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  • Open Access

Schizophrenia and reelin: a model based on prenatal stress to study epigenetics, brain development and behavior

Biological Research201649:16

https://doi.org/10.1186/s40659-016-0076-5

©  Negrón-Oyarzo et al. 2016

  • Received: 15 November 2015
  • Accepted: 22 February 2016
  • Published:

Abstract

Schizophrenia is a severe psychiatric disorder that results in a significant disability for the patient. The disorder is characterized by impairment of the adaptive orchestration of actions, a cognitive function that is mainly dependent on the prefrontal cortex. This behavioral deficit, together with cellular and neurophysiological alterations in the prefrontal cortex, as well as reduced density of GABAergic cells and aberrant oscillatory activity, all indicate structural and functional deficits of the prefrontal cortex in schizophrenia. Among the several risk factors for the development of schizophrenia, stress during the prenatal period has been identified as crucial. Thus, it is proposed that prenatal stress induces neurodevelopmental alterations in the prefrontal cortex that are expressed as cognitive impairment observed in schizophrenia. However, the precise mechanisms that link prenatal stress with the impairment of prefrontal cortex function is largely unknown. Reelin is an extracellular matrix protein involved in the development of cortical neural connectivity at embryonic stages, and in synaptic plasticity at postnatal stages. Interestingly, down-regulation of reelin expression has been associated with epigenetic changes in the reelin gene of the prefrontal cortex of schizophrenic patients. We recently showed that, similar to schizophrenic patients, prenatal stress induces down-expression of reelin associated with the methylation of its promoter in the rodent prefrontal cortex. These alterations were paralleled with altered prefrontal cortex functional connectivity and impairment in prefrontal cortex-dependent behavioral tasks. Therefore, considering molecular, cellular, physiological and behavioral evidence, we propose a unifying framework that links prenatal stress and prefrontal malfunction through epigenetic alterations of the reelin gene.

Keywords

  • Schizophrenia
  • Prefrontal cortex
  • Prenatal stress
  • Functional connectivity
  • DNA methylation
  • Reelin

Background

Schizophrenia is a chronic psychiatric disorder that affects 0.5–1 % of the world’s population. It is characterized by a complex set of disturbances of thought, perception, and affective and social behavior that result in high social disability [1]. Although the causes of this disorder are not completely understood, clinical research has identified some factors that provide insight into the pathophysiology of this disease [2]. For example, schizophrenia is characterized by impairment of cognitive functions dependent on the prefrontal cortex (PFC; [3]), which coincides with cellular and neurophysiological alterations observed in the PFC of schizophrenic patients [4, 5]. It is also known that prenatal stress (PNS) is an important etiologic factor for the development of this disorder [6], which implies that PNS induces neurodevelopmental alterations in the PFC that are manifested as cognitive alterations observed in schizophrenic patients. In this review, we propose that PNS-induced epigenetic changes in the reelin gene, which codes for an extracellular protein involved in cortical development, could be a molecular link between prenatal stress and PFC dysfunction.

The deficit in cognitive control in schizophrenia suggests functional impairment of PFC function

The symptomatology of schizophrenia has provided some clues about the neurophysiology of the disorder. Symptoms are classified as cognitive, positive, and negative [1]. Among these symptoms, cognitive impairments are especially relevant because they impact on the normal life performance of patients. These cognitive impairments, like reduced working memory [3, 7–9], selective attention [10], and set-shifting [11], can be globally grouped as a detriment to executive control: i.e. the proper orchestration of thoughts and actions in accordance with internal goals [12]. It has been suggested that the degree of cognitive impairments, and not the severity of psychosis, is the best predictor of long-term functional outcome for affected individuals, leading to the view that cognitive deficits are the core abnormalities of the illness [13, 14]. Thus, the deficit of executive control appears to be a hallmark of schizophrenia [3, 9, 15].

