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  1. Alpha‐kinase 1 (ALPK1) is a master regulator in inflammation and has been proved to promote renal fibrosis by promoting the production of IL-1β in diabetic nephropathy (DN) mice. Pyroptosis is involved in high...

    Authors: Xinyuan Cui, Yifu Li, Shuguang Yuan, Yao Huang, Xiaojun Chen, Yachun Han, Zhiwen Liu, Zheng Li, Yang Xiao, Youliang Wang, Lin Sun, Hong Liu and Xuejing Zhu
    Citation: Biological Research 2023 56:5
  2. Spermatogonial stem cells (SSCs) are critical for sustaining spermatogenesis. Even though several regulators of SSC have been identified in rodents, the regulatory mechanism of SSC in humans has yet to be disc...

    Authors: Ning Li, Qianyin Zhou, Zhang Yi, Huan Zhang and Dai Zhou
    Citation: Biological Research 2023 56:4
  3. Contrary to the advantageous anticancer activities of curcumin (Cur), limited bioavailability and solubility hindered its efficacy. Here, nontoxic dendrosomal nano carrier with Cur was used to overcome these p...

    Authors: Elahe Seyed Hosseini, Marziyeh Alizadeh Zarei, Hossein Tarrahimofrad, Javad Zamani, Hamed Haddad Kashani, Ejaz Ahmad and Hossein Nikzad
    Citation: Biological Research 2023 56:3
  4. The testes are highly susceptible to the adverse effects of chemotherapy and radiation at all stages of life. Exposure to these threats mainly occurs during cancer treatment and as an occupational hazard in ra...

    Authors: Hamdy Y. Ismail, Nora A. Shaker, Shaymaa Hussein, Adel Tohamy, Mohamed Fathi, Hamdy Rizk and Y. R. Wally
    Citation: Biological Research 2023 56:2
  5. Cell cycle is one of the main cellular mechanisms involved in tumor progression. Almost all of the active molecular pathways in tumor cells directly or indirectly target the cell cycle progression. Therefore, ...

    Authors: Amir Sadra Zangouei, Malihe Zangoue, Negin Taghehchian, Alireza Zangooie, Hamid Reza Rahimi, Ehsan Saburi, Mahya Sadat Alavi and Meysam Moghbeli
    Citation: Biological Research 2023 56:1
  6. Based on the inconsistent literature published thus far involving infertile patients, whether intracytoplasmic sperm injection (ICSI) allows overcoming total fertilization failure due to sperm DNA fragmentatio...

    Authors: Jordi Ribas-Maynou, Sergi Novo, Marc Torres, Albert Salas-Huetos, Sergi Rovira, Marta Antich and Marc Yeste
    Citation: Biological Research 2022 55:41
  7. Cartilaginous disorders comprise a wide range of diseases that affect normal joint movement, ear and nose shape; and they have great social and economic impact. Mesenchymal stem cells (MSCs) provide a promisin...

    Authors: Taghreed Ahmed Hassan, Mohamed Ahmed Maher, Amr Fekry El Karmoty, Zainab Sabry Othman Ahmed, Marwa A Ibrahim, Hamdy Rizk and Ayman Tolba Reyad
    Citation: Biological Research 2022 55:40
  8. Alzheimer’s disease (AD), the most common form of dementia, is characterized by the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates. Importantly, Aβ and tau species are able to ac...

    Authors: Catalina Novoa, Paulina Salazar, Pedro Cisternas, Camila Gherardelli, Roberto Vera-Salazar, Juan M. Zolezzi and Nibaldo C. Inestrosa
    Citation: Biological Research 2022 55:39
  9. Excitotoxicity-induced in vivo injury models are vital to reflect the pathophysiological features of acute spinal cord injury (SCI) in humans. The duration and concentration of chemical treatment controls the ...

