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  1. Content type: Research article

    Recently, a continuous growth of interest has been observed in antimicrobial peptides (AMPs) in the light of an alarming increase in resistance of bacteria and fungi against antibiotics. AMPs are used as bioma...

    Authors: Anna Jurczak, Dorota Kościelniak, Monika Papież, Palina Vyhouskaya and Wirginia Krzyściak

    Citation: Biological Research 2015 48:61

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  2. Content type: Research article

    Theoretically human embryonic stem cells (hESCs) have the capacity to self-renew and differentiate into all human cell types. Therefore, the greatest promise of hESCs-based therapy is to replace the damaged ti...

    Authors: Haide Chen, Yang Li, Xijuan Lin, Di Cui, Chun Cui, Hui Li and Lei Xiao

    Citation: Biological Research 2015 48:59

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  3. Content type: Research article

    Limonoids are highly oxygenated compounds with a prototypical structure. Their occurrence in the plant kingdom is mainly confined to plant families of Meliaceae and Rutaceae. Owing to their wide range of phar...

    Authors: Jean P. Dzoyem, Armelle T. Tsamo, Raduis Melong, Pierre Mkounga, Augustin E. Nkengfack, Lyndy J. McGaw and Jacobus N. Eloff

    Citation: Biological Research 2015 48:57

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  4. Content type: Research article

    Endometriosis, pro-inflammatory and invasive benign disease estrogen dependent, abnormally express in endometria the enzyme P450Arom, positively regulated by steroid factor-1 (SF-1). Our objective was to study th...

    Authors: Jazmin Castro, Germán Araya, Pamela Inostroza, Paulina Hidalgo, Reinaldo González-Ramos, Hugo Sovino, M. Angélica Boric, Ariel Fuentes and M. Cecilia Johnson

    Citation: Biological Research 2015 48:56

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  5. Content type: Research article

    In the central nervous system, interleukin-10 (IL-10) provides trophic and survival effects directly on neurons, modulates neurite plasticity, and has a pivotal importance in the neuronal regeneration in neuro...

    Authors: S. Koriauli, N. Natsvlishvili, T. Barbakadze and D. Mikeladze

    Citation: Biological Research 2015 48:55

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  6. Content type: Research article

    Impaired wound healing is a complication of diabetes and a serious problem in clinical practice. We previously found that whey protein (WP) was able to regulate wound healing normally in streptozotocin (STZ)-d...

    Authors: Rasha R. Ahmed, Ayman Mahmoud, Osama M. Ahmed, Ali Metwalli and Hossam Ebaid

    Citation: Biological Research 2015 48:54

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  7. Content type: Research article

    Metabolic syndrome is a growing worldwide health problem. We evaluated the effects of wine grape powder (WGP), rich in antioxidants and fiber, in a rat model of metabolic syndrome induced by a high fructose di...

    Authors: Romina Hernández-Salinas, Valerie Decap, Alberto Leguina, Patricio Cáceres, Druso Perez, Ines Urquiaga, Rodrigo Iturriaga and Victoria Velarde

    Citation: Biological Research 2015 48:53

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  8. Content type: Research article

    Glycoproteins play a critical role in the cellular activities of eukaryotes. Sialic acid is typically the outermost monosaccharide of glycolipids and glycoproteins, and is necessary for normal development.

    Authors: Yangui Liang, Qiang Hua, Pengwei Pan, Jie Yang and Qi Zhang

    Citation: Biological Research 2015 48:52

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  9. Content type: Research article

    The Tridax procumbens flavonoids (TPF), are well known for their medicinal properties among local natives. The TPF are traditionally used for dropsy, anaemia, arthritis, gout, asthma, ulcer, piles, and urinary pr...

    Authors: Md. Abdullah Al Mamun, Kamrul Islam, Md. Jahangir Alam, Amina Khatun, M. Masihul Alam, Md. Abdul Alim Al-Bari and Md. Jahangir Alam

    Citation: Biological Research 2015 48:51

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  10. Content type: Research article

    DNA methylation is commonly linked with the silencing of the gene expression for many tumor suppressor genes. As such, determining DNA methylation patterns should aid, in times to come, in the diagnosis and pe...

