Kaur R, Kaur M, Singh J. Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies. Cardiovasc Diabetol. 2018;17:121.
CAS
PubMed
PubMed Central
Google Scholar
Yip WCY, Sequeira IR, Plank LD, Poppitt SD. Prevalence of pre-diabetes across ethnicities: a review of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) for classification of dysglycaemia. Nutrients. 2017;9:1273.
PubMed Central
Google Scholar
Yates T, Khunti K, Bull F, Gorely T, Davies MJ. The role of physical activity in the management of impaired glucose tolerance: a systematic review. Diabetologia. 2007;50:1116–26.
CAS
PubMed
PubMed Central
Google Scholar
Xiang AH, Trigo E, Martinez M, Katkhouda N, Beale E, Wang X, et al. Impact of gastric banding versus metformin on beta-cell function in adults with impaired glucose tolerance or mild type 2 diabetes. Diabetes Care. 2018;41:2544–51.
CAS
PubMed
PubMed Central
Google Scholar
Kanat M, Mari A, Norton L, Winnier D, DeFronzo RA, Jenkinson C, et al. Distinct beta-cell defects in impaired fasting glucose and impaired glucose tolerance. Diabetes. 2012;61:447–53.
CAS
PubMed
PubMed Central
Google Scholar
Axelsen LN, Calloe K, Braunstein TH, Riemann M, Hofgaard JP, Liang B, et al. Diet-induced pre-diabetes slows cardiac conductance and promotes arrhythmogenesis. Cardiovasc Diabetol. 2015;14:87.
PubMed
PubMed Central
Google Scholar
Stull AJ. Lifestyle Approaches and Glucose Intolerance. Am J Lifestyle Med. 2016;10:406–16.
PubMed
PubMed Central
Google Scholar
Zhang F, Wan Q, Cao H, Tang L, Li D, Lu Q, et al. Identical anthropometric characteristics of impaired fasting glucose combined with impaired glucose tolerance and newly diagnosed type 2 diabetes: anthropometric indicators to predict hyperglycaemia in a community-based prospective cohort study in southwest China. BMJ Open. 2018;8:e019735.
PubMed
PubMed Central
Google Scholar
Long J, Song J, Zhong L, Liao Y, Liu L, Li X. Palmatine: a review of its pharmacology, toxicity and pharmacokinetics. Biochimie. 2019;162:176–84.
CAS
PubMed
Google Scholar
Wei XY, Tao JH, Cui X, Jiang S, Qian DW, Duan JA. Comparative pharmacokinetics of six major bioactive components in normal and type 2 diabetic rats after oral administration of Sanhuang Xiexin Decoction extracts by UPLC-TQ MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1061–1062:248–55.
PubMed
Google Scholar
Jia F, Zou G, Fan J, Yuan Z. Identification of palmatine as an inhibitor of West Nile virus. Arch Virol. 2010;155:1325–9.
CAS
PubMed
Google Scholar
Wang L, Wang X, Zhang SL, Zhu XM, Liu YQ, Song ZJ, et al. Gastroprotective effect of palmatine against acetic acid-induced gastric ulcers in rats. J Nat Med. 2017;71:257–64.
CAS
PubMed
Google Scholar
Khaksari M, Esmaili S, Abedloo R, Khastar H. Palmatine ameliorates nephrotoxicity and hepatotoxicity induced by gentamicin in rats. Arch Physiol Biochem. 2019. https://doi.org/10.1080/13813455.2019.1633354.
Article
PubMed
Google Scholar
Patel MB, Mishra S. Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia. Phytomedicine. 2011;18:1045–52.
CAS
PubMed
Google Scholar
Ning N, He K, Wang Y, Zou Z, Wu H, Li X, et al. Hypolipidemic effect and mechanism of palmatine from coptis chinensis in hamsters fed high-fat diet. Phytother Res. 2015;29:668–73.
CAS
PubMed
Google Scholar
Yan B, Wang D, Dong S, Cheng Z, Na L, Sang M, et al. Palmatine inhibits TRIF-dependent NF-kappaB pathway against inflammation induced by LPS in goat endometrial epithelial cells. Int Immunopharmacol. 2017;45:194–200.
CAS
PubMed
Google Scholar
Hambright HG, Batth IS, Xie J, Ghosh R, Kumar AP. Palmatine inhibits growth and invasion in prostate cancer cell: potential role for rpS6/NFkappaB/FLIP. Mol Carcinog. 2015;54:1227–34.
