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  1. Intracranial aneurysm (IA) is the most common cerebrovascular disease, and subarachnoid hemorrhage caused by its rupture can seriously impede nerve function. Pyroptosis is an inflammatory mode of cell death wh...

    Authors: Donglin Zhou, Yimin Zhu, Peng Jiang, Tongfu Zhang, Jianfeng Zhuang, Tao Li, Linzeng Qi and Yunyan Wang
    Citation: Biological Research 2023 56:50
  2. The endoplasmic reticulum (ER) contacts endosomes in all parts of a motor neuron, including the axon and presynaptic terminal, to move structural proteins, proteins that send signals, and lipids over long dist...

    Authors: Francisca Bertin, Jorge Jara-Wilde, Benedikt Auer, Andrés Köhler-Solís, Carolina González-Silva, Ulrich Thomas and Jimena Sierralta
    Citation: Biological Research 2023 56:49
  3. To elucidate the role of Mucin1 (MUC1) in the trophoblast function (glucose uptake and apoptosis) of gestational diabetes mellitus (GDM) women through the Wnt/β-catenin pathway.

    Authors: Shuang-Shuang Cui, Ping Zhang, Lu Sun, Yu-Lin-Lan Yuan, Jingyun Wang, Feng-Xiang Zhang and Ruiman Li
    Citation: Biological Research 2023 56:48
  4. Chemotherapeutic drugs can cause reproductive damage by affecting sperm quality and other aspects of male fertility. Stem cells are thought to alleviate the damage caused by chemotherapy drugs and to play role...

    Authors: YuSheng Zhang, YaNan Liu, Zi Teng, ZeLin Wang, Peng Zhu, ZhiXin Wang, FuJun Liu and XueXia Liu
    Citation: Biological Research 2023 56:47
  5. The genomes of present-day non-Africans are composed of 1–3% of Neandertal-derived DNA as a consequence of admixture events between Neandertals and anatomically modern humans about 50–60 thousand years ago. Ne...

    Authors: Margherita Piccardi, Manuel Gentiluomo, Stefania Bertoncini, Raffaele Pezzilli, Bálint Erőss, Stefania Bunduc, Faik G. Uzunoglu, Renata Talar-Wojnarowska, Tomas Vanagas, Cosimo Sperti, Martin Oliverius, Mateus Nóbrega Aoki, Stefano Ermini, Tamás Hussein, Ugo Boggi, Krzysztof Jamroziak…
    Citation: Biological Research 2023 56:46
  6. Hypertrophic cardiomyopathy (HCM), an autosomal dominant genetic disease, is the main cause of sudden death in adolescents and athletes globally. Hypoxia and immune factors have been revealed to be related to ...

    Authors: Haozhen Yu, Lanxin Gu, Linfang Du, Zhao Dong, Zhuang Li, Mujun Yu, Yue Yin, Yishi Wang, Lu Yu and Heng Ma
    Citation: Biological Research 2023 56:45
  7. Malignant cells adopt anoikis resistance to survive anchorage-free stresses and initiate cancer metastasis. It is still unknown how varying periods of anchorage loss contribute to anoikis resistance, cell migr...

    Authors: Rungroch Sungthong, Hnin Ei Ei Khine, Somruethai Sumkhemthong, Pithi Chanvorachote, Rossarin Tansawat and Chatchai Chaotham
    Citation: Biological Research 2023 56:44
  8. For more than 20 years, Saccharomyces cerevisiae has served as a model organism for genetic studies and molecular biology, as well as a platform for biotechnology (e.g., wine production). One of the important eco...

    Authors: Eduardo I. Kessi-Pérez, Eric Acuña, Camila Bastías, Leyanis Fundora, Manuel Villalobos-Cid, Andrés Romero, Sakshi Khaiwal, Matteo De Chiara, Gianni Liti, Francisco Salinas and Claudio Martínez
    Citation: Biological Research 2023 56:43
  9. Hyperbaric oxygen treatment (HBOT) has been reported to modulate the proliferation of neural and mesenchymal stem cell populations, but the molecular mechanisms underlying these effects are not completely unde...

    Authors: Ignacio Casanova-Maldonado, David Arancibia, Pablo Lois, Isaac Peña-Villalobos and Verónica Palma
    Citation: Biological Research 2023 56:41
  10. Polar microalgae contain unique compounds that enable them to adapt to extreme environments. As the skin barrier is our first line of defense against external threats, polar microalgae extracts may possess res...

