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  1. miR-214 was demonstrated to be upregulated in models of renal disease and promoted fibrosis in renal injury independent of TGF-β signaling in vivo. However, the detailed role of miR-214 in acute kidney injury ...

    Authors: Xiaoguang Zhu, Wenwen Li and Huicong Li

    Citation: Biological Research 2018 51:31

    Content type: Research article

    Published on:

  2. With 29 Km2, the Fildes Peninsula is the largest ice free area in King George Island and probably in Antarctica. The region is house of six permanent bases including the only airport in the South Shetlands, which...

    Authors: Diego Knop Henriques, Bárbara Guedes Costa Silva, Gustavo Emílio Zuñiga and Paulo Eduardo Aguiar Saraiva Câmara

    Citation: Biological Research 2018 51:29

    Content type: Research article

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  3. Pectinase enzymes catalyze the breakdown of pectin, a key component of the plant cell wall. At industrial level, pectinases are used in diverse applications, especially in food-processing industry. Currently, ...

    Authors: Gabriela Poveda, Carlos Gil-Durán, Inmaculada Vaca, Gloria Levicán and Renato Chávez

    Citation: Biological Research 2018 51:28

    Content type: Research article

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  4. The domestic cat serves as an animal model for assisted reproductive studies of endangered felid species. To date, there are no data on the protein alterations following cryopreservation of oocytes in felid fa...

    Authors: Bongkoch Turathum, Sittiruk Roytrakul, Chinarat Changsangfa, Morakot Sroyraya, Supita Tanasawet, Yindee Kitiyanant and Kulnasan Saikhun

    Citation: Biological Research 2018 51:27

    Content type: Research article

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  8. The exact cause of cancer is one of the most immutable medical questions of the century. Cancer as an evolutionary disease must have a purpose and understanding the purpose is more important than decoding the ...

    Authors: Mukesh Yadav, Payal Chatterjee, Simran Tolani, Jaya Kulkarni, Meenakshi Mulye, Namrata Chauhan, Aditi Sakhi and Sakshi Gorey

    Citation: Biological Research 2018 51:23

    Content type: Review

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  10. To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease.

    Authors: Ruhui Lin, Long Li, Yingzheng Zhang, Sheng Huang, Shangjie Chen, Jiao Shi, Peiyuan Zhuo, Hao Jin, Zuanfang Li, Weilin Liu, Zhifu Wang, Lidian Chen and Jing Tao

    Citation: Biological Research 2018 51:21

    Content type: Research Article

    Published on:

  11. Concerns have been raised about this article [1] relating to the appropriateness of the use of the shRNA (5′-GCGGAGGGTTTGAAAGAATATCTCGAGATATTCTTTCAAACCCTCCGCTTTTTT-3′) as a non-targeting control and similariti...

    Authors: Xiaolan Zhao, Man Chen and Jishan Tan

    Citation: Biological Research 2018 51:20

    Content type: Correction

    Published on:

    The original article was published in Biological Research 2016 49:26

  12. Concerns have been raised about this article [1] relating to the appropriateness of the use of the shRNA (5′-GCGGAGGGTTTGAAAGAATATCTCGAGATATTCTTTCAAACCCTCCGCTTTTTT-3′) as a non-targeting control and similariti...

    Authors: Zeya Pan, Hao Pan, Jin Zhang, Yun Yang, Hui Liu, Yuan Yang, Gang Huang, Junsheng Ni, Jian Huang and Weiping Zhou

    Citation: Biological Research 2018 51:19

    Content type: Correction

    Published on:

    The original article was published in Biological Research 2015 48:18

  13. Arsenic trioxide (As2O3), a drug that has been used in China for approximately two thousand years, induces cell death in a variety of cancer cell types, including neuroblastoma (NB). The tyrosine kinase receptor ...

    Authors: Xilin Xiong, Yang Li, Ling Liu, Kai Qi, Chi Zhang, Yueqin Chen and Jianpei Fang

    Citation: Biological Research 2018 51:18

    Content type: Research article

    Published on:

  14. Improper control on reactive oxygen species (ROS) elimination process and formation of free radicals causes tissue dysfunction. Pineal hormone melatonin is considered a potent regulator of such oxidative dama...

