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  1. Retinopathy of Prematurity (ROP) is a proliferative retinal vascular disease occurring in the retina of premature infants and is the main cause of childhood blindness. Nowadays anti-VEGF and retinal photocoagu...

    Authors: Yatu Guo, Jiahui Qin, Ruiqiang Sun, Peng Hao, Zhixin Jiang, Yuchuan Wang, Zhiqi Gao, Huan Zhang, Keliang Xie and Wei Zhang
    Citation: Biological Research 2024 57:43
  2. Prenatal alcohol exposure (PAE) has serious physical consequences for children such as behavioral disabilities, growth disorders, neuromuscular problems, impaired motor coordination, and decreased muscle tone....

    Authors: Ronald Vargas-Foitzick, Bayron García-Ordenes, Donovan Iratchet, Angie Acuña, Spencer Alcayaga, Cristian Fernández, Karla Toledo, Marianela Rodríguez, Carolina Naranjo, René Bustamante and Paola A Haeger
    Citation: Biological Research 2024 57:41
  3. The brain cortex is responsible for many higher-level cognitive functions. Disruptions during cortical development have long-lasting consequences on brain function and are associated with the etiology of brain...

    Authors: Bastián I. Cortés, Rodrigo C. Meza, Carlos Ancatén-González, Nicolás M. Ardiles, María-Ignacia Aránguiz, Hideaki Tomita, David R. Kaplan, Francisca Cornejo, Alexia Nunez-Parra, Pablo R. Moya, Andrés E. Chávez and Gonzalo I. Cancino
    Citation: Biological Research 2024 57:40
  4. Spreading depression (SD) is an intriguing phenomenon characterized by massive slow brain depolarizations that affect neurons and glial cells. This phenomenon is repetitive and produces a metabolic overload th...

    Authors: Juan E. Tichauer, Matías Lira, Waldo Cerpa, Juan A. Orellana, Juan C. Sáez and Maximiliano Rovegno
    Citation: Biological Research 2024 57:39
  5. Helicase for meiosis 1 (HFM1), a putative DNA helicase expressed in germ-line cells, has been reported to be closely associated with premature ovarian insufficiency (POI). However, the underlying molecular mec...

    Authors: Chenyi Zhong, Huiyuan Wang, Xiong Yuan, Yuheng He, Jing Cong, Rui Yang, Wenjie Ma, Li Gao, Chao Gao, Yugui Cui, Jie Wu, Rongrong Tan and Danhua Pu
    Citation: Biological Research 2024 57:36
  6. Genetically modified pigs are considered ideal models for studying human diseases and potential sources for xenotransplantation research. However, the somatic cell nuclear transfer (SCNT) technique utilized to...

    Authors: Eunhye Kim, Lian Cai, Hyerin Choi, Mirae Kim and Sang-Hwan Hyun
    Citation: Biological Research 2024 57:35
  7. Studies have suggested that endoplasmic reticulum stress (ERS) is involved in neurological dysfunction and that electroacupuncture (EA) attenuates neuropathic pain (NP) via undefined pathways. However, the rol...

    Authors: Lin-Wei Ma, Yu-Fan Liu, Hui Zhang, Chang-Jun Huang, Ang Li, Xin-Zhe Qu, Jia-Piao Lin, Yan Yang and Yong-Xing Yao
    Citation: Biological Research 2024 57:34
  8. There is a need for novel treatments for neuroblastoma, despite the emergence of new biological and immune treatments, since refractory pediatric neuroblastoma is still a medical challenge. Phyto cannabinoids ...

    Authors: Elizabeth Tapia-Tapia, Pablo Aránguiz, Rodrigo Diaz, Luis Espinoza, Caroline R Weinstein-Oppenheimer and Mauricio Cuellar
    Citation: Biological Research 2024 57:33
  9. The liver serves as a metabolic hub within the human body, playing a crucial role in various essential functions, such as detoxification, nutrient metabolism, and hormone regulation. Therefore, protecting the ...

    Authors: Mohamed Hussein Abdelgalil, Reem H. Elhammamy, Hanan M. Ragab, Eman Sheta and Ahmed Wahid
    Citation: Biological Research 2024 57:32
  10. Members of the β-subfamily of connexins contain an intracellular pocket surrounded by amino acid residues from the four transmembrane helices. The presence of this pocket has not previously been investigated i...

