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  1. Content type: Research article

    A highly regulated trafficking of cargo vesicles in eukaryotes performs protein delivery to a variety of cellular compartments of endomembrane system. The two main routes, the secretory and the endocytic pathw...

    Authors: Beatriz Vásquez-Soto, Nicolás Manríquez, Mirna Cruz-Amaya, Jan Zouhar, Natasha V Raikhel and Lorena Norambuena

    Citation: Biological Research 2015 48:39

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  2. Content type: Research article

    Doxycycline (DC) has been shown to possess non-antibiotic properties including Fas/Fas Ligand (FasL)-mediated apoptosis against several tumor types in the concentration range of 10–40 µg/mL. However, the effec...

    Authors: Jung Mi Yoon, Sushruta Koppula, Se Jong Huh, Sun Jin Hur and Chan Gil Kim

    Citation: Biological Research 2015 48:38

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  3. Content type: Research article

    The antiepileptic drugs carbamazepine and gabapentin are effective in treating neuropathic pain and trigeminal neuralgia. In the present study, to analyze the effects of carbamazepine and gabapentin on neuron...

    Authors: Akiko Matsumoto, Hirofumi Arisaka, Yuki Hosokawa, Shigeki Sakuraba, Takeo Sugita, Nobuo Umezawa, Yuki Kaku, Kazu-ichi Yoshida and Shun-ichi Kuwana

    Citation: Biological Research 2015 48:36

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  4. Content type: Research article

    The current state of the art in medical genetics is to identify and classify the functional (deleterious) or non-functional (neutral) single amino acid substitutions (SAPs), also known as non-synonymous SNPs (...

    Authors: Shabana Kouser Ali, C George Priya Doss, D Thirumal Kumar and Hailong Zhu

    Citation: Biological Research 2015 48:35

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  5. Content type: Research article

    Salmonella enterica serovar Typhi (S. Typhi) stg operon, encoding a chaperone/usher fimbria (CU), contributes to an increased adherence to human epithelial cells. However, one report s...

    Authors: Liliana Berrocal, Juan A Fuentes, A Nicole Trombert, Matías R Jofré, Nicolás A Villagra, Luis M Valenzuela and Guido C Mora

    Citation: Biological Research 2015 48:34

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  6. Content type: Research article

    The epicuticular waxy layer of plant leaves enhances the extreme environmental stress tolerance. However, the relationship between waxy layer and saline tolerance was not established well. The epicuticular wax...

    Authors: Chunxue Yang, Shurong Ma, Imshik Lee, Jaineung Kim and Shenkui Liu

    Citation: Biological Research 2015 48:33

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  7. Content type: Research article

    Acute coronary syndromes (ACS) are complex and polygenic diseases which are a real problem of public health. These syndromes require multidisciplinary studies to understand the pathogenesis mechanisms and meta...

    Authors: Abdelkader Chalghoum, Yosri Noichri, Ines Karkouch, Azza Dandana, Bruno Baudin, Guieder Jeridi, Salima Ferchichi and Abdelhédi Miled

    Citation: Biological Research 2015 48:32

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  8. Content type: Research article

    Chemerin, encoded by the retinoic acid receptor responder 2 (RARRES2) gene is an adipocytesecreted protein with autocrine/paracrine functions in adipose tissue, metabolism and inflammation with a recently desc...

    Authors: Rafael González-Alvarez, María de Lourdes Garza-Rodríguez, Iván Delgado-Enciso, Víctor Manuel Treviño-Alvarado, Ricardo Canales-Del-Castillo, Laura Elia Martínez-De-Villarreal, Ángel Lugo-Trampe, María Elizabeth Tejero, Natalia E. Schlabritz-Loutsevitch, María Del Refugio Rocha-Pizaña, Shelley A. Cole, Diana Reséndez-Pérez, Mario Moises-Alvarez, Anthony G. Comuzzie, Hugo Alberto Barrera-Saldaña, Raquel Garza-Guajardo…

    Citation: Biological Research 2015 48:31

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  9. Content type: Research article

    Carbon tetrachloride (CCl4) induces hepatotoxicity in animal models, including the increased blood flow and cytokine accumulation that are characteristic of tissue inflammation. The present study investigates the...

