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  1. Review

    Mutations in BRCA1, BRCA2 and other breast and ovarian cancer susceptibility genes in Central and South American populations

    Breast cancer (BC) is the most common malignancy among women worldwide. A major advance in the understanding of the genetic etiology of BC was the discovery of BRCA1 and BRCA2 (BRCA1/2) genes, which are considere...

    Lilian Jara, Sebastian Morales, Tomas de Mayo, Patricio Gonzalez-Hormazabal, Valentina Carrasco and Raul Godoy

    Biological Research 2017 50:35

    Published on: 6 October 2017

  2. Review

    Awareness and current knowledge of breast cancer

    Breast cancer remains a worldwide public health dilemma and is currently the most common tumour in the globe. Awareness of breast cancer, public attentiveness, and advancement in breast imaging has made a posi...

    Muhammad Akram, Mehwish Iqbal, Muhammad Daniyal and Asmat Ullah Khan

    Biological Research 2017 50:33

    Published on: 2 October 2017

  3. Research article

    A simple and rapid identification method for newly emerged porcine Deltacoronavirus with loop-mediated isothermal amplification

    Porcine Deltacoronavirus (PDCoV) is a newly emerged enteropathogenic coronavirus that causes diarrhea and mortality in neonatal piglets. PDCoV has spread to many countries around the world, leading to significant...

    Fanfan Zhang, Yu Ye, Deping Song, Nannan Guo, Qi Peng, Anqi Li, Xingrong Zhou, Yanjun Chen, Min Zhang, Dongyan Huang and Yuxin Tang

    Biological Research 2017 50:30

    Published on: 21 September 2017

  4. Research article

    MiR-320 inhibits the growth of glioma cells through downregulating PBX3

    MiR-320 is downregulated in multiple cancers, including glioma and acts as tumor suppressor through inhibiting tumor cells proliferation and inducing apoptosis. PBX3 (Pre-B cell leukemia homeobox 3), a putativ...

    Cuicui Pan, Hua Gao, Ni Zheng, Qi Gao, Yuanquan Si and Yueran Zhao

    Biological Research 2017 50:31

    Published on: 21 September 2017

  5. Research article

    Neurochemical and behavioral characterization of neuronal glutamate transporter EAAT3 heterozygous mice

    Obsessive–compulsive disorder (OCD) is a severe neuropsychiatric condition affecting 1–3% of the worldwide population. OCD has a strong genetic component, and the SLC1A1 gene that encodes neuronal glutamate trans...

    Luis F. González, Francisca Henríquez-Belmar, Claudia Delgado-Acevedo, Marisol Cisternas-Olmedo, Gloria Arriagada, Ramón Sotomayor-Zárate, Dennis L. Murphy and Pablo R. Moya

    Biological Research 2017 50:29

    Published on: 19 September 2017

  6. Research article

    Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation

    The Tridax procumbens extracts (TPE) are known for their ethno-medicinal properties to increase osteogenic functioning in mesenchymal stem cells. Recently, we found that the T. procumbens flavonoids (TPF) signifi...

    Md. Abdullah Al Mamun, Mohammad Jakir Hosen, Amina Khatun, M. Masihul Alam and Md. Abdul Alim Al-Bari

    Biological Research 2017 50:28

    Published on: 8 September 2017

  7. Research article

    Neuron-derived CCL2 contributes to microglia activation and neurological decline in hepatic encephalopathy

    CCL2 was up-regulated in neurons and involved in microglia activation and neurological decline in mice suffering from hepatic encephalopathy (HE). However, no data exist concerning the effect of neuron-derived...

    Li Zhang, Jinyun Tan, Xiaoping Jiang, Weiwei Qian, Ting Yang, Xijun Sun, Zhaohui Chen and Qiwen Zhu

    Biological Research 2017 50:26

    Published on: 4 September 2017

  8. Review

    A review on plant importance, biotechnological aspects, and cultivation challenges of jojoba plant

    Jojoba is considered a promising oil crop and is cultivated for diverse purposes in many countries. The jojoba seed produces unique high-quality oil with a wide range of applications such as medical and indust...