    Authors: Felipe Villanelo, Peter J. Minogue, Jaime Maripillán, Mauricio Reyna-Jeldes, Joaquin Jensen-Flores, Isaac E. García, Eric C. Beyer, Tomás Pérez-Acle, Viviana M. Berthoud and Agustín D. Martínez
    Citation: Biological Research 2024 57:31
  11. Mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2), are present in most gliomas. IDH1 mutation is an important prognostic marker in glioma. However, its regulatory mechanism in glioma remains incomplet...

    Authors: Haiting Zhao, Li Meng, Peng Du, Xinbin Liao, Xin Mo, Mengqi Gong, Jiaxin Chen and Yiwei Liao
    Citation: Biological Research 2024 57:30
  12. We recently reported that upregulation of Musashi 2 (MSI2) protein in the rare neuromuscular disease myotonic dystrophy type 1 contributes to the hyperactivation of the muscle catabolic processes autophagy and...

    Authors: Nerea Moreno, Maria Sabater-Arcis, Teresa Sevilla, Manuel Perez Alonso, Jessica Ohana, Ariadna Bargiela and Ruben Artero
    Citation: Biological Research 2024 57:29
  13. The activated microglia have been reported as pillar factors in neuropathic pain (NP) pathology, but the molecules driving pain-inducible microglial activation require further exploration. In this study, we in...

    Authors: Yinghao Xing, Pei Li, Yuanyuan Jia, Kexin Zhang, Ming Liu and Jingjing Jiang
    Citation: Biological Research 2024 57:28
  14. Aberrant gluconeogenesis is considered among primary drivers of hyperglycemia under insulin resistant conditions, with multiple studies pointing towards epigenetic dysregulation. Here we examine the role of mi...

    Authors: Shaheen Wasil Kabeer, Shivam Sharma, Shalemraju Sriramdasu and Kulbhushan Tikoo
    Citation: Biological Research 2024 57:27
  15. Vitamin C (ascorbate) is a water-soluble antioxidant and an important cofactor for various biosynthetic and regulatory enzymes. Mice can synthesize vitamin C thanks to the key enzyme gulonolactone oxidase (Gul...

    Authors: Lucie Aumailley, Antoine Bodein, Pauline Adjibade, Mickaël Leclercq, Sylvie Bourassa, Arnaud Droit, Rachid Mazroui and Michel Lebel
    Citation: Biological Research 2024 57:26
  16. Prostate cancer (PCa) is a major urological disease that is associated with significant morbidity and mortality in men. LLGL2 is the mammalian homolog of Lgl. It acts as a tumor suppressor in breast and hepati...

    Authors: Geum-Lan Hong, Kyung-Hyun Kim, Yae-Ji Kim, Hui-Ju Lee, Sung-Pil Cho, Seung-Yun Han, Seung Woo Yang, Jong-Soo Lee, Shin-Kwang Kang, Jae-Sung Lim and Ju-Young Jung
    Citation: Biological Research 2024 57:25
  17. Despite the record speed of developing vaccines and therapeutics against the SARS-CoV-2 virus, it is not a given that such success can be secured in future pandemics. In addition, COVID-19 vaccination and appl...

    Authors: Binan Zhao, Haoran Peng, Yanjing Zhang, Jie Zhang, Desheng Kong, Sai Cao, Yan Li, Dan Yang, Chuanwen Sun, Xinyi Pu, Ping Zhao, Yan Xu, Kai Zhao and Liangzhi Xie
    Citation: Biological Research 2024 57:24
  18. Obesity, associated with the intake of a high-fat diet (HFD), and anxiety are common among those living in modern urban societies. Recent studies suggest a role of microbiome-gut-brain axis signaling, includin...

    Authors: Sylvana I. S. Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E. Hassell Jr., Christopher E. Stamper, Mathew R. Arnold, Jared D. Heinze, Christine L. Foxx, Margaret M. Lieb, Kristin E. Cler, Bree L. Karns, Sophia Jaekel, Kelsey M. Loupy, Fernanda C. S. Silva, Deoclécio Alves Chianca-Jr., Christopher A. Lowry and Rodrigo Cunha de Menezes
    Citation: Biological Research 2024 57:23
  19. Chromatin dynamics is deeply involved in processes that require access to DNA, such as transcriptional regulation. Among the factors involved in chromatin dynamics at gene regulatory regions are general regula...