The PFC is considered the main brain area involved in executive control [12, 16]. The cognitive symptoms of schizophrenia suggest a functional impairment in the PFC as a core neurological dimension, a feature known as “hypofrontality” [3]. This functional deficit seems to be strongly related to altered neural oscillatory synchrony in the PFC [17–19], functional alterations that correlate with cognitive deficits in schizophrenic patients [4, 20]. The gamma-frequency band (30–80 Hz), the most evident neurophysiological parameter affected in schizophrenia, is required for the implementation of executive control by the PFC [21, 22], suggesting that altered gamma oscillations are implicated in cognitive dysfunction [23]. It has been shown that transmagnetic stimulation applied to the gamma-frequency band in the PFC alleviates cognitive symptoms in some schizophrenic patients [24].

The PFC of schizophrenic patients also displays profound alterations at the cellular level, like a reduction of the mean clustering distance between cells by alterations in neuropile volume [25]. It has also been observed that schizophrenics have fewer dendritic spines in pyramidal neurons than non-schizophrenic post-mortem subjects [26]. However, the inhibitory GABAergic neurons seem to be the most affected neuronal population in the PFC of schizophrenic patients. One of the most consistent findings in postmortem studies in the PFC of individuals with schizophrenia is the reduced mRNA expression of GAD67, the enzyme that synthesizes GABA [27]. In addition, reduced density of GABAergic cells, and decreased amounts of inhibitory axon terminals have been found post-mortem in the PFC of schizophrenic patients [5, 28, 29]. This evidence has led to consider schizophrenia as a disease of impaired inhibitory transmission in the PFC [30–32]. Given that GABAergic interneurons are strongly implicated in the emergence of gamma-frequency oscillations in cortical networks [33–35], this evidence suggests that cellular impairments may underlie neurophysiological PFC alterations related to cognitive impairment in schizophrenia [32].

The effects of prenatal stress on the PFC as a neurodevelopmental factor for schizophrenia

Some cognitive and neurophysiological alterations observed in schizophrenic patients are evident during early childhood, before patients manifest diagnosed symptoms [36–39]. This, together with the prenatal development of cellular components altered in schizophrenia, like cortical microcircuit connectivity and GABAergic transmission [26, 40, 41], all suggest that schizophrenia can also be considered a neurodevelopmental disorder, especially focused on the development of the PFC [38, 42, 43]. Thus, current evidence indicates that neurodevelopmental cellular alterations in the PFC, particularly those related to inhibitory transmission, is associated to abnormal functional connectivity in the PFC, resulting in an impairment of executive functions in schizophrenic patients [43]. But, how are these neurodevelopmental alterations in the PFC acquired?

Among the several acquired and environmental factors involved in the development of schizophrenia [44], the suffering of threatening situations by the pregnant mother during gestation, i.e. PNS, has been considered a strong environmental risk factor [6]. In support of this idea, it has been shown that the number of individuals with diagnoses of schizophrenia is significantly higher among individuals with prenatal loss of their fathers than among individuals whose fathers died during their first year of childhood [45]. Accordingly, van Os and Selten [46] found a higher cumulative incidence of schizophrenia among individuals prenatally exposed to the 1940 invasion of the Netherlands by the German army, suggesting that maternal stress during pregnancy may contribute to the development of vulnerability to schizophrenia. Similarly, Betts et al. [47] showed that stressful prenatal life events predicted psychotic experiences in adulthood. Finally, Levine et al. [48] found that PNS associated to exposure to the holocaust constitutes a consistent risk factor for schizophrenia. Thus, taking in consideration the essential role of PNS as a development risk factor for schizophrenia, and that this disorder is characterized by functional impairment of the PFC, two critical questions arise: (1) Does PNS produce functional impairment of the PFC associated with schizophrenia? And if so, (2) How does this process occur?

