The previous studies have demonstrated the reduction of thiamine diphosphate is specific to Alzheimer’s disease (AD) and causal factor of brain glucose hypometabolism, which is considered as a neurodegenerativ...
Authors: Qiujian Yu, Huimin Liu, Shaoming Sang, Lulan Chen, Yingya Zhao, Yun Wang and Chunjiu Zhong
Atherosclerotic cardiovascular disease is highly prevalent and its underlying pathogenesis involves dyslipidemia including pro-atherogenic high density lipoprotein (HDL) remodeling. Vitamins C and E have been ...
Authors: S. Contreras-Duarte, P. Chen, M. Andía, S. Uribe, P. Irarrázaval, S. Kopp, S. Kern, G. Marsche, D. Busso, C. Wadsack and A. Rigotti
New evidence demonstrates that aging and dyslipidemia are closely associated with oxidative stress, DNA damage and apoptosis in some cells and extravascular tissues. However, in monocytes, which are naturally ...
Authors: Thais A. Jacinto, Giselle S. Meireles, Ananda T. Dias, Rafaela Aires, Marcella L. Porto, Agata L. Gava, Elisardo C. Vasquez, Thiago Melo C. Pereira, Bianca P. Campagnaro and Silvana S. Meyrelles
miR-214 was demonstrated to be upregulated in models of renal disease and promoted fibrosis in renal injury independent of TGF-β signaling in vivo. However, the detailed role of miR-214 in acute kidney injury ...
Minimal residual disease is that not detected by conventional imaging studies and clinically the patient remains disease free. However, with time these dormant cells will awaken and disease progression occurs,...
Psoriasis is a complex, chronic inflammatory skin disease with substantial negative effects on patient quality of life. Long non-coding RNAs (lncRNAs) are able to be involved in multitudes of cellular processe...
With 29 Km2, the Fildes Peninsula is the largest ice free area in King George Island and probably in Antarctica. The region is house of six permanent bases including the only airport in the South Shetlands, which...
Authors: Diego Knop Henriques, Bárbara Guedes Costa Silva, Gustavo Emílio Zuñiga and Paulo Eduardo Aguiar Saraiva Câmara
Pectinase enzymes catalyze the breakdown of pectin, a key component of the plant cell wall. At industrial level, pectinases are used in diverse applications, especially in food-processing industry. Currently, ...
Authors: Gabriela Poveda, Carlos Gil-Durán, Inmaculada Vaca, Gloria Levicán and Renato Chávez
Diffuse intrinsic pontine glioma (DIPG) is the main cause of pediatric brain tumor death. This study was designed to identify key genes associated with DIPG.
Authors: Li Wei, Fei He, Wen Zhang, Wenhua Chen and Bo Yu
The domestic cat serves as an animal model for assisted reproductive studies of endangered felid species. To date, there are no data on the protein alterations following cryopreservation of oocytes in felid fa...
Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), an enzyme required for de novo purine biosynthesis, is associated with and involved in tumorigenesi...
Authors: Minjun Meng, Yanling Chen, Jianbo Jia, Lianghui Li and Sumei Yang
The exact cause of cancer is one of the most immutable medical questions of the century. Cancer as an evolutionary disease must have a purpose and understanding the purpose is more important than decoding the ...
Concerns have been raised about this article [1] relating to the appropriateness of the use of the shRNA (5′-GCGGAGGGTTTGAAAGAATATCTCGAGATATTCTTTCAAACCCTCCGCTTTTTT-3′) as a non-targeting control and similariti...
Authors: Xiaolan Zhao, Man Chen and Jishan Tan
Citation:Biological Research
2018
51:20
Published on: 22 June 2018
The
original article was published in Biological Research
2016
49:26
Concerns have been raised about this article [1] relating to the appropriateness of the use of the shRNA (5′-GCGGAGGGTTTGAAAGAATATCTCGAGATATTCTTTCAAACCCTCCGCTTTTTT-3′) as a non-targeting control and similariti...
Authors: Zeya Pan, Hao Pan, Jin Zhang, Yun Yang, Hui Liu, Yuan Yang, Gang Huang, Junsheng Ni, Jian Huang and Weiping Zhou
Citation:Biological Research
2018
51:19
Published on: 22 June 2018
The
original article was published in Biological Research
2015
48:18
Arsenic trioxide (As2O3), a drug that has been used in China for approximately two thousand years, induces cell death in a variety of cancer cell types, including neuroblastoma (NB). The tyrosine kinase receptor ...
Authors: Xilin Xiong, Yang Li, Ling Liu, Kai Qi, Chi Zhang, Yueqin Chen and Jianpei Fang
Improper control on reactive oxygen species (ROS) elimination process and formation of free radicals causes tissue dysfunction. Pineal hormone melatonin is considered a potent regulator of such oxidative dama...
