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  1. Osteoarthritis (OA) is one of the most common rheumatic diseases of which clinical symptoms includes swelling, synovitis and inflammatory pain, affect patients’ daily life. It was reported that non-coding RNAs...

    Authors: Feng Tian, Junhu Wang, Zhanhua Zhang and Jie Yang

    Citation: Biological Research 2020 53:9

    Content type: Research article

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  2. The intracellular concentration of heavy-metal cations, such as copper, nickel, and zinc is pivotal for the mycobacterial response to the hostile environment inside macrophages. To date, copper transport media...

    Authors: Andrés León-Torres, Epifania Arango, Eliana Castillo and Carlos Y. Soto

    Citation: Biological Research 2020 53:6

    Content type: Research article

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  3. LincRNAs have been revealed to be tightly associated with various tumorigeneses and cancer development, but the roles of specific lincRNA on tumor-related angiogenesis was hardly studied. Here, we aimed to inv...

    Authors: Qing Zhu, Jingchao Li, Qi Wu, Yongxia Cheng, Huizhe Zheng, Tao Zhan, Hongwei Wang, Yue Yang, Hongyan Wang, Ye Liu and Sufen Guo

    Citation: Biological Research 2020 53:5

    Content type: Research article

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  4. Pigmentation development, is a complex process regulated by many transcription factors during development. With the development of the RNA sequencing (RNA-seq), non-coding RNAs, such as miRNAs, lncRNAs, and ci...

    Authors: Zhiwei Zhu, Yueyue Ma, Yuan Li, Pengfei Li, Zhixue Cheng, Huifeng Li, Lihuan Zhang and Zhongwei Tang

    Citation: Biological Research 2020 53:4

    Content type: Research article

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  5. The pellicle, the acellular organic material deposited on the surface of tooth enamel, has been thought to be derived from saliva. In this study, protein compositions of the pellicle, gingival crevicular fluid...

    Authors: Hibiki Odanaka, Takashi Obama, Naoko Sawada, Marika Sugano, Hiroyuki Itabe and Matsuo Yamamoto

    Citation: Biological Research 2020 53:3

    Content type: Research article

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  6. The budding yeast Saccharomyces cerevisiae has been considered for more than 20 years as a premier model organism for biological sciences, also being the main microorganism used in wide industrial applications, l...

    Authors: Eduardo I. Kessi-Pérez, Jennifer Molinet and Claudio Martínez

    Citation: Biological Research 2020 53:2

    Content type: Review

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  7. Long non-coding RNA small molecule RNA host gene 1 (SNHG1) was previously identified to be relevant with Parkinson’s disease (PD) pathogenesis. This work aims to further elucidate the regulatory networks of SN...

    Authors: Jun Zhao, Lijiao Geng, Yong Chen and Chunfang Wu

    Citation: Biological Research 2020 53:1

    Content type: Research article

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  9. Recent studies have confirmed that RASAL1 has an antitumor effect in many cancers, but its functional role and the molecular mechanism underlying in colon cancer has not been investigated.

    Authors: Guangchuan Wang, Zhen Li, Xiao Li, Chunqing Zhang and Lipan Peng

    Citation: Biological Research 2019 52:60

    Content type: Research article

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  10. In varicose veins, vascular smooth muscle cells (VSMCs) often shows phenotypic transition and abnormal proliferation and migration. Evidence suggests the FOXC2–Notch pathway may be involved in the pathogenesis...

    Authors: Chuang Zhang, Huixiang Li and Xueli Guo

    Citation: Biological Research 2019 52:59

    Content type: Research article

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  11. Our previous study showed that knockdown of long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) attenuated myocardial apoptosis in mouse acute myocardial infarction (AMI...

    Authors: Hao Hu, Jiawei Wu, Xiaofan Yu, Junling Zhou, Hua Yu and Likun Ma

    Citation: Biological Research 2019 52:58

    Content type: Research article

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  12. Gastric cancer is a common malignant tumor with high morbidity and mortality worldwide, which seriously affects human health. Gramicidin is a short peptide antibiotic which could be used for treating infection...

    Authors: Tingting Chen, Yong Wang, Yang Yang, Kaikai Yu, Xiangliao Cao, Fang Su, Huanbai Xu, Yongde Peng, Yudong Hu, Feng Qian and Zishu Wang

    Citation: Biological Research 2019 52:57

    Content type: Research article

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  13. ADP-glucose pyrophosphorylase (AGPase), the key enzyme in plant starch biosynthesis, is a heterotetramer composed of two identical large subunits and two identical small subunits. AGPase has plastidial and cyt...

