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  1. Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM).

    Authors: Haitian Chen, Shaofeng Zhang, Yanxin Wu, Zhuyu Li, Dongyu Wang, Shiqin Cai and Zilian Wang
    Citation: Biological Research 2021 54:14
  2. Multiple sclerosis (MS) is a central nervous system disease with a high disability rate. Modern molecular biology techniques have identified a number of key genes and diagnostic markers to MS, but the etiology...

    Authors: Xin Chen, Huiqing Hou, Huimin Qiao, Haolong Fan, Tianyi Zhao and Mei Dong
    Citation: Biological Research 2021 54:12
  3. Atherosclerosis (AS) is the most common type in cardiovascular disease. Due to its complex pathogenesis, the exact etiology of AS is unclear. circRNA has been shown to play an essential role in most diseases. ...

    Authors: Xiaohao Zhang, Junying Lu, Qinghua Zhang, Qiang Luo and Bin Liu
    Citation: Biological Research 2021 54:11
  4. Parkinson’s disease (PD) is a common age-related neurodegenerative disorder worldwide. This research aimed to investigate the effects and mechanism underlying long non-coding RNA metastasis-associated lung ade...

    Authors: Kefeng Lv, Yuhua Liu, Yanbing Zheng, Shaowen Dai, Peifeng Yin and Haifeng Miao
    Citation: Biological Research 2021 54:10
  5. PGF2α is essential for the induction of the corpus luteum regression which in turn reduces progesterone production. Early growth response (EGR) proteins are Cys2-His2-type zinc-finger transcription factor that...

    Authors: Meeti Punetha, Sai Kumar, Avishek Paul, Bosco Jose, Jaya Bharati, Arvind Sonwane, Jonathan A. Green, Kristin Whitworth and Mihir Sarkar
    Citation: Biological Research 2021 54:9
  6. This study aimed to investigate the potential role and molecular mechanism of lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in cerebral ischemia/reperfusion injury.

    Authors: Ying Jia, Lian Yi, Qianqian Li, Tingjiao Liu and Shanshan Yang
    Citation: Biological Research 2021 54:8
  7. Mitochondria play a significant role in plant cytoplasmic male sterility (CMS). In our previous study, mitochondrial complex I genes, nad4, nad5, and nad7 showed polymorphisms between the transgenic CMS line M2BS...

    Authors: Danfeng Tang, Fan Wei, Aziz Khan, Fazal Munsif and Ruiyang Zhou
    Citation: Biological Research 2021 54:6
  8. Early-life stress in the form of maternal separation can be associated with alterations in offspring neurodevelopment and brain functioning. Here, we aimed to investigate the potential impact of prolonged mate...

    Authors: Zdenka Drastichova, Vladimir Rudajev, Gergely Pallag and Jiri Novotny
    Citation: Biological Research 2021 54:4
  9. Testosterone regulates nutrient and energy balance to maintain protein synthesis and metabolism in cardiomyocytes, but supraphysiological concentrations induce cardiac hypertrophy. Previously, we determined th...

    Authors: Mayarling Francisca Troncoso, Mario Pavez, Carlos Wilson, Daniel Lagos, Javier Duran, Sebastián Ramos, Genaro Barrientos, Patricio Silva, Paola Llanos, Carla Basualto-Alarcón, B. Daan Westenbrink, Sergio Lavandero and Manuel Estrada
    Citation: Biological Research 2021 54:3
  10. The preventive and therapeutic medical utilization of this plant is an age-long practice across the globe. This study aimed to validate the impact of dark purple blossoms of basil (Ocimum basilicum L.) aqueous ex...

    Authors: Mariam Abdulaziz Alkhateeb, Wedad Refaiea Al-Otaibi, Qwait AlGabbani, Amena Ali Alsakran, Alaa Ahmed Alnafjan, Amani Mohammed Alotaibi and Wedad Saeed Al-Qahtani
    Citation: Biological Research 2021 54:2
  11. Neuronal apoptosis plays a critical event in the pathogenesis of early brain injury after subarachnoid hemorrhage (SAH). This study investigated the roles of Tauroursodeoxycholic acid (TUDCA) in attenuate neur...

    Authors: Huihui Wu, Nini Yu, Xia Wang, Yina Yang and Hui Liang
    Citation: Biological Research 2020 53:56
  12. Gunnera tinctoria has been collected by Mapuche-Pewenche people for food and medicinal purposes. The high polyphenol content of methanolic extract from G. tinctoria leaves with chemical constituents such as ellag...