    Jameel R. Al-Obaidi, Mohammed Farouq Halabi, Nasser S. AlKhalifah, Shanavaskhan Asanar, Abdulrahman A. Al-Soqeer and M. F. Attia

    Biological Research 2017 50:25

    Published on: 24 August 2017

  9. Research article

    S100A8 inhibits PDGF-induced proliferation of airway smooth muscle cells dependent on the receptor for advanced glycation end-products

    Airway remodeling is a key feature of asthma, characterized by increased proliferation of airway smooth muscle cells (ASMCs). S100A8 is a calcium-binding protein with a potential to regulate cell proliferation...

    Yu-Dong Xu, Yu Wang, Lei-Miao Yin, Ling-Ling Peng, Gyoung-Hee Park and Yong-Qing Yang

    Biological Research 2017 50:23

    Published on: 21 June 2017

  10. Research article

    Rapid culture-based detection of living mycobacteria using microchannel electrical impedance spectroscopy (m-EIS)

    Multiple techniques exist for detecting Mycobacteria, each having its own advantages and drawbacks. Among them, automated culture-based systems like the BACTEC-MGIT™ are popular because they are inexpensive, reli...

    Roli Kargupta, Sachidevi Puttaswamy, Aiden J. Lee, Timothy E. Butler, Zhongyu Li, Sounak Chakraborty and Shramik Sengupta

    Biological Research 2017 50:21

    Published on: 10 June 2017

  11. Short report

    Meristem culture and subsequent micropropagation of Chilean strawberry (Fragaria chiloensis (L.) Duch.)

    Vegetative propagation of Fragaria sp. is traditionally carried out using stolons. This system of propagation, in addition to being slow, can spread plant diseases, particularly serious being viral. In vitro cult...

    Karla A. Quiroz, Miguel Berríos, Basilio Carrasco, Jorge B. Retamales, Peter D. S. Caligari and Rolando García-Gonzáles

    Biological Research 2017 50:20

    Published on: 2 June 2017

  12. Research article

    BRD4 inhibition suppresses cell growth, migration and invasion of salivary adenoid cystic carcinoma

    Bromodomain-containing protein 4 (BRD4) inhibition is a new therapeutic strategy for many malignancies. In this study, we aimed to explore the effect of BRD4 inhibition by JQ1 on in vitro cell growth, migratio...

    Limei Wang, Xiuyin Wu, Ruolin Wang, Chengzhe Yang, Zhi Li, Cunwei Wang, Fenghe Zhang and Pishan Yang

    Biological Research 2017 50:19

    Published on: 25 May 2017

  13. Review

    Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent

    Realgar is a naturally occurring arsenic sulfide (or Xionghuang, in Chinese). It contains over 90% tetra-arsenic tetra-sulfide (As4S4). Currently, realgar has been confirmed the antitumor activities, both in vitr...

    Peng Chen, Ruixiang Xu, Lei Yan, Zhengrong Wu, Yan Wei, Wenbin Zhao, Xin Wang, Qinjian Xie and Hongyu Li

    Biological Research 2017 50:17

    Published on: 22 May 2017

  14. Research article

    Expression of cocaine- and amphetamine-regulated transcript (CART) in hen ovary

    Cocaine- and amphetamine-regulated transcript (CART), discovered initially by via differential display RT-PCR analysis of brains of rats administered cocaine, is expressed mainly in central nervous system or n...

    Pengfei Li, Xuejing Yu, Jianshan Xie, Xiaolei Yao, Wenzhong Liu, Jianbo Yao, Zhiwei Zhu and Lihua Lyu

    Biological Research 2017 50:18

    Published on: 22 May 2017

  15. Research article

    Morphological, molecular and FTIR spectroscopic analysis during the differentiation of kidney cells from pluripotent stem cells

    Kidney diseases are a global health problem. Currently, over 2 million people require dialysis or transplant which are associated with high morbidity and mortality; therefore, new researches focused on regener...

    Monica Maribel Mata-Miranda, Gustavo Jesus Vazquez-Zapien, Marlon Rojas-Lopez, Virginia Sanchez-Monroy, David Guillermo Perez-Ishiwara and Raul Jacobo Delgado-Macuil

    Biological Research 2017 50:14

    Published on: 4 April 2017

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