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  1. Metastatic melanoma has a high mortality rate and poor survival. This is associated with efficient metastatic colonization, but the underlying mechanisms remain elusive. Communication between cancer stem cells...

    Authors: Xiaoshuang Li, Doudou Liu, Hao Chen, Bin Zeng, Qiting Zhao, Yuhan Zhang, Yuting Chen, Jianyu Wang and H. Rosie Xing
    Citation: Biological Research 2022 55:29
  2. Atopic dermatitis (AD) is highly comorbid with negative emotions such as anxiety and depression. Although acupuncture has demonstrated efficacy in AD, its influence on comorbid anxiety and depression remains u...

    Authors: Mijung Yeom, Sora Ahn, Sun-Young Jang, Jae-Hwan Jang, Youngrye Lee, Dae-Hyun Hahm and Hi-Joon Park
    Citation: Biological Research 2022 55:28
  3. Cytokinin signal transduction is mediated by a two-component system (TCS). Two-component systems are utilized in plant responses to hormones as well as to biotic and abiotic environmental stimuli. In plants, resp...

    Authors: Lanjie Zhao, Lixue Guo, Xuke Lu, Waqar Afzal Malik, Yuexin Zhang, Jing Wang, Xiugui Chen, Shuai Wang, Junjuan Wang, Delong Wang and Wuwei Ye
    Citation: Biological Research 2022 55:27
  4. Unsubstantiated concerns have been raised on the potential correlation between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and infertility, leading to vaccine hesitancy in reproduc...

    Authors: Jialyu Huang, Leizhen Xia, Lifeng Tian, Hancheng Fan, Dingfei Xu, Xiaoyan Ai, Xingwu Wu, Jia Chen, Genbao Xing, Lingling Huang, Huijun Zuo, Jia Chen, Mengxi Li, Ke Zhang, Peipei Liu, Jiaying Lin…
    Citation: Biological Research 2022 55:26
  5. Recent advances in the synthesis of bioactive nanoparticles resulted in the discovery and introduction of new bioactive nanoparticles to the pharmaceutical industry. In this regard, this research is aimed to s...

    Authors: Ghasem Rahimi, Kalateh Shah Mohammad, Mahsa Zarei, Mohammad Shokoohi, Ehsan Oskoueian, Mahsa Rastegar Moghaddam Poorbagher and Ehsan Karimi
    Citation: Biological Research 2022 55:24
  6. Human Gut Microbiota (HGM) is composed of more than one thousand species, playing an important role in the health status of individuals. Dysbiosis (an HGM imbalance) is augmented as chronic kidney disease (CKD...

    Authors: María V. Miranda, Fernanda C. González, Osvaldo S. Paredes-Godoy, Mario A. Maulén, Claudio C. Vásquez† and Waldo A. Díaz-Vásquez
    Citation: Biological Research 2022 55:23
  7. Retinal neurodegeneration is induced by a variety of environmental insults and stresses, but the exact mechanisms are unclear. In the present study, we explored the involvement of cytosolic mitochondrial DNA (...

    Authors: Yue Guo, Dekang Gan, Fangyuan Hu, Yun Cheng, Jian Yu, Boya Lei, Qinmeng Shu, Ruiping Gu and Gezhi Xu
    Citation: Biological Research 2022 55:22
  8. The study of the stress responses in bacteria has given us a wealth of information regarding the mechanisms employed by these bacteria in aggressive or even non-optimal living conditions. This information has ...

    Authors: Derie E. Fuentes, Lillian G. Acuña and Iván L. Calderón
    Citation: Biological Research 2022 55:21
  9. Driver mutations are the genetic components responsible for tumor initiation and progression. These variants, which may be inherited, influence cancer risk and therefore underlie many familial cancers. The pre...

