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  1. Research article

    S100A8 inhibits PDGF-induced proliferation of airway smooth muscle cells dependent on the receptor for advanced glycation end-products

    Airway remodeling is a key feature of asthma, characterized by increased proliferation of airway smooth muscle cells (ASMCs). S100A8 is a calcium-binding protein with a potential to regulate cell proliferation...

    Yu-Dong Xu, Yu Wang, Lei-Miao Yin, Ling-Ling Peng, Gyoung-Hee Park and Yong-Qing Yang

    Biological Research 2017 50:23

    Published on: 21 June 2017

  2. Research article

    Rapid culture-based detection of living mycobacteria using microchannel electrical impedance spectroscopy (m-EIS)

    Multiple techniques exist for detecting Mycobacteria, each having its own advantages and drawbacks. Among them, automated culture-based systems like the BACTEC-MGIT™ are popular because they are inexpensive, reli...

    Roli Kargupta, Sachidevi Puttaswamy, Aiden J. Lee, Timothy E. Butler, Zhongyu Li, Sounak Chakraborty and Shramik Sengupta

    Biological Research 2017 50:21

    Published on: 10 June 2017

  3. Short report

    Meristem culture and subsequent micropropagation of Chilean strawberry (Fragaria chiloensis (L.) Duch.)

    Vegetative propagation of Fragaria sp. is traditionally carried out using stolons. This system of propagation, in addition to being slow, can spread plant diseases, particularly serious being viral. In vitro cult...

    Karla A. Quiroz, Miguel Berríos, Basilio Carrasco, Jorge B. Retamales, Peter D. S. Caligari and Rolando García-Gonzáles

    Biological Research 2017 50:20

    Published on: 2 June 2017

  4. Research article

    BRD4 inhibition suppresses cell growth, migration and invasion of salivary adenoid cystic carcinoma

    Bromodomain-containing protein 4 (BRD4) inhibition is a new therapeutic strategy for many malignancies. In this study, we aimed to explore the effect of BRD4 inhibition by JQ1 on in vitro cell growth, migratio...

    Limei Wang, Xiuyin Wu, Ruolin Wang, Chengzhe Yang, Zhi Li, Cunwei Wang, Fenghe Zhang and Pishan Yang

    Biological Research 2017 50:19

    Published on: 25 May 2017

  5. Review

    Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent

    Realgar is a naturally occurring arsenic sulfide (or Xionghuang, in Chinese). It contains over 90% tetra-arsenic tetra-sulfide (As4S4). Currently, realgar has been confirmed the antitumor activities, both in vitr...

    Peng Chen, Ruixiang Xu, Lei Yan, Zhengrong Wu, Yan Wei, Wenbin Zhao, Xin Wang, Qinjian Xie and Hongyu Li

    Biological Research 2017 50:17

    Published on: 22 May 2017

  6. Research article

    Expression of cocaine- and amphetamine-regulated transcript (CART) in hen ovary

    Cocaine- and amphetamine-regulated transcript (CART), discovered initially by via differential display RT-PCR analysis of brains of rats administered cocaine, is expressed mainly in central nervous system or n...

    Pengfei Li, Xuejing Yu, Jianshan Xie, Xiaolei Yao, Wenzhong Liu, Jianbo Yao, Zhiwei Zhu and Lihua Lyu

    Biological Research 2017 50:18

    Published on: 22 May 2017

  7. Research article

    Morphological, molecular and FTIR spectroscopic analysis during the differentiation of kidney cells from pluripotent stem cells

    Kidney diseases are a global health problem. Currently, over 2 million people require dialysis or transplant which are associated with high morbidity and mortality; therefore, new researches focused on regener...

    Monica Maribel Mata-Miranda, Gustavo Jesus Vazquez-Zapien, Marlon Rojas-Lopez, Virginia Sanchez-Monroy, David Guillermo Perez-Ishiwara and Raul Jacobo Delgado-Macuil

    Biological Research 2017 50:14

    Published on: 4 April 2017

  8. Research article

    Musk gland seasonal development and musk secretion are regulated by the testis in muskrat (Ondatra zibethicus)

    The muskrat is a seasonal breeder. Males secrete musk to attract females during the breeding season. The testosterone binding to the androgen receptor (AR) in musk glands of muskrat may play an important role ...