    Authors: Fabiana Greyce Oliveira Almeida, Priscila Ferreira de Aquino, Afonso Duarte Leão de Souza, Antonia Queiroz Lima de Souza, Sonia do Carmo Vinhote, Thaís Messias Mac-Cormick, Marcelo Soares da Mota Silva, Sidney Raimundo Silva Chalub, Juliana de Saldanha da Gama Fischer, Paulo Costa Carvalho and Maria da Gloria da Costa Carvalho

    Citation: Biological Research 2015 48:50

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  11. Content type: Research article

    The Mediterranean diet is a healthy diet with positive scientific evidence of preventing chronic diseases. Bioactive components support the healthy properties of the Mediterranean diet. Antioxidants and fiber,...

    Authors: Inés Urquiaga, Sonia D’Acuña, Druso Pérez, Sara Dicenta, Guadalupe Echeverría, Attilio Rigotti and Federico Leighton

    Citation: Biological Research 2015 48:49

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  12. Content type: Research article

    The collective cell migration of stratified epithelial cells is considered to be an important phenomenon in wound healing, development, and cancer invasion; however, little is known about the mechanisms involv...

    Authors: Taro Mikami, Keiichiro Yoshida, Hajime Sawada, Michiyo Esaki, Kazunori Yasumura and Michio Ono

    Citation: Biological Research 2015 48:48

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  13. Content type: Research article

    Although numerous efforts have been made, the pathogenesis underlying lung squamous-cell carcinoma (SCC) remains unclear. This study aimed to identify the CNV-driven genes by an integrated analysis of both the...

    Authors: Zhao Yang, Bing Zhuan, Ying Yan, Simin Jiang and Tao Wang

    Citation: Biological Research 2015 48:47

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  14. Content type: Research article

    Clinical use of chemotherapeutic drug, cisplatin is limited by its toxicity and drug resistance. Therefore, efforts continue for the discovery of novel combination therapies with cisplatin, to increase efficac...

    Authors: Thangjam Davis Singh, Heikrujam Thoihen Meitei, Adhikarimayum Lakhikumar Sharma, Asem Robinson, Lisam Shanjukumar Singh and Thiyam Ramsing Singh

    Citation: Biological Research 2015 48:46

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  15. Content type: Research article

    Low survival rate of transplanted cells compromises the efficacy of cell therapy. Hexokinase II (HKII) is known to have anti-apoptotic activity through its interaction with mitochondria. The objective was to i...

    Authors: Seahyoung Lee, Ina Yun, Onju Ham, Se-Yeon Lee, Chang Yeon Lee, Jun-Hee Park, Jiyun Lee, Hyang-Hee Seo, Eunhyun Choi and Ki-Chul Hwang

    Citation: Biological Research 2015 48:45

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  16. Content type: Research article

    The fetus is surrounded by the amniotic fluid (AF) contained by the amniotic sac of the pregnant female. The AF is directly conveyed to the fetus during pregnancy. Although AF has recently been reported as an ...

    Authors: Yongwoo Jang, Eun-Kyung Kim, Won-Sik Shim, Ki-Min Song and Sung Min Kim

    Citation: Biological Research 2015 48:44

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  17. Content type: Research article

    Gossypol is a chemical present in the seeds of cotton plants (Gossypium sp.) that reduces fertility in farm animals. Vitamin E is an antioxidant and may help to protect cells and tissues against the deleterious e...

    Authors: Andréia T Santana, Marieli Guelfi, Hyllana C D Medeiros, Marco A Tavares, Paulo F V Bizerra and Fábio E Mingatto

    Citation: Biological Research 2015 48:43

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  18. Content type: Research article

    Previous reports have described a decrease in retinal temperature and clinical improvement of wet age-related macular degeneration (AMD) after vitrectomy. We hypothesized that the retinal temperature decrease ...

    Authors: Masayuki Takeyama, Masahiko Yoneda, Masahiko Gosho, Masayoshi Iwaki and Masahiro Zako

    Citation: Biological Research 2015 48:42

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  19. Content type: Research article

    CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disea...

    Authors: Hiroshi Takahashi, Kazuhiko Ikeda, Kazuei Ogawa, Syunnichi Saito, Alain M Ngoma, Yumiko Mashimo, Koki Ueda, Miki Furukawa, Akiko Shichishima-Nakamura, Hiroshi Ohkawara, Kenneth E Nollet, Hitoshi Ohto and Yasuchika Takeishi

    Citation: Biological Research 2015 48:41

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  20. Content type: Research article

    We have investigated the potential anticancer effects of karanjin, a principal furanoflavonol constituent of the Chinese medicine Fordia cauliflora, using cytotoxic assay, cell cycle arrest, and induction of apop...

