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  1. chronic hypoxia increases basal ventilation and pulmonary vascular resistance, with variable changes in arterial blood pressure and heart rate, but it’s impact on heart rate variability and autonomic regulatio...

    Authors: Julio Alcayaga, Rodrigo Del Rio, Esteban A. Moya, Matías Freire and Rodrigo Iturriaga

    Citation: Biological Research 2018 51:57

    Content type: Research article

    Published on:

  3. The Antarctic continent is a source of extreme microorganisms. Millions of years of isolation have produced unique biodiversity with adaptive responses to its extreme environment. Although the Antarctic climat...

    Authors: Patricio A. M. Flores, Daniela N. Correa-Llantén and Jenny M. Blamey

    Citation: Biological Research 2018 51:55

    Content type: Research article

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  4. Hyperpigmentation disorders such as post-inflammatory hyperpigmentation are major concerns not only in light-skinned people but also in Asian populations with darker skin. The anti-tyrosinase and immunomodulat...

    Authors: Pornanong Aramwit, Natthanej Luplertlop, Tapanee Kanjanapruthipong and Sumate Ampawong

    Citation: Biological Research 2018 51:54

    Content type: Research article

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  6. Phosphoinositide-3-kinase, regulatory subunit 1 (PIK3R1) could regulate cancer cell proliferation important for cancer cell proliferation; however, its role in Hepatocellular carcinoma (HCC) remains largely un...

    Authors: Xuejun Ai, Lei Xiang, Zhi Huang, Shi Zhou, Shuai Zhang, Tao Zhang and Tianpeng Jiang

    Citation: Biological Research 2018 51:52

    Content type: Research article

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  9. Antarctic bryophytes (mosses and liverworts) are resilient to physiologically extreme environmental conditions including elevated levels of ultraviolet (UV) radiation due to depletion of stratospheric ozone. M...

    Authors: Melinda J. Waterman, Jessica Bramley-Alves, Rebecca E. Miller, Paul A. Keller and Sharon A. Robinson

    Citation: Biological Research 2018 51:49

    Content type: Research article

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  10. In field, C. quitensis is subjected to many abiotic extreme environmental conditions, such as low temperatures, high UV-B, salinity and reduced water potentials, but not metal or metalloid high concentrations in ...

    Authors: Rodrigo A. Contreras, Marisol Pizarro, Hans Köhler, Claudio A. Sáez and Gustavo E. Zúñiga

    Citation: Biological Research 2018 51:48

    Content type: Research Article

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  11. Increased levels of greenhouse gases in the atmosphere and associated climatic variability is primarily responsible for inducing heat waves, flooding and drought stress. Among these, water scarcity is a major ...

    Authors: Aziz Khan, Xudong Pan, Ullah Najeeb, Daniel Kean Yuen Tan, Shah Fahad, Rizwan Zahoor and Honghai Luo

    Citation: Biological Research 2018 51:47

    Content type: Review

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  12. The negative effects of environmental stresses, such as low temperature, high temperature, salinity, drought, heavy metal stress, and biotic stress significantly decrease crop productivity. Plant hormones are ...

    Authors: Ali Anwar, Yumei Liu, Rongrong Dong, Longqiang Bai, Xianchang Yu and Yansu Li

    Citation: Biological Research 2018 51:46

    Content type: Review

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  14. Emerging evidence indicate that miRNAs play an important role on gastric cancer (GC) progression via regulating several downstream targets, but it is still partially uncovered. This study aimed to explore the ...

    Authors: Bin Song, Juan Du, De-feng Song, Ji-chen Ren and Ye Feng

    Citation: Biological Research 2018 51:44

    Content type: Research article

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  15. CircRNAs are widespread in plants and play important roles in response to abiotic stresses. Low nitrogen (LN) promotes the growth of plant root system, allowing it to explore more nitrogen. However, whether ci...

    Authors: Yongzhe Ren, Huifang Yue, Le Li, Yanhua Xu, Zhiqiang Wang, Zeyu Xin and Tongbao Lin

    Citation: Biological Research 2018 51:43

    Content type: Research article

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  16. Polymorphic microsatellite markers were developed for Gaultheria pumila (Ericaceae) to evaluate genetic diversity and population structure within its native range in Chile. This is a very important Ericaceae ende...