It has been shown in humans that stressing situations experienced by the mother during pregnancy affect PFC-dependent cognitive functions of the offspring, like working memory, control of anxiety, and learning strategies [49–52]. Similarly, research in rodents have shown that PNS affects cognitive functions dependent on the limbic and prelimbic cortex, (the rodent homologue and analogue to the human PFC [53]), manifested as impairment of working memory [54], increase of aversive remote memory [55] (Fig. 1) or decreased recall of the extinction of conditioned fear [56]. These data indicate that PNS affects cognitive functions dependent on the PFC at adulthood [57, 58], which could be related to the pathogenesis of schizophrenia [48, 59]. At a neurophysiological level, PNS alters neuronal synchronization between the PFC and the hippocampus, connectivity relevant to the consolidation of memories [58, 60] together with a decreased firing rate in the PFC in vivo [55] (Fig. 2). Coincidently, these neurophysiological alterations are paralleled with the persistence of aversive remote memory [53, 55] (Fig. 1), a PFC-dependent cognitive function [61].
Fig. 1
Fig. 1

Prenatal stress produces long-term persistence of spatial memory and decreases learning retention in a passive avoidance test. a Control and PNS mice were trained for 4 days to locate the escape in the Barnes maze test. Latency to find the escape was assessed 1 (recent memory) and 10 days (remote memory) after training. Right panel example of tracking plots for 2 mice (Control and PNS) in the Barnes maze during recent and remote memory testing. Left panel bar chart showing the latency to escape for both groups of mice in the two memory conditions (*P < 0.05; Bonferroni post hoc after 2-way ANOVA). b In the passive avoidance learning-retention test, latency time to enter the dark chamber of the shuttle box was measured, where a mild foot shock was delivered on day 2. There were significant differences (Bonferroni post hoc after 2-way ANOVA) in the latency time between control and PNS rats on days four and five post-shock. Data are presented as mean ± SEM. Adapted from [55, 125]

Fig. 2
Fig. 2

Prenatal stress decreases firing rate in the PFC and disrupts functional connectivity between the PFC and hippocampus. Control and PNS mice were subjected to in vivo local field potential recording under urethane anesthesia in the hippocampus and PFC, after either recent or remote memory testing in the Barnes maze. a Representative recordings for each group and condition displaying the hippocampal LFP filtered at 100–300 Hz (upper) and its correlative prefrontal LFP filtered at 300–5 Hz (lower). Asterisks indicate sharp wave ripples (SWR) cross-correlated with spikes from PFC cells. b Mean firing rate of spontaneously firing neurons in the PFC (**P < 0.01; Mann–Whitney U test). Data are shown as mean ± SEM. c Mean normalized cross-correlation between significantly correlated PFC single units to hippocampal SWRs. Note the significant difference of discharge in the PFC 200 ms after the ripple onset in remote memory in PNS group (*P < 0.05; Wilcoxon signed rank test). Data are presented as mean ± SEM. Adapted from [55]

At the cellular level, there is abundant evidence suggesting that PNS affects the correct development of the PFC in rodents. For example, dendritic ramification of pyramidal neurons is disrupted in prenatally stressed adults rats [62], morphological alterations that are also evident during earlier developing stages like early childhood [63] and adolescence [64]. PNS not only affects pyramidal neurons in the PFC, but also the development of inhibitory neurons. For example, PNS decreases the number of PV+ interneurons in the PFC [65], and delays tangential migration of inhibitory neurons in the developing neocortex [64]. This is especially important since, as mentioned above, a reduction in inhibitory neuronal activity in the PFC has been proposed as an important physiopathological feature of schizophrenic patients [31, 32]. Altogether, these data suggest that PNS induces cellular neurodevelopmental alterations expressed as neurophysiological alterations in the PFC, as observed in schizophrenia [66]. However, the precise molecular mechanism by which PNS contributes to the development of schizophrenia remains elusive.