    Authors: Sebastian Morales-Pison, Patricio Gonzalez-Hormazabal, Julio C. Tapia, Alexis Salas-Burgos, Sandra Ampuero, Fernando Gómez, Enrique Waugh, José Miguel Reyes and Lilian Jara
    Citation: Biological Research 2022 55:20
  10. Acidophilic microorganisms like Leptospirillum sp. CF-1 thrive in environments with extremely low pH and high concentrations of dissolved heavy metals that can induce the generation of reactive oxygen species (RO...

    Authors: Rivera-Araya Javier, Riveros Matías, Ferrer Alonso, Chávez Renato and Levicán Gloria
    Citation: Biological Research 2022 55:19
  11. Glutamate and voltage-gated sodium channels, both have been the target of intense investigation for its involvement in carcinogenesis and progression of malignant disease. Breast cancer with increased level of...

    Authors: Irfan Irsyad Azahar, Nur Aishah Sharudin, Ahmad Hafiz Murtadha Noor Din, Ahmad Tarmizi Che Has, Siti Norasikin Mohd Nafi, Hasnan Jaafar and Noor Fatmawati Mokhtar
    Citation: Biological Research 2022 55:18
  12. This opinion review explores the microbiology of tellurite, TeO32− and selenite, SeO32− oxyanions, two similar Group 16 chalcogen elements, but with slightly different physicochemical properties that lead to intr...

    Authors: Janine Kessi, Raymond J. Turner and Davide Zannoni
    Citation: Biological Research 2022 55:17
  13. Betahistine is a clinical medication for the treatment of benign paroxysmal positional vertigo (BPPV). Otolin, a secreted glycoprotein with a C-terminal globular domain homologous to the immune complement C1q,...

    Authors: Jing Hui, Qi Lei, Zhi Ji and Dingjing Zi
    Citation: Biological Research 2022 55:16
  14. The assessment of sperm DNA integrity has been proposed as a complementary test to conventional mammalian semen analysis. In this sense, single-strand (SSB) and double-strand (DSB) DNA breaks, the two types of...

    Authors: Yentel Mateo-Otero, Marc Llavanera, Sandra Recuero, Ariadna Delgado-Bermúdez, Isabel Barranco, Jordi Ribas-Maynou and Marc Yeste
    Citation: Biological Research 2022 55:15
  15. Diabetic retinopathy (DR) is a specific microvascular complication arising from diabetes, and its pathogenesis is not completely understood. tRNA-derived stress-induced RNAs (tiRNAs), a new type of small nonco...

    Authors: Yan Xu, Haidong Zou, Qi Ding, Yuelan Zou, Chun Tang, Yuyu Lu and Xun Xu
    Citation: Biological Research 2022 55:14
  16. Tellurium is a rare metalloid that exerts high toxicity on cells, especially on bacteria, partly due to reactive oxygen species (ROS) generation. Moreover, it has also been observed that tellurite can target f...

    Authors: P. Muñoz-Diaz, K. Jiménez, R. Luraschi, F. Cornejo, M. Figueroa, C. Vera, A. Rivas-Pardo, J. M. Sandoval, C. Vásquez and F. Arenas
    Citation: Biological Research 2022 55:13
  17. The Atacama salt flat is located in northern Chile, at 2300 m above sea level, and has a high concentration of lithium, being one of the main extraction sites in the world. The effect of lithium on microorgani...

    Authors: N. Bruna, E. Galliani, P. Oyarzún, D. Bravo, F. Fuentes and J. M. Pérez-Donoso
    Citation: Biological Research 2022 55:12
  18. Functional bioengineered tooth regeneration using autologous or allogeneic alternative differentiated cells sources are thought to have a great potential in replacing conventional dentures. This study investig...

    Authors: Benson Koh, Farynna Hana Ab Rahman, Najwa Amira Matlan, Manissha Rajan, Aimi Yasmin Musta’ain, Mohamad Ridhwan Mohd Jeffry Lee, Roszalina Ramli, Siti Salmiah Mohd Yunus, Ruszymah Binti Hj Idrus and Muhammad Dain Yazid
    Citation: Biological Research 2022 55:11
  19. Listeria monocytogenes is a foodborne pathogen that causes listeriosis in humans. This pathogen activates multiple regulatory mechanisms in response to stress, and cobalamin biosynthesis might have a potential ro...