    Authors: Jie Dong, Yongxing Zheng, Yihan Fu, Jinxi Wang, Shasha Yuan, Yonghua Wang, Qidi Zhu, Xingqi Ou, Gezi Li and Guozhang Kang

    Citation: Biological Research 2019 52:56

    Content type: Research article

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  14. Epanorin (EP) is a secondary metabolite of the Acarospora lichenic species. EP has been found in lichenic extracts with antimicrobial activity, and UV-absorption properties have been described for closely related...

    Authors: Juan Palacios-Moreno, Cecilia Rubio, Wanda Quilhot, M. Fernanda Cavieres, Eduardo de la Peña, Natalia V. Quiñones, Hugo Díaz, Flavio Carrión, Carlos F. Henríquez-Roldán and Caroline R. Weinstein-Oppenheimer

    Citation: Biological Research 2019 52:55

    Content type: Research article

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  16. Oxidative stress is the hallmark of diabetic encephalopathy, which may be caused by hyperglycaemic toxicity. We aimed to discover pharmacologic targets to restore redox homeostasis. We identified the transcrip...

    Authors: Jiangpei Zhao, Lerong Liu, Xia Li, Lingxiao Zhang, Jing Lv, Xueli Guo, Hui Chen and Tongfeng Zhao

    Citation: Biological Research 2019 52:53

    Content type: Research article

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  17. Long noncoding RNAs (lncRNAs) have been reported to be associated with dermis process during burn wound healing. This study aimed to investigate the role of lncRNA X-inactive specific transcript (XIST) in huma...

    Authors: Wei Cao and Youping Feng

    Citation: Biological Research 2019 52:52

    Content type: Research article

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  18. The leafcutter ant (Atta cephalotes) is associated with losses in the agricultural sector, due to its defoliating activity; for its control, biological, mechanical and chemical methods have been developed, the la...

    Authors: Fabian Felipe Fernandez Daza, Ginna Rodriguez Roman, Marino Valencia Rodriguez, Ivan Andres Gonzalez Vargas, Heiber Cardenas Heano, Marney Pascoli Cereda and Raul Alberto Cuervo Mulet

    Citation: Biological Research 2019 52:51

    Content type: Research article

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  20. Psoriasis is a common and intractable skin disease affecting the physical and mental health of patients. The accumulation of ROS is involved in the pathogenesis of psoriasis and antioxidants are believed to be...

    Authors: Wuyuntana Wang, Yuhai, Huan Wang, Chasuna and Bagenna

    Citation: Biological Research 2019 52:49

    Content type: Research article

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  21. Light exposure is a common stress factor in in vitro manipulation of embryos in the reproductive center. Many studies have shown the deleterious effects of high-intensity light exposure in different animal emb...

    Authors: Bo Lv, Chaojie Liu, Yu Chen, Lingbin Qi, Lu Wang, Yazhong Ji and Zhigang Xue

    Citation: Biological Research 2019 52:48

    Content type: Research article

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  22. Rubella or German measles is an infection caused by rubella virus (RV). Infection of children and adults is usually characterized by a mild exanthematous febrile illness. However, RV is a major cause of birth ...

    Authors: Suji George, Rajlakshmi Viswanathan and Gajanan N. Sapkal

    Citation: Biological Research 2019 52:47

    Content type: Review

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  23. One of the most extreme environments on our planet is the Maritime Antarctic territory, due to its low-water availability, which restricts the development of plants. Sanionia uncinata Hedw. (Amblystegiaceae), the...

    Authors: Marisol Pizarro, Rodrigo A. Contreras, Hans Köhler and Gustavo E. Zúñiga

    Citation: Biological Research 2019 52:46

    Content type: Research article

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  24. Resveratrol was reported to trigger the apoptosis of fibroblast-like synoviocytes in adjuvant arthritis rats but the subcellular mechanism remains unclear. Since ER stress, mitochondrial dysfunction and oxidat...

    Authors: Jinsen Lu, Jiazhao Yang, Yongshun Zheng, Shiyuan Fang and Xiaoyu Chen

    Citation: Biological Research 2019 52:45

    Content type: Research article

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  25. Free fatty acid receptor 1 (FFAR1) is G-protein coupled receptor predominantly expressed in pancreatic β-cells that is activated by a variety of free fatty acids (FFAs). Once activated, it promotes glucose-sti...

