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  1. Content type: Review

    Aquaporins (AQP) are channel proteins belonging to the Major Intrinsic Protein (MIP) superfamily that play an important role in plant water relations. The main role of aquaporins in plants is transport of wate...

    Authors: Ranganathan Kapilan, Maryam Vaziri and Janusz J. Zwiazek

    Citation: Biological Research 2018 51:4

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  2. Content type: Research article

    The WNT pathway regulates intestinal stem cells and is frequently disrupted in intestinal adenomas. The pathway contains several potential biotargets for interference, including the poly-ADP ribosyltransferase...

    Authors: Jens Henrik Norum, Ellen Skarpen, Andreas Brech, Raoul Kuiper, Jo Waaler, Stefan Krauss and Therese Sørlie

    Citation: Biological Research 2018 51:3

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  3. Content type: Research article

    This study determined the regulatory effects of inducible T-cell co-stimulators (ICOS) in human hepatocellular carcinoma HepG2 cells using a RNA interference (RNAi) technique.

    Authors: Yaning Wei, Yanan Wang, Aimin Zang, Yanhong Shang, Zizheng Song, Zhiyu Wang, Yangyang Wang and Hua Yang

    Citation: Biological Research 2018 51:2

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  4. Content type: Research article

    Understanding the molecular basis underlying the formation of bone-forming osteocytes and lipid-storing adipocytes will help provide insights into the cause of disorders originating in stem/progenitor cells an...

    Authors: Alma Madrigal, Lun Tan and Yuanxiang Zhao

    Citation: Biological Research 2017 50:43

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  5. Content type: Research article

    Fresh frozen plasma (FFP) administration may increase the risk of nosocomial infections in parallel with the development of immune modulation. This could be driven by soluble mediators, possibly influencing th...

    Authors: Mariana Patlán, Fausto Sánchez-Muñoz, Luis M. Amezcua-Guerra, Adriana Granados, Araceli Páez, Felipe Massó, Ana M. Mejía, Angeles Soster, Rafael Bojalil, Lenin Pavón, Luis A. Jiménez-Zamudio and Ricardo Márquez-Velasco

    Citation: Biological Research 2017 50:42

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  6. Content type: Research article

    The marine environment is a rich source of bioactive natural products. Many of the marine bioactive compounds have been derived successfully from molluscs. Euchelus asper is a marine mollusc which is commonly fou...

    Authors: Sweta Agrawal, Sachin Chaugule, Shashank More, Gargi Rane and Madhavi Indap

    Citation: Biological Research 2017 50:41

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  7. Content type: Research article

    Programmed cell death 5 (PDCD5) is an apoptosis-related gene cloned from TF-1 cells whose primary biological functions are to promote apoptosis and immune regulation. The effects and mechanisms exerted by key ...

    Authors: Feng Yuan, Junfeng Wang, Keshi Zhang, Zhao Li and Zhenpeng Guan

    Citation: Biological Research 2017 50:40

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  8. Content type: Research article

    Ferredoxin NADP(H) oxidoreductases (EC (FNR) are flavoenzymes present in photosynthetic organisms; they are relevant for the production of reduced donors to redox reactions, i.e. in photosynthesis, t...

    Authors: María Alejandra Vorphal, Carola Bruna, Traudy Wandersleben, Jorge Dagnino-Leone, Francisco Lobos-González, Elena Uribe, José Martínez-Oyanedel and Marta Bunster

    Citation: Biological Research 2017 50:39

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  9. Content type: Short report

    The nuclear architecture of meiotic prophase spermatocytes is based on higher-order patterns of spatial associations among chromosomal domains and consequently is prone to modification by chromosomal rearrange...

    Authors: Soledad Berríos, Raúl Fernández-Donoso and Eliana Ayarza

    Citation: Biological Research 2017 50:38

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  10. Content type: Review

    Breast cancer (BC) is the most common malignancy among women worldwide. A major advance in the understanding of the genetic etiology of BC was the discovery of BRCA1 and BRCA2 (BRCA1/2) genes, which are considere...

    Authors: Lilian Jara, Sebastian Morales, Tomas de Mayo, Patricio Gonzalez-Hormazabal, Valentina Carrasco and Raul Godoy

    Citation: Biological Research 2017 50:35

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  11. Content type: Review

    Breast cancer remains a worldwide public health dilemma and is currently the most common tumour in the globe. Awareness of breast cancer, public attentiveness, and advancement in breast imaging has made a posi...

