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  1. Content type: Research Article

    Hypoxia microenvironment plays a crucial role during tumor progression and it tends to exhibit poor prognosis and make resistant to various conventional therapies. HIF-1α acts as an important transcriptional r...

    Authors: Nishant Kumar Rana, Priya Singh and Biplob Koch

    Citation: Biological Research 2019 52:12

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  2. Content type: Research Article

    The present study aimed to investigate the underlying role of interferon-regulatory factor 2 (IRF2)–inositol polyphosphate-4-phosphatase, type-II (INPP4B) axis in the regulation of autophagy in acute myeloid l...

    Authors: Feng Zhang, Jiajia Li, Junfeng Zhu, Lin Liu, Kai Zhu, Shuang Cheng, RuDi Lv and Pingping Zhang

    Citation: Biological Research 2019 52:11

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  3. Content type: Research Article

    Non-canonical Wnt pathways play important roles in liver fibrosis. Notum is a newly discovered inhibitor to Wnt proteins. This study was to investigate anti-fibrotic effects of Notum.

    Authors: Wenting Li, Xiaolan Yu, Chuanlong Zhu, Zheng Wang, Zonghao Zhao, Yi Li and Yonghong Zhang

    Citation: Biological Research 2019 52:10

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  4. Content type: Research article

    Fava beans (FBs) have long been used as food, and their principal disadvantage is derived from their haemotoxicity. We hypothesized that FB ingestion alters the intestinal gene expression pattern, thereby indu...

    Authors: Guankui Du, Man Xiao, Qiwei Zhu, Chen Zhou, Ao Wang and Wangwei Cai

    Citation: Biological Research 2019 52:9

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  5. Content type: Letter to the Editor

    Cervical cancer (CC) ranks third in the morbidity and mortality of female cancer around the world. Derlin1 has been found to be overexpressed in several human cancers. However, it is still unclear about its ro...

    Authors: Ling Li, Ming Liu, Zhihu Zhang, Wei Zhang, Naifu Liu, Xiugui Sheng and Ping Wei

    Citation: Biological Research 2019 52:8

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  6. Content type: Research Article

    Currently, the prognosis of patients with non-small cell lung cancer (NSCLC) remains dismal; hence, it is critical to identify effective anti-NSCLC agents with limited side effects. This study aimed to evaluat...

    Authors: Xiaoli Liu, Qingfeng Jiang, Huaimin Liu and Suxia Luo

    Citation: Biological Research 2019 52:7

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  7. Content type: Research article

    Pollen development is an energy-consuming process that particularly occurs during meiosis. Low levels of adenosine triphosphate (ATP) may cause cell death, resulting in CMS (cytoplasmic male sterility). DNA se...

    Authors: Xiangjun Kong, Dongmei Liu, Jie Zheng, Aziz Khan, Bin Li, Yong Diao and Ruiyang Zhou

    Citation: Biological Research 2019 52:6

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  8. Content type: Research article

    A moderately thermophilic, slightly halophilic, aerobic, Gram-stain negative, bacterial strain, SLM16, was isolated from a mixed of seawater–sand-sediment sample collected from a coastal fumarole located in Wh...

    Authors: Sebastián L. Márquez and Jenny M. Blamey

    Citation: Biological Research 2019 52:5

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  9. Content type: Research article

    Epidermal growth factor receptor family members such as ErbB1 and ErbB3 are involved in tumor progression and metastasis. Although, there are various reports about the prognostic value of EGFR members separate...

    Authors: Meysam Moghbeli, Yasha Makhdoumi, Mehrdad Soltani Delgosha, Azadeh Aarabi, Ezzat Dadkhah, Bahram Memar, Abbas Abdollahi and Mohammad Reza Abbaszadegan

    Citation: Biological Research 2019 52:2

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  10. Content type: Research article

    Ethnomedicinally, the family Polygonaceae is famous for the management of cancer. Various species of this family have been reported with anticancer potentials. This study was designed to isolate anticancer com...