    Authors: Rolando Garcia-Gonzales, José Pico-Mendoza, Karla Quiroz, Basilio Carrasco, Pablo Cáceres, Borys Chong-Perez, Hugo Pino, Marjorie Seiltgens, Eglis Greck and Peter D. S. Caligari

    Citation: Biological Research 2018 51:42

    Content type: Short report

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  17. Osteoarthritis (OA) can be defined as degradation of articular cartilage of the joint, and is the most common degenerative disease. To regenerate the damaged cartilage, different experimental approaches includ...

    Authors: Dong-Sik Chae, Chang Youn Lee, Jiyun Lee, Hyang-Hee Seo, Chong-Hyuk Choi, Seahyoung Lee and Ki-Chul Hwang

    Citation: Biological Research 2018 51:41

    Content type: Research article

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  18. The biomechanical properties of maize stalks largely determine their lodging resistance, which affects crop yield per unit area. However, the quantitative and qualitative relationship between micro-phenotypes ...

    Authors: Ying Zhang, Jianjun Du, Jinglu Wang, Liming Ma, Xianju Lu, Xiaodi Pan, Xinyu Guo and Chunjiang Zhao

    Citation: Biological Research 2018 51:40

    Content type: Research article

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  19. SET domain bifurcated 1 (SETDB1) has been widely considered as an oncogene playing a critical role in many human cancers, including breast cancer. Nevertheless, the molecular mechanism by which SETDB1 regulate...

    Authors: Milu Wu, Baohua Fan, Qijing Guo, Yan Li, Rong Chen, Nannan Lv, Yinzhuo Diao and Yushuang Luo

    Citation: Biological Research 2018 51:39

    Content type: Research article

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  20. Hydrogen sulfide has been shown to improve the quality of oocytes destined for in vitro fertilization. Although hydrogen sulfide is capable of modulating ion channel activity in somatic cells, the role of hydr...

    Authors: Jan Nevoral, Tereza Zalmanova, Kristyna Hoskova, Miriam Stiavnicka, Petr Hosek, Ales Petelak and Jaroslav Petr

    Citation: Biological Research 2018 51:38

    Content type: Short report

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  22. Whole transcriptome RNA variant analyses have shown that adenosine deaminases acting on RNA (ADAR) enzymes modify a large proportion of cellular RNAs, contributing to transcriptome diversity and cancer evolution....

    Authors: Eduardo A. Sagredo, Alejandro Blanco, Alfredo I. Sagredo, Paola Pérez, Gonzalo Sepúlveda-Hermosilla, Fernanda Morales, Bettina Müller, Ricardo Verdugo, Katherine Marcelain, Olivier Harismendy and Ricardo Armisén

    Citation: Biological Research 2018 51:36

    Content type: Research article

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  23. The previous studies have demonstrated the reduction of thiamine diphosphate is specific to Alzheimer’s disease (AD) and causal factor of brain glucose hypometabolism, which is considered as a neurodegenerativ...

    Authors: Qiujian Yu, Huimin Liu, Shaoming Sang, Lulan Chen, Yingya Zhao, Yun Wang and Chunjiu Zhong

    Citation: Biological Research 2018 51:35

    Content type: Research article

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  24. Atherosclerotic cardiovascular disease is highly prevalent and its underlying pathogenesis involves dyslipidemia including pro-atherogenic high density lipoprotein (HDL) remodeling. Vitamins C and E have been ...

    Authors: S. Contreras-Duarte, P. Chen, M. Andía, S. Uribe, P. Irarrázaval, S. Kopp, S. Kern, G. Marsche, D. Busso, C. Wadsack and A. Rigotti

    Citation: Biological Research 2018 51:34

    Content type: Research article

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  25. New evidence demonstrates that aging and dyslipidemia are closely associated with oxidative stress, DNA damage and apoptosis in some cells and extravascular tissues. However, in monocytes, which are naturally ...