    Authors: Anam Anjum, Yt Jun Cheah, Muhammad Da’in Yazid, Muhammad Fauzi Daud, Jalilah Idris, Min Hwei Ng, Amaramalar Selvi Naicker, Ohnmar Htwe Ismail, Ramesh Kumar Athi Kumar, Geok Chin Tan, Yin Ping Wong, Mohd Kaisan Mahadi and Yogeswaran Lokanathan
    Citation: Biological Research 2022 55:38
  10. Diabetes mellitus (DM) has glucose variability that is of such relevance that the appearance of vascular complications in patients with DM has been attributed to hyperglycemic and dysglycemic events. It is kno...

    Authors: Manuel Vásquez-Muñoz, Alexis Arce-Álvarez, Cristian Álvarez, Rodrigo Ramírez-Campillo, Fernando A. Crespo, Dayana Arias, Camila Salazar-Ardiles, Mikel Izquierdo and David C. Andrade
    Citation: Biological Research 2022 55:37
  11. The assessment of oocyte quality is, nowadays, a major challenge in aquaculture, oocyte cryopreservation, and environmental science. Oocyte quality is a determining factor in fertilization and embryo developme...

    Authors: Alessandra Gallo, Maria Consiglia Esposito, Raffaele Boni and Elisabetta Tosti
    Citation: Biological Research 2022 55:34
  12. Ionizing radiations (IR) have widespread useful applications in our daily life; however, they have unfavorable effects on reproductive health. Maintaining testicular health following IR exposure is an importan...

    Authors: Maggie E. Amer, Azza I. Othman, Hajer Mohammed Abozaid and Mohamed A. El-Missiry
    Citation: Biological Research 2022 55:33
  13. Designed mimetic molecules are attractive tools in biopharmaceuticals and synthetic biology. They require mass and functional production for the assessment of upcoming challenges in the near future. The DARPin...

    Authors: Maryam Ehsasatvatan, Bahram Baghban Kohnehrouz, Ashraf Gholizadeh, Hamideh Ofoghi and Dariush Shanehbandi
    Citation: Biological Research 2022 55:32
  14. Genetic modification of living organisms has been a prosperous activity for research and development of agricultural, industrial and biomedical applications. Three decades have passed since the first genetical...

    Authors: Pablo Rozas, Eduardo I. Kessi-Pérez and Claudio Martínez
    Citation: Biological Research 2022 55:31
  15. Xenotransplantation has been primarily performed using fresh donor tissue to study testicular development for about 20 years, and whether the cultured tissue would be a suitable donor is unclear. In this study...

    Authors: Yubo Ma, Juan Chen, Hecheng Li, Fangshi Xu, Tie Chong, Ziming Wang and Liandong Zhang
    Citation: Biological Research 2022 55:30
  16. Metastatic melanoma has a high mortality rate and poor survival. This is associated with efficient metastatic colonization, but the underlying mechanisms remain elusive. Communication between cancer stem cells...

    Authors: Xiaoshuang Li, Doudou Liu, Hao Chen, Bin Zeng, Qiting Zhao, Yuhan Zhang, Yuting Chen, Jianyu Wang and H. Rosie Xing
    Citation: Biological Research 2022 55:29
  17. Atopic dermatitis (AD) is highly comorbid with negative emotions such as anxiety and depression. Although acupuncture has demonstrated efficacy in AD, its influence on comorbid anxiety and depression remains u...

    Authors: Mijung Yeom, Sora Ahn, Sun-Young Jang, Jae-Hwan Jang, Youngrye Lee, Dae-Hyun Hahm and Hi-Joon Park
    Citation: Biological Research 2022 55:28

    The Correction to this article has been published in Biological Research 2022 55:36

  18. Cytokinin signal transduction is mediated by a two-component system (TCS). Two-component systems are utilized in plant responses to hormones as well as to biotic and abiotic environmental stimuli. In plants, resp...

