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  1. Neuronal apoptosis plays a critical event in the pathogenesis of early brain injury after subarachnoid hemorrhage (SAH). This study investigated the roles of Tauroursodeoxycholic acid (TUDCA) in attenuate neur...

    Authors: Huihui Wu, Nini Yu, Xia Wang, Yina Yang and Hui Liang

    Citation: Biological Research 2020 53:56

    Content type: Research article

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  2. Gunnera tinctoria has been collected by Mapuche-Pewenche people for food and medicinal purposes. The high polyphenol content of methanolic extract from G. tinctoria leaves with chemical constituents such as ellag...

    Authors: Constanza Sabando, Maité Rodríguez-Díaz, Walther Ide, Edgar Pastene, Marcia Avello, Mario Simirgiotis, Susana Rojas, Enrique Villarroel, Tiare Silva-Grecchi, Cristian Gutiérrez, Rebeca Bouza, Bárbara Cicchelli, Marcelo González and Saddys Rodríguez-Llamazares

    Citation: Biological Research 2020 53:55

    Content type: Research article

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  3. UV-B signaling in plants is mediated by UVR8, which interacts with transcriptional factors to induce root morphogenesis. However, research on the downstream molecules of UVR8 signaling in roots is still scarce...

    Authors: Meiting Du, Yanhong Wang, Huize Chen and Rong Han

    Citation: Biological Research 2020 53:54

    Content type: Research article

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  4. Our previous study indicated that aerobic exercise relieves cognitive impairment in patients with vascular cognitive impairment (VCI) via regulating brain-derived neurotrophic factor (BDNF), but the mechanism ...

    Authors: Jing Wang, Yali Niu, Huaying Tao, Mina Xue and Chunxiao Wan

    Citation: Biological Research 2020 53:53

    Content type: Research article

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  5. Chinese hamster ovary (CHO) cells are the most commonly used mammalian host cell in the commercial-scale production of biopharmaceutical proteins. Modification of genes involved in apoptosis may improve the pr...

    Authors: Fatemeh Safari, Safar Farajnia, Abbas Behzad Behbahani, Habib Zarredar, Mazyar Barekati-Mowahed and Hesam Dehghani

    Citation: Biological Research 2020 53:52

    Content type: Research article

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  7. Acupuncture, a therapy of traditional Chinese medicine, is confirmed to exert the therapeutic action on polycystic ovary syndrome (PCOS). However, the detailed therapeutic mechanisms of acupuncture in PCOS rem...

    Authors: Yan Peng, Xinming Yang, Xi Luo, Chunhong Liu, Xia Cao, Hongyan Wang and Liyuan Guo

    Citation: Biological Research 2020 53:50

    Content type: Research article

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  8. Although OIP5-AS1 has been characterized as an oncogenic lncRNA in many types of cancer, its role and underlying mechanism in ovarian carcinoma (OC) remains unknown. This study aimed to investigate the role of...

    Authors: Xingzhi Jiang, Zhongxue Ye, Yafen Jiang, Wen Yu and Qian Fang

    Citation: Biological Research 2020 53:49

    Content type: Research article

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  9. Psoriasis is a common chronic inflammatory skin disease. Keratinocytes hyperproliferation and excessive inflammatory response contribute to psoriasis pathogenesis. The agents able to attenuate keratinocytes hy...

    Authors: Jintao Gao, Fangru Chen, Huanan Fang, Jing Mi, Qi Qi and Mengjuan Yang

    Citation: Biological Research 2020 53:48

    Content type: Research article

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  10. Nitrogen is the main limiting nutrient after carbon, hydrogen and oxygen for photosynthetic process, phyto-hormonal, proteomic changes and growth-development of plants to complete its lifecycle. Excessive and ...