    Authors: Andrea Oyarzún-Cisterna, Cristián Gidi, Fernanda Raiqueo, Roberto Amigo, Camila Rivas, Marcela Torrejón and José L. Gutiérrez
    Citation: Biological Research 2024 57:22
  20. Research on prostate cancer is mostly performed using cell lines derived from metastatic disease, not reflecting stages of tumor initiation or early progression. Establishment of cancer cell lines derived from...

    Authors: Simon Lange, Anna Kuntze, Neele Wüstmann, Theresa Reckers, Verena Humberg, Wilhelm G. Dirks, Sebastian Huss, Julia Vieler, Andres Jan Schrader, Martin Bögemann, Katrin Schlack and Christof Bernemann
    Citation: Biological Research 2024 57:21
  21. Diabetes mellitus (DM) is a global epidemic with increasing incidences. DM is a metabolic disease associated with chronic hyperglycemia. Aside from conventional treatments, there is no clinically approved cure...

    Authors: Omar I. Badr, Mohamed M. Kamal, Shohda A. El-Maraghy and Heba R. Ghaiad
    Citation: Biological Research 2024 57:20
  22. Astrocytes Ca2+ signaling play a central role in the modulation of neuronal function. Activation of metabotropic glutamate receptors (mGluR) by glutamate released during an increase in synaptic activity triggers ...

    Authors: Mariela Puebla, Manuel F. Muñoz, Mauricio A. Lillo, Jorge E. Contreras and Xavier F. Figueroa
    Citation: Biological Research 2024 57:19
  23. Patients with liver cirrhosis may show minimal hepatic encephalopathy (MHE) with mild cognitive impairment and motor incoordination. Rats with chronic hyperammonemia reproduce these alterations. Motor incoordi...

    Authors: Yaiza M. Arenas, Adrià López-Gramaje, Carmina Montoliu, Marta Llansola and Vicente Felipo
    Citation: Biological Research 2024 57:18
  24. Disseminated neoplasia (DN) is a proliferative cell disorder of the circulatory system of bivalve mollusks. The disease is transmitted between individuals and can also be induced by external chemical agents su...

    Authors: Gloria Arriagada, Johan Quezada, Nicolas Merino-Veliz, Fernando Avilés, Diana Tapia-Cammas, Jorge Gomez, Daniela Curotto, Juan A. Valdes, Pablo A. Oyarzún, Cristian Gallardo-Escárate, Michael J. Metzger and Marco Alvarez
    Citation: Biological Research 2024 57:17
  25. Protein-encoding genes only constitute less than 2% of total human genomic sequences, and 98% of genetic information was previously referred to as “junk DNA”. Meanwhile, non-coding RNAs (ncRNAs) consist of app...

    Authors: Qing Yao, Tailin He, Jian-You Liao, Rongdong Liao, Xiaohao Wu, Lijun Lin and Guozhi Xiao
    Citation: Biological Research 2024 57:16
  26. Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that...

    Authors: Gonzalo I. Gómez, Tanhia F. Alvear, Daniela A. Roa, Arantza Farias-Pasten, Sergio A. Vergara, Luis A. Mellado, Claudio J. Martinez-Araya, Juan Prieto-Villalobos, Claudia García-Rodríguez, Natalia Sánchez, Juan C. Sáez, Fernando C. Ortíz and Juan A. Orellana
    Citation: Biological Research 2024 57:15
  27. Galectins are soluble glycan-binding proteins that interact with a wide range of glycoproteins and glycolipids and modulate a broad spectrum of physiological and pathological processes. The expression and subc...

    Authors: Elisa Perez-Moreno, Claudia Oyanadel, Adely de la Peña, Ronny Hernández, Francisca Pérez-Molina, Claudia Metz, Alfonso González and Andrea Soza
    Citation: Biological Research 2024 57:14
  28. Endometrial fibrosis, a significant characteristic of intrauterine adhesion (IUA), is caused by the excessive differentiation and activation of endometrial stromal cells (ESCs). Glutaminolysis is the metabolic...

    Authors: Pei Chen, Chaoshuang Ye, Yunke Huang, Bingning Xu, Tianyu Wu, Yuanhang Dong, Yang Jin, Li Zhao, Changchang Hu, Jingxia Mao and Ruijin Wu
    Citation: Biological Research 2024 57:13
  29. Bacterial aromatic degradation may cause oxidative stress. The long-chain flavodoxin FldX1 of Paraburkholderia xenovorans LB400 counteracts reactive oxygen species (ROS). The aim of this study was to evaluate the...