    Authors: Umar Farooq, Sadia Naz, Afshan Shams, Yasir Raza, Ayaz Ahmed, Umer Rashid and Abdul Sadiq

    Citation: Biological Research 2019 52:1

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  11. Content type: Research article

    Studies have demonstrated that transforming growth factor beta-1 (TGF-β1) exhibits oncogenic activity in different types of cancer, including ovarian cancer (OC). However, its regulatory mechanism in OC and wh...

    Authors: Yanqiu Wang, Jun Xiang, Jianjun Wang and Yazhong Ji

    Citation: Biological Research 2018 51:58

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  12. Content type: Research article

    chronic hypoxia increases basal ventilation and pulmonary vascular resistance, with variable changes in arterial blood pressure and heart rate, but it’s impact on heart rate variability and autonomic regulatio...

    Authors: Julio Alcayaga, Rodrigo Del Rio, Esteban A. Moya, Matías Freire and Rodrigo Iturriaga

    Citation: Biological Research 2018 51:57

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  13. Content type: Research article

    The Antarctic continent is a source of extreme microorganisms. Millions of years of isolation have produced unique biodiversity with adaptive responses to its extreme environment. Although the Antarctic climat...

    Authors: Patricio A. M. Flores, Daniela N. Correa-Llantén and Jenny M. Blamey

    Citation: Biological Research 2018 51:55

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  14. Content type: Research article

    Hyperpigmentation disorders such as post-inflammatory hyperpigmentation are major concerns not only in light-skinned people but also in Asian populations with darker skin. The anti-tyrosinase and immunomodulat...

    Authors: Pornanong Aramwit, Natthanej Luplertlop, Tapanee Kanjanapruthipong and Sumate Ampawong

    Citation: Biological Research 2018 51:54

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  15. Content type: Research article

    Phosphoinositide-3-kinase, regulatory subunit 1 (PIK3R1) could regulate cancer cell proliferation important for cancer cell proliferation; however, its role in Hepatocellular carcinoma (HCC) remains largely un...

    Authors: Xuejun Ai, Lei Xiang, Zhi Huang, Shi Zhou, Shuai Zhang, Tao Zhang and Tianpeng Jiang

    Citation: Biological Research 2018 51:52

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  16. Content type: Research article

    Antarctic bryophytes (mosses and liverworts) are resilient to physiologically extreme environmental conditions including elevated levels of ultraviolet (UV) radiation due to depletion of stratospheric ozone. M...

    Authors: Melinda J. Waterman, Jessica Bramley-Alves, Rebecca E. Miller, Paul A. Keller and Sharon A. Robinson

    Citation: Biological Research 2018 51:49

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  17. Content type: Research Article

    In field, C. quitensis is subjected to many abiotic extreme environmental conditions, such as low temperatures, high UV-B, salinity and reduced water potentials, but not metal or metalloid high concentrations in ...

    Authors: Rodrigo A. Contreras, Marisol Pizarro, Hans Köhler, Claudio A. Sáez and Gustavo E. Zúñiga

    Citation: Biological Research 2018 51:48

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  18. Content type: Review

    Increased levels of greenhouse gases in the atmosphere and associated climatic variability is primarily responsible for inducing heat waves, flooding and drought stress. Among these, water scarcity is a major ...

    Authors: Aziz Khan, Xudong Pan, Ullah Najeeb, Daniel Kean Yuen Tan, Shah Fahad, Rizwan Zahoor and Honghai Luo

    Citation: Biological Research 2018 51:47

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  19. Content type: Review

    The negative effects of environmental stresses, such as low temperature, high temperature, salinity, drought, heavy metal stress, and biotic stress significantly decrease crop productivity. Plant hormones are ...

    Authors: Ali Anwar, Yumei Liu, Rongrong Dong, Longqiang Bai, Xianchang Yu and Yansu Li

    Citation: Biological Research 2018 51:46

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  20. Content type: Research article

    Emerging evidence indicate that miRNAs play an important role on gastric cancer (GC) progression via regulating several downstream targets, but it is still partially uncovered. This study aimed to explore the ...