    Authors: Muhammad Akram, Mehwish Iqbal, Muhammad Daniyal and Asmat Ullah Khan

    Citation: Biological Research 2017 50:33

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  12. Content type: Research article

    Growing evidence has supported that long non-coding RNAs (lncRNAs) could play vital roles in the development, progression, and prognosis of colorectal cancer (CRC). However, little is known about the clinical ...

    Authors: Xiaogang Shen, Yifeng Bai, Bin Luo and Xiaogang Zhou

    Citation: Biological Research 2017 50:32

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  13. Content type: Research article

    MiR-320 is downregulated in multiple cancers, including glioma and acts as tumor suppressor through inhibiting tumor cells proliferation and inducing apoptosis. PBX3 (Pre-B cell leukemia homeobox 3), a putativ...

    Authors: Cuicui Pan, Hua Gao, Ni Zheng, Qi Gao, Yuanquan Si and Yueran Zhao

    Citation: Biological Research 2017 50:31

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  14. Content type: Research article

    Porcine Deltacoronavirus (PDCoV) is a newly emerged enteropathogenic coronavirus that causes diarrhea and mortality in neonatal piglets. PDCoV has spread to many countries around the world, leading to significant...

    Authors: Fanfan Zhang, Yu Ye, Deping Song, Nannan Guo, Qi Peng, Anqi Li, Xingrong Zhou, Yanjun Chen, Min Zhang, Dongyan Huang and Yuxin Tang

    Citation: Biological Research 2017 50:30

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  15. Content type: Research article

    Obsessive–compulsive disorder (OCD) is a severe neuropsychiatric condition affecting 1–3% of the worldwide population. OCD has a strong genetic component, and the SLC1A1 gene that encodes neuronal glutamate trans...

    Authors: Luis F. González, Francisca Henríquez-Belmar, Claudia Delgado-Acevedo, Marisol Cisternas-Olmedo, Gloria Arriagada, Ramón Sotomayor-Zárate, Dennis L. Murphy and Pablo R. Moya

    Citation: Biological Research 2017 50:29

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  16. Content type: Research article

    The Tridax procumbens extracts (TPE) are known for their ethno-medicinal properties to increase osteogenic functioning in mesenchymal stem cells. Recently, we found that the T. procumbens flavonoids (TPF) signifi...

    Authors: Md. Abdullah Al Mamun, Mohammad Jakir Hosen, Amina Khatun, M. Masihul Alam and Md. Abdul Alim Al-Bari

    Citation: Biological Research 2017 50:28

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  17. Content type: Research article

    CCL2 was up-regulated in neurons and involved in microglia activation and neurological decline in mice suffering from hepatic encephalopathy (HE). However, no data exist concerning the effect of neuron-derived...

    Authors: Li Zhang, Jinyun Tan, Xiaoping Jiang, Weiwei Qian, Ting Yang, Xijun Sun, Zhaohui Chen and Qiwen Zhu

    Citation: Biological Research 2017 50:26

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  18. Content type: Review

    Jojoba is considered a promising oil crop and is cultivated for diverse purposes in many countries. The jojoba seed produces unique high-quality oil with a wide range of applications such as medical and indust...

    Authors: Jameel R. Al-Obaidi, Mohammed Farouq Halabi, Nasser S. AlKhalifah, Shanavaskhan Asanar, Abdulrahman A. Al-Soqeer and M. F. Attia

    Citation: Biological Research 2017 50:25

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  19. Content type: Research article

    Airway remodeling is a key feature of asthma, characterized by increased proliferation of airway smooth muscle cells (ASMCs). S100A8 is a calcium-binding protein with a potential to regulate cell proliferation...

    Authors: Yu-Dong Xu, Yu Wang, Lei-Miao Yin, Ling-Ling Peng, Gyoung-Hee Park and Yong-Qing Yang

    Citation: Biological Research 2017 50:23

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  20. Content type: Research article

    Hypertrophic scarring (HS) is a severe disease, and results from unusual wound healing. Col1A1 could promote the hypertrophic scar formation, and the expression of Col1A1 in HS tissue was markedly higher than ...

    Authors: Sheng Bi, Linlin Chai, Xi Yuan, Chuan Cao and Shirong Li

    Citation: Biological Research 2017 50:22

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  21. Content type: Research article

    Multiple techniques exist for detecting Mycobacteria, each having its own advantages and drawbacks. Among them, automated culture-based systems like the BACTEC-MGIT™ are popular because they are inexpensive, reli...