    Authors: Jian-Ru Guo, Qian-Qian Chen, Christopher Wai-Kei Lam and Wei Zhang

    Citation: Biological Research 2015 48:40

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  21. Content type: Research article

    A highly regulated trafficking of cargo vesicles in eukaryotes performs protein delivery to a variety of cellular compartments of endomembrane system. The two main routes, the secretory and the endocytic pathw...

    Authors: Beatriz Vásquez-Soto, Nicolás Manríquez, Mirna Cruz-Amaya, Jan Zouhar, Natasha V Raikhel and Lorena Norambuena

    Citation: Biological Research 2015 48:39

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  22. Content type: Research article

    Doxycycline (DC) has been shown to possess non-antibiotic properties including Fas/Fas Ligand (FasL)-mediated apoptosis against several tumor types in the concentration range of 10–40 µg/mL. However, the effec...

    Authors: Jung Mi Yoon, Sushruta Koppula, Se Jong Huh, Sun Jin Hur and Chan Gil Kim

    Citation: Biological Research 2015 48:38

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  23. Content type: Research article

    The antiepileptic drugs carbamazepine and gabapentin are effective in treating neuropathic pain and trigeminal neuralgia. In the present study, to analyze the effects of carbamazepine and gabapentin on neuron...

    Authors: Akiko Matsumoto, Hirofumi Arisaka, Yuki Hosokawa, Shigeki Sakuraba, Takeo Sugita, Nobuo Umezawa, Yuki Kaku, Kazu-ichi Yoshida and Shun-ichi Kuwana

    Citation: Biological Research 2015 48:36

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  24. Content type: Research article

    The current state of the art in medical genetics is to identify and classify the functional (deleterious) or non-functional (neutral) single amino acid substitutions (SAPs), also known as non-synonymous SNPs (...

    Authors: Shabana Kouser Ali, C George Priya Doss, D Thirumal Kumar and Hailong Zhu

    Citation: Biological Research 2015 48:35

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  25. Content type: Research article

    Salmonella enterica serovar Typhi (S. Typhi) stg operon, encoding a chaperone/usher fimbria (CU), contributes to an increased adherence to human epithelial cells. However, one report s...

    Authors: Liliana Berrocal, Juan A Fuentes, A Nicole Trombert, Matías R Jofré, Nicolás A Villagra, Luis M Valenzuela and Guido C Mora

    Citation: Biological Research 2015 48:34

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  26. Content type: Research article

    The epicuticular waxy layer of plant leaves enhances the extreme environmental stress tolerance. However, the relationship between waxy layer and saline tolerance was not established well. The epicuticular wax...

    Authors: Chunxue Yang, Shurong Ma, Imshik Lee, Jaineung Kim and Shenkui Liu

    Citation: Biological Research 2015 48:33

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  27. Content type: Research article

    Acute coronary syndromes (ACS) are complex and polygenic diseases which are a real problem of public health. These syndromes require multidisciplinary studies to understand the pathogenesis mechanisms and meta...

    Authors: Abdelkader Chalghoum, Yosri Noichri, Ines Karkouch, Azza Dandana, Bruno Baudin, Guieder Jeridi, Salima Ferchichi and Abdelhédi Miled

    Citation: Biological Research 2015 48:32

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  28. Content type: Research article

    Chemerin, encoded by the retinoic acid receptor responder 2 (RARRES2) gene is an adipocytesecreted protein with autocrine/paracrine functions in adipose tissue, metabolism and inflammation with a recently desc...

    Authors: Rafael González-Alvarez, María de Lourdes Garza-Rodríguez, Iván Delgado-Enciso, Víctor Manuel Treviño-Alvarado, Ricardo Canales-Del-Castillo, Laura Elia Martínez-De-Villarreal, Ángel Lugo-Trampe, María Elizabeth Tejero, Natalia E. Schlabritz-Loutsevitch, María Del Refugio Rocha-Pizaña, Shelley A. Cole, Diana Reséndez-Pérez, Mario Moises-Alvarez, Anthony G. Comuzzie, Hugo Alberto Barrera-Saldaña, Raquel Garza-Guajardo…

    Citation: Biological Research 2015 48:31

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  29. Content type: Research article

    Carbon tetrachloride (CCl4) induces hepatotoxicity in animal models, including the increased blood flow and cytokine accumulation that are characteristic of tissue inflammation. The present study investigates the...