    Authors: YoonHee Lim, So-Hyun Park, Eun Jae Kim, HeeJun Lim, Jinsun Jang, In-Sun Hong, Sanghee Kim and YunJae Jung
    Citation: Biological Research 2023 56:40
  11. Electroacupuncture (EA) is a complementary and alternative therapy which has shown protective effects on vascular cognitive impairment (VCI). However, the underlying mechanisms are not entirely understood.

    Authors: Yaling Dai, Sinuo Wang, Minguang Yang, Peiyuan Zhuo, Yanyi Ding, Xiaoling Li, Yajun Cao, Xiaoqin Guo, Huawei Lin, Jing Tao, Lidian Chen and Weilin Liu
    Citation: Biological Research 2023 56:36
  12. High mountainous environments are of particular interest as they play an essential role for life and human societies, while being environments which are highly vulnerable to climate change and land use intensi...

    Authors: Constanza Aguado-Norese, Valentina Cárdenas, Alexis Gaete, Dinka Mandakovic, Javiera Vasquez-Dean, Christian Hodar, Marco Pfeiffer and Mauricio Gonzalez
    Citation: Biological Research 2023 56:35
  13. Dilated cardiomyopathy (DCM) is a primary myocardial disease, leading to heart failure and excessive risk of sudden cardiac death with rather poorly understood pathophysiology. In 2015, Parvari's group ident...

    Authors: Nataly Korover, Sharon Etzion, Alexander Cherniak, Tatiana Rabinski, Aviva Levitas, Yoram Etzion, Rivka Ofir, Ruti Parvari and Smadar Cohen
    Citation: Biological Research 2023 56:34
  14. Voltage-dependent anion selective channels (VDACs) are the most abundant mitochondrial outer membrane proteins, encoded in mammals by three genes, VDAC1, 2 and 3, mostly ubiquitously expressed. As 'mitochondrial ...

    Authors: Xena Giada Pappalardo, Pierpaolo Risiglione, Federica Zinghirino, Angela Ostuni, Daniela Luciano, Faustino Bisaccia, Vito De Pinto, Francesca Guarino and Angela Messina
    Citation: Biological Research 2023 56:33
  15. Melanoma is one of the most aggressive and deadliest skin tumor. Cholesterol content in melanoma cells is elevated, and a portion of it accumulates into lipid rafts. Therefore, the plasma membrane cholesterol ...

    Authors: Ambroise Wu, Ewa Mazurkiewicz, Piotr Donizy, Krzysztof Kotowski, Małgorzata Pieniazek, Antonina J. Mazur, Aleksander Czogalla and Tomasz Trombik
    Citation: Biological Research 2023 56:32
  16. The main features of polycystic ovary syndrome (PCOS) are abnormal follicular development and ovulatory dysfunction, which are caused by excessive apoptosis of ovarian granulosa cells. Acupuncture has been sho...

    Authors: Xiaohong Chen, Hengzhen He, Bingcai Long, Binli Wei, Peng Yang, Xiaoying Huang, Qian Wang, Jing Lin and Hongliang Tang
    Citation: Biological Research 2023 56:31
  17. Skeletal muscle is sensitive to bile acids (BA) because it expresses the TGR5 receptor for BA. Cholic (CA) and deoxycholic (DCA) acids induce a sarcopenia-like phenotype through TGR5-dependent mechanisms. Besi...

    Authors: Johanna Abrigo, Hugo Olguín, Franco Tacchi, Josué Orozco-Aguilar, Mayalen Valero-Breton, Jorge Soto, Mauricio Castro-Sepúlveda, Alvaro A. Elorza, Felipe Simon and Claudio Cabello-Verrugio
    Citation: Biological Research 2023 56:30
  18. Duchenne muscular dystrophy (DMD) is an X-linked lethal genetic disorder for which there is no effective treatment. Previous studies have shown that stem cell transplantation into mdx mice can promote muscle r...

    Authors: Haimei Cen, Pin Fan, Yuting Ding, Bin Luo, Hong Luo, Menglong Chen and Yu Zhang
    Citation: Biological Research 2023 56:29
  19. Skeletal muscle generates force and movements and maintains posture. Under pathological conditions, muscle fibers suffer an imbalance in protein synthesis/degradation. This event causes muscle mass loss and de...