    Authors: Mohamed M. Hafez, Naif O. Al-Harbi, Ali Rashed Al-Hoshani, Khaled A. Al-hosaini, Shakir D. Al Shrari, Salim S. Al Rejaie, Mohamed M. Sayed-Ahmed and Othman A. Al-Shabanah

    Citation: Biological Research 2015 48:30

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  10. Content type: Research article

    Leptin, the cytokine produced by white adipose tissue is known to regulate food energy homeostasis through its hypothalamic receptor. In vitro studies have demonstrated that leptin plays a major role in angiogene...

    Authors: Reji Manjunathan and Malathi Ragunathan

    Citation: Biological Research 2015 48:29

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  11. Content type: Research article

    Ruta graveolens L. (R. graveolens) is a medicinal plant employed in non-traditional medicines that has various therapeutic properties, including anthelmintic, and vasodilatory actions, among ot...

    Authors: Luis Águila, Jenny Ruedlinger, Karina Mansilla, José Ordenes, Raúl Salvatici, Rui Ribeiro de Campos and Fernando Romero

    Citation: Biological Research 2015 48:28

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  12. Content type: Research article

    The CCCTC-binding factor (CTCF) is a highly conserved insulator protein that plays various roles in many cellular processes. CTCF is one of the main architecture proteins in higher eukaryotes, and in combinati...

    Authors: Wenlong Shen, Dong Wang, Bingyu Ye, Minglei Shi, Yan Zhang and Zhihu Zhao

    Citation: Biological Research 2015 48:27

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  13. Content type: Research article

    Transforming growth factor (TGF)-β is involved in many physiologic processes, it often promotes metastasis, and its high expression is correlated with poor prognosis. In the present study, we analyzed the corr...

    Authors: Yijie Chen, Lin Ma, Qian He, Shaobo Zhang, Chenghua Zhang and Wei Jia

    Citation: Biological Research 2015 48:26

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  14. Content type: Research article

    Mechanical strain plays a great role in growth and differentiation of osteoblast. A previous study indicated that integrin-β (β1, β5) mediated osteoblast proliferation promoted by mechanical tensile strain. Ho...

    Authors: Qiangcheng Zeng, Yong Guo, Yongming Liu, Ruixin Li, Xinchang Zhang, Lu Liu, Yang Wang, Xizheng Zhang and Xianqiong Zou

    Citation: Biological Research 2015 48:25

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  15. Content type: Research article

    The development of clean or novel alternative energy has become a global trend that will shape the future of energy. In the present study, 3 microbial strains with different oxygen requirements, including Clostri...

    Authors: Peng Chen, Yuxia Wang, Lei Yan, Yiqing Wang, Suyue Li, Xiaojuan Yan, Ningbo Wang, Ning Liang and Hongyu Li

    Citation: Biological Research 2015 48:24

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  16. Content type: Research article

    Hepcidin, encoding by HAMP gene, is the pivotal regulator of iron metabolism, controlling the systemic absorption and transportation of irons from intracellular stores. Abnormal levels of HAMP expression alter...

    Authors: Bin Song, Qi Bian, Cheng-Hao Shao, An-An Liu, Wei Jing, Rui Liu, Yi-Jie Zhang, Ying-Qi Zhou, Gang Li and Gang Jin

    Citation: Biological Research 2015 48:23

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  17. Content type: Short report

    Pseudomonas aeruginosa is known to be a multidrug resistant opportunistic pathogen. Particularly, P. aeruginosa PAO1 polyphosphate kinase mutant (ppk1) is deficient in motility, quorum sensing,...

    Authors: Javiera Ortiz-Severín, Macarena Varas, Catalina Bravo-Toncio, Nicolás Guiliani and Francisco P Chávez

    Citation: Biological Research 2015 48:22

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  18. Content type: Research article

    Atriplex laciniata L. was investigated for phenolic, flavonoid contents, antioxidant, anticholinesterase activities, in an attempt to explore its effectiveness in Alzheimer’s and other neurolog...

    Authors: Zul Kamal, Farhat Ullah, Muhammad Ayaz, Abdul Sadiq, Sajjad Ahmad, Anwar Zeb, Abid Hussain and Muhammad Imran

    Citation: Biological Research 2015 48:21

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  19. Content type: Research article

    Rumex species are traditionally used for the treatment of neurological disorders including headache, migraine, depression, paralysis etc. Several species have been scientifically validated for ...

