Baron R. Mechanisms of Disease: neuropathic pain-a clinical perspective. Nature Clin Pract Neurol. 2006;2:95–106.
Google Scholar
Vardeh D, Mannion RJ, Woolf CJ, et al. Toward a mechanism-based approach to pain diagnosis. J Pain. 2016;17:50–69.
Google Scholar
Friebel U, Eickhoff SB, Lotze M. Coordinate-based meta-analysis of experimentally induced and chronic persistent neuropathic pain. Neuroimage. 2011;58:1070–80.
PubMed
Google Scholar
Vaculín S, Franek M, Rokyta R. Dorsal rhizotomy changes the spontaneous neuronal activity of nuclei in the medial thalamus. Physiol Res. 2000;49:279–83.
PubMed
Google Scholar
Hsueh-Chieh Lu, Jen-Chuen H, Ching-Liang Lu, et al. Neuronal correlates in the modulation of placebo analgesia in experimentally-induced esophageal pain: a 3T-fMRI study. Pain. 2010;148:75–83.
Google Scholar
Whitt JL, Masri R, Pulimood SN, et al. Pathological activity in mediodorsal thalamus of rats with spinal cord injury pain. J Neurosci. 2013;33:3915–26.
CAS
PubMed
PubMed Central
Google Scholar
Zhang S, Chiang CY, Xie YF, et al. Central sensitization in thalamic nociceptive neurons induced by mustard oil application to rat molar tooth pulp. Neuroscience. 2006;142:833–42.
CAS
PubMed
Google Scholar
Zhao X, Xu M, Jorgenson K, et al. Neurochemical changes in patients with chronic low back pain detected by proton magnetic resonance spectroscopy: a systematic review. Neuroimage Clin. 2017;13:33–8.
PubMed
Google Scholar
Henderson LA, Peck CC, Petersen ET, et al. Chronic pain: lost inhibition? J Neurosci. 2013;33:7574.
CAS
PubMed
PubMed Central
Google Scholar
Sorensen L, Siddall PJ, Trenell MI, et al. Differences in metabolites in pain-processing brain regions in patients with diabetes and painful neuropathy. Diabetes Care. 2008;31:980–1.
PubMed
Google Scholar
Grachev ID, Ramachandran TS, Thomas PS, et al. Association between dorsolateral prefrontal N-acetyl aspartate and depression in chronic back pain: an in vivo proton magnetic resonance spectroscopy study. J Neural Transmission. 2003;110:287–312.
CAS
Google Scholar
Amirmohseni S, Segelcke D, Reichl S, et al. Characterization of incisional and inflammatory pain in rats using functional tools of MRI. Neuroimage. 2016;127:110–22.
PubMed
Google Scholar
Harris RE, Clauw DJ. Imaging central neurochemical alterations in chronic pain with proton magnetic resonance spectroscopy. Neurosci Lett. 2012;520:192–6.
CAS
PubMed
Google Scholar
Liang S, Lin Y, Lin B, et al. Resting-state functional magnetic resonance imaging analysis of brain functional activity in rats with ischemic stroke treated by electro-acupuncture. J Stroke Cerebrovasc Dis. 2017;26(9):1953–9.
PubMed
Google Scholar
Pere B-V, Judit H, Francisco R, et al. Neuroplasticity of supraspinal structures associated with pathological pain. Anat Rec (Hoboken). 2017;300:1481–501.
Google Scholar
Chao TH, Chen JH, Yen CT. Plasticity changes in forebrain activity and functional connectivity during neuropathic pain development in rats with sciatic spared nerve injury. Mol Brain. 2018;11:55.
PubMed
PubMed Central
Google Scholar
Bill McCarberg, John P. Pain Pathways and Nervous System Plasticity: Learning and Memory in Pain. Pain Med. 2019;20:2421–37.
Google Scholar
Youssef AM, Gustin SM, Nash PG, et al. Differential brain activity in subjects with painful trigeminal neuropathy and painful temporomandibular disorder. Pain. 2014;155:467–75.
