Articles

Allergens of the urushiol family promote mitochondrial dysfunction by inhibiting the electron transport at the level of cytochromes b and chemically modify cytochrome c₁

Urushiols are pro-electrophilic haptens that cause severe contact dermatitis mediated by CD8⁺ effector T-cells and downregulated by CD4⁺ T-cells. However, the molecular mechanism by which urushiols stimulate inna...

Authors: Rodrigo Pacheco, Sergio A. Quezada, Alexis M. Kalergis, María Inés Becker, Jorge Ferreira and Alfredo E. De Ioannes

The SREBP (Sterol Regulatory Element-Binding Protein) pathway: a regulatory bridge between carotenogenesis and sterol biosynthesis in the carotenogenic yeast Xanthophyllomyces dendrorhous

Xanthophyllomyces dendrorhous is a basidiomycete yeast that naturally produces the red–orange carotenoid astaxanthin, which has remarkable antioxidant properties. The biosynthesis of carotenoids and sterols share...

Authors: Melissa Gómez, Marcelo Baeza, Víctor Cifuentes and Jennifer Alcaíno

Antisense noncoding mitochondrial RNA-2 gives rise to miR-4485-3p by Dicer processing in vitro

The antisense noncoding mitochondrial RNAs (ASncmtRNAs) derive from the mitochondrial 16S gene. Knockdown of these transcripts with chemically-modified antisense oligonucleotides induces proliferative arrest, ...

Authors: Nicole Farfán, Nicole Sanhueza, Macarena Briones, Luis O. Burzio and Verónica A. Burzio

Heart rate and cardiac autonomic responses to concomitant deep breathing, hand grip exercise, and circulatory occlusion in healthy young adult men and women

Deep breathing (DB) and handgrip (HG) exercise -with and without circulatory occlusion (OC) in muscle-, have been shown to have beneficial effects on cardiovascular function; however, the combination of these ...

Authors: David C. Andrade, Claudia Melipillan, Camilo Toledo, Angélica Rios-Gallardo, Noah J. Marcus, Fernando C. Ortiz, Gonzalo Martinez, Paula Muñoz Venturelli and Rodrigo Del Rio

Structural and functional alterations in heart and skeletal muscle following severe TAC in mice: impact of moderate exercise training

Heart failure (HF) is the leading cause of death in western countries. Cardiac dysfunction is accompanied by skeletal alterations resulting in muscle weakness and fatigue. Exercise is an accepted interventiona...

Authors: Julia Böttner, Sarah Werner, Volker Adams, Sarah Knauth, Angela Kricke, Holger Thiele and Petra Büttner

miR-146a-5p-mediated suppression on trophoblast cell progression and epithelial-mesenchymal transition in preeclampsia

This study aims to identify the effect of miR-146a-5p on trophoblast cell invasion as well as the mechanism in preeclampsia (PE).

Authors: Pingping Peng, Huamei Song, Chenghong Xie, Wenfei Zheng, Huigai Ma, Dandan Xin, Jingqiong Zhan, Xiaoqing Yuan, Aihua Chen, Jing Tao and Jufang Qin

Retraction Note to: LncRNA HCG11 regulates proliferation and apoptosis of vascular smooth muscle cell through targeting miR‑144‑3p/FOXF1 axis in atherosclerosis

Authors: Yi Liu, Xiyun Cui, Cong Wang and Sihai Zhao

Effects of foliar spray of agricultural grade mineral oil in springtime, in combination with potassium and calcium sulfates on the phenological and biophysical indices of clusters, and foliar nutritional levels in grapevine (Vitis vinifera L.) cv. Sultana (Id. Thompson seedless, Sultanina)

Improving the nutritional condition of grapevine in spring to regulate bloom, fruit set, and yield is among the management goals of vineyards.

Authors: Rouhollah Karimi, Abbas Saberi and Ali Khadivi

Demethylzeylasteral (T-96) initiates extrinsic apoptosis against prostate cancer cells by inducing ROS-mediated ER stress and suppressing autophagic flux

Demethylzeylasteral (T-96) is a pharmacologically active triterpenoid monomer extracted from Tripterygium wilfordii Hook F (TWHF) that has been reported to exhibit anti-neoplastic effects against several types of...

Authors: Dong-lin Yang, Ya-jun Zhang, Liu-jun He, Chun-sheng Hu, Li-xia Gao, Jiu-hong Huang, Yan Tang, Jie Luo, Dian-yong Tang and Zhong-zhu Chen

Association between single-nucleotide polymorphisms in miRNA and breast cancer risk: an updated review

Breast cancer (BC), a heterogeneous, aggressive illness with high mortality, is essentially a genomic disease. While the high-penetrance genes BRCA1 and BRCA2 play important roles in tumorigenesis, moderate- and ...

