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  1. Osteoporosis is a common metabolic bone disease, influenced by genetic and environmental factors, that increases bone fragility and fracture risk and, therefore, has a serious adverse effect on the quality of ...

    Authors: Yang Yang, Wang Yujiao, Wang Fang, Yuan Linhui, Guo Ziqi, Wei Zhichen, Wang Zirui and Wang Shengwang

    Citation: Biological Research 2020 53:40

    Content type: Review

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  2. The impaired glucose tolerance (IGT) is a representative prediabetes characterized by defective glucose homeostasis, and palmatine (PAL) is a natural isoquinoline alkaloid with multiple pharmacological effects...

    Authors: Xusheng Tian, Yukun Zhang, Han Li, Yunfeng Li, Ning Wang, Wei Zhang and Boyan Ma

    Citation: Biological Research 2020 53:39

    Content type: Research article

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  3. Long non-coding RNA (lncRNA) small nucleolar RNA host gene 14 (SNHG14) is associated with cerebral ischemia–reperfusion (CI/R) injury. This work aims to explore the role of SNHG14 in CI/R injury.

    Authors: Zexiang Deng, Hao Ou, Fei Ren, Yujiao Guan, Ye Huan, Hongwei Cai and Bei Sun

    Citation: Biological Research 2020 53:38

    Content type: Research article

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  4. Soil salinity causes huge economic losses to agriculture productivity in arid and semiarid areas worldwide. The affected plants face disturbances in osmotic adjustment, nutrient transport, ionic toxicity and r...

    Authors: Suliman A. Al-Khateeb, Abdullatif A. Al-Khateeb, Muhammad N. Sattar and Akbar S. Mohmand

    Citation: Biological Research 2020 53:37

    Content type: Research article

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  5. To investigate the thalamic neurotransmitters and functional connections in the development of chronic constriction injury (CCI)-induced neuropathic pain.

    Authors: Zhifu Wang, Sheng Huang, Xiangmei Yu, Long Li, Minguang Yang, Shengxiang Liang, Weilin Liu and Jing Tao

    Citation: Biological Research 2020 53:36

    Content type: Research article

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  6. Spinal cord injury (SCI) is a severe central nervous system trauma. The present study aimed to evaluate the effect of HIF-1α on inflammation in spinal cord injury (SCI) to uncover the molecular mechanisms of a...

    Authors: Xigong Li, Xianfeng Lou, Sanzhong Xu, Junhua Du and Junsong Wu

    Citation: Biological Research 2020 53:35

    Content type: Research article

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  8. Circulating RNA (circRNA) regulates various bioactivities in cells. A better understanding of the exosomal circRNA can provide novel insights into the pathogenesis and treatment of Graves’ disease (GD). We aim...

    Authors: Ying Sun, Wei Wang, Yuxiao Tang, Daping Wang, Liang Li, Min Na, Guantong Jiang, Qian Li, Shulin Chen and Jin Zhou

    Citation: Biological Research 2020 53:32

    Content type: Research article

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  9. In modern societies, sleep deprivation is a serious health problem. This problem could be induced by a variety of reasons, including lifestyle habits or neurological disorders. Chronic sleep deprivation (CSD) ...

    Authors: Mahboobeh Erfanizadeh, Ali Noorafshan, Mohammad Reza Namavar, Saied Karbalay-Doust and Tahereh Talaei-Khozani

    Citation: Biological Research 2020 53:31

    Content type: Research article

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  10. We developed simple sequence repeats (SSR) for Eremanthus erythropappus (DC.) MacLeish, an endangered tree species endemic to the Brazilian Savanna and Atlantic Forest biomes, and tested their transferability to ...

    Authors: Lucas Fernandes Rocha, Natália Ribeiro Paula, Alison Gonçalves Nazareno and Dulcinéia de Carvalho

    Citation: Biological Research 2020 53:30

    Content type: Short report

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  11. Arid environments are defined by the lack of water availability, which is directly related to the mean annual precipitation (MAP), and high values of solar irradiation, which impacts the community composition ...

    Authors: Javiera Vásquez-Dean, Felipe Maza, Isidora Morel, Rodrigo Pulgar and Mauricio González

    Citation: Biological Research 2020 53:29

    Content type: Review

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  12. Kidney ischemia–reperfusion injury is a common pathophysiological phenomenon in the clinic. A large number of studies have found that the tyrosine protein kinase/signal transducer and activator of transcriptio...