    Authors: Lanjie Zhao, Lixue Guo, Xuke Lu, Waqar Afzal Malik, Yuexin Zhang, Jing Wang, Xiugui Chen, Shuai Wang, Junjuan Wang, Delong Wang and Wuwei Ye
    Citation: Biological Research 2022 55:27
  19. Unsubstantiated concerns have been raised on the potential correlation between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and infertility, leading to vaccine hesitancy in reproduc...

    Authors: Jialyu Huang, Leizhen Xia, Lifeng Tian, Hancheng Fan, Dingfei Xu, Xiaoyan Ai, Xingwu Wu, Jia Chen, Genbao Xing, Lingling Huang, Huijun Zuo, Jia Chen, Mengxi Li, Ke Zhang, Peipei Liu, Jiaying Lin…
    Citation: Biological Research 2022 55:26
  20. Recent advances in the synthesis of bioactive nanoparticles resulted in the discovery and introduction of new bioactive nanoparticles to the pharmaceutical industry. In this regard, this research is aimed to s...

    Authors: Ghasem Rahimi, Kalateh Shah Mohammad, Mahsa Zarei, Mohammad Shokoohi, Ehsan Oskoueian, Mahsa Rastegar Moghaddam Poorbagher and Ehsan Karimi
    Citation: Biological Research 2022 55:24
  21. Human Gut Microbiota (HGM) is composed of more than one thousand species, playing an important role in the health status of individuals. Dysbiosis (an HGM imbalance) is augmented as chronic kidney disease (CKD...

    Authors: María V. Miranda, Fernanda C. González, Osvaldo S. Paredes-Godoy, Mario A. Maulén, Claudio C. Vásquez† and Waldo A. Díaz-Vásquez
    Citation: Biological Research 2022 55:23
  22. Retinal neurodegeneration is induced by a variety of environmental insults and stresses, but the exact mechanisms are unclear. In the present study, we explored the involvement of cytosolic mitochondrial DNA (...

    Authors: Yue Guo, Dekang Gan, Fangyuan Hu, Yun Cheng, Jian Yu, Boya Lei, Qinmeng Shu, Ruiping Gu and Gezhi Xu
    Citation: Biological Research 2022 55:22
  23. The study of the stress responses in bacteria has given us a wealth of information regarding the mechanisms employed by these bacteria in aggressive or even non-optimal living conditions. This information has ...

    Authors: Derie E. Fuentes, Lillian G. Acuña and Iván L. Calderón
    Citation: Biological Research 2022 55:21
  24. Driver mutations are the genetic components responsible for tumor initiation and progression. These variants, which may be inherited, influence cancer risk and therefore underlie many familial cancers. The pre...

    Authors: Sebastian Morales-Pison, Patricio Gonzalez-Hormazabal, Julio C. Tapia, Alexis Salas-Burgos, Sandra Ampuero, Fernando Gómez, Enrique Waugh, José Miguel Reyes and Lilian Jara
    Citation: Biological Research 2022 55:20
  25. Acidophilic microorganisms like Leptospirillum sp. CF-1 thrive in environments with extremely low pH and high concentrations of dissolved heavy metals that can induce the generation of reactive oxygen species (RO...

    Authors: Rivera-Araya Javier, Riveros Matías, Ferrer Alonso, Chávez Renato and Levicán Gloria
    Citation: Biological Research 2022 55:19
  26. Glutamate and voltage-gated sodium channels, both have been the target of intense investigation for its involvement in carcinogenesis and progression of malignant disease. Breast cancer with increased level of...

    Authors: Irfan Irsyad Azahar, Nur Aishah Sharudin, Ahmad Hafiz Murtadha Noor Din, Ahmad Tarmizi Che Has, Siti Norasikin Mohd Nafi, Hasnan Jaafar and Noor Fatmawati Mokhtar
    Citation: Biological Research 2022 55:18
  27. This opinion review explores the microbiology of tellurite, TeO32− and selenite, SeO32− oxyanions, two similar Group 16 chalcogen elements, but with slightly different physicochemical properties that lead to intr...