Reelin as a molecular candidate for cellular alterations in schizophrenia

Among molecular candidates involved in the development of schizophrenia [66–69], reelin seems to be an important link between prenatal stress and cellular and physiological alterations observed in schizophrenia. Reelin is a 400~ kD extracellular matrix glycoprotein coded by a 450-bp gene located in the human chromosome 7q22 and in the murine chromosome 5 [70]. The reelin gene has multiple cis elements, including for transcription factors involved in neurodevelopment like Sp1, Tbr-1 and Pax6, and for signal transduction like CREB [71, 72]. The protein exerts its function through the union with the VLDLR and ApoER2 receptors. This coupling elicits the intracellular phosphorylation and activation of the adaptor protein disabled 1 (mDab1), which initiates a signaling pathway that ends with the modulation of the cytoskeleton of actin and microtubules [73]. Among the several molecular candidates for the physiopathology of schizophrenia (for review see [74]), clinical and preclinical evidence indicates reelin is a relevant component [75–78]. Below we review the evidence that supports reelin as a molecular candidate for the cellular disruptions produced in schizophrenia.

Reelin participates in prenatal development and shapes post-natal neural connectivity in the neocortex

Reelin protein is expressed in mammals during brain development, principally by Cajal-Retzius neurons in superficial layers of the neocortex and the hippocampus [79–81]. In rodents, cortical and hippocampal Cajal-Retzius neurons degenerate progressively to postnatal day 14 [82, 83], limiting the production and secretion of reelin to GABAergic interneurons from postnatal day 8 to adulthood [83–85]. The role of reelin in neurodevelopment has been well demonstrated, especially by regulating the radial migration of excitatory neurons and the establishment of the “inside-out” neurogenetic gradient [73, 86–88]. The reeler mouse (homocygote knock-out for reelin, and thereby deficient for reelin; [89]), has a clear disruption of cortical layers. In addition it has been demonstrated that reeler mice display an aberrant disposition of inteneurons in the neocortex [90, 91], and that positioned neurons fail to connect to each other and to form a correct cortical architecture [73, 80, 92]. On the other hand, the heterozygous reeler mouse (HRM), which has 50 % expression of reelin and is used as a model for schizophrenia [93], does not have the inversion of the cortical layers observed in homozygous reeler mice [94]. However, it has reduced dendritic length and complexity and spine density compared with wild type animals [95, 96]. Importantly, the HRM mouse also displays decreased cortical GABA biosynthesis [97] and decreased cortical GAD67 [96, 98].

Reelin also participates in the remodeling of neuronal connectivity in the adult brain modulating synaptogenesis [99], synaptic plasticity [100–104] and neurotransmitter release [105]. The HRM display a decrease in spine density in parallel to lack of NMDA receptor dependent long-term potentiation in the PFC [106]. Furthermore, in vivo enhancement of reelin signaling increases cognitive ability, synaptic plasticity, and dendritic spine density [103]. Altogether, this evidence indicates that reelin modulates cortical neuronal connectivity in both pre- and postnatal stages.

Reduced expression of reelin and hypermethylation of the reelin promoter is found in the PFC of schizophrenic patients

Impagnatiello et al. [107] were the first to report that reelin mRNA and protein expression were significantly lower in the PFC of post-mortem schizophrenic patients. This reduction in reelin expression reached 50 %, and was especially evident in superficial cortical layers [107]. This finding was later replicated by others [76, 108–110].

In recent years it has been proposed that epigenetic mechanisms like DNA methylation play an important role in the gene-environment interaction in the development of psychiatric disorders, including schizophrenia [111–113]. It has been shown that the promoter of the reelin gene, together with sequences flanking exon 1, contains near 120 CpG islands [114]. The reelin promoter in in vitro assays is methylated in non-reelin expressing cells, and demethylated in reelin expressing cells [114], indicates that reelin expression is controlled by the methylation of its promoter. The reelin promoter is hypermethylated in the brain of schizophrenic post-mortem patients [39, 72, 115–117]. This reduction of reelin and hypermethylation of its promoter in schizophrenic patients is restricted to GABAergic neurons in the PFC [118]. Thus, the down-regulation of reelin expression documented in schizophrenic patients might be the consequence of inappropriate promoter hypermethylation [114], especially in GABAergic neurons.