Authors: Trinidad Arancibia, Sebastian Morales-Pison, Edio Maldonado and Lilian Jara

DNMT1-mediated PPARα methylation aggravates damage of retinal tissues in diabetic retinopathy mice

Peroxisome proliferator-activated receptor alpha (PPARα) is associated with diabetic retinopathy (DR), and the underlying mechanism is still unclear. Aim of this work was to investigate the mechanism of PPARα ...

Authors: Ying Zhu, Xinru Wang, Xiaoyun Zhou, Lexi Ding, Dan Liu and Huizhuo Xu

Electroacupuncture suppresses glucose metabolism and GLUT-3 expression in medial prefrontal cortical in rats with neuropathic pain

Accumulating evidence has demonstrated that the electroacupuncture (EA) stimulation could effectively alleviate neuropathic pain. The medial prefrontal cortex (mPFC) is a vital part of the cortical representat...

Authors: Menghong Jiang, Xiaomei Chen, Liangping Zhang, Weiting Liu, Xiangmei Yu, Zhifu Wang and Meifeng Zheng

Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies

The Ras family of small Guanosine Triphosphate (GTP)-binding proteins (G proteins) represents one of the main components of intracellular signal transduction required for normal cardiac growth, but is also cri...

Authors: Manuel Ramos-Kuri, Sri Harika Meka, Fabio Salamanca-Buentello, Roger J. Hajjar, Larissa Lipskaia and Elie R. Chemaly

Cisplatin-induced hydroxyl radicals mediate pro-survival autophagy in human lung cancer H460 cells

Accumulated evidence demonstrates cisplatin, a recommended chemotherapy, modulating pro-survival autophagic response that contributes to treatment failure in lung cancer patients. However, distinct mechanisms ...

Authors: Somruethai Sumkhemthong, Eakachai Prompetchara, Pithi Chanvorachote and Chatchai Chaotham

Circulating miR-146a as a possible candidate biomarker in the indeterminate phase of Chagas disease

Chagas disease is considered important and presents intense inflammatory and fibrotic processes induced by the perpetuation of the parasite in the affected tissues and organs. Therefore, it is necessary to inq...

Authors: Martha Alicia Ballinas-Verdugo, Rogelio Frank Jiménez-Ortega, Eduardo Martínez-Martínez, Nancy Rivas, Erick Abraham Contreras-López, Roxana Carbó, Fausto Sánchez, Rafael Bojalil, Ricardo Márquez-Velasco, Fausto Sánchez-Muñoz and Ricardo Alejandre-Aguilar

OUTBREAK: a user-friendly georeferencing online tool for disease surveillance

The current COVID-19 pandemic has already claimed more than 3.7 million victims and it will cause more deaths in the coming months. Tools that track the number and locations of cases are critical for surveilla...

Authors: Raúl Arias-Carrasco, Jeevan Giddaluru, Lucas E. Cardozo, Felipe Martins, Vinicius Maracaja-Coutinho and Helder I. Nakaya

Exploration of silicon functions to integrate with biotic stress tolerance and crop improvement

In the era of climate change, due to increased incidences of a wide range of various environmental stresses, especially biotic and abiotic stresses around the globe, the performance of plants can be affected b...

Authors: Xiu-Peng Song, Krishan K. Verma, Dan-Dan Tian, Xiao-Qiu Zhang, Yong-Jian Liang, Xing Huang, Chang-Ning Li and Yang-Rui Li

Identification of 5-methylcytosine-related signature for predicting prognosis in ovarian cancer

Ovarian cancer is one of the most common malignancies often resulting in a poor prognosis. 5-methylcytosine (m5C) is a common epigenetic modification with roles in eukaryotes. However, the expression and funct...

Authors: Lei Wang and Song Gao

Mvda is required for zebrafish early development

The MVD gene mutations are identified in porokeratosis, which is considered a skin-specific autoinflammatory keratinization disease. However, the biological function of MVD gene remains largely unknown. Therefore...

Authors: Wenghong Wong, Yike Huang, Zhuanbin Wu, Yu Kong, Jing Luan, Qiaoan Zhang, Jiewen Pan, Kexiang Yan and Zhenghua Zhang

Manuka honey enhanced sensitivity of HepG2, hepatocellular carcinoma cells, for Doxorubicin and induced apoptosis through inhibition of Wnt/β-catenin and ERK1/2

Recently, there is increasing awareness focused on the identification of naturally occurring anticancer agents derived from natural products. Manuka honey (MH) has been recognized for its biological properties...