    Authors: Laura Rodríguez-Castro, Roberto E. Durán, Valentina Méndez, Flavia Dorochesi, Daniela Zühlke, Katharina Riedel and Michael Seeger
    Citation: Biological Research 2024 57:12
  30. Extracellular vesicles (EVs) and their cargoes, including MicroRNAs (miRNAs) play a crucial role in cell-to-cell communication. We previously demonstrated the upregulation of bta-mir-148b in EVs from oviductal...

    Authors: Karina Cañón-Beltrán, Yulia N Cajas, Vasileios Almpanis, Sandra Guisado Egido, Alfonso Gutierrez-Adan, Encina M González and Dimitrios Rizos
    Citation: Biological Research 2024 57:11
  31. The senescence of renal tubular epithelial cells (RTECs) is crucial in the progression of diabetic kidney disease (DKD). Accumulating evidence suggests a close association between insufficient mitophagy and RT...

    Authors: Yuanyuan Luo, Lingxiao Zhang, Ning Su, Lerong Liu and Tongfeng Zhao
    Citation: Biological Research 2024 57:10
  32. Parkinson’s disease (PD) is characterized by death of dopaminergic neurons leading to dopamine deficiency, excessive α-synuclein facilitating Lewy body formation, etc. Latroeggtoxin-VI (LETX-VI), a proteinaceo...

    Authors: Dianmei Yu, Haiyan Wang, Yiwen Zhai, Zhixiang Lei, Minglu Sun, Si Chen, Panfeng Yin and Xianchun Wang
    Citation: Biological Research 2024 57:9
  33. The central nervous system (CNS) is home to neuronal and glial cells. Traditionally, glia was disregarded as just the structural support across the brain and spinal cord, in striking contrast to neurons, alway...

    Authors: Piotr Rogujski, Barbara Lukomska, Miroslaw Janowski and Luiza Stanaszek
    Citation: Biological Research 2024 57:8
  34. The convergence of hypervirulence and carbapenem resistance in the bacterial pathogen Klebsiella pneumoniae represents a critical global health concern. Hypervirulent K. pneumoniae (hvKp) strains, frequently from...

    Authors: Matías Gálvez-Silva, Patricio Arros, Camilo Berríos-Pastén, Aura Villamil, Paula I. Rodas, Ingrid Araya, Rodrigo Iglesias, Pamela Araya, Juan C. Hormazábal, Constanza Bohle, Yahua Chen, Yunn-Hwen Gan, Francisco P. Chávez, Rosalba Lagos and Andrés E. Marcoleta
    Citation: Biological Research 2024 57:7
  35. The monthly regeneration of human endometrial tissue is maintained by the presence of human endometrial mesenchymal stromal/stem cells (eMSC), a cell population co-expressing the perivascular markers CD140b an...

    Authors: Tianqi Li, Rachel W.S. Chan, Raymond H.W. Li, Ernest H.Y. Ng, Songying Zhang and William S.B. Yeung
    Citation: Biological Research 2024 57:6
  36. Basal energetic metabolism in sperm, particularly oxidative phosphorylation, is known to condition not only their oocyte fertilising ability, but also the subsequent embryo development. While the molecular pat...

    Authors: Yentel Mateo-Otero, Marc Llavanera, Marc Torres-Garrido and Marc Yeste
    Citation: Biological Research 2024 57:5
  37. Fibrous scars frequently form at the sites of bone nonunion when attempts to repair bone fractures have failed. However, the detailed mechanism by which fibroblasts, which are the main components of fibrous sc...

    Authors: Fei Huang, Guozhen Wei, Hai Wang, Ying Zhang, Wenbin Lan, Yun Xie and Gui Wu
    Citation: Biological Research 2024 57:4
  38. Sensorineural hearing loss (SNHL) poses a major threat to both physical and mental health; however, there is still a lack of effective drugs to treat the disease. Recently, novel biological therapies, such as ...