Reduced expression of reelin in animal models produces schizophrenic-like features

Genetic animal models in which the expression of reelin is decreased display cognitive, physiological and cellular features similar to those found in schizophrenic patients. For example, reeler mice show increased cognitive impairment and stereotypic behavior [98]. Importantly, the HRM displays a deficit in PFC-dependent cognitive abilities, such as reversal learning and recall of fear extinction [106, 119], together with impairment in the acquisition of operant tasks [120] and increased anxiety [121]. Moreover, overexpression of reelin prevents the manifestation of behavioral phenotypes related to schizophrenia [122]. Although it has not been as heavily described as the reeler mice, the HRM also displays cellular features in the PFC similar to those of schizophrenic patients, such as decreased GAD67 mRNA, GAD67 protein, and fewer GAD67 positive cells in the PFC [96, 119]. Finally, reelin knockdown animals specifically in the PFC show decreased working memory [123]. Together, this evidence suggests a critical role for reelin in the deficits observed in schizophrenia.

Interaction between PNS, reelin expression and PFC-cognitive impairment observed in schizophrenia

Prenatal stress may induce DNA methylation of several gene promoters, including reelin [124]. Our research and that of others have shown that PNS in rodents reduces the expression of reelin in the PFC in adulthood [125, 126] (Fig. 3), which is accompanied by increased methylation of the reelin promoter [125, 126] (Fig. 3). PNS-induced own-regulation of reelin by DNA methylation is similar to that found in schizophrenic patients [115]. Together, this evidence places reelin and the epigenetic regulation of its expression as likely targets for the development of PNS-induced neuropsychiatric pathology. We have shown that PNS impairs cognitive functions dependent on the PFC, such as the consolidation of memory and passive avoidance (Fig. 1; [55, 125]). In the first case, this behavioral impairment is paralleled with decreased neural activity in the PFC and altered neuronal synchrony between the PFC and hippocampus [55] (Fig. 2). Altogether, the evidence suggests a relationship between epigenetic alterations induced by PNS on the reelin gene, with PFC impairment observed in schizophrenia.
Fig. 3
Fig. 3

Prenatal stress reduces reelin expressing neurons and increases reelin methylation in the PFC. a Microphotographs of reelin-expressing neurons in the PFC prenatally (E20). Control brains show numerous clusters of Cajal-Retzius neurons while the PNS (stress) group shows only a few isolated Cajal-Retzius neurons. Scale bars 50 μm. b Bar chart of neurons immunoreactive for reelin (expressed as neurons/mm3). Values are mean ± SEM. c Representative agarose gel electrophoresis showing PCR product of the amplification of the distal reelin promoter region containing an HpaII site (−786/−625). As control, PCR product of the amplification of Ric8B promoter (digestion insensitive to methylation) and RunX promoter (without HpaII sensitive regions) after digestion with HpaII or MspI. d DNA methylation differences between control and PNS (stress) groups were quantified by determining changes in pixel density at the bands amplified by PCR and visualized through conventional DNA electrophoresis. Adapted with modifications from [125]

Conclusion

Considering molecular, histological, and physiological evidence based on the PNS paradigm, we propose a model that links molecular, neurophysiological and cognitive alterations observed in schizophrenia (Fig. 4). In this model, PNS-induced epigenetic modifications in the reelin promoter produce down-expression of reelin during prenatal development [125, 126]. As several other researchers have shown, this results in the prenatal reduction of the number of interneurons synthesizing GABA, together with an aberrant layer positioning of cortical interneurons [31, 91, 127] and the reduction of dendritic length and complexity of pyramidal neurons in the PFC [63, 95, 96]. Thus, PNS may impair the development of correct neuronal connectivity in the PFC before birth, which in subsequent developmental stages is expressed as an aberrant functional connectivity of the neural network in the PFC, or between PFC and other structures [19, 55]. Finally, the alteration of the functional connectivity required to implement executive control by the PFC [21, 22] is evidenced as abnormal PFC-dependent cognitive functions [4, 20, 23], which are a hallmark of schizophrenia [3, 9, 19].
Fig. 4
Fig. 4