    Authors: Xiaoying Zhao, Erfei Zhang, Xiaofen Ren, Xiaoli Bai, Dongming Wang, Ling Bai, Danlei Luo, Zheng Guo, Qiang Wang and Jianxin Yang

    Citation: Biological Research 2020 53:28

    Content type: Research article

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  13. Circular RNA (circRNA) is highly expressed in the brain tissue, but its molecular mechanism in cerebral ischemia–reperfusion remains unclear. Here, we explored the role and underlying mechanisms of circRNA ant...

    Authors: Su Jiang, Gaonian Zhao, Jun Lu, Min Jiang, Zhenggang Wu, Yujing Huang, Jing Huang, Jinghua Shi, Jing Jin, Xinxuan Xu and Xuehua Pu

    Citation: Biological Research 2020 53:27

    Content type: Research article

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  14. There is an emerging field to put into practice new strategies for developing molecules with antimicrobial properties. In this line, several metals and metalloids are currently being used for these purposes, a...

    Authors: C. Muñoz-Villagrán, F. Contreras, F. Cornejo, M. Figueroa, D. Valenzuela-Bezanilla, R. Luraschi, C. Reinoso, J. Rivas-Pardo, C. Vásquez, M. Castro and F. Arenas

    Citation: Biological Research 2020 53:26

    Content type: Research article

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  15. Hypoxia inducible factor-1 (HIF-1) is considered as the most activated transcriptional factor in response to low oxygen level or hypoxia. HIF-1 binds the hypoxia response element (HRE) sequence in the promoter...

    Authors: Fatemeh Sadeghi, Gholam Ali Kardar, Mohammad Reza Bolouri, Farzad Nasri, Maryam Sadri and Reza Falak

    Citation: Biological Research 2020 53:25

    Content type: Research article

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  16. BMPR-1B is part of the transforming growth factor β super family and plays a pivotal role in ewe litter size. Functional loss of exon-8 mutations in the BMPR-1B gene (namely the FecB gene) can increase both th...

    Authors: Jianlei Jia, Jipeng Jin, Qian Chen, Zan Yuan, Haiqin Li, Junhao Bian and Linsheng Gui

    Citation: Biological Research 2020 53:24

    Content type: Research article

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  17. Abscisic acid-, stress-, and ripening-induced (ASR) genes are a class of plant specific transcription factors (TFs), which play important roles in plant development, growth and abiotic stress responses. The wheat...

    Authors: Huawei Li, Haiying Guan, Qicui Zhuo, Zongshuai Wang, Shengdong Li, Jisheng Si, Bin Zhang, Bo Feng, Ling-an Kong, Fahong Wang, Zheng Wang and Lishun Zhang

    Citation: Biological Research 2020 53:23

    Content type: Research article

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  18. Duchenne muscular dystrophy (DMD) is a devastating genetic muscular disorder with no effective treatment that is caused by the loss of dystrophin. Human induced pluripotent stem cells (hiPSCs) offer a promisin...

    Authors: Ruojie He, Huan Li, Liang Wang, Yaqin Li, Yu Zhang, Menglong Chen, Yuling Zhu and Cheng Zhang

    Citation: Biological Research 2020 53:22

    Content type: Research article

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  19. Liriodendron chinense ranges widely in subtropical China and northern Vietnam; however, it inhabits several small, isolated populations and is now an endangered species due to its limited seed production. The obj...

    Authors: Bin Li, Furong Lin, Ping Huang, Wenying Guo and Yongqi Zheng

    Citation: Biological Research 2020 53:21

    Content type: Research article

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  20. The role of interleukin family in colon cancer remained controversial. The purpose of this study was to investigate the association between interleukin family and colon cancer progression through bioinformatic...

    Authors: Xiyi Wei, Yuan Zhang, Zhou Yang, Yeqin Sha, Yitong Pan, Yusheng Chen and Lei Cai

    Citation: Biological Research 2020 53:20

    Content type: Research article

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  21. Breast cancer is the most common cancer types among women. Recent researches have focused on determining the efficiency of alternative molecules and miRNAs in breast cancer treatment. The aim of this study was...

    Authors: Elif Değerli, Vildan Torun and Demet Cansaran-Duman

    Citation: Biological Research 2020 53:19

    Content type: Research article

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  22. Cisplatin resistance (DDP-resistance) remains one of the major causes of poor prognosis in females with ovarian cancer. Long non-coding RNAs (lncRNAs) have been shown to participate in the regulation of cellul...

    Authors: Yun Zhang, Hao Ai, Xue Fan, Suxian Chen, Yadi Wang and Lili Liu

    Citation: Biological Research 2020 53:18

    Content type: Research article

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  23. Inflammation and apoptosis are considered to be two main factors affecting ischemic brain injury and the subsequent reperfusion damage. MiR-19a-3p has been reported to be a possible novel biomarker in ischemic...