    Authors: Roli Kargupta, Sachidevi Puttaswamy, Aiden J. Lee, Timothy E. Butler, Zhongyu Li, Sounak Chakraborty and Shramik Sengupta

    Citation: Biological Research 2017 50:21

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  22. Content type: Short report

    Vegetative propagation of Fragaria sp. is traditionally carried out using stolons. This system of propagation, in addition to being slow, can spread plant diseases, particularly serious being viral. In vitro cult...

    Authors: Karla A. Quiroz, Miguel Berríos, Basilio Carrasco, Jorge B. Retamales, Peter D. S. Caligari and Rolando García-Gonzáles

    Citation: Biological Research 2017 50:20

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  23. Content type: Research article

    Bromodomain-containing protein 4 (BRD4) inhibition is a new therapeutic strategy for many malignancies. In this study, we aimed to explore the effect of BRD4 inhibition by JQ1 on in vitro cell growth, migratio...

    Authors: Limei Wang, Xiuyin Wu, Ruolin Wang, Chengzhe Yang, Zhi Li, Cunwei Wang, Fenghe Zhang and Pishan Yang

    Citation: Biological Research 2017 50:19

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  24. Content type: Research article

    Cocaine- and amphetamine-regulated transcript (CART), discovered initially by via differential display RT-PCR analysis of brains of rats administered cocaine, is expressed mainly in central nervous system or n...

    Authors: Pengfei Li, Xuejing Yu, Jianshan Xie, Xiaolei Yao, Wenzhong Liu, Jianbo Yao, Zhiwei Zhu and Lihua Lyu

    Citation: Biological Research 2017 50:18

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  25. Content type: Review

    Realgar is a naturally occurring arsenic sulfide (or Xionghuang, in Chinese). It contains over 90% tetra-arsenic tetra-sulfide (As4S4). Currently, realgar has been confirmed the antitumor activities, both in vitr...

    Authors: Peng Chen, Ruixiang Xu, Lei Yan, Zhengrong Wu, Yan Wei, Wenbin Zhao, Xin Wang, Qinjian Xie and Hongyu Li

    Citation: Biological Research 2017 50:17

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  26. Content type: Research article

    Ubiquitin specific peptidase 39 (USP39), an essential factor in the assembly of the mature spliceosome complex, has an aberrant expression in several cancer. However, its function and the corresponding mechani...

    Authors: Zhihua Gan, Kun Han, Shuchen Lin, Haiyan Hu, Zan Shen and Daliu Min

    Citation: Biological Research 2017 50:15

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  27. Content type: Research article

    Kidney diseases are a global health problem. Currently, over 2 million people require dialysis or transplant which are associated with high morbidity and mortality; therefore, new researches focused on regener...

    Authors: Monica Maribel Mata-Miranda, Gustavo Jesus Vazquez-Zapien, Marlon Rojas-Lopez, Virginia Sanchez-Monroy, David Guillermo Perez-Ishiwara and Raul Jacobo Delgado-Macuil

    Citation: Biological Research 2017 50:14

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  28. Content type: Research article

    Cimicifuga racemosa is one of the herbs used for the treatment of climacteric syndrome, and it has been cited as an alternative therapy to estrogen. Apart from hectic fevers, dyspareun...

    Authors: Yun-Meng Da, Kai-Yu Niu, Shu-Ya Liu, Ke Wang, Wen-Juan Wang, Jing Jia, Li-Hua Qin and Wen-Pei Bai

    Citation: Biological Research 2017 50:11

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  29. Content type: Research article

    The muskrat is a seasonal breeder. Males secrete musk to attract females during the breeding season. The testosterone binding to the androgen receptor (AR) in musk glands of muskrat may play an important role ...

    Authors: Tianxiang Zhang, Dong Peng, Lei Qi, Weixuan Li, Mengyuan Fan, Jiachen Shen, Liangliang Yang, Yihua Wang, Wenxia Wang, Xiaolong Hu, Ruibo Cai, Ran Zhou, Yuting Wei, Juntong Zhou, Shuang Yang, Defu Hu…

    Citation: Biological Research 2017 50:10

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  30. Content type: Research article

    A number of dysregulated miRNAs have been identified and are proposed to have significant roles in the pathogenesis of type 2 diabetes mellitus or renal pathology. Alpinia oxyphylla has shown significant anti-inf...

    Authors: Guankui Du, Man Xiao, Xuezi Zhang, Maoyu Wen, Chi Pang, Shangfei Jiang, Shenggang Sang and Yiqiang Xie

    Citation: Biological Research 2017 50:9

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  31. Content type: Research article

    CD4+ T cells play an important role in the initiation of an immune response by providing help to other cells. Among the helper T subsets, interferon-γ (IFN-γ)-secreting T helper 1 (Th1) and IL-17-secreting T help...