Theoretical model to link prenatal stress, reelin and PFC cognitive impairment. This model, which unifies molecular, cellular and clinical organizational criteria, proposes that PNS induces methylation of the reelin promoter, resulting in the down-expression of reelin in synthesizing cortical neurons, the effects of which begin to manifest themselves in the prenatal development and are maintained during consequent developmental stages to adulthood. In prenatal stages, down-expression of reelin produces alterations in neuronal cytoskeleton dynamics that result in deviances from normal neuronal architecture of the PFC, such as altered positioning of neurons, reduction of dendritic complexity, and reduction of the number of GABAergic neurons, resulting in altered developmental neuronal connectivity. Due to the stability of epigenetic alterations, down-expression of reelin continues during postnatal stages to adulthood, where it is manifested as an impairment of activity-dependent synaptic plasticity. These structural and functional alterations modify neuronal connectivity, especially in GABAergic interneurons, leading to altered functional connectivity in the PFC expressed as decreased oscillatory activity, especially at the gamma-frequency band. Given that functional connectivity is required for the implementation of executive function by the PFC, these changes can manifest themselves as cognitive and behavioral impairments dependent on the PFC. Finally, this model does not exclude other candidate genes that may also be affected by PNS and impact on the symptomatology of schizophrenia

Note however that this model does not imply that reelin is the only link between PNS and schizophrenia, as other PNS-regulated genes like GAD67 and BDNF [126, 128] may also impact on the symptomatology of schizophrenia. Finally, due to lack of experimental evidence, this model has some gaps in important aspects. For example, it is unknown whether PNS affects the neurophysiological properties of GABAergic interneurons and therefore, the proper functioning of the prefrontal neural network. It is also unknown how these cellular alterations induced by PNS affect the functional connectivity within the PFC and between the PFC and other structures, specifically during the implementation of executive behavioral functions. Future research will assess these undetermined issues, which can contribute to understanding the neurobiology of schizophrenia.

Abbreviations

PNS: 

prenatal stress

PFC: 

prefrontal cortex

HRM: 

heterozygous reeler mice

Declarations

Authors’ contributions

All authors wrote the draft, and read and approved the final manuscript. All authors read and approved the final manuscript.

Acknowledgements

We were supported by Millennium Center for the Neuroscience of Memory, NC10-001-F, of the Ministry of Economy, Development and Tourism, Chile (FA); and FONDECYT for postdoctoral grant no. 3140370 to I.N.-O.

Competing interests

The authors declare that they have no competing interests.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Departamento de Psiquiatría, Escuela de Medicina, and Centro Interdisciplinario de Neurociencia, Pontificia Universidad Católica de Chile, Santiago, Chile