    Authors: Muhammad Anas, Fen Liao, Krishan K. Verma, Muhammad Aqeel Sarwar, Aamir Mahmood, Zhong-Liang Chen, Qiang Li, Xu-Peng Zeng, Yang Liu and Yang-Rui Li

    Citation: Biological Research 2020 53:47

    Content type: Review

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  11. Kidney cancer is one of the most common cancers in the world. It is necessary to clarify its underlying mechanism and find its prognostic biomarkers. Current studies showed that SHMT2 may be participated in se...

    Authors: Huan Wang, Tie Chong, Bo-Yong Li, Xiao-San Chen and Wen-Bo Zhen

    Citation: Biological Research 2020 53:46

    Content type: Original paper

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  12. Skeletal muscle has an important role in regulating whole-body energy homeostasis, and energy production depends on the efficient function of mitochondria. We demonstrated previously that AT-rich interactive d...

    Authors: Yuri Okazaki, Jennifer Murray, Ali Ehsani, Jessica Clark, Robert H. Whitson, Lisa Hirose, Noriyuki Yanaka and Keiichi Itakura

    Citation: Biological Research 2020 53:45

    Content type: Research article

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  13. Atherosclerosis (AS) is the main pathological basis of coronary heart disease, cerebral infarction and peripheral vascular disease, which seriously endanger people’s life and health. In recent years, long non-...

    Authors: Yi Liu, Xiyun Cui, Cong Wang and Sihai Zhao

    Citation: Biological Research 2020 53:44

    Content type: Research article

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  14. Histone deacetylase (HDAC) inhibitors are promising anticancer drugs but their effect on tumor treatment has been disappointing mainly due to the acquisition of HDAC inhibitor resistance. However, the mechanis...

    Authors: Won Chan Hwang, Dong Woo Kang, Youra Kang, Younghoon Jang, Jung-Ae Kim and Do Sik Min

    Citation: Biological Research 2020 53:34

    Content type: Research article

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  15. Breast cancer, the most common cancer in women worldwide, causes the vast majority of cancer-related deaths. Undoubtedly, tumor metastasis and recurrence are responsible for more than 90 percent of these death...

    Authors: Danxia Cao, Han Zhu, Qian Zhao, Jianming Huang, Cixiang Zhou, Jianrong He and Yongjun Liang

    Citation: Biological Research 2020 53:43

    Content type: Research article

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  16. Basal-like breast cancer (BLBC) or triple-negative breast cancer (TNBC) is an aggressive and highly metastatic subtype of human breast cancer. The present study aimed to elucidate the potential tumor-suppressi...

    Authors: Jaehyuk Yang, Seung Jun Lee, Yongseok Kwon, Li Ma and Jongchan Kim

    Citation: Biological Research 2020 53:42

    Content type: Research article

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  17. Tumor angiogenesis is an essential event for tumor growth and metastasis. It has been showed that REC8, a component of the meiotic cohesion complex, played a vital role in Epithelial-Mesenchymal Transition (EM...

    Authors: Miao Liu, Wanfu Xu, Mingmin Su and Pingsheng Fan

    Citation: Biological Research 2020 53:41

    Content type: Research article

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  18. Osteoporosis is a common metabolic bone disease, influenced by genetic and environmental factors, that increases bone fragility and fracture risk and, therefore, has a serious adverse effect on the quality of ...

    Authors: Yang Yang, Wang Yujiao, Wang Fang, Yuan Linhui, Guo Ziqi, Wei Zhichen, Wang Zirui and Wang Shengwang

    Citation: Biological Research 2020 53:40

    Content type: Review

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  19. The impaired glucose tolerance (IGT) is a representative prediabetes characterized by defective glucose homeostasis, and palmatine (PAL) is a natural isoquinoline alkaloid with multiple pharmacological effects...

    Authors: Xusheng Tian, Yukun Zhang, Han Li, Yunfeng Li, Ning Wang, Wei Zhang and Boyan Ma

    Citation: Biological Research 2020 53:39

    Content type: Research article

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  20. Long non-coding RNA (lncRNA) small nucleolar RNA host gene 14 (SNHG14) is associated with cerebral ischemia–reperfusion (CI/R) injury. This work aims to explore the role of SNHG14 in CI/R injury.