Authors: Heba R. Al Refaey, Al-Sayeda A. Newairy, Mayssaa M. Wahby, Chris Albanese, Mohamed Elkewedi, Muhammad Umer Choudhry and Ahmed S. Sultan

Functional relationship between photosynthetic leaf gas exchange in response to silicon application and water stress mitigation in sugarcane

Water stress is one of the serious abiotic stresses that negatively influences the growth, development and production of sugarcane in arid and semi-arid regions. However, silicon (Si) has been applied as an al...

Authors: Krishan K. Verma, Xiu-Peng Song, Chhedi Lal Verma, Zhong-Liang Chen, Vishnu D. Rajput, Kai-Chao Wu, Fen Liao, Gan-Lin Chen and Yang-Rui Li

The role of circular RNA circ_0008285 in gestational diabetes mellitus by regulating the biological functions of trophoblasts

Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM).

Authors: Haitian Chen, Shaofeng Zhang, Yanxin Wu, Zhuyu Li, Dongyu Wang, Shiqin Cai and Zilian Wang

NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI-positive H. pylori

Helicobacter pylori is detected by pathogen recognition receptors including toll-like receptors (TLR) and nucleotide-binding oligomerization domain (NOD)-like receptors, eliciting an innate immune response agains...

Authors: Patricio Gonzalez-Hormazabal, Diana Pelaez, Maher Musleh, Marco Bustamante, Juan Stambuk, Raul Pisano, Hector Valladares, Enrique Lanzarini, Hector Chiong, Jose Suazo, Luis A. Quiñones, Nelson M. Varela, V. Gonzalo Castro, Lilian Jara and Zoltan Berger

Identification of blood-derived candidate gene markers and a new 7-gene diagnostic model for multiple sclerosis

Multiple sclerosis (MS) is a central nervous system disease with a high disability rate. Modern molecular biology techniques have identified a number of key genes and diagnostic markers to MS, but the etiology...

Authors: Xin Chen, Huiqing Hou, Huimin Qiao, Haolong Fan, Tianyi Zhao and Mei Dong

CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis

Atherosclerosis (AS) is the most common type in cardiovascular disease. Due to its complex pathogenesis, the exact etiology of AS is unclear. circRNA has been shown to play an essential role in most diseases. ...

Authors: Xiaohao Zhang, Junying Lu, Qinghua Zhang, Qiang Luo and Bin Liu

Long non‐coding RNA MALAT1 regulates cell proliferation and apoptosis via miR-135b-5p/GPNMB axis in Parkinson’s disease cell model

Parkinson’s disease (PD) is a common age-related neurodegenerative disorder worldwide. This research aimed to investigate the effects and mechanism underlying long non-coding RNA metastasis-associated lung ade...

Authors: Kefeng Lv, Yuhua Liu, Yanbing Zheng, Shaowen Dai, Peifeng Yin and Haifeng Miao

Deciphering the functional role of EGR1 in Prostaglandin F2 alpha induced luteal regression applying CRISPR in corpus luteum of buffalo

PGF2α is essential for the induction of the corpus luteum regression which in turn reduces progesterone production. Early growth response (EGR) proteins are Cys2-His2-type zinc-finger transcription factor that...

Authors: Meeti Punetha, Sai Kumar, Avishek Paul, Bosco Jose, Jaya Bharati, Arvind Sonwane, Jonathan A. Green, Kristin Whitworth and Mihir Sarkar

LncRNA MALAT1 aggravates oxygen‐glucose deprivation/reoxygenation-induced neuronal endoplasmic reticulum stress and apoptosis via the miR-195a-5p/HMGA1 axis

This study aimed to investigate the potential role and molecular mechanism of lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in cerebral ischemia/reperfusion injury.

Authors: Ying Jia, Lian Yi, Qianqian Li, Tingjiao Liu and Shanshan Yang

Lotus leaf flavonoids induce apoptosis of human lung cancer A549 cells through the ROS/p38 MAPK pathway

Leaves of the natural plant lotus are used in traditional Chinese medicine and tea production. They are rich in flavonoids.

Authors: Xiang-Bo Jia, Quan Zhang, Lei Xu, Wen-Jian Yao and Li Wei

Degradation of mitochondrial structure and deficiency of complex I were associated with the transgenic CMS of rice

Mitochondria play a significant role in plant cytoplasmic male sterility (CMS). In our previous study, mitochondrial complex I genes, nad4, nad5, and nad7 showed polymorphisms between the transgenic CMS line M2BS...