PubMed
Google Scholar
Chen-Tung Y, Pen-Li L. Thalamus and pain. Acta Anaesthesiol Taiwan. 2013;51:73–80.
Google Scholar
Kun-Long H, Su-Jane W, Ying-Chou W, et al. Upregulation of presynaptic proteins and protein kinases associated with enhanced glutamate release from axonal terminals (synaptosomes) of the medial prefrontal cortex in rats with neuropathic pain. Pain. 2014;155:377–87.
Google Scholar
Guida F, Luongo L, Marmo F, et al. Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice. Mol Brain. 2015;8:47.
CAS
PubMed
PubMed Central
Google Scholar
Ainhoa B, Claudia F-M, Sarah L, et al. Longitudinal structural and functional brain network alterations in a mouse model of neuropathic pain. Neuroscience. 2018;387:104–15.
Google Scholar
Hubbard CS, Khan SA, Xu S, et al. Behavioral, metabolic and functional brain changes in a rat model of chronic neuropathic pain: a longitudinal MRI study. Neuroimage. 2015;107:333–44.
PubMed
Google Scholar
Ghanbari A, Asgari AR, Kaka GR, et al. In vivo microdialysis of glutamate in ventroposterolateral nucleus of thalamus following electrolytic lesion of spinothalamic tract in rats. Exp Brain Res. 2014;232:415–21.
CAS
PubMed
Google Scholar
Gutzeit A, Meier D, Froehlich JM, et al. Differential NMR spectroscopy reactions of anterior/posterior and right/left insular subdivisions due to acute dental pain. Eur Radiol. 2013;23:450–60.
PubMed
Google Scholar
Nicolás F, Eva A, Laura V, et al. Higher glutamate+glutamine and reduction of N-acetylaspartate in posterior cingulate according to age range in patients with cognitive impairment and/or pain. Acad Radiol. 2014;21:1211–7.
Google Scholar
Kun Lv, Wenwen S, Rui T, et al. Neurotransmitter alterations in the anterior cingulate cortex in Crohn's disease patients with abdominal pain: a preliminary MR spectroscopy study. Neuroimage Clin. 2018;20:793–9.
Google Scholar
Ye-Ha J, Hyeonjin K, Yeon SJ, et al. Peripheral and central metabolites affecting depression, anxiety, suicidal ideation, and anger in complex regional pain syndrome patients using a magnetic resonance spectroscopy: a pilot study. Psychiatry Investig. 2018;15:891–9.
Google Scholar
Baslow Morris H, Hrabe J, Guilfoyle DN. Dynamic relationship between neurostimulation and N-acetylaspartate metabolism in the human visual cortex: evidence that NAA functions as a molecular water pump during visual stimulation. J Mol Neurosci. 2007;32:235–45.
CAS
PubMed
Google Scholar
Maheshwari SR, Fatterpekar GM, Castillo M, et al. Proton MR spectroscopy of the brain. Semin Ultrasound CT MRI. 2000;21:434–51.
CAS
Google Scholar
Pattany Pradip M, Yezierski Robert P, Widerström-Noga Eva G, et al. Proton magnetic resonance spectroscopy of the thalamus in patients with chronic neuropathic pain after spinal cord injury. Am J Neuroradiol. 2002;23:901–5.
CAS
PubMed
Google Scholar
Widerström-Noga E, Cruz-Almeida Y, Felix Elizabeth R, et al. Somatosensory phenotype is associated with thalamic metabolites and pain intensity after spinal cord injury. Pain. 2015;156:166–74.
PubMed
PubMed Central
Google Scholar
Gustin Sylvia M, Peck Chris C, Wilcox Sophie L, et al. Different pain, different brain: thalamic anatomy in neuropathic and non-neuropathic chronic pain syndromes. J Neurosci. 2011;31:5956–64.
CAS
PubMed
PubMed Central
Google Scholar
Sei F, Miyuki M, Toshiro I, et al. N-Acetylaspartate concentrations in the thalami of neuropathic pain patients and healthy comparison subjects measured with (1)H-MRS. Magn Reson Imaging. 2006;24:75–9.
