Articles

The NK1 receptor antagonist NKP608 inhibits proliferation of human colorectal cancer cells via Wnt signaling pathway

Neurokinin1 (NK1) receptor has played a vital role in the development of tumor. However, NKP608 as a NK1 receptor antagonist whether has the effect of the resistance of colorectal cancer is still unclear. Ther...

Authors: Xiao-Ling Niu, Jian-Feng Hou and Jing-Xiang Li

MicroRNA-1247 inhibits cell proliferation by directly targeting ZNF346 in childhood neuroblastoma

Neuroblastoma (NB) represents the most common extracranial solid tumor in children. Accumulating evidence shows that microRNAs (miRs) play an important role in the carcinogenesis of NB. Here, we investigated t...

Authors: Tingting Wu, Yun Lin and Zhongguo Xie

In vitro chemokine (C-C motif) receptor 6-dependent non-inflammatory chemotaxis during spermatogenesis

Chemokine (C-C motif) receptor 6 (CCR6) is present in sperm and plays a significant role in sperm motility and chemotaxis acting in the reproductive tracts. However, the expression and functional significance ...

Authors: Ruiying Diao, Xueyong Cai, Lu Liu, Lihua Yang, YongGang Duan, Zhiming Cai, Yaoting Gui and Lisha Mou

CMPD1 inhibited human gastric cancer cell proliferation by inducing apoptosis and G2/M cell cycle arrest

Gastric cancer occupies the fourth highest morbidity rate of cancers worldwide. Clinical therapies of gastric cancer remain limited because of uncertainty of mechanisms and shortness of effective medicine. Thu...

Authors: Yu Li, Depeng Zhang, Kaikai Yu, Yudong Hu, Qiong Wu, Feng Qian and Zishu Wang

Independent prognostic genes and mechanism investigation for colon cancer

We aimed to explore the potential molecular mechanism and independent prognostic genes for colon cancer (CC).

Authors: Chunsheng Li, Zhen Shen, Yangyang Zhou and Wei Yu

Berberine ameliorates diabetic nephropathy by inhibiting TLR4/NF-κB pathway

Diabetic nephropathy (DN) is the leading cause of end-stage renal failure, contributing to severe morbidity and mortality in diabetic patients. Berberine (BBR) has been well characterized to exert renoprotecti...

Authors: Liping Zhu, Jiakai Han, Rongrong Yuan, Lei Xue and Wuyan Pang

HSP70 from the Antarctic sea urchin Sterechinus neumayeri: molecular characterization and expression in response to heat stress

Heat stress proteins are implicated in stabilizing and refolding denatured proteins in vertebrates and invertebrates. Members of the Hsp70 gene family comprise the cognate heat shock protein (Hsc70) and induci...

Authors: Marcelo González-Aravena, Camila Calfio, Luis Mercado, Byron Morales-Lange, Jorn Bethke, Julien De Lorgeril and César A. Cárdenas

Transcriptome analysis of phosphorus stress responsiveness in the seedlings of Dongxiang wild rice (Oryza rufipogon Griff.)

Low phosphorus availability is a major factor restricting rice growth. Dongxiang wild rice (Oryza rufipogon Griff.) has many useful genes lacking in cultivated rice, including stress resistance to phosphorus defi...

Authors: Qian-Wen Deng, Xiang-Dong Luo, Ya-Ling Chen, Yi Zhou, Fan-Tao Zhang, Biao-Lin Hu and Jian-Kun Xie

Study on the relationship between expression patterns of cocaine-and amphetamine regulated transcript and hormones secretion in porcine ovarian follicles

Cocaine-and amphetamine regulated transcript (CART) is an endogenous neuropeptide, which is widespread in animals, plays a key role in regulation of follicular atresia in cattle and sheep. Among animal ovaries, C...

Authors: Pengfei Li, Jinzhu Meng, Jiongjie Jing, Qingling Hao, Zhiwei Zhu, Jianbo Yao and Lihua Lyu

Impaired T cell-mediated hepatitis in peroxisome proliferator activated receptor alpha (PPARα)-deficient mice

Peroxisome proliferator activated receptor alpha (PPARα), a regulator of enzymes involved in β oxidation, has been reported to influence lymphocyte activation. The purpose of this study was to determine whethe...