CAS
PubMed
Google Scholar
Sangeetha MK, Priya CDM, Vasanthi HR. Anti-diabetic property of Tinospora cordifolia and its active compound is mediated through the expression of Glut-4 in L6 myotubes. Phytomedicine. 2013;20:246–8.
CAS
PubMed
Google Scholar
Shen Y, Guan S, Ge H, Xiong W, He L, Liu L, et al. Effects of palmatine on rats with comorbidity of diabetic neuropathic pain and depression. Brain Res Bull. 2018;139:56–66.
CAS
PubMed
Google Scholar
Zhang Q, Sun X, Xiao X, Zheng J, Li M, Yu M, et al. Maternal chromium restriction leads to glucose metabolism imbalance in mice offspring through insulin signaling and Wnt signaling pathways. Int J Mol Sci. 2016;17:1767.
PubMed Central
Google Scholar
Li L, Krznar P, Erban A, Agazzi A, Martin-Levilain J, Supale S, et al. Metabolomics identifies a biomarker revealing in vivo loss of functional β-cell mass before diabetes onset. Diabetes. 2019;68:2272–86.
CAS
PubMed
Google Scholar
Youl E, Bardy G, Magous R, Cros G, Sejalon F, Virsolvy A, et al. Quercetin potentiates insulin secretion and protects INS-1 pancreatic beta-cells against oxidative damage via the ERK1/2 pathway. Br J Pharmacol. 2010;161:799–814.
CAS
PubMed
PubMed Central
Google Scholar
Ozaki KI, Awazu M, Tamiya M, Iwasaki Y, Harada A, Kugisaki S, et al. Targeting the ERK signaling pathway as a potential treatment for insulin resistance and type 2 diabetes. Am J Physiol Endocrinol Metab. 2016;310:E643–51.
PubMed
Google Scholar
Lee T, Yun S, Jeong JH, Jung TW. Asprosin impairs insulin secretion in response to glucose and viability through TLR4/JNK-mediated inflammation. Mol Cell Endocrinol. 2019;486:96–104.
CAS
PubMed
Google Scholar
Pratley RE, Weyer C. Progression from IGT to type 2 diabetes mellitus: the central role of impaired early insulin secretion. Curr Diab Rep. 2002;2:242–8.
PubMed
Google Scholar
Surwit RS, Kuhn CM, Cochrane C, McCubbin JA, Feinglos MN. Diet-induced type II diabetes in C57BL/6J mice. Diabetes. 1988;37:1163–7.
CAS
PubMed
Google Scholar
Pour OR, Dagogo-Jack S. Prediabetes as a therapeutic target. Clin Chem. 2011;57:215–20.
CAS
PubMed
Google Scholar
Di Bonito P, Pacifico L, Chiesa C, Valerio G, Miraglia Del Giudice E, Maffeis C, et al. Impaired fasting glucose and impaired glucose tolerance in children and adolescents with overweight/obesity. J Endocrinol Invest. 2017;40:409–16.
PubMed
Google Scholar
Phillips P. Oral glucose tolerance testing. Aust Fam Physician. 2012;41:391–3.
PubMed
Google Scholar
Nicholas LM, Valtat B, Medina A, Andersson L, Abels M, Mollet IG, et al. Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic beta-cells. Mol Metab. 2017;6:651–63.
CAS
PubMed
PubMed Central
Google Scholar
Weidmann P, de Coyrten M. Insulin resistance and hyperinsulinemia in hypertension. J Hypertens. 1995;13:S65–72.
CAS
Google Scholar
Zhang Y, Wang L, Zhang J, Li Y, He Q, Li H, et al. Probiotic Lactobacillus casei Zhang ameliorates high-fructose-induced impaired glucose tolerance in hyperinsulinemia rats. Eur J Nutr. 2014;53:221–32.
CAS
PubMed
Google Scholar
Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuñiga FA. Association between insulin resistance and the development of cardiovascular disease. Cardiovas Diabetol. 2018;17:122–122.
CAS
Google Scholar
Mezza T, Cinti F, Cefalo CMA, Pontecorvi A, Kulkarni RN, Giaccari A. Beta-cell fate in human insulin resistance and type 2 diabetes: a perspective on islet plasticity. Diabetes. 2019;68:1121–9.
CAS
PubMed
PubMed Central
Google Scholar
Wu L, Chen G, Liu W, Yang X, Gao J, Huang L, et al. Intramuscular injection of exogenous leptin induces adiposity, glucose intolerance and fatty liver by repressing the JAK2-STAT3/PI3K pathway in a rat model. Gen Comp Endocrinol. 2017;252:88–96.