    Authors: Josué Orozco-Aguilar, Franco Tacchi, Francisco Aguirre, Mayalen Valero-Breton, Mauricio Castro-Sepulveda, Felipe Simon and Claudio Cabello-Verrugio
    Citation: Biological Research 2023 56:28
  20. The underlying mechanism of Parkinson’s disease are still unidentified, but excitotoxicity, oxidative stress, and neuroinflammation are considered key actors. Proliferator activated receptors (PPARs) are trans...

    Authors: Andrea Antonosante, Vanessa Castelli, Martina Sette, Margherita Alfonsetti, Mariano Catanesi, Elisabetta Benedetti, Matteo Ardini, Annamaria Cimini and Michele d’Angelo
    Citation: Biological Research 2023 56:27
  21. Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal horn neurons. Inhibition of abnormal dendritic spine remodeling can relieve neuropathic...

    Authors: Qiaoyun Wu, Chenchen Cai, Xinwang Ying, Yujun Zheng, Jiaying Yu, Xiaoxue Gu, Wenzhan Tu, Xinfa Lou, Guanhu Yang, Ming Li and Songhe Jiang
    Citation: Biological Research 2023 56:26
  22. Mechanoreceptor activation modulates GABA neuron firing and dopamine (DA) release in the mesolimbic DA system, an area implicated in reward and substance abuse. The lateral habenula (LHb), the lateral hypothal...

    Authors: Han Byeol Jang, DanBi Ahn, Suchan Chang, Hyung Kyu Kim, Bong Hyo Lee, Sang Chan Kim, Scott C. Steffensen, Kyle B. Bills, Hubert Lee and Hee Young Kim
    Citation: Biological Research 2023 56:25
  23. Authors: Ivanka Jiménez-Dinamarca, Yolanda Prado, Pablo Tapia, Sebastian Gatica, Clemens Alt, Charles P. Lin, Cristian Reyes-Martínez, Carmen G. Feijóo, Cristobal Aravena, Alejandra González-Canacer, Simón Correa, Diego Varela, Claudio Cabello-Verrugio and Felipe Simon
    Citation: Biological Research 2023 56:24

    The original article was published in Biological Research 2023 56:8

  24. Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a rare inherited skin disease caused by variants in the COL7A1 gene, coding for type VII collagen (C7), an important component of anchoring fibrils in the base...

    Authors: Cristian De Gregorio, Evelyng Catalán, Gabriel Garrido, Pilar Morandé, Jimena Castillo Bennett, Catalina Muñoz, Glenda Cofré, Ya-Lin Huang, Bárbara Cuadra, Paola Murgas, Margarita Calvo, Fernando Altermatt, María Joao Yubero, Francis Palisson, Andrew P. South, Marcelo Ezquer…
    Citation: Biological Research 2023 56:23
  25. The COVID-19 pandemic has caused a large number of diseases worldwide. There are few vaccines to constrain this disease and the value of them is high. In this sense, the antigens of the vaccine platform Sobera...

    Authors: Leina Moro-Pérez, Tammy Boggiano-Ayo, Sum Lai Lozada-Chang, Olga Lidia Fernández-Saiz, Kathya Rashida de la Luz and Jose Alberto Gómez-Pérez
    Citation: Biological Research 2023 56:22
  26. Satellite cells are tissue-specific stem cells primarily responsible for the regenerative capacity of skeletal muscle. Satellite cell function and maintenance are regulated by extrinsic and intrinsic mechanism...

    Authors: Felipe Cabezas, Claudio Cabello-Verrugio, Natalia González, Jeremy Salas, Manuel J. Ramírez, Eduardo de la Vega and Hugo C. Olguín
    Citation: Biological Research 2023 56:21
  27. Ischemia-reperfusion (IR) induces increased release of extracellular vesicles in the heart and exacerbates myocardial IR injury. We have previously shown that propofol attenuates hypoxia/reoxygenation (HR)-ind...

    Authors: Xiaojun Zhang, Changsen Wang, Hao Xu, Shuyun Cai, Keyu Liu, Simeng Li, Linming Chen, Siman Shen, Xiaoxia Gu, Jing Tang, Zhengyuan Xia, Zhe Hu, Xiaotang Ma and Liangqing Zhang
    Citation: Biological Research 2023 56:20
  28. AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle pr...