Authors: Ian N. Hines, Michael Kremer, Sherri M. Moore and Michael D. Wheeler

Regulation of aquaporins in plants under stress

Aquaporins (AQP) are channel proteins belonging to the Major Intrinsic Protein (MIP) superfamily that play an important role in plant water relations. The main role of aquaporins in plants is transport of wate...

Authors: Ranganathan Kapilan, Maryam Vaziri and Janusz J. Zwiazek

The tankyrase inhibitor G007-LK inhibits small intestine LGR5⁺ stem cell proliferation without altering tissue morphology

The WNT pathway regulates intestinal stem cells and is frequently disrupted in intestinal adenomas. The pathway contains several potential biotargets for interference, including the poly-ADP ribosyltransferase...

Authors: Jens Henrik Norum, Ellen Skarpen, Andreas Brech, Raoul Kuiper, Jo Waaler, Stefan Krauss and Therese Sørlie

Inducible T-cell co-stimulators regulate the proliferation and invasion of human hepatocellular carcinoma HepG2 cells

This study determined the regulatory effects of inducible T-cell co-stimulators (ICOS) in human hepatocellular carcinoma HepG2 cells using a RNA interference (RNAi) technique.

Authors: Yaning Wei, Yanan Wang, Aimin Zang, Yanhong Shang, Zizheng Song, Zhiyu Wang, Yangyang Wang and Hua Yang

CCAT2 is an oncogenic long non-coding RNA in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive with poor prognosis. Long non-coding RNAs (lncRNAs), a group of non-coding RNAs, play important roles in the progression of PDAC. This study aimed t...

Authors: Yi Cai, Xiaomei Li, Peng Shen and Dong Zhang

Expression regulation and functional analysis of RGS2 and RGS4 in adipogenic and osteogenic differentiation of human mesenchymal stem cells

Understanding the molecular basis underlying the formation of bone-forming osteocytes and lipid-storing adipocytes will help provide insights into the cause of disorders originating in stem/progenitor cells an...

Authors: Alma Madrigal, Lun Tan and Yuanxiang Zhao

Effect of fresh frozen plasma on the in vitro activation of U937 monocytes: a potential role for the age of blood donors and their underlying cytokine profile

Fresh frozen plasma (FFP) administration may increase the risk of nosocomial infections in parallel with the development of immune modulation. This could be driven by soluble mediators, possibly influencing th...

Authors: Mariana Patlán, Fausto Sánchez-Muñoz, Luis M. Amezcua-Guerra, Adriana Granados, Araceli Páez, Felipe Massó, Ana M. Mejía, Angeles Soster, Rafael Bojalil, Lenin Pavón, Luis A. Jiménez-Zamudio and Ricardo Márquez-Velasco

Methanolic extract of Euchelus asper exhibits in-ovo anti-angiogenic and in vitro anti-proliferative activities

The marine environment is a rich source of bioactive natural products. Many of the marine bioactive compounds have been derived successfully from molluscs. Euchelus asper is a marine mollusc which is commonly fou...

Authors: Sweta Agrawal, Sachin Chaugule, Shashank More, Gargi Rane and Madhavi Indap

Programmed cell death 5 transgenic mice attenuates adjuvant induced arthritis by 2 modifying the T lymphocytes balance

Programmed cell death 5 (PDCD5) is an apoptosis-related gene cloned from TF-1 cells whose primary biological functions are to promote apoptosis and immune regulation. The effects and mechanisms exerted by key ...

Authors: Feng Yuan, Junfeng Wang, Keshi Zhang, Zhao Li and Zhenpeng Guan

Molecular and functional characterization of ferredoxin NADP(H) oxidoreductase from Gracilaria chilensis and its complex with ferredoxin

Ferredoxin NADP(H) oxidoreductases (EC 1.18.1.2) (FNR) are flavoenzymes present in photosynthetic organisms; they are relevant for the production of reduced donors to redox reactions, i.e. in photosynthesis, t...

Authors: María Alejandra Vorphal, Carola Bruna, Traudy Wandersleben, Jorge Dagnino-Leone, Francisco Lobos-González, Elena Uribe, José Martínez-Oyanedel and Marta Bunster

Synaptic configuration of quadrivalents and their association with the XY bivalent in spermatocytes of Robertsonian heterozygotes of Mus domesticus

The nuclear architecture of meiotic prophase spermatocytes is based on higher-order patterns of spatial associations among chromosomal domains and consequently is prone to modification by chromosomal rearrange...