    Authors: Zhaohui Chai, Jiangbiao Gong, Peidong Zheng and Jiesheng Zheng

    Citation: Biological Research 2020 53:17

    Content type: Research article

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  25. Current South American populations trace their origins mainly to three continental ancestries, i.e. European, Amerindian and African. Individual variation in relative proportions of each of these ancestries ma...

    Authors: Ricardo A. Verdugo, Alex Di Genova, Luisa Herrera, Mauricio Moraga, Mónica Acuña, Soledad Berríos, Elena Llop, Carlos Y. Valenzuela, M. Leonor Bustamante, Dayhana Digman, Adriana Symon, Soledad Asenjo, Pamela López, Alejandro Blanco, José Suazo, Emmanuelle Barozet…

    Citation: Biological Research 2020 53:15

    Content type: Research article

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  27. Gallbladder cancer (GBC) is the most common tumor of the biliary tract. The incidence of GBC shows a large geographic variability, being particularly frequent in Native American populations. In Chile, GBC repr...

    Authors: Patricia García, Carolina Bizama, Lorena Rosa, Jaime A. Espinoza, Helga Weber, Javier Cerda-Infante, Marianela Sánchez, Viviana P. Montecinos, Justo Lorenzo-Bermejo, Felix Boekstegers, Marcela Dávila-López, Francisca Alfaro, Claudia Leiva-Acevedo, Zasha Parra, Diego Romero, Sumie Kato…

    Citation: Biological Research 2020 53:13

    Content type: Research article

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  28. Mast cells (MCs) have been found to play a critical role during development of inflammatory bowel disease (IBD) that characterized by dysregulation of inflammation and impaired intestinal barrier function. How...

    Authors: Musheng Li, Junhong Zhao, Meiwan Cao, Ruitao Liu, Guanhua Chen, Songyu Li, Yuanwen Xie, Jing Xie, Yang Cheng, Ling Huang, Mingmin Su, Yuxin Xu, Mingyue Zheng, Kejian Zou, Lanlan Geng, Wanfu Xu…

    Citation: Biological Research 2020 53:12

    Content type: Research article

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  31. Rice is the staple food of many people around the world. However, most rice varieties, especially widely grown indica varieties and hybrids, are sensitive to cold stress. In order to provide a basis for the utili...

    Authors: Mengliang Xu, Xiangzhen Li, Xiang Mo, Siyu Tu, Yanchun Cui and Daichang Yang

    Citation: Biological Research 2020 53:8

    Content type: Research article

    Published on:

  32. Osteoarthritis (OA) is one of the most common rheumatic diseases of which clinical symptoms includes swelling, synovitis and inflammatory pain, affect patients’ daily life. It was reported that non-coding RNAs...

    Authors: Feng Tian, Junhu Wang, Zhanhua Zhang and Jie Yang

    Citation: Biological Research 2020 53:9

    Content type: Research article

    Published on:

  33. The intracellular concentration of heavy-metal cations, such as copper, nickel, and zinc is pivotal for the mycobacterial response to the hostile environment inside macrophages. To date, copper transport media...

    Authors: Andrés León-Torres, Epifania Arango, Eliana Castillo and Carlos Y. Soto

    Citation: Biological Research 2020 53:6

    Content type: Research article

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  34. LincRNAs have been revealed to be tightly associated with various tumorigeneses and cancer development, but the roles of specific lincRNA on tumor-related angiogenesis was hardly studied. Here, we aimed to inv...

    Authors: Qing Zhu, Jingchao Li, Qi Wu, Yongxia Cheng, Huizhe Zheng, Tao Zhan, Hongwei Wang, Yue Yang, Hongyan Wang, Ye Liu and Sufen Guo

    Citation: Biological Research 2020 53:5

    Content type: Research article

    Published on:

  35. Pigmentation development, is a complex process regulated by many transcription factors during development. With the development of the RNA sequencing (RNA-seq), non-coding RNAs, such as miRNAs, lncRNAs, and ci...

    Authors: Zhiwei Zhu, Yueyue Ma, Yuan Li, Pengfei Li, Zhixue Cheng, Huifeng Li, Lihuan Zhang and Zhongwei Tang

    Citation: Biological Research 2020 53:4

    Content type: Research article

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  36. The pellicle, the acellular organic material deposited on the surface of tooth enamel, has been thought to be derived from saliva. In this study, protein compositions of the pellicle, gingival crevicular fluid...

    Authors: Hibiki Odanaka, Takashi Obama, Naoko Sawada, Marika Sugano, Hiroyuki Itabe and Matsuo Yamamoto

    Citation: Biological Research 2020 53:3

    Content type: Research article

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  37. The budding yeast Saccharomyces cerevisiae has been considered for more than 20 years as a premier model organism for biological sciences, also being the main microorganism used in wide industrial applications, l...

