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  1. The monthly regeneration of human endometrial tissue is maintained by the presence of human endometrial mesenchymal stromal/stem cells (eMSC), a cell population co-expressing the perivascular markers CD140b an...

    Authors: Tianqi Li, Rachel W.S. Chan, Raymond H.W. Li, Ernest H.Y. Ng, Songying Zhang and William S.B. Yeung
    Citation: Biological Research 2024 57:6
  2. Basal energetic metabolism in sperm, particularly oxidative phosphorylation, is known to condition not only their oocyte fertilising ability, but also the subsequent embryo development. While the molecular pat...

    Authors: Yentel Mateo-Otero, Marc Llavanera, Marc Torres-Garrido and Marc Yeste
    Citation: Biological Research 2024 57:5
  3. Fibrous scars frequently form at the sites of bone nonunion when attempts to repair bone fractures have failed. However, the detailed mechanism by which fibroblasts, which are the main components of fibrous sc...

    Authors: Fei Huang, Guozhen Wei, Hai Wang, Ying Zhang, Wenbin Lan, Yun Xie and Gui Wu
    Citation: Biological Research 2024 57:4
  4. Sensorineural hearing loss (SNHL) poses a major threat to both physical and mental health; however, there is still a lack of effective drugs to treat the disease. Recently, novel biological therapies, such as ...

    Authors: Huan Liu, Huijuan Kuang, Yiru Wang, Lili Bao, Wanxin Cao, Lu Yu, Meihao Qi, Renfeng Wang, Xiaoshan Yang, Qingyuan Ye, Feng Ding, Lili Ren, Siying Liu, Furong Ma and Shiyu Liu
    Citation: Biological Research 2024 57:3
  5. Increasing evidence suggests a double-faceted role of alpha-synuclein (α-syn) following infection by a variety of viruses, including SARS-CoV-2. Although α-syn accumulation is known to contribute to cell toxic...

    Authors: Fiona Limanaqi, Silvia Zecchini, Irma Saulle, Sergio Strizzi, Claudia Vanetti, Micaela Garziano, Gioia Cappelletti, Debora Parolin, Sonia Caccia, Daria Trabattoni, Claudio Fenizia, Mario Clerici and Mara Biasin
    Citation: Biological Research 2024 57:2
  6. Tumor-derived small extracellular vesicles (sEVs) can promote tumorigenic and metastatic capacities in less aggressive recipient cells mainly through the biomolecules in their cargo. However, despite recent ad...

    Authors: Eduardo Durán-Jara, Matías del Campo, Valentina Gutiérrez, Ignacio Wichmann, César Trigo, Marcelo Ezquer and Lorena Lobos-González
    Citation: Biological Research 2024 57:1
  7. Growing evidence has suggested that Type I Interferon (I-IFN) plays a potential role in the pathogenesis of Down Syndrome (DS). This work investigates the underlying function of MX1, an effector gene of I-IFN,...

    Authors: Zhenglong Guo, Yongchang Zhu, Hai Xiao, Ranran Dai, Wenke Yang, Wei Xue, Xueying Zhang, Bingtao Hao and Shixiu Liao
    Citation: Biological Research 2023 56:67
  8. Abnormal remodeling of the pulmonary vasculature, characterized by the proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) along with dysregulated glycolysis, is a pathognomonic feat...

    Authors: Yi-Chia Wu, Wei-Ting Wang, Ming-Chun Yang, Yu-Tsun Su, Jwu-Lai Yeh, Jong-Hau Hsu and Jiunn-Ren Wu
    Citation: Biological Research 2023 56:66
  9. Impaired pattern separation occurs in the early stage of Alzheimer’s disease (AD), and hippocampal dentate gyrus (DG) neurogenesis participates in pattern separation. Here, we investigated whether spatial memo...

    Authors: Yanyi Ding, Long Li, Sinuo Wang, Yajun Cao, Minguang Yang, Yaling Dai, Huawei Lin, Jianhong Li, Yulu Liu, Zhifu Wang, Weilin Liu and Jing Tao
    Citation: Biological Research 2023 56:65
  10. Asthma is a heterogenous disease that characterized by airway remodeling. SYVN1 (Synoviolin 1) acts as an E3 ligase to mediate the suppression of endoplasmic reticulum (ER) stress through ubiquitination and de...