    Authors: Constanza Sabando, Maité Rodríguez-Díaz, Walther Ide, Edgar Pastene, Marcia Avello, Mario Simirgiotis, Susana Rojas, Enrique Villarroel, Tiare Silva-Grecchi, Cristian Gutiérrez, Rebeca Bouza, Bárbara Cicchelli, Marcelo González and Saddys Rodríguez-Llamazares
    Citation: Biological Research 2020 53:55
  13. UV-B signaling in plants is mediated by UVR8, which interacts with transcriptional factors to induce root morphogenesis. However, research on the downstream molecules of UVR8 signaling in roots is still scarce...

    Authors: Meiting Du, Yanhong Wang, Huize Chen and Rong Han
    Citation: Biological Research 2020 53:54
  14. Our previous study indicated that aerobic exercise relieves cognitive impairment in patients with vascular cognitive impairment (VCI) via regulating brain-derived neurotrophic factor (BDNF), but the mechanism ...

    Authors: Jing Wang, Yali Niu, Huaying Tao, Mina Xue and Chunxiao Wan
    Citation: Biological Research 2020 53:53
  15. Chinese hamster ovary (CHO) cells are the most commonly used mammalian host cell in the commercial-scale production of biopharmaceutical proteins. Modification of genes involved in apoptosis may improve the pr...

    Authors: Fatemeh Safari, Safar Farajnia, Abbas Behzad Behbahani, Habib Zarredar, Mazyar Barekati-Mowahed and Hesam Dehghani
    Citation: Biological Research 2020 53:52
  16. Acupuncture, a therapy of traditional Chinese medicine, is confirmed to exert the therapeutic action on polycystic ovary syndrome (PCOS). However, the detailed therapeutic mechanisms of acupuncture in PCOS rem...

    Authors: Yan Peng, Xinming Yang, Xi Luo, Chunhong Liu, Xia Cao, Hongyan Wang and Liyuan Guo
    Citation: Biological Research 2020 53:50
  17. Although OIP5-AS1 has been characterized as an oncogenic lncRNA in many types of cancer, its role and underlying mechanism in ovarian carcinoma (OC) remains unknown. This study aimed to investigate the role of...

    Authors: Xingzhi Jiang, Zhongxue Ye, Yafen Jiang, Wen Yu and Qian Fang
    Citation: Biological Research 2020 53:49
  18. Psoriasis is a common chronic inflammatory skin disease. Keratinocytes hyperproliferation and excessive inflammatory response contribute to psoriasis pathogenesis. The agents able to attenuate keratinocytes hy...

    Authors: Jintao Gao, Fangru Chen, Huanan Fang, Jing Mi, Qi Qi and Mengjuan Yang
    Citation: Biological Research 2020 53:48
  19. Nitrogen is the main limiting nutrient after carbon, hydrogen and oxygen for photosynthetic process, phyto-hormonal, proteomic changes and growth-development of plants to complete its lifecycle. Excessive and ...

    Authors: Muhammad Anas, Fen Liao, Krishan K. Verma, Muhammad Aqeel Sarwar, Aamir Mahmood, Zhong-Liang Chen, Qiang Li, Xu-Peng Zeng, Yang Liu and Yang-Rui Li
    Citation: Biological Research 2020 53:47
  20. Kidney cancer is one of the most common cancers in the world. It is necessary to clarify its underlying mechanism and find its prognostic biomarkers. Current studies showed that SHMT2 may be participated in se...

    Authors: Huan Wang, Tie Chong, Bo-Yong Li, Xiao-San Chen and Wen-Bo Zhen
    Citation: Biological Research 2020 53:46
  21. Skeletal muscle has an important role in regulating whole-body energy homeostasis, and energy production depends on the efficient function of mitochondria. We demonstrated previously that AT-rich interactive d...

    Authors: Yuri Okazaki, Jennifer Murray, Ali Ehsani, Jessica Clark, Robert H. Whitson, Lisa Hirose, Noriyuki Yanaka and Keiichi Itakura
    Citation: Biological Research 2020 53:45

    The Correction to this article has been published in Biological Research 2022 55:6

  22. Atherosclerosis (AS) is the main pathological basis of coronary heart disease, cerebral infarction and peripheral vascular disease, which seriously endanger people’s life and health. In recent years, long non-...

    Authors: Yi Liu, Xiyun Cui, Cong Wang and Sihai Zhao
    Citation: Biological Research 2020 53:44
  23. Histone deacetylase (HDAC) inhibitors are promising anticancer drugs but their effect on tumor treatment has been disappointing mainly due to the acquisition of HDAC inhibitor resistance. However, the mechanis...