Google Scholar
Gustin SM, Wrigley PJ, Youssef AM, et al. Thalamic activity and biochemical changes in individuals with neuropathic pain after spinal cord injury. Pain. 2014;155:1027–36.
CAS
PubMed
PubMed Central
Google Scholar
Tao Gu, Lei L, Yun J, et al. Acupuncture therapy in treating migraine: results of a magnetic resonance spectroscopy imaging study. J Pain Res. 2018;11:889–900.
Google Scholar
Shigemura T, Kishida S, Eguchi Y, et al. Proton magnetic resonance spectroscopy of the thalamus in patients with osteoarthritis of the hip. Bone Joint Res. 2012;1:8–12.
CAS
PubMed
PubMed Central
Google Scholar
Shoji Y, Shin-ichi K, Shin-ichi K. Assessment of pain due to lumbar spine diseases using MR spectroscopy: a preliminary report. J Orthop Sci. 2013;18:363–8.
Google Scholar
Lino B, Susie M, Shelly B, et al. Trigeminal neuropathic pain alters responses in CNS circuits to mechanical (brush) and thermal (cold and heat) stimuli. Neurosci. 2006;26:10646–57.
Google Scholar
Witting N, Kupers RC, Svensson P, et al. A PET activation study of brush-evoked allodynia in patients with nerve injury pain. Pain. 2006;120:145–54.
PubMed
Google Scholar
Mouraux A, Diukova A, Lee MC, et al. A multisensory investigation of the functional significance of the“pain matrix”. Neuroimage. 2011;54:2237–49.
PubMed
Google Scholar
Moseley GL. A pain neuromatrix approach to patients with chronic pain. Man Ther. 2003;8:130–40.
CAS
PubMed
Google Scholar
Iannetti G, Mouraux A. From the neuromatrix to the pain matrix (and back). Exp Brain Res. 2010;205:1–12.
CAS
PubMed
Google Scholar
Roland P. Functional brain imaging: what has it brought to our understanding of neuropathic pain? A special focus on allodynic pain mechanisms. Pain. 2016;157:S67–71.
Google Scholar
Okihiro O, Kazuya I, Ryo O, et al. Sequential variation in brain functional magnetic resonance imaging after peripheral nerve injury: A rat study. Neurosci Lett. 2018;673:150–6.
Google Scholar
Yonghui G, Chen S, Qiuling X, et al. Proteomic analysis of differential proteins related to anti-nociceptive effect of electroacupuncture in the hypothalamus following neuropathic pain in rats. Neurochem Res. 2013;38:1467–78.
Google Scholar
Ikeda R, Takahashi Y, Inoue K, et al. NMDA receptor-independent synaptic plasticity in the central amygdala in the rat model of neuropathic pain. Pain. 2007;127:161–72.
CAS
PubMed
Google Scholar
Chang C, Shyu BC. A fMRI study of brain activations during non-noxious and noxious electrical stimulation of the sciatic nerve of rats. Brain Res. 2001;897(1–2):71–81.
CAS
PubMed
Google Scholar
Ching Y, Wang C, Tay T, et al. Altered sensory insular connectivity in chronic postsurgical pain patients. Front Hum Neurosci. 2018;12:483.
PubMed
PubMed Central
Google Scholar
Han J, Cha M, Kwon M, et al. In vivo voltage-sensitive dye imaging of the insular cortex in nerve-injured rats. Neurosci Lett. 2016;634:146–52.
CAS
PubMed
Google Scholar
Peyron R, Fauchon C. Functional imaging of pain. Rev Neurol (Paris). 2019;175:38–45.
CAS
Google Scholar
Wang Y, Zhang Y, Zhang J, et al. Structural and functional abnormalities of the insular cortex in trigeminal neuralgia: a multimodal magnetic resonance imaging analysis. Pain. 2018;159:507–14.
PubMed
Google Scholar