Authors: Mahammed Moniruzzaman, Indranath Ghosal, Debjit Das and Suman Bhusan Chakraborty
Stathmin as a critical protein involved in microtubule polymerization, is necessary for survival of cancer cells. However, extremely little is known about Stathmin in glioblastoma. So, this study was designed ...
Translational research to develop pharmaceutical and surgical treatments for pterygium requires a reliable and easy to produce animal model. Extracellular matrix and fibroblast are important components of pter...
Authors: Judith Zavala, Julio C. Hernandez-Camarena, Brenda Salvador-Gálvez, José E. Pérez-Saucedo, Amin Vela-Martinez and Jorge E. Valdez-García
Neurokinin1 (NK1) receptor has played a vital role in the development of tumor. However, NKP608 as a NK1 receptor antagonist whether has the effect of the resistance of colorectal cancer is still unclear. Ther...
Authors: Xiao-Ling Niu, Jian-Feng Hou and Jing-Xiang Li
Neuroblastoma (NB) represents the most common extracranial solid tumor in children. Accumulating evidence shows that microRNAs (miRs) play an important role in the carcinogenesis of NB. Here, we investigated t...
Chemokine (C-C motif) receptor 6 (CCR6) is present in sperm and plays a significant role in sperm motility and chemotaxis acting in the reproductive tracts. However, the expression and functional significance ...
Authors: Ruiying Diao, Xueyong Cai, Lu Liu, Lihua Yang, YongGang Duan, Zhiming Cai, Yaoting Gui and Lisha Mou
Gastric cancer occupies the fourth highest morbidity rate of cancers worldwide. Clinical therapies of gastric cancer remain limited because of uncertainty of mechanisms and shortness of effective medicine. Thu...
Authors: Yu Li, Depeng Zhang, Kaikai Yu, Yudong Hu, Qiong Wu, Feng Qian and Zishu Wang
Diabetic nephropathy (DN) is the leading cause of end-stage renal failure, contributing to severe morbidity and mortality in diabetic patients. Berberine (BBR) has been well characterized to exert renoprotecti...
Authors: Liping Zhu, Jiakai Han, Rongrong Yuan, Lei Xue and Wuyan Pang
Heat stress proteins are implicated in stabilizing and refolding denatured proteins in vertebrates and invertebrates. Members of the Hsp70 gene family comprise the cognate heat shock protein (Hsc70) and induci...
Authors: Marcelo González-Aravena, Camila Calfio, Luis Mercado, Byron Morales-Lange, Jorn Bethke, Julien De Lorgeril and César A. Cárdenas
Low phosphorus availability is a major factor restricting rice growth. Dongxiang wild rice (Oryza rufipogon Griff.) has many useful genes lacking in cultivated rice, including stress resistance to phosphorus defi...
Authors: Qian-Wen Deng, Xiang-Dong Luo, Ya-Ling Chen, Yi Zhou, Fan-Tao Zhang, Biao-Lin Hu and Jian-Kun Xie
Cocaine-and amphetamine regulated transcript (CART) is an endogenous neuropeptide, which is widespread in animals, plays a key role in regulation of follicular atresia in cattle and sheep. Among animal ovaries, C...
Authors: Pengfei Li, Jinzhu Meng, Jiongjie Jing, Qingling Hao, Zhiwei Zhu, Jianbo Yao and Lihua Lyu
Peroxisome proliferator activated receptor alpha (PPARα), a regulator of enzymes involved in β oxidation, has been reported to influence lymphocyte activation. The purpose of this study was to determine whethe...
Authors: Ian N. Hines, Michael Kremer, Sherri M. Moore and Michael D. Wheeler
Aquaporins (AQP) are channel proteins belonging to the Major Intrinsic Protein (MIP) superfamily that play an important role in plant water relations. The main role of aquaporins in plants is transport of wate...
Authors: Ranganathan Kapilan, Maryam Vaziri and Janusz J. Zwiazek
The WNT pathway regulates intestinal stem cells and is frequently disrupted in intestinal adenomas. The pathway contains several potential biotargets for interference, including the poly-ADP ribosyltransferase...
Authors: Jens Henrik Norum, Ellen Skarpen, Andreas Brech, Raoul Kuiper, Jo Waaler, Stefan Krauss and Therese Sørlie
This study determined the regulatory effects of inducible T-cell co-stimulators (ICOS) in human hepatocellular carcinoma HepG2 cells using a RNA interference (RNAi) technique.
Authors: Yaning Wei, Yanan Wang, Aimin Zang, Yanhong Shang, Zizheng Song, Zhiyu Wang, Yangyang Wang and Hua Yang
Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive with poor prognosis. Long non-coding RNAs (lncRNAs), a group of non-coding RNAs, play important roles in the progression of PDAC. This study aimed t...
Authors: Yi Cai, Xiaomei Li, Peng Shen and Dong Zhang
Understanding the molecular basis underlying the formation of bone-forming osteocytes and lipid-storing adipocytes will help provide insights into the cause of disorders originating in stem/progenitor cells an...