References

  1. American Psychiatric Association. DSM-V. 2013; 1.Google Scholar
  2. Bromet EJ, Bromet EJ, Fennig S, Fennig S. Epidemiology and natural history of schizophrenia. Biol Psychiatry. 1999;46(7):871–81.PubMedView ArticleGoogle Scholar
  3. Senkowski D, Gallinat J. Dysfunctional prefrontal gamma-band oscillations reflect working memory and other cognitive deficits in schizophrenia. Biol Psychiatry. 2015;77(12):1010–9.PubMedView ArticleGoogle Scholar
  4. Basar-Eroglu, Brand A, Hildebrandt H, Karolina Kedzior K, Mathes B, Schmiedt C. Working memory related gamma oscillations in schizophrenia patients. Int J Psychophysiol. 2007;64(1):39–45.PubMedView ArticleGoogle Scholar
  5. Hashimoto T, Volk DW, Eggan SM, Mirnics K, Pierri JN, Sun Z, Sampson AR, Lewis DA. Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia. J Neurosci. 2003;23(15):6315–26.PubMedGoogle Scholar
  6. Brixey SN, Gallagher BJ, McFalls JA, Parmelee LF. Gestational and neonatal factors in the etiology of schizophrenia. J Clin Psychol. 1993;49(3):447–56.PubMedView ArticleGoogle Scholar
  7. Park S, Holzman PS. Schizophrenics show spatial working memory deficits. Arch Gen Psychiatry. 1992;49(12):975–82.PubMedView ArticleGoogle Scholar
  8. Goldman-Rakic PS. Cellular basis of working memory. Neuron. 1995;14(3):477–85.PubMedView ArticleGoogle Scholar
  9. Lee J, Park S. Working memory impairments in schizophrenia: a meta-analysis. J Abnorm Psychol. 2005;114(4):599–611.PubMedView ArticleGoogle Scholar
  10. Hepp HH, Maier S, Hermle L, Spitzer M. The Stroop effect in schizophrenic patients. Schizophr Res. 1996;22(3):187–95.PubMedView ArticleGoogle Scholar
  11. Gold JM, Carpenter C, Randolph C, Goldberg TE, Weinberger DR. Auditory Working Memory and wisconsin card sorting test performance in schizophrenia. Arch Gen Psychiatry. 1997;54:159–65.PubMedView ArticleGoogle Scholar
  12. Fuster JM. The prefrontal cortex—an update: time is of the essence. Neuron. 2001;30(2):319–33.PubMedView ArticleGoogle Scholar
  13. Barch DM. The cognitive neuroscience of schizophrenia. Annu Rev Clin Psychol. 2005;1:321–53.PubMedView ArticleGoogle Scholar
  14. Lewis DA. Cortical circuit dysfunction and cognitive deficits in schizophrenia—implications for preemptive interventions. Eur J Neurosci. 2012;35(12):1871–8.PubMedPubMed CentralView ArticleGoogle Scholar
  15. Lesh TA, Niendam TA, Minzenberg MJ, Carter CS. Cognitive control deficits in schizophrenia: mechanisms and meaning. Neuropsychopharmacology. 2011;36(1):316–38.PubMedPubMed CentralView ArticleGoogle Scholar
  16. Miller EK, Cohen JD. An integrative theory of prefrontal cortex function. Annu Rev Neurosci. 2001;24:167–202.PubMedView ArticleGoogle Scholar
  17. Cho RY, Konecky RO, Carter CS. Impairments in frontal cortical gamma synchrony and cognitive control in schizophrenia. Proc Natl Acad Sci USA. 2006;103(52):19878–83.PubMedPubMed CentralView ArticleGoogle Scholar
  18. Yeragani VK, Cashmere D, Miewald J, Tancer M, Keshavan MS. Decreased coherence in higher frequency ranges (beta and gamma) between central and frontal EEG in patients with schizophrenia: a preliminary report. Psychiatry Res. 2006;141(1):53–60.PubMedView ArticleGoogle Scholar
  19. Uhlhaas PJ, Singer W. Abnormal neural oscillations and synchrony in schizophrenia. Nat Rev Neurosci. 2010;11(2):100–13.PubMedView ArticleGoogle Scholar
  20. Light GA, Hsu JL, Hsieh MH, Meyer-Gomes K, Sprock J, Swerdlow NR, Braff DL. Gamma band oscillations reveal neural network cortical coherence dysfunction in schizophrenia patients. Biol Psychiatry. 2006;60(11):1231–40.PubMedView ArticleGoogle Scholar
  21. Fries P. Neuronal gamma-band synchronization as a fundamental process in cortical computation. Annu Rev Neurosci. 2009;32:209–24.PubMedView ArticleGoogle Scholar
  22. Bosman CA, Lansink CS, Pennartz CMA. Functions of gamma-band synchronization in cognition: from single circuits to functional diversity across cortical and subcortical systems. Eur J Neurosci. 2014;39(11):1982–99.PubMedView ArticleGoogle Scholar