    Authors: Camilla Maria Fontana, Francesca Terrin, Nicola Facchinello, Giacomo Meneghetti, Alberto Dinarello, Lisa Gambarotto, Annalisa Zuccarotto, Micol Caichiolo, Ginevra Brocca, Ranieri Verin, Francesca Nazio, Oliana Carnevali, Francesco Cecconi, Paolo Bonaldo and Luisa Dalla Valle
    Citation: Biological Research 2023 56:19
  29. Isolation of nuclei or nuclear proteins is a prerequisite for western blot, nuclear proteome profiling, and other evaluations of nuclear proteins. Here, we developed a simple method for in situ isolation of nu...

    Authors: Ying Qin, Yun Zhou, Kun Wang, Jiaxuan Gu, Zhihao Xiong, Wendiao Zhang and Yong Chen
    Citation: Biological Research 2023 56:18
  30. Spontaneous spheroid culture is a novel three-dimensional (3D) culture strategy for the rapid and efficient selection of progenitor cells. The objectives of this study are to investigate the pluripotency and d...

    Authors: Ni Li, Xiaofeng Dai, Fei Yang, Yang Sun, Xingwen Wu, Qianrong Zhou, Kai Chen, Jian Sun, Wei Bi, Le Shi and Youcheng Yu
    Citation: Biological Research 2023 56:17
  31. Diabetes mellitus (DM) is highly susceptible to diabetic hind limb ischemia (DHI). MicroRNA (MiR)-17-5p is downregulated in DM and plays a key role in vascular protection. Endothelial progenitor cell (EPC)-rel...

    Authors: Qunwen Pan, Xiaobing Xu, Wen He, Yan Wang, Zhi Xiang, Xiaojuan Jin, Qiong Tang, Ting Zhao and Xiaotang Ma
    Citation: Biological Research 2023 56:16
  32. Splenectomy may lead to severe postoperative complications, including sepsis and cancers. A possible solution to this problem is heterotopic autotransplantation of the spleen. Splenic autografts rapidly restor...

    Authors: Andrey Elchaninov, Polina Vishnyakova, Anastasiya Lokhonina, Viktoria Kiseleva, Egor Menyailo, Maria Antonova, Aiaz Mamedov, Irina Arutyunyan, Galina Bolshakova, Dmitry Goldshtein, Xuhui Bao, Timur Fatkhudinov and Gennady Sukhikh
    Citation: Biological Research 2023 56:15
  33. The endocannabinoid system (ECS) regulates energy metabolism, has been implicated in the pathogenesis of metabolic diseases and exerts its actions mainly through the type 1 cannabinoid receptor (CB1). Likewise...

    Authors: Carlos Sepúlveda, Juan Manuel Rodríguez, Matías Monsalves-Álvarez, Camila Donoso-Barraza, Francisco Pino-de la Fuente, Isabelle Matías, Thierry Leste-Lasserre, Philippe Zizzari, Eugenia Morselli, Daniela Cota, Miguel Llanos and Rodrigo Troncoso
    Citation: Biological Research 2023 56:14
  34. Drought stress has significantly hampered agricultural productivity worldwide and can also result in modifications to DNA methylation levels. However, the dynamics of DNA methylation and its association with t...

    Authors: Ling Wang, Lei Wang, Meilian Tan, Linhai Wang, Wei Zhao, Jun You, Lijun Wang, Xingchu Yan and Wei Wang
    Citation: Biological Research 2023 56:12
  35. Nonalcoholic fatty pancreatitis (NAFP) is one of the metabolic syndrome manifestations that need further studies to determine its molecular determinants and find effective medications. We aimed to investigate ...

    Authors: Reda Albadawy, Amany Helmy Hasanin, Sara H. A. Agwa, Shaimaa Hamady, Reham Hussein Mohamed, Eman Gomaa, Mohamed Othman, Yahia A. Yahia, Amani Mohamed Abdel Ghani and Marwa Matboli
    Citation: Biological Research 2023 56:11
  36. The biological tube is a basal biology structure distributed in all multicellular animals, from worms to humans, and has diverse biological functions. Formation of tubular system is crucial for embryogenesis a...

    Authors: Xiuke Ouyang, Bingtong Wu, Haiyan Yu and Bo Dong
    Citation: Biological Research 2023 56:10
  37. Knowledge about regulating transcription factors (TFs) for osteoblastogenesis from mesenchymal stem cells (MSCs) is limited. Therefore, we investigated the relationship between genomic regions subject to DNA-m...