    Authors: Mahammed Moniruzzaman, Indranath Ghosal, Debjit Das and Suman Bhusan Chakraborty

    Citation: Biological Research 2018 51:17

    Content type: Research article

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  15. Stathmin as a critical protein involved in microtubule polymerization, is necessary for survival of cancer cells. However, extremely little is known about Stathmin in glioblastoma. So, this study was designed ...

    Authors: Ping Liu, Junyan Yu, Xiangyang Tian, Jianlan Chang, Ying Zhang, Rong Zhang, Ningning Zhang, Ranxing Huang, Lulu Li, Xianli Qiao and Hongliang Guo

    Citation: Biological Research 2018 51:16

    Content type: Research article

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  16. Translational research to develop pharmaceutical and surgical treatments for pterygium requires a reliable and easy to produce animal model. Extracellular matrix and fibroblast are important components of pter...

    Authors: Judith Zavala, Julio C. Hernandez-Camarena, Brenda Salvador-Gálvez, José E. Pérez-Saucedo, Amin Vela-Martinez and Jorge E. Valdez-García

    Citation: Biological Research 2018 51:15

    Content type: Research Article

    Published on:

  17. Neurokinin1 (NK1) receptor has played a vital role in the development of tumor. However, NKP608 as a NK1 receptor antagonist whether has the effect of the resistance of colorectal cancer is still unclear. Ther...

    Authors: Xiao-Ling Niu, Jian-Feng Hou and Jing-Xiang Li

    Citation: Biological Research 2018 51:14

    Content type: Research Article

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  19. Chemokine (C-C motif) receptor 6 (CCR6) is present in sperm and plays a significant role in sperm motility and chemotaxis acting in the reproductive tracts. However, the expression and functional significance ...

    Authors: Ruiying Diao, Xueyong Cai, Lu Liu, Lihua Yang, YongGang Duan, Zhiming Cai, Yaoting Gui and Lisha Mou

    Citation: Biological Research 2018 51:12

    Content type: Research article

    Published on:

  20. Gastric cancer occupies the fourth highest morbidity rate of cancers worldwide. Clinical therapies of gastric cancer remain limited because of uncertainty of mechanisms and shortness of effective medicine. Thu...

    Authors: Yu Li, Depeng Zhang, Kaikai Yu, Yudong Hu, Qiong Wu, Feng Qian and Zishu Wang

    Citation: Biological Research 2018 51:11

    Content type: Research article

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  23. Heat stress proteins are implicated in stabilizing and refolding denatured proteins in vertebrates and invertebrates. Members of the Hsp70 gene family comprise the cognate heat shock protein (Hsc70) and induci...

    Authors: Marcelo González-Aravena, Camila Calfio, Luis Mercado, Byron Morales-Lange, Jorn Bethke, Julien De Lorgeril and César A. Cárdenas

    Citation: Biological Research 2018 51:8

    Content type: Research article

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  24. Low phosphorus availability is a major factor restricting rice growth. Dongxiang wild rice (Oryza rufipogon Griff.) has many useful genes lacking in cultivated rice, including stress resistance to phosphorus defi...

    Authors: Qian-Wen Deng, Xiang-Dong Luo, Ya-Ling Chen, Yi Zhou, Fan-Tao Zhang, Biao-Lin Hu and Jian-Kun Xie

    Citation: Biological Research 2018 51:7

    Content type: Research article

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  25. Cocaine-and amphetamine regulated transcript (CART) is an endogenous neuropeptide, which is widespread in animals, plays a key role in regulation of follicular atresia in cattle and sheep. Among animal ovaries, C...

    Authors: Pengfei Li, Jinzhu Meng, Jiongjie Jing, Qingling Hao, Zhiwei Zhu, Jianbo Yao and Lihua Lyu

    Citation: Biological Research 2018 51:6

    Content type: Research article

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  26. Peroxisome proliferator activated receptor alpha (PPARα), a regulator of enzymes involved in β oxidation, has been reported to influence lymphocyte activation. The purpose of this study was to determine whethe...