Authors: Soledad Berríos, Raúl Fernández-Donoso and Eliana Ayarza

Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma

Regenerating gene IA (REGIA) plays an important role in tissue regeneration and tumors prognosis of epithelium origin. However, the role of REGIA in nasopharyngeal carcinoma (NPC) is unclear. This study aims t...

Authors: Haijie Xing, Xiangdong Chen and Yaofeng Han

Piceatannol induced apoptosis through up-regulation of microRNA-181a in melanoma cells

Melanoma took top position among the lethal cancers and, despite there have been some great attempts made to increase the natural life of patients with metastatic disease, long-lasting and complete remissions ...

Authors: Maotao Du, Zhong Zhang and Tao Gao

Mutations in BRCA1, BRCA2 and other breast and ovarian cancer susceptibility genes in Central and South American populations

Breast cancer (BC) is the most common malignancy among women worldwide. A major advance in the understanding of the genetic etiology of BC was the discovery of BRCA1 and BRCA2 (BRCA1/2) genes, which are considere...

Authors: Lilian Jara, Sebastian Morales, Tomas de Mayo, Patricio Gonzalez-Hormazabal, Valentina Carrasco and Raul Godoy

The comparative mitogenomics and phylogenetics of the two grouse-grasshoppers (Insecta, Orthoptera, Tetrigoidea)

This study aimed to reveal the mitochondrial genomes (mtgenomes) of Tetrix japonica and Alulatettix yunnanensis, and the phylogenetics of Orthoptera species.

Authors: Yufang Sun, Dianfeng Liu, Bo Xiao and Guofang Jiang

Awareness and current knowledge of breast cancer

Breast cancer remains a worldwide public health dilemma and is currently the most common tumour in the globe. Awareness of breast cancer, public attentiveness, and advancement in breast imaging has made a posi...

Authors: Muhammad Akram, Mehwish Iqbal, Muhammad Daniyal and Asmat Ullah Khan

Upregulation of lncRNA BANCR associated with the lymph node metastasis and poor prognosis in colorectal cancer

Growing evidence has supported that long non-coding RNAs (lncRNAs) could play vital roles in the development, progression, and prognosis of colorectal cancer (CRC). However, little is known about the clinical ...

Authors: Xiaogang Shen, Yifeng Bai, Bin Luo and Xiaogang Zhou

MiR-320 inhibits the growth of glioma cells through downregulating PBX3

MiR-320 is downregulated in multiple cancers, including glioma and acts as tumor suppressor through inhibiting tumor cells proliferation and inducing apoptosis. PBX3 (Pre-B cell leukemia homeobox 3), a putativ...

Authors: Cuicui Pan, Hua Gao, Ni Zheng, Qi Gao, Yuanquan Si and Yueran Zhao

A simple and rapid identification method for newly emerged porcine Deltacoronavirus with loop-mediated isothermal amplification

Porcine Deltacoronavirus (PDCoV) is a newly emerged enteropathogenic coronavirus that causes diarrhea and mortality in neonatal piglets. PDCoV has spread to many countries around the world, leading to significant...

Authors: Fanfan Zhang, Yu Ye, Deping Song, Nannan Guo, Qi Peng, Anqi Li, Xingrong Zhou, Yanjun Chen, Min Zhang, Dongyan Huang and Yuxin Tang

Neurochemical and behavioral characterization of neuronal glutamate transporter EAAT3 heterozygous mice

Obsessive–compulsive disorder (OCD) is a severe neuropsychiatric condition affecting 1–3% of the worldwide population. OCD has a strong genetic component, and the SLC1A1 gene that encodes neuronal glutamate trans...

Authors: Luis F. González, Francisca Henríquez-Belmar, Claudia Delgado-Acevedo, Marisol Cisternas-Olmedo, Gloria Arriagada, Ramón Sotomayor-Zárate, Dennis L. Murphy and Pablo R. Moya

Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation

The Tridax procumbens extracts (TPE) are known for their ethno-medicinal properties to increase osteogenic functioning in mesenchymal stem cells. Recently, we found that the T. procumbens flavonoids (TPF) signifi...

Authors: Md. Abdullah Al Mamun, Mohammad Jakir Hosen, Amina Khatun, M. Masihul Alam and Md. Abdul Alim Al-Bari

miR-22 suppresses tumorigenesis and improves radiosensitivity of breast cancer cells by targeting Sirt1

miR-22 has been shown to be frequently downregulated and act as a tumor suppressor in multiple cancers including breast cancers. However, the role of miR-22 in regulating the radioresistance of breast cancer c...