    Authors: Bing Dai, Si Liu, Wenxin Shen, Li Chen, Qianlan Zhou, Lina Han, Qinzhen Zhang and Lishen Shan
    Citation: Biological Research 2023 56:64
  11. In December 2022 the US Food and Drug Administration (FDA) removed the requirement that drugs in development must undergo animal testing before clinical evaluation, a declaration that now demands the establish...

    Authors: Javiera Obreque, Luis Vergara-Gómez, Nicolás Venegas, Helga Weber, Gareth I. Owen, Pablo Pérez-Moreno, Pamela Leal, Juan Carlos Roa and Carolina Bizama
    Citation: Biological Research 2023 56:63
  12. Atherosclerosis (AS), a significant contributor to cardiovascular disease (CVD), is steadily rising with the aging of the global population. Pyroptosis and apoptosis, both caspase-mediated cell death mechanism...

    Authors: Lin Cong, Xiankun Liu, Yiming Bai, Qin Qin, Lili Zhao, Ying Shi, Yunpeng Bai and Zhigang Guo
    Citation: Biological Research 2023 56:62
  13. The decline in the quantity and quality of mitochondria are closely associated with infertility, particularly in advanced maternal age. Transferring autologous mitochondria into the oocytes of infertile female...

    Authors: Zhixin Jiang, Cheng Shi, Hongjing Han, Min Fu, Honglan Zhu, Tingting Han, Jia Fei, Yining Huang, Zhiping Jin, Jianan He, Yanbin Wang, Xi Chen and Huan Shen
    Citation: Biological Research 2023 56:60
  14. Neural progenitor cells (NPCs) are essential for in vitro drug screening and cell-based therapies for brain-related disorders, necessitating well-defined and reproducible culture systems. Current strategies em...

    Authors: Ceheng Liao, Ying Guan, Jihui Zheng, Xue Wang, Meixia Wang, Zhouhai Zhu, Qiyuan Peng, Hong-Hui Wang and Meng Li
    Citation: Biological Research 2023 56:59
  15. Anther development and pollen fertility of cytoplasmic male sterility (CMS) conditioned by Gossypium harknessii cytoplasm (CMS-D2) restorer lines are susceptible to continuous high-temperature (HT) stress in sum...

    Authors: Meng Zhang, Xuexian Zhang, Ruijie Wang, Rong Zang, Liping Guo, Tingxiang Qi, Huini Tang, Liangliang Chen, Hailin Wang, Xiuqin Qiao, Jianyong Wu and Chaozhu Xing
    Citation: Biological Research 2023 56:58
  16. Obstructive sleep apnea (OSA) is characterized by recurrent episodes of chronic intermittent hypoxia (CIH), which has been linked to the development of sympathoexcitation and hypertension. Furthermore, it has ...

    Authors: Katherin Pereyra, Alexandra Las Heras, Camilo Toledo, Esteban Díaz-Jara, Rodrigo Iturriaga and Rodrigo Del Rio
    Citation: Biological Research 2023 56:57
  17. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An aspect of high uncertainty is whether the SARS-CoV-2 per se or the systemic inflammation ...

    Authors: Juan Prieto-Villalobos, Claudia M. Lucero, Maximiliano Rovegno, Gonzalo I. Gómez, Mauricio A. Retamal and Juan A. Orellana
    Citation: Biological Research 2023 56:56
  18. Angiotensin converting enzyme 2 (ACE2) plays a crucial role in the infection cycle of SARS-CoV-2 responsible for formation of COVID-19 pandemic. In the cardiovascular system, the virus enters the cells by bind...

    Authors: Sona Cacanyiova, Martina Cebova, Fedor Simko, Tomas Baka, Iveta Bernatova, Michal Kluknavsky, Stefan Zorad, Katarina Krskova, Ezgi Shaman, Anna Zemancikova, Andrej Barta, Basak G. Aydemir and Andrea Berenyiova
    Citation: Biological Research 2023 56:55
  19. Endotoxic shock (ExSh) and cecal ligature and puncture (CLP) are models that induce sepsis. In this work, we investigated early immunologic and histopathologic changes induced by ExSh or CLP models in female a...