    Authors: Janine Kessi, Raymond J. Turner and Davide Zannoni
    Citation: Biological Research 2022 55:17
  28. Betahistine is a clinical medication for the treatment of benign paroxysmal positional vertigo (BPPV). Otolin, a secreted glycoprotein with a C-terminal globular domain homologous to the immune complement C1q,...

    Authors: Jing Hui, Qi Lei, Zhi Ji and Dingjing Zi
    Citation: Biological Research 2022 55:16
  29. The assessment of sperm DNA integrity has been proposed as a complementary test to conventional mammalian semen analysis. In this sense, single-strand (SSB) and double-strand (DSB) DNA breaks, the two types of...

    Authors: Yentel Mateo-Otero, Marc Llavanera, Sandra Recuero, Ariadna Delgado-Bermúdez, Isabel Barranco, Jordi Ribas-Maynou and Marc Yeste
    Citation: Biological Research 2022 55:15
  30. Diabetic retinopathy (DR) is a specific microvascular complication arising from diabetes, and its pathogenesis is not completely understood. tRNA-derived stress-induced RNAs (tiRNAs), a new type of small nonco...

    Authors: Yan Xu, Haidong Zou, Qi Ding, Yuelan Zou, Chun Tang, Yuyu Lu and Xun Xu
    Citation: Biological Research 2022 55:14
  31. Tellurium is a rare metalloid that exerts high toxicity on cells, especially on bacteria, partly due to reactive oxygen species (ROS) generation. Moreover, it has also been observed that tellurite can target f...

    Authors: P. Muñoz-Diaz, K. Jiménez, R. Luraschi, F. Cornejo, M. Figueroa, C. Vera, A. Rivas-Pardo, J. M. Sandoval, C. Vásquez and F. Arenas
    Citation: Biological Research 2022 55:13
  32. The Atacama salt flat is located in northern Chile, at 2300 m above sea level, and has a high concentration of lithium, being one of the main extraction sites in the world. The effect of lithium on microorgani...

    Authors: N. Bruna, E. Galliani, P. Oyarzún, D. Bravo, F. Fuentes and J. M. Pérez-Donoso
    Citation: Biological Research 2022 55:12
  33. Functional bioengineered tooth regeneration using autologous or allogeneic alternative differentiated cells sources are thought to have a great potential in replacing conventional dentures. This study investig...

    Authors: Benson Koh, Farynna Hana Ab Rahman, Najwa Amira Matlan, Manissha Rajan, Aimi Yasmin Musta’ain, Mohamad Ridhwan Mohd Jeffry Lee, Roszalina Ramli, Siti Salmiah Mohd Yunus, Ruszymah Binti Hj Idrus and Muhammad Dain Yazid
    Citation: Biological Research 2022 55:11
  34. Listeria monocytogenes is a foodborne pathogen that causes listeriosis in humans. This pathogen activates multiple regulatory mechanisms in response to stress, and cobalamin biosynthesis might have a potential ro...

    Authors: L. Vásquez, A. Parra, A. M. Quesille-Villalobos, G. Gálvez, P. Navarrete, M. Latorre, M. Toro, M. González and A. Reyes-Jara
    Citation: Biological Research 2022 55:9
  35. Salmonella Typhimurium is a Gram-negative pathogen that causes a systemic disease in mice resembling typhoid fever. During its infective cycle, S. Typhimurium is phagocytized by macrophages and proliferates insid...

    Authors: A. C. Briones, D. Lorca, A. Cofre, C. E. Cabezas, G. I. Krüger, C. Pardo-Esté, M. S. Baquedano, C. R. Salinas, M. Espinoza, J. Castro-Severyn, F. Remonsellez, A. A. Hidalgo, E. H. Morales and C. P. Saavedra
    Citation: Biological Research 2022 55:8
  36. Aerobic metabolism generates reactive oxygen species that may cause critical harm to the cell. The aim of this study is the characterization of the stress responses in the model aromatic-degrading bacterium Parab...