    Authors: Won Chan Hwang, Dong Woo Kang, Youra Kang, Younghoon Jang, Jung-Ae Kim and Do Sik Min
    Citation: Biological Research 2020 53:34
  24. Breast cancer, the most common cancer in women worldwide, causes the vast majority of cancer-related deaths. Undoubtedly, tumor metastasis and recurrence are responsible for more than 90 percent of these death...

    Authors: Danxia Cao, Han Zhu, Qian Zhao, Jianming Huang, Cixiang Zhou, Jianrong He and Yongjun Liang
    Citation: Biological Research 2020 53:43
  25. Basal-like breast cancer (BLBC) or triple-negative breast cancer (TNBC) is an aggressive and highly metastatic subtype of human breast cancer. The present study aimed to elucidate the potential tumor-suppressi...

    Authors: Jaehyuk Yang, Seung Jun Lee, Yongseok Kwon, Li Ma and Jongchan Kim
    Citation: Biological Research 2020 53:42
  26. Tumor angiogenesis is an essential event for tumor growth and metastasis. It has been showed that REC8, a component of the meiotic cohesion complex, played a vital role in Epithelial-Mesenchymal Transition (EM...

    Authors: Miao Liu, Wanfu Xu, Mingmin Su and Pingsheng Fan
    Citation: Biological Research 2020 53:41
  27. Osteoporosis is a common metabolic bone disease, influenced by genetic and environmental factors, that increases bone fragility and fracture risk and, therefore, has a serious adverse effect on the quality of ...

    Authors: Yang Yang, Wang Yujiao, Wang Fang, Yuan Linhui, Guo Ziqi, Wei Zhichen, Wang Zirui and Wang Shengwang
    Citation: Biological Research 2020 53:40
  28. The impaired glucose tolerance (IGT) is a representative prediabetes characterized by defective glucose homeostasis, and palmatine (PAL) is a natural isoquinoline alkaloid with multiple pharmacological effects...

    Authors: Xusheng Tian, Yukun Zhang, Han Li, Yunfeng Li, Ning Wang, Wei Zhang and Boyan Ma
    Citation: Biological Research 2020 53:39
  29. Long non-coding RNA (lncRNA) small nucleolar RNA host gene 14 (SNHG14) is associated with cerebral ischemia–reperfusion (CI/R) injury. This work aims to explore the role of SNHG14 in CI/R injury.

    Authors: Zexiang Deng, Hao Ou, Fei Ren, Yujiao Guan, Ye Huan, Hongwei Cai and Bei Sun
    Citation: Biological Research 2020 53:38
  30. Soil salinity causes huge economic losses to agriculture productivity in arid and semiarid areas worldwide. The affected plants face disturbances in osmotic adjustment, nutrient transport, ionic toxicity and r...

    Authors: Suliman A. Al-Khateeb, Abdullatif A. Al-Khateeb, Muhammad N. Sattar and Akbar S. Mohmand
    Citation: Biological Research 2020 53:37
  31. To investigate the thalamic neurotransmitters and functional connections in the development of chronic constriction injury (CCI)-induced neuropathic pain.

    Authors: Zhifu Wang, Sheng Huang, Xiangmei Yu, Long Li, Minguang Yang, Shengxiang Liang, Weilin Liu and Jing Tao
    Citation: Biological Research 2020 53:36
  32. Spinal cord injury (SCI) is a severe central nervous system trauma. The present study aimed to evaluate the effect of HIF-1α on inflammation in spinal cord injury (SCI) to uncover the molecular mechanisms of a...

    Authors: Xigong Li, Xianfeng Lou, Sanzhong Xu, Junhua Du and Junsong Wu
    Citation: Biological Research 2020 53:35
  33. Circulating RNA (circRNA) regulates various bioactivities in cells. A better understanding of the exosomal circRNA can provide novel insights into the pathogenesis and treatment of Graves’ disease (GD). We aim...

    Authors: Ying Sun, Wei Wang, Yuxiao Tang, Daping Wang, Liang Li, Min Na, Guantong Jiang, Qian Li, Shulin Chen and Jin Zhou
    Citation: Biological Research 2020 53:32
  34. In modern societies, sleep deprivation is a serious health problem. This problem could be induced by a variety of reasons, including lifestyle habits or neurological disorders. Chronic sleep deprivation (CSD) ...

    Authors: Mahboobeh Erfanizadeh, Ali Noorafshan, Mohammad Reza Namavar, Saied Karbalay-Doust and Tahereh Talaei-Khozani
    Citation: Biological Research 2020 53:31
  35. We developed simple sequence repeats (SSR) for Eremanthus erythropappus (DC.) MacLeish, an endangered tree species endemic to the Brazilian Savanna and Atlantic Forest biomes, and tested their transferability to ...