    Authors: Zexiang Deng, Hao Ou, Fei Ren, Yujiao Guan, Ye Huan, Hongwei Cai and Bei Sun

    Citation: Biological Research 2020 53:38

    Content type: Research article

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  21. Soil salinity causes huge economic losses to agriculture productivity in arid and semiarid areas worldwide. The affected plants face disturbances in osmotic adjustment, nutrient transport, ionic toxicity and r...

    Authors: Suliman A. Al-Khateeb, Abdullatif A. Al-Khateeb, Muhammad N. Sattar and Akbar S. Mohmand

    Citation: Biological Research 2020 53:37

    Content type: Research article

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  22. To investigate the thalamic neurotransmitters and functional connections in the development of chronic constriction injury (CCI)-induced neuropathic pain.

    Authors: Zhifu Wang, Sheng Huang, Xiangmei Yu, Long Li, Minguang Yang, Shengxiang Liang, Weilin Liu and Jing Tao

    Citation: Biological Research 2020 53:36

    Content type: Research article

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  23. Spinal cord injury (SCI) is a severe central nervous system trauma. The present study aimed to evaluate the effect of HIF-1α on inflammation in spinal cord injury (SCI) to uncover the molecular mechanisms of a...

    Authors: Xigong Li, Xianfeng Lou, Sanzhong Xu, Junhua Du and Junsong Wu

    Citation: Biological Research 2020 53:35

    Content type: Research article

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  25. Circulating RNA (circRNA) regulates various bioactivities in cells. A better understanding of the exosomal circRNA can provide novel insights into the pathogenesis and treatment of Graves’ disease (GD). We aim...

    Authors: Ying Sun, Wei Wang, Yuxiao Tang, Daping Wang, Liang Li, Min Na, Guantong Jiang, Qian Li, Shulin Chen and Jin Zhou

    Citation: Biological Research 2020 53:32

    Content type: Research article

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  26. In modern societies, sleep deprivation is a serious health problem. This problem could be induced by a variety of reasons, including lifestyle habits or neurological disorders. Chronic sleep deprivation (CSD) ...

    Authors: Mahboobeh Erfanizadeh, Ali Noorafshan, Mohammad Reza Namavar, Saied Karbalay-Doust and Tahereh Talaei-Khozani

    Citation: Biological Research 2020 53:31

    Content type: Research article

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  27. We developed simple sequence repeats (SSR) for Eremanthus erythropappus (DC.) MacLeish, an endangered tree species endemic to the Brazilian Savanna and Atlantic Forest biomes, and tested their transferability to ...

    Authors: Lucas Fernandes Rocha, Natália Ribeiro Paula, Alison Gonçalves Nazareno and Dulcinéia de Carvalho

    Citation: Biological Research 2020 53:30

    Content type: Short report

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  28. Arid environments are defined by the lack of water availability, which is directly related to the mean annual precipitation (MAP), and high values of solar irradiation, which impacts the community composition ...

    Authors: Javiera Vásquez-Dean, Felipe Maza, Isidora Morel, Rodrigo Pulgar and Mauricio González

    Citation: Biological Research 2020 53:29

    Content type: Review

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  29. Kidney ischemia–reperfusion injury is a common pathophysiological phenomenon in the clinic. A large number of studies have found that the tyrosine protein kinase/signal transducer and activator of transcriptio...

    Authors: Xiaoying Zhao, Erfei Zhang, Xiaofen Ren, Xiaoli Bai, Dongming Wang, Ling Bai, Danlei Luo, Zheng Guo, Qiang Wang and Jianxin Yang

    Citation: Biological Research 2020 53:28

    Content type: Research article

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  30. Circular RNA (circRNA) is highly expressed in the brain tissue, but its molecular mechanism in cerebral ischemia–reperfusion remains unclear. Here, we explored the role and underlying mechanisms of circRNA ant...