    Authors: Rafael Bojalil, Armando Ruíz-Hernández, Arturo Villanueva-Arias, Luis Manuel Amezcua-Guerra, Sergio Cásarez-Alvarado, Ana María Hernández-Dueñas, Verónica Rodríguez-Galicia, Lenin Pavón, Brenda Marquina, Enrique Becerril-Villanueva, Rogelio Hernández-Pando and Ricardo Márquez-Velasco
    Citation: Biological Research 2023 56:54
  20. In vitro incubation of epididymal and vas deferens sperm with Mn2+ induces Sperm Chromatin Fragmentation (SCF), a mechanism that causes double-stranded breaks in toroid-linker regions (TLRs). Whether this mechani...

    Authors: Estel Viñolas-Vergés, Marc Yeste, Ferran Garriga, Sergi Bonet, Yentel Mateo-Otero and Jordi Ribas-Maynou
    Citation: Biological Research 2023 56:53
  21. Ischemic stroke is a severe type of stroke with high disability and mortality rates. In recent years, microglial exosome-derived miRNAs have been shown to be promising candidates for the treatment of ischemic ...

    Authors: Si-si Li, Jia-jia Wu, Xiang-xin Xing, Yu-lin Li, Jie Ma, Yu-jie Duan, Jun-peng Zhang, Chun-lei Shan, Xu-yun Hua, Mou-xiong Zheng and Jian-guang Xu
    Citation: Biological Research 2023 56:52
  22. Nitric oxide is produced by different nitric oxide synthases isoforms. NO activates two signaling pathways, one dependent on soluble guanylate cyclase and protein kinase G, and other where NO post-translationa...

    Authors: T. Koning, F. Cordova, G. Aguilar, J. Sarmiento, G. A. Mardones, M. Boric, M. Varas-Godoy, A. Lladser, W. N. Duran, P. Ehrenfeld and F. A. Sanchez
    Citation: Biological Research 2023 56:51
  23. Intracranial aneurysm (IA) is the most common cerebrovascular disease, and subarachnoid hemorrhage caused by its rupture can seriously impede nerve function. Pyroptosis is an inflammatory mode of cell death wh...

    Authors: Donglin Zhou, Yimin Zhu, Peng Jiang, Tongfu Zhang, Jianfeng Zhuang, Tao Li, Linzeng Qi and Yunyan Wang
    Citation: Biological Research 2023 56:50
  24. The endoplasmic reticulum (ER) contacts endosomes in all parts of a motor neuron, including the axon and presynaptic terminal, to move structural proteins, proteins that send signals, and lipids over long dist...

    Authors: Francisca Bertin, Jorge Jara-Wilde, Benedikt Auer, Andrés Köhler-Solís, Carolina González-Silva, Ulrich Thomas and Jimena Sierralta
    Citation: Biological Research 2023 56:49
  25. To elucidate the role of Mucin1 (MUC1) in the trophoblast function (glucose uptake and apoptosis) of gestational diabetes mellitus (GDM) women through the Wnt/β-catenin pathway.

    Authors: Shuang-Shuang Cui, Ping Zhang, Lu Sun, Yu-Lin-Lan Yuan, Jingyun Wang, Feng-Xiang Zhang and Ruiman Li
    Citation: Biological Research 2023 56:48
  26. Chemotherapeutic drugs can cause reproductive damage by affecting sperm quality and other aspects of male fertility. Stem cells are thought to alleviate the damage caused by chemotherapy drugs and to play role...

    Authors: YuSheng Zhang, YaNan Liu, Zi Teng, ZeLin Wang, Peng Zhu, ZhiXin Wang, FuJun Liu and XueXia Liu
    Citation: Biological Research 2023 56:47
  27. The genomes of present-day non-Africans are composed of 1–3% of Neandertal-derived DNA as a consequence of admixture events between Neandertals and anatomically modern humans about 50–60 thousand years ago. Ne...

    Authors: Margherita Piccardi, Manuel Gentiluomo, Stefania Bertoncini, Raffaele Pezzilli, Bálint Erőss, Stefania Bunduc, Faik G. Uzunoglu, Renata Talar-Wojnarowska, Tomas Vanagas, Cosimo Sperti, Martin Oliverius, Mateus Nóbrega Aoki, Stefano Ermini, Tamás Hussein, Ugo Boggi, Krzysztof Jamroziak…
    Citation: Biological Research 2023 56:46
  28. Hypertrophic cardiomyopathy (HCM), an autosomal dominant genetic disease, is the main cause of sudden death in adolescents and athletes globally. Hypoxia and immune factors have been revealed to be related to ...