Authors: Xia Zhang, Yuehua Li, Dan Wang and Xiaoer Wei

Neuron-derived CCL2 contributes to microglia activation and neurological decline in hepatic encephalopathy

CCL2 was up-regulated in neurons and involved in microglia activation and neurological decline in mice suffering from hepatic encephalopathy (HE). However, no data exist concerning the effect of neuron-derived...

Authors: Li Zhang, Jinyun Tan, Xiaoping Jiang, Weiwei Qian, Ting Yang, Xijun Sun, Zhaohui Chen and Qiwen Zhu

A review on plant importance, biotechnological aspects, and cultivation challenges of jojoba plant

Jojoba is considered a promising oil crop and is cultivated for diverse purposes in many countries. The jojoba seed produces unique high-quality oil with a wide range of applications such as medical and indust...

Authors: Jameel R. Al-Obaidi, Mohammed Farouq Halabi, Nasser S. AlKhalifah, Shanavaskhan Asanar, Abdulrahman A. Al-Soqeer and M. F. Attia

TMPYP4 exerted antitumor effects in human cervical cancer cells through activation of p38 mitogen-activated protein kinase

The aim of the present study was to investigate the potential effects of the 5,10,15,20-tetrakis (1-methylpyridinium-4-yl) porphyrin (TMPyP4) on the proliferation and apoptosis of human cervical cancer cells a...

Authors: Ming-Jun Cheng and Yun-Gui Cao

S100A8 inhibits PDGF-induced proliferation of airway smooth muscle cells dependent on the receptor for advanced glycation end-products

Airway remodeling is a key feature of asthma, characterized by increased proliferation of airway smooth muscle cells (ASMCs). S100A8 is a calcium-binding protein with a potential to regulate cell proliferation...

Authors: Yu-Dong Xu, Yu Wang, Lei-Miao Yin, Ling-Ling Peng, Gyoung-Hee Park and Yong-Qing Yang

MicroRNA-98 inhibits the cell proliferation of human hypertrophic scar fibroblasts via targeting Col1A1

Hypertrophic scarring (HS) is a severe disease, and results from unusual wound healing. Col1A1 could promote the hypertrophic scar formation, and the expression of Col1A1 in HS tissue was markedly higher than ...

Authors: Sheng Bi, Linlin Chai, Xi Yuan, Chuan Cao and Shirong Li

Rapid culture-based detection of living mycobacteria using microchannel electrical impedance spectroscopy (m-EIS)

Multiple techniques exist for detecting Mycobacteria, each having its own advantages and drawbacks. Among them, automated culture-based systems like the BACTEC-MGIT™ are popular because they are inexpensive, reli...

Authors: Roli Kargupta, Sachidevi Puttaswamy, Aiden J. Lee, Timothy E. Butler, Zhongyu Li, Sounak Chakraborty and Shramik Sengupta

Meristem culture and subsequent micropropagation of Chilean strawberry (Fragaria chiloensis (L.) Duch.)

Vegetative propagation of Fragaria sp. is traditionally carried out using stolons. This system of propagation, in addition to being slow, can spread plant diseases, particularly serious being viral. In vitro cult...

Authors: Karla A. Quiroz, Miguel Berríos, Basilio Carrasco, Jorge B. Retamales, Peter D. S. Caligari and Rolando García-Gonzáles

BRD4 inhibition suppresses cell growth, migration and invasion of salivary adenoid cystic carcinoma

Bromodomain-containing protein 4 (BRD4) inhibition is a new therapeutic strategy for many malignancies. In this study, we aimed to explore the effect of BRD4 inhibition by JQ1 on in vitro cell growth, migratio...

Authors: Limei Wang, Xiuyin Wu, Ruolin Wang, Chengzhe Yang, Zhi Li, Cunwei Wang, Fenghe Zhang and Pishan Yang

Expression of cocaine- and amphetamine-regulated transcript (CART) in hen ovary

Cocaine- and amphetamine-regulated transcript (CART), discovered initially by via differential display RT-PCR analysis of brains of rats administered cocaine, is expressed mainly in central nervous system or n...