Authors: Danfeng Tang, Fan Wei, Aziz Khan, Fazal Munsif and Ruiyang Zhou

Exo70 intracellular redistribution after repeated mild traumatic brain injury

Exo70 is a subunit of the greater exocyst complex, a collection of proteins that oversees cellular membrane addition and polarized exocytosis by acting as a tethering intermediate between the plasma membrane a...

Authors: Matías Lira, Pedro Zamorano and Waldo Cerpa

Proteome profiling of different rat brain regions reveals the modulatory effect of prolonged maternal separation on proteins involved in cell death-related processes

Early-life stress in the form of maternal separation can be associated with alterations in offspring neurodevelopment and brain functioning. Here, we aimed to investigate the potential impact of prolonged mate...

Authors: Zdenka Drastichova, Vladimir Rudajev, Gergely Pallag and Jiri Novotny

Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy

Testosterone regulates nutrient and energy balance to maintain protein synthesis and metabolism in cardiomyocytes, but supraphysiological concentrations induce cardiac hypertrophy. Previously, we determined th...

Authors: Mayarling Francisca Troncoso, Mario Pavez, Carlos Wilson, Daniel Lagos, Javier Duran, Sebastián Ramos, Genaro Barrientos, Patricio Silva, Paola Llanos, Carla Basualto-Alarcón, B. Daan Westenbrink, Sergio Lavandero and Manuel Estrada

Low-temperature extracts of Purple blossoms of basil (Ocimum basilicum L.) intervened mitochondrial translocation contributes prompted apoptosis in human breast cancer cells

The preventive and therapeutic medical utilization of this plant is an age-long practice across the globe. This study aimed to validate the impact of dark purple blossoms of basil (Ocimum basilicum L.) aqueous ex...

Authors: Mariam Abdulaziz Alkhateeb, Wedad Refaiea Al-Otaibi, Qwait AlGabbani, Amena Ali Alsakran, Alaa Ahmed Alnafjan, Amani Mohammed Alotaibi and Wedad Saeed Al-Qahtani

Influence of kaolin application on most important fruit and leaf characteristics of two apple cultivars under sustained deficit irrigation

Apple is one of the oldest and most valuable fruits. Water restriction is one of the major problems in the production of this fruit in some planting areas.

Authors: Somayeh Faghih, Zabihollah Zamani, Reza Fatahi and Mohammad Omidi

Tauroursodeoxycholic acid attenuates neuronal apoptosis via the TGR5/ SIRT3 pathway after subarachnoid hemorrhage in rats

Neuronal apoptosis plays a critical event in the pathogenesis of early brain injury after subarachnoid hemorrhage (SAH). This study investigated the roles of Tauroursodeoxycholic acid (TUDCA) in attenuate neur...

Authors: Huihui Wu, Nini Yu, Xia Wang, Yina Yang and Hui Liang

Improvement of endothelial function by Gunnera tinctoria extract with antioxidant properties

Gunnera tinctoria has been collected by Mapuche-Pewenche people for food and medicinal purposes. The high polyphenol content of methanolic extract from G. tinctoria leaves with chemical constituents such as ellag...

Authors: Constanza Sabando, Maité Rodríguez-Díaz, Walther Ide, Edgar Pastene, Marcia Avello, Mario Simirgiotis, Susana Rojas, Enrique Villarroel, Tiare Silva-Grecchi, Cristian Gutiérrez, Rebeca Bouza, Bárbara Cicchelli, Marcelo González and Saddys Rodríguez-Llamazares

Actin filaments mediated root growth inhibition by changing their distribution under UV-B and hydrogen peroxide exposure in Arabidopsis

UV-B signaling in plants is mediated by UVR8, which interacts with transcriptional factors to induce root morphogenesis. However, research on the downstream molecules of UVR8 signaling in roots is still scarce...

Authors: Meiting Du, Yanhong Wang, Huize Chen and Rong Han

Knockdown of lncRNA TUG1 inhibits hippocampal neuronal apoptosis and participates in aerobic exercise-alleviated vascular cognitive impairment

Our previous study indicated that aerobic exercise relieves cognitive impairment in patients with vascular cognitive impairment (VCI) via regulating brain-derived neurotrophic factor (BDNF), but the mechanism ...

Authors: Jing Wang, Yali Niu, Huaying Tao, Mina Xue and Chunxiao Wan

Caspase-7 deficiency in Chinese hamster ovary cells reduces cell proliferation and viability

Chinese hamster ovary (CHO) cells are the most commonly used mammalian host cell in the commercial-scale production of biopharmaceutical proteins. Modification of genes involved in apoptosis may improve the pr...