CAS
PubMed
Google Scholar
Remedi MS, Emfinger C. Pancreatic β-cell identity in diabetes. Diabetes Obes Metab. 2016;18(Suppl 1):110–6.
CAS
PubMed
PubMed Central
Google Scholar
Jung HA, Min B-S, Yokozawa T, Lee J-H, Kim YS, Choi JS. Anti-alzheimer and antioxidant activities of coptidis rhizoma alkaloids. Biol Pharm Bull. 2009;32:1433–8.
CAS
PubMed
Google Scholar
Ma W-K, Li H, Dong C-L, He X, Guo C-R, Zhang C-F, et al. Palmatine from Mahonia bealei attenuates gut tumorigenesis in ApcMin/+ mice via inhibition of inflammatory cytokines. Mol Med Rep. 2016;14:491–8.
CAS
PubMed
PubMed Central
Google Scholar
Sun Y, Liu WZ, Liu T, Feng X, Yang N, Zhou HF. Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis. J Recept Signal Transduct Res. 2015;35:600–4.
CAS
PubMed
Google Scholar
Wang Y, Hai B, Niu X, Ai L, Cao Y, Li R, et al. Chronic intermittent hypoxia disturbs insulin secretion and causes pancreatic injury via the MAPK signaling pathway. Biochem Cell Biol. 2017;95:415–20.
CAS
PubMed
Google Scholar
Hirosumi JF, Tuncman GF, Chang LF, Gorgun CZ, Uysal KT, Maeda K, Maeda KF, Karin MF, et al. A central role for JNK in obesity and insulin resistance. Nature. 2002;420(6913):333–6.
CAS
PubMed
Google Scholar
Xu X, Tian J, Li QY. Downregulation of HOTTIP regulates insulin secretion and cell cycle in islet beta cells via inhibiting MEK/ERK pathway. Eur Rev Med Pharmacol Sci. 2018;22:4962–8.
CAS
PubMed
Google Scholar
Carstensen-Kirberg M, Röhrig K, Niersmann C, Ouwens DM, Belgardt BF, Roden M, et al. Sfrp5 increases glucose-stimulated insulin secretion in the rat pancreatic beta cell line INS-1E. PLoS ONE. 2019;14:e0213650–e50.
Google Scholar
Kim M, Song K, Kim YS. Alantolactone improves palmitate-induced glucose intolerance and inflammation in both lean and obese states in vitro: adipocyte and adipocyte-macrophage co-culture system. Int Immunopharmacol. 2017;49:187–94.
CAS
PubMed
Google Scholar
Zhu Y, Zhang X, Zhang L, Zhang M, Li L, Luo D, et al. Perilipin5 protects against lipotoxicity and alleviates endoplasmic reticulum stress in pancreatic beta-cells. Nutr Metab (Lond). 2019;16:50.
PubMed
PubMed Central
Google Scholar
Zhang G-Y, Lu D, Duan S-F, Gao Y-R, Liu S-Y, Hong Y, et al. Hydrogen sulfide alleviates lipopolysaccharide-induced diaphragm dysfunction in rats by reducing apoptosis and inflammation through ROS/MAPK and TLR4/NF-κB signaling pathways. Oxid Med Cell Longev. 2018;2018:9647809–09.
Google Scholar
Wang A, Zhang H, Liang Z, Xu K, Qiu W, Tian Y, et al. U0126 attenuates ischemia/reperfusion-induced apoptosis and autophagy in myocardium through MEK/ERK/EGR-1 pathway. Eur J Pharmacol. 2016;788:280–5.
CAS
PubMed
Google Scholar
Pasparakis M, Vandenabeele P. Necroptosis and its role in inflammation. Nature. 2015;517:311–20.
CAS
PubMed
Google Scholar
Zhang XP, Lin Q, Zhou YF. Progress of study on the relationship between mediators of inflammation and apoptosis in acute pancreatitis. Dig Dis Sci. 2007;52:1199–205.
CAS
PubMed
Google Scholar
Fan WJ, Li HP, Zhu HS, Sui SP, Chen PG, Deng Y, et al. NF-κB is involved in the LPS-mediated proliferation and apoptosis of MAC-T epithelial cells as part of the subacute ruminal acidosis response in cows. Biotechnol Lett. 2016;38:1839–49.
CAS
PubMed
Google Scholar