Authors: Alma Madrigal, Lun Tan and Yuanxiang Zhao
Fresh frozen plasma (FFP) administration may increase the risk of nosocomial infections in parallel with the development of immune modulation. This could be driven by soluble mediators, possibly influencing th...
Authors: Mariana Patlán, Fausto Sánchez-Muñoz, Luis M. Amezcua-Guerra, Adriana Granados, Araceli Páez, Felipe Massó, Ana M. Mejía, Angeles Soster, Rafael Bojalil, Lenin Pavón, Luis A. Jiménez-Zamudio and Ricardo Márquez-Velasco
The marine environment is a rich source of bioactive natural products. Many of the marine bioactive compounds have been derived successfully from molluscs. Euchelus asper is a marine mollusc which is commonly fou...
Authors: Sweta Agrawal, Sachin Chaugule, Shashank More, Gargi Rane and Madhavi Indap
Programmed cell death 5 (PDCD5) is an apoptosis-related gene cloned from TF-1 cells whose primary biological functions are to promote apoptosis and immune regulation. The effects and mechanisms exerted by key ...
Authors: Feng Yuan, Junfeng Wang, Keshi Zhang, Zhao Li and Zhenpeng Guan
Ferredoxin NADP(H) oxidoreductases (EC 1.18.1.2) (FNR) are flavoenzymes present in photosynthetic organisms; they are relevant for the production of reduced donors to redox reactions, i.e. in photosynthesis, t...
Authors: María Alejandra Vorphal, Carola Bruna, Traudy Wandersleben, Jorge Dagnino-Leone, Francisco Lobos-González, Elena Uribe, José Martínez-Oyanedel and Marta Bunster
The nuclear architecture of meiotic prophase spermatocytes is based on higher-order patterns of spatial associations among chromosomal domains and consequently is prone to modification by chromosomal rearrange...
Authors: Soledad Berríos, Raúl Fernández-Donoso and Eliana Ayarza
Regenerating gene IA (REGIA) plays an important role in tissue regeneration and tumors prognosis of epithelium origin. However, the role of REGIA in nasopharyngeal carcinoma (NPC) is unclear. This study aims t...
Authors: Haijie Xing, Xiangdong Chen and Yaofeng Han
Melanoma took top position among the lethal cancers and, despite there have been some great attempts made to increase the natural life of patients with metastatic disease, long-lasting and complete remissions ...
Breast cancer (BC) is the most common malignancy among women worldwide. A major advance in the understanding of the genetic etiology of BC was the discovery of BRCA1 and BRCA2 (BRCA1/2) genes, which are considere...
Authors: Lilian Jara, Sebastian Morales, Tomas de Mayo, Patricio Gonzalez-Hormazabal, Valentina Carrasco and Raul Godoy
This study aimed to reveal the mitochondrial genomes (mtgenomes) of Tetrix japonica and Alulatettix yunnanensis, and the phylogenetics of Orthoptera species.
Authors: Yufang Sun, Dianfeng Liu, Bo Xiao and Guofang Jiang
Breast cancer remains a worldwide public health dilemma and is currently the most common tumour in the globe. Awareness of breast cancer, public attentiveness, and advancement in breast imaging has made a posi...
Authors: Muhammad Akram, Mehwish Iqbal, Muhammad Daniyal and Asmat Ullah Khan
Growing evidence has supported that long non-coding RNAs (lncRNAs) could play vital roles in the development, progression, and prognosis of colorectal cancer (CRC). However, little is known about the clinical ...
Authors: Xiaogang Shen, Yifeng Bai, Bin Luo and Xiaogang Zhou
Porcine Deltacoronavirus (PDCoV) is a newly emerged enteropathogenic coronavirus that causes diarrhea and mortality in neonatal piglets. PDCoV has spread to many countries around the world, leading to significant...
Authors: Fanfan Zhang, Yu Ye, Deping Song, Nannan Guo, Qi Peng, Anqi Li, Xingrong Zhou, Yanjun Chen, Min Zhang, Dongyan Huang and Yuxin Tang
MiR-320 is downregulated in multiple cancers, including glioma and acts as tumor suppressor through inhibiting tumor cells proliferation and inducing apoptosis. PBX3 (Pre-B cell leukemia homeobox 3), a putativ...
Authors: Cuicui Pan, Hua Gao, Ni Zheng, Qi Gao, Yuanquan Si and Yueran Zhao
Obsessive–compulsive disorder (OCD) is a severe neuropsychiatric condition affecting 1–3% of the worldwide population. OCD has a strong genetic component, and the SLC1A1 gene that encodes neuronal glutamate trans...
Authors: Luis F. González, Francisca Henríquez-Belmar, Claudia Delgado-Acevedo, Marisol Cisternas-Olmedo, Gloria Arriagada, Ramón Sotomayor-Zárate, Dennis L. Murphy and Pablo R. Moya