    Authors: L. Vásquez, A. Parra, A. M. Quesille-Villalobos, G. Gálvez, P. Navarrete, M. Latorre, M. Toro, M. González and A. Reyes-Jara
    Citation: Biological Research 2022 55:9
  20. Salmonella Typhimurium is a Gram-negative pathogen that causes a systemic disease in mice resembling typhoid fever. During its infective cycle, S. Typhimurium is phagocytized by macrophages and proliferates insid...

    Authors: A. C. Briones, D. Lorca, A. Cofre, C. E. Cabezas, G. I. Krüger, C. Pardo-Esté, M. S. Baquedano, C. R. Salinas, M. Espinoza, J. Castro-Severyn, F. Remonsellez, A. A. Hidalgo, E. H. Morales and C. P. Saavedra
    Citation: Biological Research 2022 55:8
  21. Aerobic metabolism generates reactive oxygen species that may cause critical harm to the cell. The aim of this study is the characterization of the stress responses in the model aromatic-degrading bacterium Parab...

    Authors: Valentina Méndez, Laura Rodríguez-Castro, Roberto E. Durán, Gabriel Padrón and Michael Seeger
    Citation: Biological Research 2022 55:7
  22. G protein coupled receptor kinase 2 (GRK2) has been demonstrated to play a crucial role in the development of chronic pain. Acupuncture is an alternative therapy widely used for pain management. In this study,...

    Authors: Yu Chen, Yang Zhou, Xiao-Chen Li, Xue Ma, Wen-Li Mi, Yu-Xia Chu, Yan-Qing Wang and Qi-Liang Mao-Ying
    Citation: Biological Research 2022 55:5
  23. The internal NAD(P)H dehydrogenase (NDA) gene family was a member of the NAD(P)H dehydrogenase (ND) gene family, mainly involved in the non-phosphorylated respiratory pathways in mitochondria and played crucia...

    Authors: Yapeng Fan, Yuexin Zhang, Cun Rui, Hong Zhang, Nan Xu, Jing Wang, Mingge Han, Xuke Lu, Xiugui Chen, Delong Wang, Shuai Wang, Lixue Guo, Lanjie Zhao, Hui Huang, Junjuan Wang, Liangqing Sun…
    Citation: Biological Research 2022 55:4
  24. Authors: Karla G. Schwarz, Katherin V. Pereyra, Camilo Toledo, David C. Andrade, Hugo S. Díaz, Esteban Díaz-Jara, Domiziana Ortolani, Angélica Rios-Gallardo, Paulina Arias, Alexandra Las Heras, Ignacio Vera, Fernando C. Ortiz, Nibaldo C. Inestrosa, Carlos P. Vio and Rodrigo Del Rio
    Citation: Biological Research 2022 55:3

    The original article was published in Biological Research 2021 54:43

  25. Chinese hamster ovary cell line has been used routinely as a bioproduction factory of numerous biopharmaceuticals. So far, various engineering strategies have been recruited to improve the production efficienc...

    Authors: Fatemeh Safari and Bahman Akbari
    Citation: Biological Research 2022 55:2
  26. Maize (Zea mays L.) is a widely cultivated cereal and has been used as an optimum heavy metal phytoremediation crop. Metallothionein (MT) proteins are small, cysteine-rich, proteins that play important roles in p...

    Authors: Canhong Gao, Kun Gao, Huixian Yang, Tangdan Ju, Jingyi Zhu, Zailin Tang, Liangxia Zhao and Qingquan Chen
    Citation: Biological Research 2022 55:1
  27. Entomopathogenic fungi (EPF) are the natural enemies of insect pests. Nevertheless, research on the use of EPF for simultaneous prevention of pest and disease agents on the same crop is limited. In this study,...