Authors: Pengfei Li, Xuejing Yu, Jianshan Xie, Xiaolei Yao, Wenzhong Liu, Jianbo Yao, Zhiwei Zhu and Lihua Lyu

Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent

Realgar is a naturally occurring arsenic sulfide (or Xionghuang, in Chinese). It contains over 90% tetra-arsenic tetra-sulfide (As₄S₄). Currently, realgar has been confirmed the antitumor activities, both in vitr...

Authors: Peng Chen, Ruixiang Xu, Lei Yan, Zhengrong Wu, Yan Wei, Wenbin Zhao, Xin Wang, Qinjian Xie and Hongyu Li

Photosynthesis at the far-red region of the spectrum in Acaryochloris marina

Acaryochloris marina is an oxygenic cyanobacterium that utilizes far-red light for photosynthesis. It has an expanded genome, which helps in its adaptability to the environment, where it ...

Authors: Syed Lal Badshah, Yahia Mabkhot and Salim S. Al-Showiman

Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro

Ubiquitin specific peptidase 39 (USP39), an essential factor in the assembly of the mature spliceosome complex, has an aberrant expression in several cancer. However, its function and the corresponding mechani...

Authors: Zhihua Gan, Kun Han, Shuchen Lin, Haiyan Hu, Zan Shen and Daliu Min

Morphological, molecular and FTIR spectroscopic analysis during the differentiation of kidney cells from pluripotent stem cells

Kidney diseases are a global health problem. Currently, over 2 million people require dialysis or transplant which are associated with high morbidity and mortality; therefore, new researches focused on regener...

Authors: Monica Maribel Mata-Miranda, Gustavo Jesus Vazquez-Zapien, Marlon Rojas-Lopez, Virginia Sanchez-Monroy, David Guillermo Perez-Ishiwara and Raul Jacobo Delgado-Macuil

Erratum to: Metabotropic glutamate receptor 5 may be involved in macrophage plasticity

Authors: Lali Shanshiashvili, Elene Tsitsilashvili, Nino Dabrundashvili, Irine Kalandadze and David Mikeladze

Proton NMR characterization of intact primary and metastatic melanoma cells in 2D & 3D cultures

To characterize the differences between the primary and metastatic melanoma cell lines grown in 2D cultures and 3D cultures.

Authors: Gokula Krishnan Ramachandran and Chen Hua Yeow

Does Cimicifuga racemosa have the effects like estrogen on the sublingual gland in ovariectomized rats?

Cimicifuga racemosa is one of the herbs used for the treatment of climacteric syndrome, and it has been cited as an alternative therapy to estrogen. Apart from hectic fevers, dyspareun...

Authors: Yun-Meng Da, Kai-Yu Niu, Shu-Ya Liu, Ke Wang, Wen-Juan Wang, Jing Jia, Li-Hua Qin and Wen-Pei Bai

Musk gland seasonal development and musk secretion are regulated by the testis in muskrat (Ondatra zibethicus)

The muskrat is a seasonal breeder. Males secrete musk to attract females during the breeding season. The testosterone binding to the androgen receptor (AR) in musk glands of muskrat may play an important role ...

Authors: Tianxiang Zhang, Dong Peng, Lei Qi, Weixuan Li, Mengyuan Fan, Jiachen Shen, Liangliang Yang, Yihua Wang, Wenxia Wang, Xiaolong Hu, Ruibo Cai, Ran Zhou, Yuting Wei, Juntong Zhou, Shuang Yang, Defu Hu…

Alpinia oxyphylla Miq. extract changes miRNA expression profiles in db-/db- mouse kidney

A number of dysregulated miRNAs have been identified and are proposed to have significant roles in the pathogenesis of type 2 diabetes mellitus or renal pathology. Alpinia oxyphylla has shown significant anti-inf...

Authors: Guankui Du, Man Xiao, Xuezi Zhang, Maoyu Wen, Chi Pang, Shangfei Jiang, Shenggang Sang and Yiqiang Xie

BJ-1108, a 6-Amino-2,4,5-trimethylpyridin-3-ol analogue, regulates differentiation of Th1 and Th17 cells to ameliorate experimental autoimmune encephalomyelitis

CD4⁺ T cells play an important role in the initiation of an immune response by providing help to other cells. Among the helper T subsets, interferon-γ (IFN-γ)-secreting T helper 1 (Th1) and IL-17-secreting T help...

Authors: Youra Kang, Maheshwor Timilshina, Tae-gyu Nam, Byeong-Seon Jeong and Jae-Hoon Chang