    Authors: Sajjad Ahmad, Farhat Ullah, Muhammad Ayaz, Abdul Sadiq and Muhammad Imran

    Citation: Biological Research 2015 48:20

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  20. Content type: Research article

    To evaluate the hepatoprotective potential and invitro cytotoxicity studies of whole plant methanol extract of Rumex vesicarius L. Methanol extract at a dose of 100 mg/kg bw and 200 mg/kg bw were assessed for its...

    Authors: Asha Tukappa NK, Ramesh L Londonkar, Hanumantappa B Nayaka and Sanjeev Kumar CB

    Citation: Biological Research 2015 48:19

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  21. Content type: Research article

    Ubiquitin Specific Peptidase 39 (USP39) is a 65 kDa SR-related protein involved in RNA splicing. Previous studies showed that USP39 is related with tumorigenesis of human breast cancer cells.

    Authors: Zeya Pan, Hao Pan, Jin Zhang, Yun Yang, Hui Liu, Yuan Yang, Gang Huang, Junsheng Ni, Jian Huang and Weiping Zhou

    Citation: Biological Research 2015 48:18

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    The Correction to this article has been published in Biological Research 2018 51:19

  22. Content type: Research article

    Karwinskia humboldtiana (Kh) is a poisonous plant of the rhamnacea family. To elucidate some of the subcellular effects of Kh toxicity, membrane fluidity and ATPase activities as hydrolytic and...

    Authors: Margarita Cid-Hernández, Ana C Ramírez-Anguiano, Genaro G Ortiz, Eddic W Morales-Sánchez, Luis J González-Ortiz, Sandra F Velasco-Ramírez and Fermín P Pacheco-Moisés

    Citation: Biological Research 2015 48:17

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  23. Content type: Research article

    The aim of the present study was to evaluate the in vitro antioxidant and free radical scavenging capacity of bioactive metabolites present in Newbouldia laevis leaf extract.

    Authors: Josiah Bitrus Habu and Bartholomew Okechukwu Ibeh

    Citation: Biological Research 2015 48:16

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  24. Content type: Research article

    Excessive production of free radicals causes direct damage to biological molecules such as DNA, proteins, lipids, carbohydrates leading to tumor development and progression. Natural antioxidant molecules from ...

    Authors: Bruno Moukette Moukette, Constant Anatole Pieme, Jacques Romain Njimou, Cabral Prosper Nya Biapa, Bravi Marco and Jeanne Yonkeu Ngogang

    Citation: Biological Research 2015 48:15

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  25. Content type: Research article

    Insects have developed resistance against Bt-transgenic plants. A multi-barrier defense system to weaken their resistance development is now necessary. One such approach is to use fusion protein genes to incre...

    Authors: Adnan Muzaffar, Sarfraz Kiani, Muhammad Azmat Ullah Khan, Abdul Qayyum Rao, Arfan Ali, Mudassar Fareed Awan, Adnan Iqbal, Idrees Ahmad Nasir, Ahmad Ali Shahid and Tayyab Husnain

    Citation: Biological Research 2015 48:14

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  26. Content type: Research article

    In order to understand feeding ecology and habitat use of coral reef fish, fatty acid composition was examined in five coral reef fishes, Thalassoma lunare, Lutjanus lutjanus, Abudefduf bengalensis, Scarus rivula...

    Authors: Takaomi Arai, Razikin Amalina and Zainudin Bachok

    Citation: Biological Research 2015 48:13

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  27. Content type: Research article

    In the present study, we examined the inhibitory effects of a methanolic extract, dichloromethane fraction, water layer, and polyhydroxylated sterols (1–4) isolated from the Vietnamese starfish Protoreaster nodos...

    Authors: Nguyen Phuong Thao, Bui Thi Thuy Luyen, Jung Eun Koo, Sohyun Kim, Young Sang Koh, Nguyen Xuan Cuong, Nguyen Hoai Nam, Phan Van Kiem, Young Ho Kim and Chau Van Minh

    Citation: Biological Research 2015 48:12

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  28. Content type: Research article

    Cadmium (Cd) is well known as one of the most toxic metals affecting the environment and can severely restrict plant growth and development. In this study, Cd toxicities were studied in strawberry cv. Camarosa...