    Authors: Haozhen Yu, Lanxin Gu, Linfang Du, Zhao Dong, Zhuang Li, Mujun Yu, Yue Yin, Yishi Wang, Lu Yu and Heng Ma
    Citation: Biological Research 2023 56:45
  29. Malignant cells adopt anoikis resistance to survive anchorage-free stresses and initiate cancer metastasis. It is still unknown how varying periods of anchorage loss contribute to anoikis resistance, cell migr...

    Authors: Rungroch Sungthong, Hnin Ei Ei Khine, Somruethai Sumkhemthong, Pithi Chanvorachote, Rossarin Tansawat and Chatchai Chaotham
    Citation: Biological Research 2023 56:44
  30. For more than 20 years, Saccharomyces cerevisiae has served as a model organism for genetic studies and molecular biology, as well as a platform for biotechnology (e.g., wine production). One of the important eco...

    Authors: Eduardo I. Kessi-Pérez, Eric Acuña, Camila Bastías, Leyanis Fundora, Manuel Villalobos-Cid, Andrés Romero, Sakshi Khaiwal, Matteo De Chiara, Gianni Liti, Francisco Salinas and Claudio Martínez
    Citation: Biological Research 2023 56:43
  31. Hyperbaric oxygen treatment (HBOT) has been reported to modulate the proliferation of neural and mesenchymal stem cell populations, but the molecular mechanisms underlying these effects are not completely unde...

    Authors: Ignacio Casanova-Maldonado, David Arancibia, Pablo Lois, Isaac Peña-Villalobos and Verónica Palma
    Citation: Biological Research 2023 56:41
  32. Polar microalgae contain unique compounds that enable them to adapt to extreme environments. As the skin barrier is our first line of defense against external threats, polar microalgae extracts may possess res...

    Authors: YoonHee Lim, So-Hyun Park, Eun Jae Kim, HeeJun Lim, Jinsun Jang, In-Sun Hong, Sanghee Kim and YunJae Jung
    Citation: Biological Research 2023 56:40
  33. Electroacupuncture (EA) is a complementary and alternative therapy which has shown protective effects on vascular cognitive impairment (VCI). However, the underlying mechanisms are not entirely understood.

    Authors: Yaling Dai, Sinuo Wang, Minguang Yang, Peiyuan Zhuo, Yanyi Ding, Xiaoling Li, Yajun Cao, Xiaoqin Guo, Huawei Lin, Jing Tao, Lidian Chen and Weilin Liu
    Citation: Biological Research 2023 56:36
  34. High mountainous environments are of particular interest as they play an essential role for life and human societies, while being environments which are highly vulnerable to climate change and land use intensi...

    Authors: Constanza Aguado-Norese, Valentina Cárdenas, Alexis Gaete, Dinka Mandakovic, Javiera Vasquez-Dean, Christian Hodar, Marco Pfeiffer and Mauricio Gonzalez
    Citation: Biological Research 2023 56:35
  35. Dilated cardiomyopathy (DCM) is a primary myocardial disease, leading to heart failure and excessive risk of sudden cardiac death with rather poorly understood pathophysiology. In 2015, Parvari's group ident...

    Authors: Nataly Korover, Sharon Etzion, Alexander Cherniak, Tatiana Rabinski, Aviva Levitas, Yoram Etzion, Rivka Ofir, Ruti Parvari and Smadar Cohen
    Citation: Biological Research 2023 56:34
  36. Voltage-dependent anion selective channels (VDACs) are the most abundant mitochondrial outer membrane proteins, encoded in mammals by three genes, VDAC1, 2 and 3, mostly ubiquitously expressed. As 'mitochondrial ...

    Authors: Xena Giada Pappalardo, Pierpaolo Risiglione, Federica Zinghirino, Angela Ostuni, Daniela Luciano, Faustino Bisaccia, Vito De Pinto, Francesca Guarino and Angela Messina
    Citation: Biological Research 2023 56:33
  37. Melanoma is one of the most aggressive and deadliest skin tumor. Cholesterol content in melanoma cells is elevated, and a portion of it accumulates into lipid rafts. Therefore, the plasma membrane cholesterol ...