    Authors: Mohamed M. Hafez, Naif O. Al-Harbi, Ali Rashed Al-Hoshani, Khaled A. Al-hosaini, Shakir D. Al Shrari, Salim S. Al Rejaie, Mohamed M. Sayed-Ahmed and Othman A. Al-Shabanah

    Citation: Biological Research 2015 48:30

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  30. Content type: Research article

    Leptin, the cytokine produced by white adipose tissue is known to regulate food energy homeostasis through its hypothalamic receptor. In vitro studies have demonstrated that leptin plays a major role in angiogene...

    Authors: Reji Manjunathan and Malathi Ragunathan

    Citation: Biological Research 2015 48:29

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  31. Content type: Research article

    Ruta graveolens L. (R. graveolens) is a medicinal plant employed in non-traditional medicines that has various therapeutic properties, including anthelmintic, and vasodilatory actions, among ot...

    Authors: Luis Águila, Jenny Ruedlinger, Karina Mansilla, José Ordenes, Raúl Salvatici, Rui Ribeiro de Campos and Fernando Romero

    Citation: Biological Research 2015 48:28

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  32. Content type: Research article

    The CCCTC-binding factor (CTCF) is a highly conserved insulator protein that plays various roles in many cellular processes. CTCF is one of the main architecture proteins in higher eukaryotes, and in combinati...

    Authors: Wenlong Shen, Dong Wang, Bingyu Ye, Minglei Shi, Yan Zhang and Zhihu Zhao

    Citation: Biological Research 2015 48:27

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  33. Content type: Research article

    Transforming growth factor (TGF)-β is involved in many physiologic processes, it often promotes metastasis, and its high expression is correlated with poor prognosis. In the present study, we analyzed the corr...

    Authors: Yijie Chen, Lin Ma, Qian He, Shaobo Zhang, Chenghua Zhang and Wei Jia

    Citation: Biological Research 2015 48:26

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  34. Content type: Research article

    Mechanical strain plays a great role in growth and differentiation of osteoblast. A previous study indicated that integrin-β (β1, β5) mediated osteoblast proliferation promoted by mechanical tensile strain. Ho...

    Authors: Qiangcheng Zeng, Yong Guo, Yongming Liu, Ruixin Li, Xinchang Zhang, Lu Liu, Yang Wang, Xizheng Zhang and Xianqiong Zou

    Citation: Biological Research 2015 48:25

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  35. Content type: Research article

    The development of clean or novel alternative energy has become a global trend that will shape the future of energy. In the present study, 3 microbial strains with different oxygen requirements, including Clostri...

    Authors: Peng Chen, Yuxia Wang, Lei Yan, Yiqing Wang, Suyue Li, Xiaojuan Yan, Ningbo Wang, Ning Liang and Hongyu Li

    Citation: Biological Research 2015 48:24

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  36. Content type: Research article

    Hepcidin, encoding by HAMP gene, is the pivotal regulator of iron metabolism, controlling the systemic absorption and transportation of irons from intracellular stores. Abnormal levels of HAMP expression alter...

    Authors: Bin Song, Qi Bian, Cheng-Hao Shao, An-An Liu, Wei Jing, Rui Liu, Yi-Jie Zhang, Ying-Qi Zhou, Gang Li and Gang Jin

    Citation: Biological Research 2015 48:23

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  37. Content type: Short report

    Pseudomonas aeruginosa is known to be a multidrug resistant opportunistic pathogen. Particularly, P. aeruginosa PAO1 polyphosphate kinase mutant (ppk1) is deficient in motility, quorum sensing,...

    Authors: Javiera Ortiz-Severín, Macarena Varas, Catalina Bravo-Toncio, Nicolás Guiliani and Francisco P Chávez

    Citation: Biological Research 2015 48:22

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  38. Content type: Research article

    Atriplex laciniata L. was investigated for phenolic, flavonoid contents, antioxidant, anticholinesterase activities, in an attempt to explore its effectiveness in Alzheimer’s and other neurolog...