    Tianxiang Zhang, Dong Peng, Lei Qi, Weixuan Li, Mengyuan Fan, Jiachen Shen, Liangliang Yang, Yihua Wang, Wenxia Wang, Xiaolong Hu, Ruibo Cai, Ran Zhou, Yuting Wei, Juntong Zhou, Shuang Yang, Defu Hu…

    Biological Research 2017 50:10

    Published on: 4 March 2017

  9. Research article

    BJ-1108, a 6-Amino-2,4,5-trimethylpyridin-3-ol analogue, regulates differentiation of Th1 and Th17 cells to ameliorate experimental autoimmune encephalomyelitis

    CD4+ T cells play an important role in the initiation of an immune response by providing help to other cells. Among the helper T subsets, interferon-γ (IFN-γ)-secreting T helper 1 (Th1) and IL-17-secreting T help...

    Youra Kang, Maheshwor Timilshina, Tae-gyu Nam, Byeong-Seon Jeong and Jae-Hoon Chang

    Biological Research 2017 50:8

    Published on: 28 February 2017

  10. Short report

    De novo transcriptome assembly, functional annotation and differential gene expression analysis of juvenile and adult E. fetida, a model oligochaete used in ecotoxicological studies

    Earthworms are sensitive to toxic chemicals present in the soil and so are useful indicator organisms for soil health. Eisenia fetida are commonly used in ecotoxicological studies; therefore the assembly of a bas...

    Michelle Thunders, Jo Cavanagh and Yinsheng Li

    Biological Research 2017 50:7

    Published on: 27 February 2017

  11. Short report

    Differential roles for pathogenicity islands SPI-13 and SPI-8 in the interaction of Salmonella Enteritidis and Salmonella Typhi with murine and human macrophages

    Salmonella pathogenicity island (SPI)-13 is conserved in many serovars of S. enterica, including S. Enteritidis, S. Typhimurium and S. Gallinarum. However, it is absent in typhoid sero...

    Rodrigo A. Espinoza, Cecilia A. Silva-Valenzuela, Fernando A. Amaya, Ítalo M. Urrutia, Inés Contreras and Carlos A. Santiviago

    Biological Research 2017 50:5

    Published on: 15 February 2017

  12. Research article

    Metabotropic glutamate receptor 5 may be involved in macrophage plasticity

    Macrophages are a functionally heterogeneous cell population and depending on microenvironments they polarize in two main groups: M1 and M2. Glutamic acid and glutamate receptors may participate in the regulat...

    Lali Shanshiashvili, Elene Tsitsilashvili, Nino Dabrundashvili, Irine Kalandadze and David Mikeladze

    Biological Research 2017 50:4

    Published on: 14 February 2017

    The Erratum to this article has been published in Biological Research 2017 50:13

  13. Research article

    Uptake of DNA by cancer cells without a transfection reagent

    Cancer cells exhibit elevated levels of glucose uptake and may obtain pre-formed, diet-derived fatty acids from the bloodstream to boost their rapid growth; they may also use nucleic acid from their microenvir...

    Yanping Kong, Xianbo Zhang, Yongliang Zhao, Yanfang Xue and Ye Zhang

    Biological Research 2017 50:2

    Published on: 21 January 2017

  14. Short report

    A spleen tyrosine kinase inhibitor attenuates the proliferation and migration of vascular smooth muscle cells

    Pathologic vascular smooth muscle cell (VSMC) proliferation and migration after vascular injury promotes the development of occlusive vascular disease. Therefore, an effective chemical agent to suppress aberra...

    Hyang-Hee Seo, Sang Woo Kim, Chang Youn Lee, Kyu Hee Lim, Jiyun Lee, Eunhyun Choi, Soyeon Lim, Seahyoung Lee and Ki-Chul Hwang

    Biological Research 2017 50:1

    Published on: 18 January 2017

  15. Research article

    Klotho sensitive regulation of dendritic cell functions by vitamin E

    Dendritic cells (DCs) are the most potent professional antigen-presenting cells for naive T cells to link innate and acquired immunity. Klotho, an anti-aging protein, participates in the regulation of Ca2+ depend...

    Nguyen Thi Xuan, Phi Thi Thu Trang, Nguyen Van Phong, Nguyen Linh Toan, Do Minh Trung, Nguyen Duy Bac, Viet Linh Nguyen, Nguyen Huy Hoang and Nong Van Hai

    Biological Research 2016 49:45

    Published on: 24 November 2016

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