    Authors: Valentina Méndez, Laura Rodríguez-Castro, Roberto E. Durán, Gabriel Padrón and Michael Seeger
    Citation: Biological Research 2022 55:7
  37. G protein coupled receptor kinase 2 (GRK2) has been demonstrated to play a crucial role in the development of chronic pain. Acupuncture is an alternative therapy widely used for pain management. In this study,...

    Authors: Yu Chen, Yang Zhou, Xiao-Chen Li, Xue Ma, Wen-Li Mi, Yu-Xia Chu, Yan-Qing Wang and Qi-Liang Mao-Ying
    Citation: Biological Research 2022 55:5
  38. The internal NAD(P)H dehydrogenase (NDA) gene family was a member of the NAD(P)H dehydrogenase (ND) gene family, mainly involved in the non-phosphorylated respiratory pathways in mitochondria and played crucia...

    Authors: Yapeng Fan, Yuexin Zhang, Cun Rui, Hong Zhang, Nan Xu, Jing Wang, Mingge Han, Xuke Lu, Xiugui Chen, Delong Wang, Shuai Wang, Lixue Guo, Lanjie Zhao, Hui Huang, Junjuan Wang, Liangqing Sun…
    Citation: Biological Research 2022 55:4
  39. Authors: Karla G. Schwarz, Katherin V. Pereyra, Camilo Toledo, David C. Andrade, Hugo S. Díaz, Esteban Díaz-Jara, Domiziana Ortolani, Angélica Rios-Gallardo, Paulina Arias, Alexandra Las Heras, Ignacio Vera, Fernando C. Ortiz, Nibaldo C. Inestrosa, Carlos P. Vio and Rodrigo Del Rio
    Citation: Biological Research 2022 55:3

    The original article was published in Biological Research 2021 54:43

  40. Chinese hamster ovary cell line has been used routinely as a bioproduction factory of numerous biopharmaceuticals. So far, various engineering strategies have been recruited to improve the production efficienc...

    Authors: Fatemeh Safari and Bahman Akbari
    Citation: Biological Research 2022 55:2
  41. Maize (Zea mays L.) is a widely cultivated cereal and has been used as an optimum heavy metal phytoremediation crop. Metallothionein (MT) proteins are small, cysteine-rich, proteins that play important roles in p...

    Authors: Canhong Gao, Kun Gao, Huixian Yang, Tangdan Ju, Jingyi Zhu, Zailin Tang, Liangxia Zhao and Qingquan Chen
    Citation: Biological Research 2022 55:1
  42. Entomopathogenic fungi (EPF) are the natural enemies of insect pests. Nevertheless, research on the use of EPF for simultaneous prevention of pest and disease agents on the same crop is limited. In this study,...

    Authors: Juan Aguilera-Sammaritano, Juan Caballero, María Deymié, Melisa Rosa, Fabio Vazquez, Delia Pappano, Bernardo Lechner and Marcia González-Teuber
    Citation: Biological Research 2021 54:44
  43. Chronic heart failure (CHF) is a global health problem. Increased sympathetic outflow, cardiac arrhythmogenesis and irregular breathing patterns have all been associated with poor outcomes in CHF. Several stud...

    Authors: Karla G. Schwarz, Katherin V. Pereyra, Camilo Toledo, David C. Andrade, Hugo S. Díaz, Esteban Díaz-Jara, Domiziana Ortolani, Angélica Rios-Gallardo, Paulina Arias, Alexandra Las Heras, Ignacio Vera, Fernando C. Ortiz, Nibaldo C. Inestrosa, Carlos P. Vio and Rodrigo Del Rio
    Citation: Biological Research 2021 54:43

    The Correction to this article has been published in Biological Research 2022 55:3