    Authors: Zul Kamal, Farhat Ullah, Muhammad Ayaz, Abdul Sadiq, Sajjad Ahmad, Anwar Zeb, Abid Hussain and Muhammad Imran

    Citation: Biological Research 2015 48:21

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  39. Content type: Research article

    Rumex species are traditionally used for the treatment of neurological disorders including headache, migraine, depression, paralysis etc. Several species have been scientifically validated for ...

    Authors: Sajjad Ahmad, Farhat Ullah, Muhammad Ayaz, Abdul Sadiq and Muhammad Imran

    Citation: Biological Research 2015 48:20

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  40. Content type: Research article

    To evaluate the hepatoprotective potential and invitro cytotoxicity studies of whole plant methanol extract of Rumex vesicarius L. Methanol extract at a dose of 100 mg/kg bw and 200 mg/kg bw were assessed for its...

    Authors: Asha Tukappa NK, Ramesh L Londonkar, Hanumantappa B Nayaka and Sanjeev Kumar CB

    Citation: Biological Research 2015 48:19

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  41. Content type: Research article

    Ubiquitin Specific Peptidase 39 (USP39) is a 65 kDa SR-related protein involved in RNA splicing. Previous studies showed that USP39 is related with tumorigenesis of human breast cancer cells.

    Authors: Zeya Pan, Hao Pan, Jin Zhang, Yun Yang, Hui Liu, Yuan Yang, Gang Huang, Junsheng Ni, Jian Huang and Weiping Zhou

    Citation: Biological Research 2015 48:18

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    The Correction to this article has been published in Biological Research 2018 51:19

  42. Content type: Research article

    Karwinskia humboldtiana (Kh) is a poisonous plant of the rhamnacea family. To elucidate some of the subcellular effects of Kh toxicity, membrane fluidity and ATPase activities as hydrolytic and...

    Authors: Margarita Cid-Hernández, Ana C Ramírez-Anguiano, Genaro G Ortiz, Eddic W Morales-Sánchez, Luis J González-Ortiz, Sandra F Velasco-Ramírez and Fermín P Pacheco-Moisés

    Citation: Biological Research 2015 48:17

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  43. Content type: Research article

    The aim of the present study was to evaluate the in vitro antioxidant and free radical scavenging capacity of bioactive metabolites present in Newbouldia laevis leaf extract.

    Authors: Josiah Bitrus Habu and Bartholomew Okechukwu Ibeh

    Citation: Biological Research 2015 48:16

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  44. Content type: Research article

    Excessive production of free radicals causes direct damage to biological molecules such as DNA, proteins, lipids, carbohydrates leading to tumor development and progression. Natural antioxidant molecules from ...

    Authors: Bruno Moukette Moukette, Constant Anatole Pieme, Jacques Romain Njimou, Cabral Prosper Nya Biapa, Bravi Marco and Jeanne Yonkeu Ngogang

    Citation: Biological Research 2015 48:15

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  45. Content type: Research article

    Insects have developed resistance against Bt-transgenic plants. A multi-barrier defense system to weaken their resistance development is now necessary. One such approach is to use fusion protein genes to incre...

    Authors: Adnan Muzaffar, Sarfraz Kiani, Muhammad Azmat Ullah Khan, Abdul Qayyum Rao, Arfan Ali, Mudassar Fareed Awan, Adnan Iqbal, Idrees Ahmad Nasir, Ahmad Ali Shahid and Tayyab Husnain

    Citation: Biological Research 2015 48:14

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  46. Content type: Research article

    In order to understand feeding ecology and habitat use of coral reef fish, fatty acid composition was examined in five coral reef fishes, Thalassoma lunare, Lutjanus lutjanus, Abudefduf bengalensis, Scarus rivula...

    Authors: Takaomi Arai, Razikin Amalina and Zainudin Bachok

    Citation: Biological Research 2015 48:13

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  47. Content type: Research article

    Cadmium (Cd) is well known as one of the most toxic metals affecting the environment and can severely restrict plant growth and development. In this study, Cd toxicities were studied in strawberry cv. Camarosa...

    Authors: Ferhad Muradoglu, Muttalip Gundogdu, Sezai Ercisli, Tarik Encu, Fikri Balta, Hawa ZE Jaafar and Muhammad Zia-Ul-Haq

    Citation: Biological Research 2015 48:11

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