Authors: Fatemeh Safari, Safar Farajnia, Abbas Behzad Behbahani, Habib Zarredar, Mazyar Barekati-Mowahed and Hesam Dehghani

Short-term perinatal oxygen exposure may impair lung development in adult mice

Hyperoxia at resuscitation increases oxidative stress, and even brief exposure to high oxygen concentrations during stabilization may trigger organ injury with adverse long-term outcomes in premature infants. ...

Authors: Vasantha H. S. Kumar, Huamei Wang and Lori Nielsen

Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance, mitochondrial dysfunction and oxidative stress

Acupuncture, a therapy of traditional Chinese medicine, is confirmed to exert the therapeutic action on polycystic ovary syndrome (PCOS). However, the detailed therapeutic mechanisms of acupuncture in PCOS rem...

Authors: Yan Peng, Xinming Yang, Xi Luo, Chunhong Liu, Xia Cao, Hongyan Wang and Liyuan Guo

LncRNA OIP5-AS1 upregulates snail expression by sponging miR-34a to promote ovarian carcinoma cell invasion and migration

Although OIP5-AS1 has been characterized as an oncogenic lncRNA in many types of cancer, its role and underlying mechanism in ovarian carcinoma (OC) remains unknown. This study aimed to investigate the role of...

Authors: Xingzhi Jiang, Zhongxue Ye, Yafen Jiang, Wen Yu and Qian Fang

Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice

Psoriasis is a common chronic inflammatory skin disease. Keratinocytes hyperproliferation and excessive inflammatory response contribute to psoriasis pathogenesis. The agents able to attenuate keratinocytes hy...

Authors: Jintao Gao, Fangru Chen, Huanan Fang, Jing Mi, Qi Qi and Mengjuan Yang

Fate of nitrogen in agriculture and environment: agronomic, eco-physiological and molecular approaches to improve nitrogen use efficiency

Nitrogen is the main limiting nutrient after carbon, hydrogen and oxygen for photosynthetic process, phyto-hormonal, proteomic changes and growth-development of plants to complete its lifecycle. Excessive and ...

Authors: Muhammad Anas, Fen Liao, Krishan K. Verma, Muhammad Aqeel Sarwar, Aamir Mahmood, Zhong-Liang Chen, Qiang Li, Xu-Peng Zeng, Yang Liu and Yang-Rui Li

Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer

Kidney cancer is one of the most common cancers in the world. It is necessary to clarify its underlying mechanism and find its prognostic biomarkers. Current studies showed that SHMT2 may be participated in se...

Authors: Huan Wang, Tie Chong, Bo-Yong Li, Xiao-San Chen and Wen-Bo Zhen

Increased glucose metabolism in Arid5b^−/− skeletal muscle is associated with the down-regulation of TBC1 domain family member 1 (TBC1D1)

Skeletal muscle has an important role in regulating whole-body energy homeostasis, and energy production depends on the efficient function of mitochondria. We demonstrated previously that AT-rich interactive d...

Authors: Yuri Okazaki, Jennifer Murray, Ali Ehsani, Jessica Clark, Robert H. Whitson, Lisa Hirose, Noriyuki Yanaka and Keiichi Itakura

RETRACTED ARTICLE: LncRNA HCG11 regulates proliferation and apoptosis of vascular smooth muscle cell through targeting miR-144-3p/FOXF1 axis in atherosclerosis

Atherosclerosis (AS) is the main pathological basis of coronary heart disease, cerebral infarction and peripheral vascular disease, which seriously endanger people’s life and health. In recent years, long non-...

Authors: Yi Liu, Xiyun Cui, Cong Wang and Sihai Zhao

Inhibition of phospholipase D2 augments histone deacetylase inhibitor-induced cell death in breast cancer cells

Histone deacetylase (HDAC) inhibitors are promising anticancer drugs but their effect on tumor treatment has been disappointing mainly due to the acquisition of HDAC inhibitor resistance. However, the mechanis...

Authors: Won Chan Hwang, Dong Woo Kang, Youra Kang, Younghoon Jang, Jung-Ae Kim and Do Sik Min

MiR-128 suppresses metastatic capacity by targeting metadherin in breast cancer cells

Breast cancer, the most common cancer in women worldwide, causes the vast majority of cancer-related deaths. Undoubtedly, tumor metastasis and recurrence are responsible for more than 90 percent of these death...

Authors: Danxia Cao, Han Zhu, Qian Zhao, Jianming Huang, Cixiang Zhou, Jianrong He and Yongjun Liang