    Authors: Juan Aguilera-Sammaritano, Juan Caballero, María Deymié, Melisa Rosa, Fabio Vazquez, Delia Pappano, Bernardo Lechner and Marcia González-Teuber
    Citation: Biological Research 2021 54:44
  28. Chronic heart failure (CHF) is a global health problem. Increased sympathetic outflow, cardiac arrhythmogenesis and irregular breathing patterns have all been associated with poor outcomes in CHF. Several stud...

    Authors: Karla G. Schwarz, Katherin V. Pereyra, Camilo Toledo, David C. Andrade, Hugo S. Díaz, Esteban Díaz-Jara, Domiziana Ortolani, Angélica Rios-Gallardo, Paulina Arias, Alexandra Las Heras, Ignacio Vera, Fernando C. Ortiz, Nibaldo C. Inestrosa, Carlos P. Vio and Rodrigo Del Rio
    Citation: Biological Research 2021 54:43

    The Correction to this article has been published in Biological Research 2022 55:3

  29. Diosmetin is a bioflavonoid compound naturally abundant in citrus fruits. It is found to perform a variety of activities, while its antitumor property in osteosarcoma, a malignant tumor with unmet clinical tre...

    Authors: Rende Ning, Guang Chen, Run Fang, Yanhui Zhang, Wenjuan Zhao and Feng Qian
    Citation: Biological Research 2021 54:40
  30. The aim of the study was to investigate the effect of mild cerebral hypoxia on haemoglobin oxygenation (HbO2), cerebrospinal fluid dynamics and cardiovascular physiology. To achieve this goal, four signals were r...

    Authors: Agnieszka Gruszecka, Monika Waskow, Marta A. Malkiewicz, J. Patrick Neary, Jyotpal Singh, Taylor Teckchandani, Gregory P. Kratzig, Magdalena Wszedybyl-Winklewska, Andrzej F. Frydrychowski, Jacek Rumiński, Natalia Głowacka, Piotr Lass, Pawel J. Winklewski and Marcin Gruszecki
    Citation: Biological Research 2021 54:39
  31. Defective chloride transport in airway epithelial cells (AECs) and the associated lung disease are the main causes of morbidity and early mortality in cystic fibrosis (CF). Abnormal airway iron homeostasis and...

    Authors: Pramila Maniam, Ama-Tawiah Essilfie, Murugan Kalimutho, Dora Ling, David M. Frazer, Simon Phipps, Gregory J. Anderson and David W. Reid
    Citation: Biological Research 2021 54:38
  32. Breast cancer is the most frequently diagnosed cancer, and no effective treatment solution has yet been found. The number of studies based on the research of novel natural compounds in the treatment of breast ...

    Authors: Demet Cansaran-Duman, Sevcan Yangın and Betül Çolak
    Citation: Biological Research 2021 54:37
  33. Melatonin 2-hydroxylase (M2H) is the first enzyme in the catabolism pathway of melatonin, which catalyzes the production of 2-hydroxymelatonin (2-OHM) from melatonin. The content of 2-hydroxymelatonin in plant...

    Authors: Yuexin Zhang, Jing Wang, Xiugui Chen, Xuke Lu, Delong Wang, Junjuan Wang, Shuai Wang, Chao Chen, Lixue Guo, Waqar Afzal Malik, Yapeng Fan, Cun Rui, Ruifeng Cui, Qinqin Wang, Yuqian Lei and Wuwei Ye
    Citation: Biological Research 2021 54:36
  34. Urushiols are pro-electrophilic haptens that cause severe contact dermatitis mediated by CD8+ effector T-cells and downregulated by CD4+ T-cells. However, the molecular mechanism by which urushiols stimulate inna...

    Authors: Rodrigo Pacheco, Sergio A. Quezada, Alexis M. Kalergis, María Inés Becker, Jorge Ferreira and Alfredo E. De Ioannes
    Citation: Biological Research 2021 54:35
  35. Xanthophyllomyces dendrorhous is a basidiomycete yeast that naturally produces the red–orange carotenoid astaxanthin, which has remarkable antioxidant properties. The biosynthesis of carotenoids and sterols share...