    Authors: Eduardo I. Kessi-Pérez, Jennifer Molinet and Claudio Martínez

    Citation: Biological Research 2020 53:2

    Content type: Review

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  38. Long non-coding RNA small molecule RNA host gene 1 (SNHG1) was previously identified to be relevant with Parkinson’s disease (PD) pathogenesis. This work aims to further elucidate the regulatory networks of SN...

    Authors: Jun Zhao, Lijiao Geng, Yong Chen and Chunfang Wu

    Citation: Biological Research 2020 53:1

    Content type: Research article

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  40. Recent studies have confirmed that RASAL1 has an antitumor effect in many cancers, but its functional role and the molecular mechanism underlying in colon cancer has not been investigated.

    Authors: Guangchuan Wang, Zhen Li, Xiao Li, Chunqing Zhang and Lipan Peng

    Citation: Biological Research 2019 52:60

    Content type: Research article

    Published on:

  41. In varicose veins, vascular smooth muscle cells (VSMCs) often shows phenotypic transition and abnormal proliferation and migration. Evidence suggests the FOXC2–Notch pathway may be involved in the pathogenesis...

    Authors: Chuang Zhang, Huixiang Li and Xueli Guo

    Citation: Biological Research 2019 52:59

    Content type: Research article

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  42. Our previous study showed that knockdown of long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) attenuated myocardial apoptosis in mouse acute myocardial infarction (AMI...

    Authors: Hao Hu, Jiawei Wu, Xiaofan Yu, Junling Zhou, Hua Yu and Likun Ma

    Citation: Biological Research 2019 52:58

    Content type: Research article

    Published on:

  43. Gastric cancer is a common malignant tumor with high morbidity and mortality worldwide, which seriously affects human health. Gramicidin is a short peptide antibiotic which could be used for treating infection...

    Authors: Tingting Chen, Yong Wang, Yang Yang, Kaikai Yu, Xiangliao Cao, Fang Su, Huanbai Xu, Yongde Peng, Yudong Hu, Feng Qian and Zishu Wang

    Citation: Biological Research 2019 52:57

    Content type: Research article

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  44. ADP-glucose pyrophosphorylase (AGPase), the key enzyme in plant starch biosynthesis, is a heterotetramer composed of two identical large subunits and two identical small subunits. AGPase has plastidial and cyt...

    Authors: Jie Dong, Yongxing Zheng, Yihan Fu, Jinxi Wang, Shasha Yuan, Yonghua Wang, Qidi Zhu, Xingqi Ou, Gezi Li and Guozhang Kang

    Citation: Biological Research 2019 52:56

    Content type: Research article

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  45. Epanorin (EP) is a secondary metabolite of the Acarospora lichenic species. EP has been found in lichenic extracts with antimicrobial activity, and UV-absorption properties have been described for closely related...

    Authors: Juan Palacios-Moreno, Cecilia Rubio, Wanda Quilhot, M. Fernanda Cavieres, Eduardo de la Peña, Natalia V. Quiñones, Hugo Díaz, Flavio Carrión, Carlos F. Henríquez-Roldán and Caroline R. Weinstein-Oppenheimer

    Citation: Biological Research 2019 52:55

    Content type: Research article

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  47. Oxidative stress is the hallmark of diabetic encephalopathy, which may be caused by hyperglycaemic toxicity. We aimed to discover pharmacologic targets to restore redox homeostasis. We identified the transcrip...

    Authors: Jiangpei Zhao, Lerong Liu, Xia Li, Lingxiao Zhang, Jing Lv, Xueli Guo, Hui Chen and Tongfeng Zhao

    Citation: Biological Research 2019 52:53

    Content type: Research article

    Published on:

  48. Long noncoding RNAs (lncRNAs) have been reported to be associated with dermis process during burn wound healing. This study aimed to investigate the role of lncRNA X-inactive specific transcript (XIST) in huma...

    Authors: Wei Cao and Youping Feng

    Citation: Biological Research 2019 52:52

    Content type: Research article

    Published on:

  49. The leafcutter ant (Atta cephalotes) is associated with losses in the agricultural sector, due to its defoliating activity; for its control, biological, mechanical and chemical methods have been developed, the la...

    Authors: Fabian Felipe Fernandez Daza, Ginna Rodriguez Roman, Marino Valencia Rodriguez, Ivan Andres Gonzalez Vargas, Heiber Cardenas Heano, Marney Pascoli Cereda and Raul Alberto Cuervo Mulet

    Citation: Biological Research 2019 52:51

    Content type: Research article

    Published on:

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