    Authors: Ferhad Muradoglu, Muttalip Gundogdu, Sezai Ercisli, Tarik Encu, Fikri Balta, Hawa ZE Jaafar and Muhammad Zia-Ul-Haq

    Citation: Biological Research 2015 48:11

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  29. Content type: Review

    The South American country Chile now boasts a life expectancy of over 80 years. As a consequence, Chile now faces the increasing social and economic burden of cancer and must implement political policy to deli...

    Authors: Jorge Jimenez de la Jara, Gabriel Bastias, Catterina Ferreccio, Cristian Moscoso, Sofia Sagues, Camilo Cid, Eduardo Bronstein, Cristian Herrera, Bruno Nervi, Alejandro Corvalan, Ethel V Velasquez, Pamela Gonzalez, Enrique Castellon, Eva Bustamante, Sergio Oñate, Eileen McNerney…

    Citation: Biological Research 2015 48:10

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  30. Content type: Research article

    Various health benefits have been attributed to Er-Miao-San (EMS), a traditional Chinese herbal formulation that contains equal amounts of cortex phellodendri (Phellodendron amurense Ruprecht) and rhizoma atracty...

    Authors: Seunghee Bae, Younjung Jung, Yeong Min Choi and Shunhua Li

    Citation: Biological Research 2015 48:8

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  31. Content type: Research article

    The present study was conducted in order to evaluate the fatty acid profile, anti-oxidant and anti-bacterial activities from the microwave aqueous extract of the leaves of three different varieties of Labisia pum...

    Authors: Ehsan Karimi, Hawa ZE Jaafar, Ali Ghasemzadeh and Mahdi Ebrahimi

    Citation: Biological Research 2015 48:9

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  32. Content type: Research article

    In this paper, we have studied the essential oils chemical composition of the leaves of seven Eucalyptus species developed in Tunisia. Eucalyptus leaves were picked from trees growing in different arboretums in T...

    Authors: Khaled Sebei, Fawzi Sakouhi, Wahid Herchi, Mohamed Larbi Khouja and Sadok Boukhchina

    Citation: Biological Research 2015 48:7

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  33. Content type: Research article

    Mesenchymal stem cells (MSCs) are considered the best candidate in stem cells therapy due to their multipotent differentiation ability, low expression of co-stimulatory molecules (CD80, CD86, CD34 and HLA-II) ...

    Authors: Li Zhang, Dan Liu, Dan Pu, Yanwen Wang, Li Li, Yanqi He, Yalun Li, Lei Li and Weimin Li

    Citation: Biological Research 2015 48:6

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  34. Content type: Research article

    The aim of our research work was to quantify total flavonoid contents in the leaves of 13 plant species family Asteraceae, 8 representatives of family Lamiaceae and 9 plant species belonging to family Rosaceae, u...

    Authors: Oksana Sytar, Klaudia Bruckova, Elena Hunkova, Marek Zivcak, Kiessoun Konate and Marian Brestic

    Citation: Biological Research 2015 48:5

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  35. Content type: Research article

    Honey is a natural product obtained from the nectar that is collected from flowers by bees. It has several properties, including those of being food and supplementary diet, and it can be used in cosmetic produ...

    Authors: Kanyaluck Jantakee and Yingmanee Tragoolpua

    Citation: Biological Research 2015 48:4

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  36. Content type: Research article

    Gap junctions between β-cells participate in the precise regulation of insulin secretion. Adherens junctions and their associated proteins are required for the formation, function and structural maintenance of...

    Authors: Ana Flávia Marçal-Pessoa, Carmen Lucia Bassi-Branco, Cristiana dos Santos Barbosa Salvatierra, Luiz Fabrizio Stoppiglia, Letícia Martins Ignacio-Souza, Sílvia Regina de Lima Reis, Roberto Vilela Veloso, Marise Auxiliadora de Barros Reis, Everardo Magalhães Carneiro, Antonio Carlos Boschero, Vanessa Cristina Arantes and Márcia Queiroz Latorraca

    Citation: Biological Research 2015 48:3

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  37. Content type: Research article

    The Eurasian grapevine (Vitis vinifera L.) is the most widely cultivated and economically important horticultural crop in the world. As a one of the origin area, Anatolia played an important role in the diversifi...