    Authors: Ian N. Hines, Michael Kremer, Sherri M. Moore and Michael D. Wheeler

    Citation: Biological Research 2018 51:5

    Content type: Research article

    Published on:

  27. Aquaporins (AQP) are channel proteins belonging to the Major Intrinsic Protein (MIP) superfamily that play an important role in plant water relations. The main role of aquaporins in plants is transport of wate...

    Authors: Ranganathan Kapilan, Maryam Vaziri and Janusz J. Zwiazek

    Citation: Biological Research 2018 51:4

    Content type: Review

    Published on:

  28. The WNT pathway regulates intestinal stem cells and is frequently disrupted in intestinal adenomas. The pathway contains several potential biotargets for interference, including the poly-ADP ribosyltransferase...

    Authors: Jens Henrik Norum, Ellen Skarpen, Andreas Brech, Raoul Kuiper, Jo Waaler, Stefan Krauss and Therese Sørlie

    Citation: Biological Research 2018 51:3

    Content type: Research article

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  29. This study determined the regulatory effects of inducible T-cell co-stimulators (ICOS) in human hepatocellular carcinoma HepG2 cells using a RNA interference (RNAi) technique.

    Authors: Yaning Wei, Yanan Wang, Aimin Zang, Yanhong Shang, Zizheng Song, Zhiyu Wang, Yangyang Wang and Hua Yang

    Citation: Biological Research 2018 51:2

    Content type: Research article

    Published on:

  31. Understanding the molecular basis underlying the formation of bone-forming osteocytes and lipid-storing adipocytes will help provide insights into the cause of disorders originating in stem/progenitor cells an...

    Authors: Alma Madrigal, Lun Tan and Yuanxiang Zhao

    Citation: Biological Research 2017 50:43

    Content type: Research article

    Published on:

  32. Fresh frozen plasma (FFP) administration may increase the risk of nosocomial infections in parallel with the development of immune modulation. This could be driven by soluble mediators, possibly influencing th...

    Authors: Mariana Patlán, Fausto Sánchez-Muñoz, Luis M. Amezcua-Guerra, Adriana Granados, Araceli Páez, Felipe Massó, Ana M. Mejía, Angeles Soster, Rafael Bojalil, Lenin Pavón, Luis A. Jiménez-Zamudio and Ricardo Márquez-Velasco

    Citation: Biological Research 2017 50:42

    Content type: Research article

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  33. The marine environment is a rich source of bioactive natural products. Many of the marine bioactive compounds have been derived successfully from molluscs. Euchelus asper is a marine mollusc which is commonly fou...

    Authors: Sweta Agrawal, Sachin Chaugule, Shashank More, Gargi Rane and Madhavi Indap

    Citation: Biological Research 2017 50:41

    Content type: Research article

    Published on:

  34. Programmed cell death 5 (PDCD5) is an apoptosis-related gene cloned from TF-1 cells whose primary biological functions are to promote apoptosis and immune regulation. The effects and mechanisms exerted by key ...

    Authors: Feng Yuan, Junfeng Wang, Keshi Zhang, Zhao Li and Zhenpeng Guan

    Citation: Biological Research 2017 50:40

    Content type: Research article

    Published on:

  35. Ferredoxin NADP(H) oxidoreductases (EC 1.18.1.2) (FNR) are flavoenzymes present in photosynthetic organisms; they are relevant for the production of reduced donors to redox reactions, i.e. in photosynthesis, t...

    Authors: María Alejandra Vorphal, Carola Bruna, Traudy Wandersleben, Jorge Dagnino-Leone, Francisco Lobos-González, Elena Uribe, José Martínez-Oyanedel and Marta Bunster

    Citation: Biological Research 2017 50:39

    Content type: Research article

    Published on:

  36. The nuclear architecture of meiotic prophase spermatocytes is based on higher-order patterns of spatial associations among chromosomal domains and consequently is prone to modification by chromosomal rearrange...

    Authors: Soledad Berríos, Raúl Fernández-Donoso and Eliana Ayarza

    Citation: Biological Research 2017 50:38

    Content type: Short report

    Published on:

  39. Breast cancer (BC) is the most common malignancy among women worldwide. A major advance in the understanding of the genetic etiology of BC was the discovery of BRCA1 and BRCA2 (BRCA1/2) genes, which are considere...