    Authors: Huan Liu, Huijuan Kuang, Yiru Wang, Lili Bao, Wanxin Cao, Lu Yu, Meihao Qi, Renfeng Wang, Xiaoshan Yang, Qingyuan Ye, Feng Ding, Lili Ren, Siying Liu, Furong Ma and Shiyu Liu
    Citation: Biological Research 2024 57:3
  39. Increasing evidence suggests a double-faceted role of alpha-synuclein (α-syn) following infection by a variety of viruses, including SARS-CoV-2. Although α-syn accumulation is known to contribute to cell toxic...

    Authors: Fiona Limanaqi, Silvia Zecchini, Irma Saulle, Sergio Strizzi, Claudia Vanetti, Micaela Garziano, Gioia Cappelletti, Debora Parolin, Sonia Caccia, Daria Trabattoni, Claudio Fenizia, Mario Clerici and Mara Biasin
    Citation: Biological Research 2024 57:2
  40. Tumor-derived small extracellular vesicles (sEVs) can promote tumorigenic and metastatic capacities in less aggressive recipient cells mainly through the biomolecules in their cargo. However, despite recent ad...

    Authors: Eduardo Durán-Jara, Matías del Campo, Valentina Gutiérrez, Ignacio Wichmann, César Trigo, Marcelo Ezquer and Lorena Lobos-González
    Citation: Biological Research 2024 57:1
  41. Growing evidence has suggested that Type I Interferon (I-IFN) plays a potential role in the pathogenesis of Down Syndrome (DS). This work investigates the underlying function of MX1, an effector gene of I-IFN,...

    Authors: Zhenglong Guo, Yongchang Zhu, Hai Xiao, Ranran Dai, Wenke Yang, Wei Xue, Xueying Zhang, Bingtao Hao and Shixiu Liao
    Citation: Biological Research 2023 56:67
  42. Abnormal remodeling of the pulmonary vasculature, characterized by the proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) along with dysregulated glycolysis, is a pathognomonic feat...

    Authors: Yi-Chia Wu, Wei-Ting Wang, Ming-Chun Yang, Yu-Tsun Su, Jwu-Lai Yeh, Jong-Hau Hsu and Jiunn-Ren Wu
    Citation: Biological Research 2023 56:66
  43. Impaired pattern separation occurs in the early stage of Alzheimer’s disease (AD), and hippocampal dentate gyrus (DG) neurogenesis participates in pattern separation. Here, we investigated whether spatial memo...

    Authors: Yanyi Ding, Long Li, Sinuo Wang, Yajun Cao, Minguang Yang, Yaling Dai, Huawei Lin, Jianhong Li, Yulu Liu, Zhifu Wang, Weilin Liu and Jing Tao
    Citation: Biological Research 2023 56:65
  44. Asthma is a heterogenous disease that characterized by airway remodeling. SYVN1 (Synoviolin 1) acts as an E3 ligase to mediate the suppression of endoplasmic reticulum (ER) stress through ubiquitination and de...

    Authors: Bing Dai, Si Liu, Wenxin Shen, Li Chen, Qianlan Zhou, Lina Han, Qinzhen Zhang and Lishen Shan
    Citation: Biological Research 2023 56:64
  45. In December 2022 the US Food and Drug Administration (FDA) removed the requirement that drugs in development must undergo animal testing before clinical evaluation, a declaration that now demands the establish...

    Authors: Javiera Obreque, Luis Vergara-Gómez, Nicolás Venegas, Helga Weber, Gareth I. Owen, Pablo Pérez-Moreno, Pamela Leal, Juan Carlos Roa and Carolina Bizama
    Citation: Biological Research 2023 56:63
  46. Atherosclerosis (AS), a significant contributor to cardiovascular disease (CVD), is steadily rising with the aging of the global population. Pyroptosis and apoptosis, both caspase-mediated cell death mechanism...

    Authors: Lin Cong, Xiankun Liu, Yiming Bai, Qin Qin, Lili Zhao, Ying Shi, Yunpeng Bai and Zhigang Guo
    Citation: Biological Research 2023 56:62
  47. The decline in the quantity and quality of mitochondria are closely associated with infertility, particularly in advanced maternal age. Transferring autologous mitochondria into the oocytes of infertile female...

    Authors: Zhixin Jiang, Cheng Shi, Hongjing Han, Min Fu, Honglan Zhu, Tingting Han, Jia Fei, Yining Huang, Zhiping Jin, Jianan He, Yanbin Wang, Xi Chen and Huan Shen
    Citation: Biological Research 2023 56:60