    Authors: Lucas Fernandes Rocha, Natália Ribeiro Paula, Alison Gonçalves Nazareno and Dulcinéia de Carvalho
    Citation: Biological Research 2020 53:30
  36. Arid environments are defined by the lack of water availability, which is directly related to the mean annual precipitation (MAP), and high values of solar irradiation, which impacts the community composition ...

    Authors: Javiera Vásquez-Dean, Felipe Maza, Isidora Morel, Rodrigo Pulgar and Mauricio González
    Citation: Biological Research 2020 53:29
  37. Kidney ischemia–reperfusion injury is a common pathophysiological phenomenon in the clinic. A large number of studies have found that the tyrosine protein kinase/signal transducer and activator of transcriptio...

    Authors: Xiaoying Zhao, Erfei Zhang, Xiaofen Ren, Xiaoli Bai, Dongming Wang, Ling Bai, Danlei Luo, Zheng Guo, Qiang Wang and Jianxin Yang
    Citation: Biological Research 2020 53:28
  38. Circular RNA (circRNA) is highly expressed in the brain tissue, but its molecular mechanism in cerebral ischemia–reperfusion remains unclear. Here, we explored the role and underlying mechanisms of circRNA ant...

    Authors: Su Jiang, Gaonian Zhao, Jun Lu, Min Jiang, Zhenggang Wu, Yujing Huang, Jing Huang, Jinghua Shi, Jing Jin, Xinxuan Xu and Xuehua Pu
    Citation: Biological Research 2020 53:27
  39. There is an emerging field to put into practice new strategies for developing molecules with antimicrobial properties. In this line, several metals and metalloids are currently being used for these purposes, a...

    Authors: C. Muñoz-Villagrán, F. Contreras, F. Cornejo, M. Figueroa, D. Valenzuela-Bezanilla, R. Luraschi, C. Reinoso, J. Rivas-Pardo, C. Vásquez, M. Castro and F. Arenas
    Citation: Biological Research 2020 53:26
  40. Hypoxia inducible factor-1 (HIF-1) is considered as the most activated transcriptional factor in response to low oxygen level or hypoxia. HIF-1 binds the hypoxia response element (HRE) sequence in the promoter...

    Authors: Fatemeh Sadeghi, Gholam Ali Kardar, Mohammad Reza Bolouri, Farzad Nasri, Maryam Sadri and Reza Falak
    Citation: Biological Research 2020 53:25
  41. BMPR-1B is part of the transforming growth factor β super family and plays a pivotal role in ewe litter size. Functional loss of exon-8 mutations in the BMPR-1B gene (namely the FecB gene) can increase both th...

    Authors: Jianlei Jia, Jipeng Jin, Qian Chen, Zan Yuan, Haiqin Li, Junhao Bian and Linsheng Gui
    Citation: Biological Research 2020 53:24
  42. Abscisic acid-, stress-, and ripening-induced (ASR) genes are a class of plant specific transcription factors (TFs), which play important roles in plant development, growth and abiotic stress responses. The wheat...

    Authors: Huawei Li, Haiying Guan, Qicui Zhuo, Zongshuai Wang, Shengdong Li, Jisheng Si, Bin Zhang, Bo Feng, Ling-an Kong, Fahong Wang, Zheng Wang and Lishun Zhang
    Citation: Biological Research 2020 53:23
  43. Duchenne muscular dystrophy (DMD) is a devastating genetic muscular disorder with no effective treatment that is caused by the loss of dystrophin. Human induced pluripotent stem cells (hiPSCs) offer a promisin...

    Authors: Ruojie He, Huan Li, Liang Wang, Yaqin Li, Yu Zhang, Menglong Chen, Yuling Zhu and Cheng Zhang
    Citation: Biological Research 2020 53:22
  44. Liriodendron chinense ranges widely in subtropical China and northern Vietnam; however, it inhabits several small, isolated populations and is now an endangered species due to its limited seed production. The obj...

    Authors: Bin Li, Furong Lin, Ping Huang, Wenying Guo and Yongqi Zheng
    Citation: Biological Research 2020 53:21
  45. The role of interleukin family in colon cancer remained controversial. The purpose of this study was to investigate the association between interleukin family and colon cancer progression through bioinformatic...

    Authors: Xiyi Wei, Yuan Zhang, Zhou Yang, Yeqin Sha, Yitong Pan, Yusheng Chen and Lei Cai
    Citation: Biological Research 2020 53:20