    Authors: Thais A. Jacinto, Giselle S. Meireles, Ananda T. Dias, Rafaela Aires, Marcella L. Porto, Agata L. Gava, Elisardo C. Vasquez, Thiago Melo C. Pereira, Bianca P. Campagnaro and Silvana S. Meyrelles

    Citation: Biological Research 2018 51:33

    Content type: Research article

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  26. Minimal residual disease is that not detected by conventional imaging studies and clinically the patient remains disease free. However, with time these dormant cells will awaken and disease progression occurs,...

    Authors: Nigel P. Murray

    Citation: Biological Research 2018 51:32

    Content type: Review

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  27. miR-214 was demonstrated to be upregulated in models of renal disease and promoted fibrosis in renal injury independent of TGF-β signaling in vivo. However, the detailed role of miR-214 in acute kidney injury ...

    Authors: Xiaoguang Zhu, Wenwen Li and Huicong Li

    Citation: Biological Research 2018 51:31

    Content type: Research article

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  28. Psoriasis is a complex, chronic inflammatory skin disease with substantial negative effects on patient quality of life. Long non-coding RNAs (lncRNAs) are able to be involved in multitudes of cellular processe...

    Authors: Jintao Gao, Fangru Chen, Mingchun Hua, Junfan Guo, Yuejuan Nong, Qinyan Tang, Fengxia Zhong and Linxiu Qin

    Citation: Biological Research 2018 51:30

    Content type: Research article

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  29. With 29 Km2, the Fildes Peninsula is the largest ice free area in King George Island and probably in Antarctica. The region is house of six permanent bases including the only airport in the South Shetlands, which...

    Authors: Diego Knop Henriques, Bárbara Guedes Costa Silva, Gustavo Emílio Zuñiga and Paulo Eduardo Aguiar Saraiva Câmara

    Citation: Biological Research 2018 51:29

    Content type: Research article

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  30. Pectinase enzymes catalyze the breakdown of pectin, a key component of the plant cell wall. At industrial level, pectinases are used in diverse applications, especially in food-processing industry. Currently, ...

    Authors: Gabriela Poveda, Carlos Gil-Durán, Inmaculada Vaca, Gloria Levicán and Renato Chávez

    Citation: Biological Research 2018 51:28

    Content type: Research article

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  31. The domestic cat serves as an animal model for assisted reproductive studies of endangered felid species. To date, there are no data on the protein alterations following cryopreservation of oocytes in felid fa...

    Authors: Bongkoch Turathum, Sittiruk Roytrakul, Chinarat Changsangfa, Morakot Sroyraya, Supita Tanasawet, Yindee Kitiyanant and Kulnasan Saikhun

    Citation: Biological Research 2018 51:27

    Content type: Research article

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  35. The exact cause of cancer is one of the most immutable medical questions of the century. Cancer as an evolutionary disease must have a purpose and understanding the purpose is more important than decoding the ...

    Authors: Mukesh Yadav, Payal Chatterjee, Simran Tolani, Jaya Kulkarni, Meenakshi Mulye, Namrata Chauhan, Aditi Sakhi and Sakshi Gorey

    Citation: Biological Research 2018 51:23

    Content type: Review

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  37. To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease.

    Authors: Ruhui Lin, Long Li, Yingzheng Zhang, Sheng Huang, Shangjie Chen, Jiao Shi, Peiyuan Zhuo, Hao Jin, Zuanfang Li, Weilin Liu, Zhifu Wang, Lidian Chen and Jing Tao

    Citation: Biological Research 2018 51:21

    Content type: Research Article

    Published on:

  38. Concerns have been raised about this article [1] relating to the appropriateness of the use of the shRNA (5′-GCGGAGGGTTTGAAAGAATATCTCGAGATATTCTTTCAAACCCTCCGCTTTTTT-3′) as a non-targeting control and similariti...