    Authors: Su Jiang, Gaonian Zhao, Jun Lu, Min Jiang, Zhenggang Wu, Yujing Huang, Jing Huang, Jinghua Shi, Jing Jin, Xinxuan Xu and Xuehua Pu

    Citation: Biological Research 2020 53:27

    Content type: Research article

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  31. There is an emerging field to put into practice new strategies for developing molecules with antimicrobial properties. In this line, several metals and metalloids are currently being used for these purposes, a...

    Authors: C. Muñoz-Villagrán, F. Contreras, F. Cornejo, M. Figueroa, D. Valenzuela-Bezanilla, R. Luraschi, C. Reinoso, J. Rivas-Pardo, C. Vásquez, M. Castro and F. Arenas

    Citation: Biological Research 2020 53:26

    Content type: Research article

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  32. Hypoxia inducible factor-1 (HIF-1) is considered as the most activated transcriptional factor in response to low oxygen level or hypoxia. HIF-1 binds the hypoxia response element (HRE) sequence in the promoter...

    Authors: Fatemeh Sadeghi, Gholam Ali Kardar, Mohammad Reza Bolouri, Farzad Nasri, Maryam Sadri and Reza Falak

    Citation: Biological Research 2020 53:25

    Content type: Research article

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  33. BMPR-1B is part of the transforming growth factor β super family and plays a pivotal role in ewe litter size. Functional loss of exon-8 mutations in the BMPR-1B gene (namely the FecB gene) can increase both th...

    Authors: Jianlei Jia, Jipeng Jin, Qian Chen, Zan Yuan, Haiqin Li, Junhao Bian and Linsheng Gui

    Citation: Biological Research 2020 53:24

    Content type: Research article

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  34. Abscisic acid-, stress-, and ripening-induced (ASR) genes are a class of plant specific transcription factors (TFs), which play important roles in plant development, growth and abiotic stress responses. The wheat...

    Authors: Huawei Li, Haiying Guan, Qicui Zhuo, Zongshuai Wang, Shengdong Li, Jisheng Si, Bin Zhang, Bo Feng, Ling-an Kong, Fahong Wang, Zheng Wang and Lishun Zhang

    Citation: Biological Research 2020 53:23

    Content type: Research article

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  35. Duchenne muscular dystrophy (DMD) is a devastating genetic muscular disorder with no effective treatment that is caused by the loss of dystrophin. Human induced pluripotent stem cells (hiPSCs) offer a promisin...

    Authors: Ruojie He, Huan Li, Liang Wang, Yaqin Li, Yu Zhang, Menglong Chen, Yuling Zhu and Cheng Zhang

    Citation: Biological Research 2020 53:22

    Content type: Research article

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  36. Liriodendron chinense ranges widely in subtropical China and northern Vietnam; however, it inhabits several small, isolated populations and is now an endangered species due to its limited seed production. The obj...

    Authors: Bin Li, Furong Lin, Ping Huang, Wenying Guo and Yongqi Zheng

    Citation: Biological Research 2020 53:21

    Content type: Research article

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  37. The role of interleukin family in colon cancer remained controversial. The purpose of this study was to investigate the association between interleukin family and colon cancer progression through bioinformatic...

    Authors: Xiyi Wei, Yuan Zhang, Zhou Yang, Yeqin Sha, Yitong Pan, Yusheng Chen and Lei Cai

    Citation: Biological Research 2020 53:20

    Content type: Research article

    Published on:

  38. Breast cancer is the most common cancer types among women. Recent researches have focused on determining the efficiency of alternative molecules and miRNAs in breast cancer treatment. The aim of this study was...