    Authors: Youra Kang, Maheshwor Timilshina, Tae-gyu Nam, Byeong-Seon Jeong and Jae-Hoon Chang

    Citation: Biological Research 2017 50:8

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  32. Content type: Short report

    Earthworms are sensitive to toxic chemicals present in the soil and so are useful indicator organisms for soil health. Eisenia fetida are commonly used in ecotoxicological studies; therefore the assembly of a bas...

    Authors: Michelle Thunders, Jo Cavanagh and Yinsheng Li

    Citation: Biological Research 2017 50:7

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  33. Content type: Short report

    Salmonella pathogenicity island (SPI)-13 is conserved in many serovars of S. enterica, including S. Enteritidis, S. Typhimurium and S. Gallinarum. However, it is absent in typhoid sero...

    Authors: Rodrigo A. Espinoza, Cecilia A. Silva-Valenzuela, Fernando A. Amaya, Ítalo M. Urrutia, Inés Contreras and Carlos A. Santiviago

    Citation: Biological Research 2017 50:5

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  34. Content type: Research article

    Macrophages are a functionally heterogeneous cell population and depending on microenvironments they polarize in two main groups: M1 and M2. Glutamic acid and glutamate receptors may participate in the regulat...

    Authors: Lali Shanshiashvili, Elene Tsitsilashvili, Nino Dabrundashvili, Irine Kalandadze and David Mikeladze

    Citation: Biological Research 2017 50:4

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    The Erratum to this article has been published in Biological Research 2017 50:13

  35. Content type: Research article

    Cancer cells exhibit elevated levels of glucose uptake and may obtain pre-formed, diet-derived fatty acids from the bloodstream to boost their rapid growth; they may also use nucleic acid from their microenvir...

    Authors: Yanping Kong, Xianbo Zhang, Yongliang Zhao, Yanfang Xue and Ye Zhang

    Citation: Biological Research 2017 50:2

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  36. Content type: Short report

    Pathologic vascular smooth muscle cell (VSMC) proliferation and migration after vascular injury promotes the development of occlusive vascular disease. Therefore, an effective chemical agent to suppress aberra...

    Authors: Hyang-Hee Seo, Sang Woo Kim, Chang Youn Lee, Kyu Hee Lim, Jiyun Lee, Eunhyun Choi, Soyeon Lim, Seahyoung Lee and Ki-Chul Hwang

    Citation: Biological Research 2017 50:1

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  37. Content type: Research article

    Dendritic cells (DCs) are the most potent professional antigen-presenting cells for naive T cells to link innate and acquired immunity. Klotho, an anti-aging protein, participates in the regulation of Ca2+ depend...

    Authors: Nguyen Thi Xuan, Phi Thi Thu Trang, Nguyen Van Phong, Nguyen Linh Toan, Do Minh Trung, Nguyen Duy Bac, Viet Linh Nguyen, Nguyen Huy Hoang and Nong Van Hai

    Citation: Biological Research 2016 49:45

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  38. Content type: Research article

    The olfactomedin-like domain (OLFML) is present in at least four families of proteins, including OLFML2A and OLFML2B, which are expressed in adult rat retina cells. However, no expression of their orthologous ...

    Authors: Diana Cristina Pérez-Ibave, Rafael González-Alvarez, Margarita de La Luz Martinez-Fierro, Gabriel Ruiz-Ayma, Maricela Luna-Muñoz, Laura Elia Martínez-De-Villarreal, María De Lourdes Garza-Rodríguez, Diana Reséndez-Pérez, Jibran Mohamed-Noriega, Raquel Garza-Guajardo, Víctor Manuel Bautista-De-Lucío, Karim Mohamed-Noriega, Oralia Barboza-Quintana, Carlos Arámburo-De-La-Hoz, Hugo Alberto Barrera-Saldaña and Irám Pablo Rodríguez-Sánchez

    Citation: Biological Research 2016 49:44

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  39. Content type: Research article

    Computer-based technology is becoming increasingly essential in biological research where drug discovery programs start with the identification of suitable drug targets. 2-Methoxyestradiol (2ME2) is a 17β-estr...

    Authors: Michelle Helen Visagie, Seema Rummurat Jaiswal and Anna Margaretha Joubert

    Citation: Biological Research 2016 49:43

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