    Authors: Rodolfo Gómez, Matt J. Barter, Ana Alonso-Pérez, Andrew J. Skelton, Carole Proctor, Gabriel Herrero-Beaumont and David A. Young
    Citation: Biological Research 2023 56:9
  38. Sepsis is an uncontrolled inflammatory response against a systemic infection that results in elevated mortality, mainly induced by bacterial products known as endotoxins, producing endotoxemia. Disseminated in...

    Authors: Ivanka Jiménez-Dinamarca, Yolanda Prado, Pablo Tapia, Sebastian Gatica, Clemens Alt, Charles P. Lin, Cristian Reyes-Martínez, Carmen G. Feijóo, Cristobal Aravena, Alejandra González-Canacer, Simón Correa, Diego Varela, Claudio Cabello-Verrugio and Felipe Simon
    Citation: Biological Research 2023 56:8

    The Correction to this article has been published in Biological Research 2023 56:24

  39. The distinct arterial and venous cell fates are dictated by a combination of various genetic factors which form diverse types of blood vessels such as arteries, veins, and capillaries. We report here that YULI...

    Authors: Hsin-Hung Lin, Ming-Wei Kuo, Tan-Chi Fan, Alice L. Yu and John Yu
    Citation: Biological Research 2023 56:7
  40. Despite representing the largest fraction of animal life, the number of insect species whose genome has been sequenced is barely in the hundreds. The order Dermaptera (the earwigs) suffers from a lack of genom...

    Authors: Sanae Kobayashi, Jonathan E. Maldonado, Alexis Gaete, Ingrid Araya, Constanza Aguado-Norese, Nicolás Cumplido, Sebastián Díaz, Alonso Espinoza, Edelmira Fernández, Felipe Gajardo, Felipe González-Ordenes, Khantati Hauyon, Piedad Maldonado, Rodrigo Maldonado, Isabel Pochet, Aníbal Riveros…
    Citation: Biological Research 2023 56:6
  41. Alpha‐kinase 1 (ALPK1) is a master regulator in inflammation and has been proved to promote renal fibrosis by promoting the production of IL-1β in diabetic nephropathy (DN) mice. Pyroptosis is involved in high...

    Authors: Xinyuan Cui, Yifu Li, Shuguang Yuan, Yao Huang, Xiaojun Chen, Yachun Han, Zhiwen Liu, Zheng Li, Yang Xiao, Youliang Wang, Lin Sun, Hong Liu and Xuejing Zhu
    Citation: Biological Research 2023 56:5
  42. Spermatogonial stem cells (SSCs) are critical for sustaining spermatogenesis. Even though several regulators of SSC have been identified in rodents, the regulatory mechanism of SSC in humans has yet to be disc...

    Authors: Ning Li, Qianyin Zhou, Zhang Yi, Huan Zhang and Dai Zhou
    Citation: Biological Research 2023 56:4
  43. Contrary to the advantageous anticancer activities of curcumin (Cur), limited bioavailability and solubility hindered its efficacy. Here, nontoxic dendrosomal nano carrier with Cur was used to overcome these p...

    Authors: Elahe Seyed Hosseini, Marziyeh Alizadeh Zarei, Hossein Tarrahimofrad, Javad Zamani, Hamed Haddad Kashani, Ejaz Ahmad and Hossein Nikzad
    Citation: Biological Research 2023 56:3
  44. The testes are highly susceptible to the adverse effects of chemotherapy and radiation at all stages of life. Exposure to these threats mainly occurs during cancer treatment and as an occupational hazard in ra...

    Authors: Hamdy Y. Ismail, Nora A. Shaker, Shaymaa Hussein, Adel Tohamy, Mohamed Fathi, Hamdy Rizk and Y. R. Wally
    Citation: Biological Research 2023 56:2
  45. Cell cycle is one of the main cellular mechanisms involved in tumor progression. Almost all of the active molecular pathways in tumor cells directly or indirectly target the cell cycle progression. Therefore, ...

    Authors: Amir Sadra Zangouei, Malihe Zangoue, Negin Taghehchian, Alireza Zangooie, Hamid Reza Rahimi, Ehsan Saburi, Mahya Sadat Alavi and Meysam Moghbeli
    Citation: Biological Research 2023 56:1