liu, Jie Zheng, Aziz Khan, Bin Li, Yong Diao and Ruiyang Zhou
A moderately thermophilic, slightly halophilic, aerobic, Gram-stain negative, bacterial strain, SLM16, was isolated from a mixed of seawater–sand-sediment sample collected from a coastal fumarole located in Wh...
Hematoporphyrin derivative (HPD) has a sensibilization effect in lung adenocarcinoma. This study was conducted to identify the target genes of HPD in lung adenocarcinoma.
Gymnema sylvestre is a medicinal woody perennial vine known for its sweetening properties and anti-diabetic therapeutic uses in the modern and traditional medicines. Its over-exploitation for the therapeutic uses...
Epidermal growth factor receptor family members such as ErbB1 and ErbB3 are involved in tumor progression and metastasis. Although, there are various reports about the prognostic value of EGFR members separate...
Authors: Meysam Moghbeli, Yasha Makhdoumi, Mehrdad Soltani Delgosha, Azadeh Aarabi, Ezzat Dadkhah, Bahram Memar, Abbas Abdollahi and Mohammad Reza Abbaszadegan
Ethnomedicinally, the family Polygonaceae is famous for the management of cancer. Various species of this family have been reported with anticancer potentials. This study was designed to isolate anticancer com...
Authors: Umar Farooq, Sadia Naz, Afshan Shams, Yasir Raza, Ayaz Ahmed, Umer Rashid and Abdul Sadiq
Studies have demonstrated that transforming growth factor beta-1 (TGF-β1) exhibits oncogenic activity in different types of cancer, including ovarian cancer (OC). However, its regulatory mechanism in OC and wh...
Authors: Yanqiu Wang, Jun Xiang, Jianjun Wang and Yazhong Ji
chronic hypoxia increases basal ventilation and pulmonary vascular resistance, with variable changes in arterial blood pressure and heart rate, but it’s impact on heart rate variability and autonomic regulatio...
Authors: Julio Alcayaga, Rodrigo Del Rio, Esteban A. Moya, Matías Freire and Rodrigo Iturriaga
Glioma is the most prevalent malignant tumor in human central nervous systems. Recently, the development of resistance to radiotherapy in glioma patients markedly vitiates the therapy outcome. MiR-153-3p has b...
The Antarctic continent is a source of extreme microorganisms. Millions of years of isolation have produced unique biodiversity with adaptive responses to its extreme environment. Although the Antarctic climat...
Authors: Patricio A. M. Flores, Daniela N. Correa-Llantén and Jenny M. Blamey
Hyperpigmentation disorders such as post-inflammatory hyperpigmentation are major concerns not only in light-skinned people but also in Asian populations with darker skin. The anti-tyrosinase and immunomodulat...
Authors: Pornanong Aramwit, Natthanej Luplertlop, Tapanee Kanjanapruthipong and Sumate Ampawong
Deubiquitination is a posttranslational protein modification prevalent in mammalian cells. Deubiquitinases regulate the functions of the target protein by removing its ubiquitin chain. In this study, the effec...
Authors: Wenbin Liu, Qi Zhang, Yuanyuan Fang and Yanan Wang
Phosphoinositide-3-kinase, regulatory subunit 1 (PIK3R1) could regulate cancer cell proliferation important for cancer cell proliferation; however, its role in Hepatocellular carcinoma (HCC) remains largely un...
Authors: Xuejun Ai, Lei Xiang, Zhi Huang, Shi Zhou, Shuai Zhang, Tao Zhang and Tianpeng Jiang
Emerging evidence showed that microRNAs (miRs) play critical roles in human cancers by functioning as either tumor suppressor or oncogene. MIR-382 was found to function as tumor suppressor in certain cancers. How...
Accumulating studies have demonstrated that high-mobility group A2 (HMGA2), an oncofetal protein, plays a role in tumor development and progression. However, the molecular role of HMGA2 in ovarian carcinoma is...
Antarctic bryophytes (mosses and liverworts) are resilient to physiologically extreme environmental conditions including elevated levels of ultraviolet (UV) radiation due to depletion of stratospheric ozone. M...
Authors: Melinda J. Waterman, Jessica Bramley-Alves, Rebecca E. Miller, Paul A. Keller and Sharon A. Robinson
In field, C. quitensis is subjected to many abiotic extreme environmental conditions, such as low temperatures, high UV-B, salinity and reduced water potentials, but not metal or metalloid high concentrations in ...
Authors: Rodrigo A. Contreras, Marisol Pizarro, Hans Köhler, Claudio A. Sáez and Gustavo E. Zúñiga
Increased levels of greenhouse gases in the atmosphere and associated climatic variability is primarily responsible for inducing heat waves, flooding and drought stress. Among these, water scarcity is a major ...
Authors: Aziz Khan, Xudong Pan, Ullah Najeeb, Daniel Kean Yuen Tan, Shah Fahad, Rizwan Zahoor and Honghai Luo
The negative effects of environmental stresses, such as low temperature, high temperature, salinity, drought, heavy metal stress, and biotic stress significantly decrease crop productivity. Plant hormones are ...
Authors: Ali Anwar, Yumei Liu, Rongrong Dong, Longqiang Bai, Xianchang Yu and Yansu Li