    Authors: Sulaiman K. Marafie, Eman M. Al-Shawaf, Jehad Abubaker and Hossein Arefanian

    Citation: Biological Research 2019 52:44

    Content type: Research article

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  26. Drought is one of the main serious problems for agriculture production which its intensity is increasing in many parts of the world, hence, improving water use efficiency is a main goal for sustainable agricul...

    Authors: Somayeh Faghih, Zabihollah Zamani, Reza Fatahi and Abdolmajid Liaghat

    Citation: Biological Research 2019 52:43

    Content type: Research article

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  27. Prognosis remains one of most crucial determinants of gastric cancer (GC) treatment, but current methods do not predict prognosis accurately. Identification of additional biomarkers is urgently required to ide...

    Authors: Wei Li, Yan Chen, Xuan Sun, Jupeng Yang, David Y. Zhang, Daguang Wang and Jian Suo

    Citation: Biological Research 2019 52:42

    Content type: Research article

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  28. Di-N-butyl-phthalate (DBP) is an endocrine disrupting substance. We investigated the adverse effect of DBP on testis of male rat and reveal its potential mechanism of MAPK signaling pathway involved this effect i...

    Authors: Hongyan Wang, Weipeng Zhou, Jing Zhang and Huan Li

    Citation: Biological Research 2019 52:41

    Content type: Research article

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  29. There are currently a number of barriers hindering the successful treatment of breast cancer, including the metastatic spread of cancer cells. In looking for new anticancer agents, we reported two novel hydraz...

    Authors: Soudeh Dehghani, Zahra Kooshafar, Ali Almasirad, Raheleh Tahmasvand, Fariborz Moayer, Ahad Muhammadnejad, Samira Shafiee and Mona Salimi

    Citation: Biological Research 2019 52:40

    Content type: Research article

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  31. Breast cancer is the second common malignant cancer among females worldwide. Accumulating studies have indicated that deregulation of miRNA expression in breast cancer will contribute to tumorigenesis and form...

    Authors: Bao Zhang, Dattatrya Shetti, Conghui Fan and Kun Wei

    Citation: Biological Research 2019 52:38

    Content type: Research article

    Published on:

  32. Berberine (BBR), a compound extracted from a variety of medicinal herbs, has been shown multiple pharmacological effects against cancer cells of different origins. Cisplatin (DDP) is known as an effective chem...

    Authors: Li Liu, Jingyan Fan, Guihai Ai, Jie Liu, Ning Luo, Caixia Li and Zhongping Cheng

    Citation: Biological Research 2019 52:37

    Content type: Research article

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  33. Recent evidences indicated that some local anaesthetic agents played a role in inhibiting the proliferation of cancer cells; Whether ropivacaine is able to promote apoptosis of hepatocellular carcinoma (HCC) c...

    Authors: Wenting Wang, Mingyue Zhu, Zhixin Xu, Wei Li, Xu Dong, Yi Chen, Bo Lin and Mengsen Li

    Citation: Biological Research 2019 52:36

    Content type: Research article

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  34. Non-small cell lung cancer (NSCLC) is one of the leading causes of death in the world. NSCLC diagnosed at an early stage can be highly curable with a positive prognosis, but biomarker limitations make it diffi...

    Authors: Hyunhee Do, Dain Kim, JiHoon Kang, Beomseok Son, Danbi Seo, HyeSook Youn, BuHyun Youn and Wanyeon Kim

    Citation: Biological Research 2019 52:35

    Content type: Research article

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  35. Psoralen is a coumarin-like and coumarin-related benzofuran glycoside, which is a commonly used traditional Chinese medicine to treat patients with kidney and spleen-yang deficiency symptom. Psoralen has been ...

    Authors: Xiaomin Wang, Peike Peng, Zhiqiang Pan, Zhaoqin Fang, Wenli Lu and Xiaomei Liu

    Citation: Biological Research 2019 52:34

    Content type: Research article

    Published on:

  36. Studies have shown that cancer susceptibility candidate 11 (CASC11), a newly discovered long non-coding RNA (lncRNA), was aberrantly overexpressed in hepatic carcinoma, gastric cancer and colorectal cancer. Howev...

    Authors: Wenchan Hsu, Lifen Liu, Xin Chen, Ying Zhang and Weipei Zhu

    Citation: Biological Research 2019 52:33

    Content type: Research article

    Published on:

  39. Chronic prostatitis has been supposed to be associated with preneoplastic lesions and cancer development. The objective of this study was to examine how chronic inflammation results in a prostatic microenviron...