    Authors: Bin Song, Juan Du, De-feng Song, Ji-chen Ren and Ye Feng

    Citation: Biological Research 2018 51:44

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  21. Content type: Research article

    CircRNAs are widespread in plants and play important roles in response to abiotic stresses. Low nitrogen (LN) promotes the growth of plant root system, allowing it to explore more nitrogen. However, whether ci...

    Authors: Yongzhe Ren, Huifang Yue, Le Li, Yanhua Xu, Zhiqiang Wang, Zeyu Xin and Tongbao Lin

    Citation: Biological Research 2018 51:43

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  22. Content type: Short report

    Polymorphic microsatellite markers were developed for Gaultheria pumila (Ericaceae) to evaluate genetic diversity and population structure within its native range in Chile. This is a very important Ericaceae ende...

    Authors: Rolando Garcia-Gonzales, José Pico-Mendoza, Karla Quiroz, Basilio Carrasco, Pablo Cáceres, Borys Chong-Perez, Hugo Pino, Marjorie Seiltgens, Eglis Greck and Peter D. S. Caligari

    Citation: Biological Research 2018 51:42

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  23. Content type: Research article

    Osteoarthritis (OA) can be defined as degradation of articular cartilage of the joint, and is the most common degenerative disease. To regenerate the damaged cartilage, different experimental approaches includ...

    Authors: Dong-Sik Chae, Chang Youn Lee, Jiyun Lee, Hyang-Hee Seo, Chong-Hyuk Choi, Seahyoung Lee and Ki-Chul Hwang

    Citation: Biological Research 2018 51:41

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  24. Content type: Research article

    The biomechanical properties of maize stalks largely determine their lodging resistance, which affects crop yield per unit area. However, the quantitative and qualitative relationship between micro-phenotypes ...

    Authors: Ying Zhang, Jianjun Du, Jinglu Wang, Liming Ma, Xianju Lu, Xiaodi Pan, Xinyu Guo and Chunjiang Zhao

    Citation: Biological Research 2018 51:40

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  25. Content type: Research article

    SET domain bifurcated 1 (SETDB1) has been widely considered as an oncogene playing a critical role in many human cancers, including breast cancer. Nevertheless, the molecular mechanism by which SETDB1 regulate...

    Authors: Milu Wu, Baohua Fan, Qijing Guo, Yan Li, Rong Chen, Nannan Lv, Yinzhuo Diao and Yushuang Luo

    Citation: Biological Research 2018 51:39

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  26. Content type: Short report

    Hydrogen sulfide has been shown to improve the quality of oocytes destined for in vitro fertilization. Although hydrogen sulfide is capable of modulating ion channel activity in somatic cells, the role of hydr...

    Authors: Jan Nevoral, Tereza Zalmanova, Kristyna Hoskova, Miriam Stiavnicka, Petr Hosek, Ales Petelak and Jaroslav Petr

    Citation: Biological Research 2018 51:38

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  27. Content type: Research article

    Whole transcriptome RNA variant analyses have shown that adenosine deaminases acting on RNA (ADAR) enzymes modify a large proportion of cellular RNAs, contributing to transcriptome diversity and cancer evolution....

    Authors: Eduardo A. Sagredo, Alejandro Blanco, Alfredo I. Sagredo, Paola Pérez, Gonzalo Sepúlveda-Hermosilla, Fernanda Morales, Bettina Müller, Ricardo Verdugo, Katherine Marcelain, Olivier Harismendy and Ricardo Armisén

    Citation: Biological Research 2018 51:36

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  28. Content type: Research article

    The previous studies have demonstrated the reduction of thiamine diphosphate is specific to Alzheimer’s disease (AD) and causal factor of brain glucose hypometabolism, which is considered as a neurodegenerativ...

    Authors: Qiujian Yu, Huimin Liu, Shaoming Sang, Lulan Chen, Yingya Zhao, Yun Wang and Chunjiu Zhong

    Citation: Biological Research 2018 51:35

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  29. Content type: Research article

    Atherosclerotic cardiovascular disease is highly prevalent and its underlying pathogenesis involves dyslipidemia including pro-atherogenic high density lipoprotein (HDL) remodeling. Vitamins C and E have been ...