    Authors: Elif Değerli, Vildan Torun and Demet Cansaran-Duman

    Citation: Biological Research 2020 53:19

    Content type: Research article

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  39. Cisplatin resistance (DDP-resistance) remains one of the major causes of poor prognosis in females with ovarian cancer. Long non-coding RNAs (lncRNAs) have been shown to participate in the regulation of cellul...

    Authors: Yun Zhang, Hao Ai, Xue Fan, Suxian Chen, Yadi Wang and Lili Liu

    Citation: Biological Research 2020 53:18

    Content type: Research article

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  40. Inflammation and apoptosis are considered to be two main factors affecting ischemic brain injury and the subsequent reperfusion damage. MiR-19a-3p has been reported to be a possible novel biomarker in ischemic...

    Authors: Zhaohui Chai, Jiangbiao Gong, Peidong Zheng and Jiesheng Zheng

    Citation: Biological Research 2020 53:17

    Content type: Research article

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  42. Current South American populations trace their origins mainly to three continental ancestries, i.e. European, Amerindian and African. Individual variation in relative proportions of each of these ancestries ma...

    Authors: Ricardo A. Verdugo, Alex Di Genova, Luisa Herrera, Mauricio Moraga, Mónica Acuña, Soledad Berríos, Elena Llop, Carlos Y. Valenzuela, M. Leonor Bustamante, Dayhana Digman, Adriana Symon, Soledad Asenjo, Pamela López, Alejandro Blanco, José Suazo, Emmanuelle Barozet…

    Citation: Biological Research 2020 53:15

    Content type: Research article

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  44. Gallbladder cancer (GBC) is the most common tumor of the biliary tract. The incidence of GBC shows a large geographic variability, being particularly frequent in Native American populations. In Chile, GBC repr...

    Authors: Patricia García, Carolina Bizama, Lorena Rosa, Jaime A. Espinoza, Helga Weber, Javier Cerda-Infante, Marianela Sánchez, Viviana P. Montecinos, Justo Lorenzo-Bermejo, Felix Boekstegers, Marcela Dávila-López, Francisca Alfaro, Claudia Leiva-Acevedo, Zasha Parra, Diego Romero, Sumie Kato…

    Citation: Biological Research 2020 53:13

    Content type: Research article

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  45. Mast cells (MCs) have been found to play a critical role during development of inflammatory bowel disease (IBD) that characterized by dysregulation of inflammation and impaired intestinal barrier function. How...

    Authors: Musheng Li, Junhong Zhao, Meiwan Cao, Ruitao Liu, Guanhua Chen, Songyu Li, Yuanwen Xie, Jing Xie, Yang Cheng, Ling Huang, Mingmin Su, Yuxin Xu, Mingyue Zheng, Kejian Zou, Lanlan Geng, Wanfu Xu…

    Citation: Biological Research 2020 53:12

    Content type: Research article

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  48. Rice is the staple food of many people around the world. However, most rice varieties, especially widely grown indica varieties and hybrids, are sensitive to cold stress. In order to provide a basis for the utili...

    Authors: Mengliang Xu, Xiangzhen Li, Xiang Mo, Siyu Tu, Yanchun Cui and Daichang Yang

    Citation: Biological Research 2020 53:8

    Content type: Research article

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  49. Osteoarthritis (OA) is one of the most common rheumatic diseases of which clinical symptoms includes swelling, synovitis and inflammatory pain, affect patients’ daily life. It was reported that non-coding RNAs...

    Authors: Feng Tian, Junhu Wang, Zhanhua Zhang and Jie Yang

    Citation: Biological Research 2020 53:9

    Content type: Research article

    Published on:

  50. The intracellular concentration of heavy-metal cations, such as copper, nickel, and zinc is pivotal for the mycobacterial response to the hostile environment inside macrophages. To date, copper transport media...

    Authors: Andrés León-Torres, Epifania Arango, Eliana Castillo and Carlos Y. Soto

    Citation: Biological Research 2020 53:6

    Content type: Research article

    Published on:

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