    Authors: Yong Gao, Lijuan Wei, Chenbang Wang, Yuanjie Huang, Weidong Li, Tianyu Li, Chaohua Mo, Huali Qin, Xiaoge Zhong, Yun Wang, Aihua Tan, Zengnan Mo, Yonghua Jiang and Yanling Hu

    Citation: Biological Research 2019 52:30

    Content type: Research article

    Published on:

  41. Hypoxic-ischemic encephalopathy (HIE) is a common disease that occurs during the perinatal period. The primary cause of neonatal HIE is related to fetal intrauterine anoxia. Carbamylated erythropoietin (CEPO),...

    Authors: Min Diao, Yi Qu, Hui Liu, Yushan Ma and Xuemei Lin

    Citation: Biological Research 2019 52:28

    Content type: Research article

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  42. To assess the expression of T-box transcription factor 4 (TBX4) during the anorectal development in normal and ethylenethiourea (ETU)-induced anorectal malformations (ARM) rat embryos.

    Authors: Meng Li, Hailan Zhang, Huiying Liu, Hongzhong Tian, Xiaobing Tang, Yuzuo Bai and Weilin Wang

    Citation: Biological Research 2019 52:27

    Content type: Research article

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  43. Acute myeloid leukemia (AML) is an aggressive and mostly incurable hematological malignancy with frequent relapses after an initial response to standard chemotherapy. Therefore, novel therapies are urgently re...

    Authors: Yubin Feng, Xiaoxiao Hua, Ruowen Niu, Yan Du, Congjian Shi, Renpeng Zhou and Fei-Hu Chen

    Citation: Biological Research 2019 52:26

    Content type: Research article

    Published on:

  44. The morphological diversity of flower organs is closely related to functional divergence within the MADS-box gene family. Bryophytes and seedless vascular plants have MADS-box genes but do not have ABCDE or AGAMO...

    Authors: Gangxu Shen, Chih-Hui Yang, Chi-Yen Shen and Keng-Shiang Huang

    Citation: Biological Research 2019 52:25

    Content type: Research article

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  46. Conjunctival filtering bleb scar formation is the main reason for the failure of glaucoma filtration surgery. Cytoglobin (Cygb) has been reported to play an important role in extracellular matrix (ECM) remodel...

    Authors: Haiying Wei, Lili Lin, Xiaomei Zhang, Zhuolei Feng, Yeqing Wang, Yan You, Xiaodan Wang and Yongsheng Hou

    Citation: Biological Research 2019 52:23

    Content type: Research article

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  47. Tumor microenvironment (TME) plays a vital role in determining the outcomes of radiotherapy. As an important component of TME, vascular endothelial cells are involved in the perivascular resistance niche (PVRN...

    Authors: Qianwen Li, Yan Zong, Ke Li, Xiaohua Jie, Jiaxin Hong, Xiaoshu Zhou, Bian Wu, Zhenyu Li, Sheng Zhang, Gang Wu and Rui Meng

    Citation: Biological Research 2019 52:22

    Content type: Research article

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  48. Defects in DNA methylation have been shown to be associated with metabolic diseases such as obesity, dyslipidemia, and hypercholesterolemia. To analyze the methylation profile of the ADRB3 gene and correlate it w...

    Authors: Raquel Patrícia Ataíde Lima, Marina Ramalho Ribeiro, Keylha Querino de Farias Lima, Elisama Araújo de Sena, Diego de Oliveira Costa, Rafaella Cristhine Pordeus Luna, Rayner Anderson Ferreira do Nascimento, Maria da Conceição Rodrigues Gonçalves, Rodrigo Pinheiro de Toledo Vianna, Ronei Marcos de Moraes, Naila Francis Paulo de Oliveira, Aléssio Tony Cavalcanti de Almeida and Maria José de Carvalho Costa

    Citation: Biological Research 2019 52:21

    Content type: Research Article

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  49. Histone acetylation is an important epigenetic modification that regulates gene activity in response to stress. Histone acetylation levels are reversibly regulated by histone acetyltransferases (HATs) and histone...

    Authors: Fan Wei, Danfeng Tang, Zengqiang Li, Muhammad Haneef Kashif, Aziz Khan, Hai Lu, Ruixing Jia and Peng Chen

    Citation: Biological Research 2019 52:20

    Content type: Research article

    Published on:

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