    Authors: Ambroise Wu, Ewa Mazurkiewicz, Piotr Donizy, Krzysztof Kotowski, Małgorzata Pieniazek, Antonina J. Mazur, Aleksander Czogalla and Tomasz Trombik
    Citation: Biological Research 2023 56:32
  38. The main features of polycystic ovary syndrome (PCOS) are abnormal follicular development and ovulatory dysfunction, which are caused by excessive apoptosis of ovarian granulosa cells. Acupuncture has been sho...

    Authors: Xiaohong Chen, Hengzhen He, Bingcai Long, Binli Wei, Peng Yang, Xiaoying Huang, Qian Wang, Jing Lin and Hongliang Tang
    Citation: Biological Research 2023 56:31
  39. Skeletal muscle is sensitive to bile acids (BA) because it expresses the TGR5 receptor for BA. Cholic (CA) and deoxycholic (DCA) acids induce a sarcopenia-like phenotype through TGR5-dependent mechanisms. Besi...

    Authors: Johanna Abrigo, Hugo Olguín, Franco Tacchi, Josué Orozco-Aguilar, Mayalen Valero-Breton, Jorge Soto, Mauricio Castro-Sepúlveda, Alvaro A. Elorza, Felipe Simon and Claudio Cabello-Verrugio
    Citation: Biological Research 2023 56:30
  40. Duchenne muscular dystrophy (DMD) is an X-linked lethal genetic disorder for which there is no effective treatment. Previous studies have shown that stem cell transplantation into mdx mice can promote muscle r...

    Authors: Haimei Cen, Pin Fan, Yuting Ding, Bin Luo, Hong Luo, Menglong Chen and Yu Zhang
    Citation: Biological Research 2023 56:29
  41. Skeletal muscle generates force and movements and maintains posture. Under pathological conditions, muscle fibers suffer an imbalance in protein synthesis/degradation. This event causes muscle mass loss and de...

    Authors: Josué Orozco-Aguilar, Franco Tacchi, Francisco Aguirre, Mayalen Valero-Breton, Mauricio Castro-Sepulveda, Felipe Simon and Claudio Cabello-Verrugio
    Citation: Biological Research 2023 56:28
  42. The underlying mechanism of Parkinson’s disease are still unidentified, but excitotoxicity, oxidative stress, and neuroinflammation are considered key actors. Proliferator activated receptors (PPARs) are trans...

    Authors: Andrea Antonosante, Vanessa Castelli, Martina Sette, Margherita Alfonsetti, Mariano Catanesi, Elisabetta Benedetti, Matteo Ardini, Annamaria Cimini and Michele d’Angelo
    Citation: Biological Research 2023 56:27
  43. Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal horn neurons. Inhibition of abnormal dendritic spine remodeling can relieve neuropathic...

    Authors: Qiaoyun Wu, Chenchen Cai, Xinwang Ying, Yujun Zheng, Jiaying Yu, Xiaoxue Gu, Wenzhan Tu, Xinfa Lou, Guanhu Yang, Ming Li and Songhe Jiang
    Citation: Biological Research 2023 56:26
  44. Mechanoreceptor activation modulates GABA neuron firing and dopamine (DA) release in the mesolimbic DA system, an area implicated in reward and substance abuse. The lateral habenula (LHb), the lateral hypothal...

    Authors: Han Byeol Jang, DanBi Ahn, Suchan Chang, Hyung Kyu Kim, Bong Hyo Lee, Sang Chan Kim, Scott C. Steffensen, Kyle B. Bills, Hubert Lee and Hee Young Kim
    Citation: Biological Research 2023 56:25
  45. Authors: Ivanka Jiménez-Dinamarca, Yolanda Prado, Pablo Tapia, Sebastian Gatica, Clemens Alt, Charles P. Lin, Cristian Reyes-Martínez, Carmen G. Feijóo, Cristobal Aravena, Alejandra González-Canacer, Simón Correa, Diego Varela, Claudio Cabello-Verrugio and Felipe Simon
    Citation: Biological Research 2023 56:24

    The original article was published in Biological Research 2023 56:8