    Authors: Sadiye Peral Eyduran, Meleksen Akin, Sezai Ercisli, Ecevit Eyduran and David Maghradze

    Citation: Biological Research 2015 48:2

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  38. Content type: Research article

    Curcuma longa Linnaeus and Zingiber officinale Roscoe are two main representatives of Zingiberaceae family studied for a wide range of therapeutic properties, including: antioxidant, anti-infla...

    Authors: Corina Danciu, Lavinia Vlaia, Florinela Fetea, Monica Hancianu, Dorina E Coricovac, Sorina A Ciurlea, Codruţa M Şoica, Iosif Marincu, Vicentiu Vlaia, Cristina A Dehelean and Cristina Trandafirescu

    Citation: Biological Research 2015 48:1

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  39. Content type: Research article

    Based on the ethnomedicinal uses and the effective outcomes of natural products in various diseases, this study was designed to evaluate Isodon rugosus as possible remedy in oxidative stress, alzheimer’s and othe...

    Authors: Anwar Zeb, Abdul Sadiq, Farhat Ullah, Sajjad Ahmad and Muhammad Ayaz

    Citation: Biological Research 2014 47:76

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  40. Content type: Research article

    BrdU is a commonly used reagent in cell proliferation assays, and WST-1 measurement is widely used to detect cell viability. However, no previous study has formally reported the combination of the two assays, ...

    Authors: Lei-Miao Yin, Ying Wei, Wen-Qian Wang, Yu Wang, Yu-Dong Xu and Yong-Qing Yang

    Citation: Biological Research 2014 47:75

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  41. Content type: Research article

    Nitrosative and oxidative stress play a key role in obesity and diabetes-related mitochondrial dysfunction. The objective was to investigate the effect of curcumin treatment on state 3 and 4 oxygen consumption...

    Authors: María G Soto-Urquieta, Sergio López-Briones, Victoriano Pérez-Vázquez, Alfredo Saavedra-Molina, Gloria A González-Hernández and Joel Ramírez-Emiliano

    Citation: Biological Research 2014 47:74

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  42. Content type: Research article

    The hippocampal CA3 area contains large amounts of vesicular zinc in the mossy fiber terminals which is released during synaptic activity, depending on presynaptic calcium. Another characteristic of these syna...

    Authors: Carlos M Matias, Jose C Dionísio, Peter Saggau and Maria Emilia Quinta-Ferreira

    Citation: Biological Research 2014 47:73

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  43. Content type: Research article

    Rootstocks play an essential role to determining orchard performance of fruit trees. Pyrus communis and Cydonia oblonga are widely used rootstocks for European pear cultivars. The lack of rootstocks adapted to di...

    Authors: Ali Ikinci, Ibrahim Bolat, Sezai Ercisli and Ossama Kodad

    Citation: Biological Research 2014 47:71

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  44. Content type: Research article

    Vascular endothelial growth factor (VEGF) is involved in the growth of new blood vessels that feed tumors and kinesin spindle protein (KSP) plays a critical role in mitosis involving in cell proliferation. Sim...

    Authors: Chung Chinh Doan, Long Thanh Le, Son Nghia Hoang, Si Minh Do and Dong Van Le

    Citation: Biological Research 2014 47:70

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  45. Content type: Research article

    Ligularia fischeri (common name Gomchwi) is known for its pharmaceutical properties and used in the treatment of jaundice, scarlet-fever, rheumatoidal arthritis, and hepatic diseases; however, little is known abo...

    Authors: Hee-Sook Park, Hye-Young Choi and Gun-Hee Kim

    Citation: Biological Research 2014 47:69

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  46. Content type: Research article

    Tribolium castaneum (Herbst) is a major pest of stored grain-based products, and cause severe damage to cereal grains throughout the world. The present investigation was aimed to determine the pesticidal and pest...

    Authors: Alam Khan, Md Shariful Islam, Moizur Rahman, Tanjeena Zaman and Md Ekramul Haque

    Citation: Biological Research 2014 47:68

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  47. Content type: Research article

    Marine invertebrate-associated microbial communities are interesting examples of complex symbiotic systems and are a potential source of biotechnological products.

    Authors: Aileen O’Connor-Sánchez, Adán J Rivera-Domínguez, César De los Santos-Briones, Lluvia K López-Aguiar, Yuri J Peña-Ramírez and Alejandra Prieto-Davo

    Citation: Biological Research 2014 47:67

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