    Authors: S. Contreras-Duarte, P. Chen, M. Andía, S. Uribe, P. Irarrázaval, S. Kopp, S. Kern, G. Marsche, D. Busso, C. Wadsack and A. Rigotti

    Citation: Biological Research 2018 51:34

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  30. Content type: Research article

    New evidence demonstrates that aging and dyslipidemia are closely associated with oxidative stress, DNA damage and apoptosis in some cells and extravascular tissues. However, in monocytes, which are naturally ...

    Authors: Thais A. Jacinto, Giselle S. Meireles, Ananda T. Dias, Rafaela Aires, Marcella L. Porto, Agata L. Gava, Elisardo C. Vasquez, Thiago Melo C. Pereira, Bianca P. Campagnaro and Silvana S. Meyrelles

    Citation: Biological Research 2018 51:33

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  31. Content type: Review

    Minimal residual disease is that not detected by conventional imaging studies and clinically the patient remains disease free. However, with time these dormant cells will awaken and disease progression occurs,...

    Authors: Nigel P. Murray

    Citation: Biological Research 2018 51:32

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  32. Content type: Research article

    miR-214 was demonstrated to be upregulated in models of renal disease and promoted fibrosis in renal injury independent of TGF-β signaling in vivo. However, the detailed role of miR-214 in acute kidney injury ...

    Authors: Xiaoguang Zhu, Wenwen Li and Huicong Li

    Citation: Biological Research 2018 51:31

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  33. Content type: Research article

    Psoriasis is a complex, chronic inflammatory skin disease with substantial negative effects on patient quality of life. Long non-coding RNAs (lncRNAs) are able to be involved in multitudes of cellular processe...

    Authors: Jintao Gao, Fangru Chen, Mingchun Hua, Junfan Guo, Yuejuan Nong, Qinyan Tang, Fengxia Zhong and Linxiu Qin

    Citation: Biological Research 2018 51:30

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  34. Content type: Research article

    With 29 Km2, the Fildes Peninsula is the largest ice free area in King George Island and probably in Antarctica. The region is house of six permanent bases including the only airport in the South Shetlands, which...

    Authors: Diego Knop Henriques, Bárbara Guedes Costa Silva, Gustavo Emílio Zuñiga and Paulo Eduardo Aguiar Saraiva Câmara

    Citation: Biological Research 2018 51:29

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  35. Content type: Research article

    Pectinase enzymes catalyze the breakdown of pectin, a key component of the plant cell wall. At industrial level, pectinases are used in diverse applications, especially in food-processing industry. Currently, ...

    Authors: Gabriela Poveda, Carlos Gil-Durán, Inmaculada Vaca, Gloria Levicán and Renato Chávez

    Citation: Biological Research 2018 51:28

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  36. Content type: Research article

    The domestic cat serves as an animal model for assisted reproductive studies of endangered felid species. To date, there are no data on the protein alterations following cryopreservation of oocytes in felid fa...

    Authors: Bongkoch Turathum, Sittiruk Roytrakul, Chinarat Changsangfa, Morakot Sroyraya, Supita Tanasawet, Yindee Kitiyanant and Kulnasan Saikhun

    Citation: Biological Research 2018 51:27

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  37. Content type: Review

    The exact cause of cancer is one of the most immutable medical questions of the century. Cancer as an evolutionary disease must have a purpose and understanding the purpose is more important than decoding the ...

    Authors: Mukesh Yadav, Payal Chatterjee, Simran Tolani, Jaya Kulkarni, Meenakshi Mulye, Namrata Chauhan, Aditi Sakhi and Sakshi Gorey

    Citation: Biological Research 2018 51:23

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  38. Content type: Research Article

    To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease.

    Authors: Ruhui Lin, Long Li, Yingzheng Zhang, Sheng Huang, Shangjie Chen, Jiao Shi, Peiyuan Zhuo, Hao Jin, Zuanfang Li, Weilin Liu, Zhifu Wang, Lidian Chen and Jing Tao

    Citation: Biological Research 2018 51:21

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