    Authors: Melissa Gómez, Marcelo Baeza, Víctor Cifuentes and Jennifer Alcaíno
    Citation: Biological Research 2021 54:34
  36. The antisense noncoding mitochondrial RNAs (ASncmtRNAs) derive from the mitochondrial 16S gene. Knockdown of these transcripts with chemically-modified antisense oligonucleotides induces proliferative arrest, ...

    Authors: Nicole Farfán, Nicole Sanhueza, Macarena Briones, Luis O. Burzio and Verónica A. Burzio
    Citation: Biological Research 2021 54:33
  37. Deep breathing (DB) and handgrip (HG) exercise -with and without circulatory occlusion (OC) in muscle-, have been shown to have beneficial effects on cardiovascular function; however, the combination of these ...

    Authors: David C. Andrade, Claudia Melipillan, Camilo Toledo, Angélica Rios-Gallardo, Noah J. Marcus, Fernando C. Ortiz, Gonzalo Martinez, Paula Muñoz Venturelli and Rodrigo Del Rio
    Citation: Biological Research 2021 54:32
  38. Heart failure (HF) is the leading cause of death in western countries. Cardiac dysfunction is accompanied by skeletal alterations resulting in muscle weakness and fatigue. Exercise is an accepted interventiona...

    Authors: Julia Böttner, Sarah Werner, Volker Adams, Sarah Knauth, Angela Kricke, Holger Thiele and Petra Büttner
    Citation: Biological Research 2021 54:31
  39. This study aims to identify the effect of miR-146a-5p on trophoblast cell invasion as well as the mechanism in preeclampsia (PE).

    Authors: Pingping Peng, Huamei Song, Chenghong Xie, Wenfei Zheng, Huigai Ma, Dandan Xin, Jingqiong Zhan, Xiaoqing Yuan, Aihua Chen, Jing Tao and Jufang Qin
    Citation: Biological Research 2021 54:30
  40. Improving the nutritional condition of grapevine in spring to regulate bloom, fruit set, and yield is among the management goals of vineyards.

    Authors: Rouhollah Karimi, Abbas Saberi and Ali Khadivi
    Citation: Biological Research 2021 54:28
  41. Demethylzeylasteral (T-96) is a pharmacologically active triterpenoid monomer extracted from Tripterygium wilfordii Hook F (TWHF) that has been reported to exhibit anti-neoplastic effects against several types of...

    Authors: Dong-lin Yang, Ya-jun Zhang, Liu-jun He, Chun-sheng Hu, Li-xia Gao, Jiu-hong Huang, Yan Tang, Jie Luo, Dian-yong Tang and Zhong-zhu Chen
    Citation: Biological Research 2021 54:27
  42. Breast cancer (BC), a heterogeneous, aggressive illness with high mortality, is essentially a genomic disease. While the high-penetrance genes BRCA1 and BRCA2 play important roles in tumorigenesis, moderate- and ...

    Authors: Trinidad Arancibia, Sebastian Morales-Pison, Edio Maldonado and Lilian Jara
    Citation: Biological Research 2021 54:26
  43. Peroxisome proliferator-activated receptor alpha (PPARα) is associated with diabetic retinopathy (DR), and the underlying mechanism is still unclear. Aim of this work was to investigate the mechanism of PPARα ...

    Authors: Ying Zhu, Xinru Wang, Xiaoyun Zhou, Lexi Ding, Dan Liu and Huizhuo Xu
    Citation: Biological Research 2021 54:25
  44. Accumulating evidence has demonstrated that the electroacupuncture (EA) stimulation could effectively alleviate neuropathic pain. The medial prefrontal cortex (mPFC) is a vital part of the cortical representat...

    Authors: Menghong Jiang, Xiaomei Chen, Liangping Zhang, Weiting Liu, Xiangmei Yu, Zhifu Wang and Meifeng Zheng
    Citation: Biological Research 2021 54:24