    Authors: Xiaolan Zhao, Man Chen and Jishan Tan

    Citation: Biological Research 2018 51:20

    Content type: Correction

    Published on:

    The original article was published in Biological Research 2016 49:26

  39. Concerns have been raised about this article [1] relating to the appropriateness of the use of the shRNA (5′-GCGGAGGGTTTGAAAGAATATCTCGAGATATTCTTTCAAACCCTCCGCTTTTTT-3′) as a non-targeting control and similariti...

    Authors: Zeya Pan, Hao Pan, Jin Zhang, Yun Yang, Hui Liu, Yuan Yang, Gang Huang, Junsheng Ni, Jian Huang and Weiping Zhou

    Citation: Biological Research 2018 51:19

    Content type: Correction

    Published on:

    The original article was published in Biological Research 2015 48:18

  40. Arsenic trioxide (As2O3), a drug that has been used in China for approximately two thousand years, induces cell death in a variety of cancer cell types, including neuroblastoma (NB). The tyrosine kinase receptor ...

    Authors: Xilin Xiong, Yang Li, Ling Liu, Kai Qi, Chi Zhang, Yueqin Chen and Jianpei Fang

    Citation: Biological Research 2018 51:18

    Content type: Research article

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  41. Improper control on reactive oxygen species (ROS) elimination process and formation of free radicals causes tissue dysfunction. Pineal hormone melatonin is considered a potent regulator of such oxidative dama...

    Authors: Mahammed Moniruzzaman, Indranath Ghosal, Debjit Das and Suman Bhusan Chakraborty

    Citation: Biological Research 2018 51:17

    Content type: Research article

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  42. Stathmin as a critical protein involved in microtubule polymerization, is necessary for survival of cancer cells. However, extremely little is known about Stathmin in glioblastoma. So, this study was designed ...

    Authors: Ping Liu, Junyan Yu, Xiangyang Tian, Jianlan Chang, Ying Zhang, Rong Zhang, Ningning Zhang, Ranxing Huang, Lulu Li, Xianli Qiao and Hongliang Guo

    Citation: Biological Research 2018 51:16

    Content type: Research article

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  43. Translational research to develop pharmaceutical and surgical treatments for pterygium requires a reliable and easy to produce animal model. Extracellular matrix and fibroblast are important components of pter...

    Authors: Judith Zavala, Julio C. Hernandez-Camarena, Brenda Salvador-Gálvez, José E. Pérez-Saucedo, Amin Vela-Martinez and Jorge E. Valdez-García

    Citation: Biological Research 2018 51:15

    Content type: Research Article

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  44. Neurokinin1 (NK1) receptor has played a vital role in the development of tumor. However, NKP608 as a NK1 receptor antagonist whether has the effect of the resistance of colorectal cancer is still unclear. Ther...

    Authors: Xiao-Ling Niu, Jian-Feng Hou and Jing-Xiang Li

    Citation: Biological Research 2018 51:14

    Content type: Research Article

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  46. Chemokine (C-C motif) receptor 6 (CCR6) is present in sperm and plays a significant role in sperm motility and chemotaxis acting in the reproductive tracts. However, the expression and functional significance ...

    Authors: Ruiying Diao, Xueyong Cai, Lu Liu, Lihua Yang, YongGang Duan, Zhiming Cai, Yaoting Gui and Lisha Mou

    Citation: Biological Research 2018 51:12

    Content type: Research article

    Published on:

  47. Gastric cancer occupies the fourth highest morbidity rate of cancers worldwide. Clinical therapies of gastric cancer remain limited because of uncertainty of mechanisms and shortness of effective medicine. Thu...

    Authors: Yu Li, Depeng Zhang, Kaikai Yu, Yudong Hu, Qiong Wu, Feng Qian and Zishu Wang

    Citation: Biological Research 2018 51:11

    Content type: Research article

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  50. Heat stress proteins are implicated in stabilizing and refolding denatured proteins in vertebrates and invertebrates. Members of the Hsp70 gene family comprise the cognate heat shock protein (Hsc70) and induci...

    Authors: Marcelo González-Aravena, Camila Calfio, Luis Mercado, Byron Morales-Lange, Jorn Bethke, Julien De Lorgeril and César A. Cárdenas

    Citation: Biological Research 2018 51:8

    Content type: Research article

    Published on:

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