    Authors: Lilian Jara, Sebastian Morales, Tomas de Mayo, Patricio Gonzalez-Hormazabal, Valentina Carrasco and Raul Godoy

    Citation: Biological Research 2017 50:35

    Content type: Review

    Published on:

  41. Breast cancer remains a worldwide public health dilemma and is currently the most common tumour in the globe. Awareness of breast cancer, public attentiveness, and advancement in breast imaging has made a posi...

    Authors: Muhammad Akram, Mehwish Iqbal, Muhammad Daniyal and Asmat Ullah Khan

    Citation: Biological Research 2017 50:33

    Content type: Review

    Published on:

  42. Growing evidence has supported that long non-coding RNAs (lncRNAs) could play vital roles in the development, progression, and prognosis of colorectal cancer (CRC). However, little is known about the clinical ...

    Authors: Xiaogang Shen, Yifeng Bai, Bin Luo and Xiaogang Zhou

    Citation: Biological Research 2017 50:32

    Content type: Research article

    Published on:

  43. MiR-320 is downregulated in multiple cancers, including glioma and acts as tumor suppressor through inhibiting tumor cells proliferation and inducing apoptosis. PBX3 (Pre-B cell leukemia homeobox 3), a putativ...

    Authors: Cuicui Pan, Hua Gao, Ni Zheng, Qi Gao, Yuanquan Si and Yueran Zhao

    Citation: Biological Research 2017 50:31

    Content type: Research article

    Published on:

  44. Porcine Deltacoronavirus (PDCoV) is a newly emerged enteropathogenic coronavirus that causes diarrhea and mortality in neonatal piglets. PDCoV has spread to many countries around the world, leading to significant...

    Authors: Fanfan Zhang, Yu Ye, Deping Song, Nannan Guo, Qi Peng, Anqi Li, Xingrong Zhou, Yanjun Chen, Min Zhang, Dongyan Huang and Yuxin Tang

    Citation: Biological Research 2017 50:30

    Content type: Research article

    Published on:

  45. Obsessive–compulsive disorder (OCD) is a severe neuropsychiatric condition affecting 1–3% of the worldwide population. OCD has a strong genetic component, and the SLC1A1 gene that encodes neuronal glutamate trans...

    Authors: Luis F. González, Francisca Henríquez-Belmar, Claudia Delgado-Acevedo, Marisol Cisternas-Olmedo, Gloria Arriagada, Ramón Sotomayor-Zárate, Dennis L. Murphy and Pablo R. Moya

    Citation: Biological Research 2017 50:29

    Content type: Research article

    Published on:

  46. The Tridax procumbens extracts (TPE) are known for their ethno-medicinal properties to increase osteogenic functioning in mesenchymal stem cells. Recently, we found that the T. procumbens flavonoids (TPF) signifi...

    Authors: Md. Abdullah Al Mamun, Mohammad Jakir Hosen, Amina Khatun, M. Masihul Alam and Md. Abdul Alim Al-Bari

    Citation: Biological Research 2017 50:28

    Content type: Research article

    Published on:

  48. CCL2 was up-regulated in neurons and involved in microglia activation and neurological decline in mice suffering from hepatic encephalopathy (HE). However, no data exist concerning the effect of neuron-derived...

    Authors: Li Zhang, Jinyun Tan, Xiaoping Jiang, Weiwei Qian, Ting Yang, Xijun Sun, Zhaohui Chen and Qiwen Zhu

    Citation: Biological Research 2017 50:26

    Content type: Research article

    Published on:

  49. Jojoba is considered a promising oil crop and is cultivated for diverse purposes in many countries. The jojoba seed produces unique high-quality oil with a wide range of applications such as medical and indust...

    Authors: Jameel R. Al-Obaidi, Mohammed Farouq Halabi, Nasser S. AlKhalifah, Shanavaskhan Asanar, Abdulrahman A. Al-Soqeer and M. F. Attia

    Citation: Biological Research 2017 50:25

    Content type: Review

    Published on:

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