  23. Barch DM, Ceaser A. Cognition in schizophrenia: core psychological and neural mechanisms. Trends Cogn Sci. 2012;16(1):27–34.PubMedView ArticleGoogle Scholar
  24. Farzan F, Barr MS, Sun Y, Fitzgerald PB, Daskalakis ZJ. Transcranial magnetic stimulation on the modulation of gamma oscillations in schizophrenia. Ann NY Acad Sci. 2012;1265:25–35.PubMedView ArticleGoogle Scholar
  25. Casanova MF, Kreczmanski P, Trippe J, Switala A, Heinsen H, Steinbusch HWM, Schmitz C. Neuronal distribution in the neocortex of schizophrenic patients. Psychiatry Res. 2008;158(3):267–77.PubMedView ArticleGoogle Scholar
  26. Garey L. When cortical development goes wrong: schizophrenia as a neurodevelopmental disease of microcircuits. J Anat. 2010;217(4):324–33.PubMedPubMed CentralView ArticleGoogle Scholar
  27. Volk DW, Austin MC, Pierri JN, Sampson AR, Lewis DA. Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia. Arch Gen Psychiatry. 2000;57(3):237–45.PubMedView ArticleGoogle Scholar
  28. Hashimoto T, Bazmi HH, Mirnics K, Wu Q, Sampson AR, Lewis DA. Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia. Am J Psychiatry. 2008;165(4):479–89.PubMedPubMed CentralView ArticleGoogle Scholar
  29. Bristow GC, Bostrom JA, Haroutunian V, Sodhi MS. Sex differences in GABAergic gene expression occur in the anterior cingulate cortex in schizophrenia. Schizophr Res. 2015;167:57.PubMedView ArticleGoogle Scholar
  30. Lewis DA, Hashimoto T, Volk DW. Cortical inhibitory neurons and schizophrenia. Nat Rev Neurosci. 2005;6(4):312–24.PubMedView ArticleGoogle Scholar
  31. Fine R, Zhang J, Stevens HE. Prenatal stress and inhibitory neuron systems: implications for neuropsychiatric disorders. Mol Psychiatry. 2014;19(6):641–51.PubMedPubMed CentralView ArticleGoogle Scholar
  32. Gonzalez-Burgos G, Cho RY, Lewis DA. Alterations in cortical network oscillations and parvalbumin neurons in schizophrenia. Biol Psychiatry. 2015;77(12):1031–40.PubMedView ArticleGoogle Scholar
  33. Freund TF. Interneuron diversity series: rhythm and mood in perisomatic inhibition. Trends Neurosci. 2003;26(9):489–95.PubMedView ArticleGoogle Scholar
  34. Lewis DA, Curley AA, Glausier JR, Volk DW. Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia. Trends Neurosci. 2012;35(1):57–67.PubMedPubMed CentralView ArticleGoogle Scholar
  35. Cardin JA, Carlen M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai L-H, Moore CI. Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature. 2009;459(7247):663–7.PubMedPubMed CentralView ArticleGoogle Scholar
  36. Jones P, Rodgers B, Murray R, Marmot M. Child development risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet. 1994;344(8934):1398–402.PubMedView ArticleGoogle Scholar
  37. Cannon TD, van Erp TGM, Bearden CE, Loewy R, Thompson P, Toga AW, Huttunen MO, Keshavan MS, Seidman LJ, Tsuang MT. Early and late neurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactions. Schizophr Bull. 2003;29(4):653–69.PubMedView ArticleGoogle Scholar
  38. Catts VS, Fung SJ, Long LE, Joshi D, Vercammen A, Allen KM, Fillman SG, Rothmond DA, Sinclair D, Tiwari Y, Tsai S-Y, Weickert TW, ShannonWeickert C. Rethinking schizophrenia in the context of normal neurodevelopment. Front Cell Neurosci. 2013;7:60.PubMedPubMed CentralView ArticleGoogle Scholar
  39. Tochigi M, Iwamoto K, Bundo M, Komori A, Sasaki T, Kato N, Kato T. Methylation status of the reelin promoter region in the brain of schizophrenic patients. Biol Psychiatry. 2008;63(5):530–3.PubMedView ArticleGoogle Scholar
  40. Zecevic N, Hu F, Jakovcevski I. Interneurons in the developing human neocortex. Dev Neurobiol. 2011;71(1):18–33.PubMedPubMed CentralView ArticleGoogle Scholar
  41. Opris I, Casanova MF. Prefrontal cortical minicolumn: from executive control to disrupted cognitive processing. Brain. 2014;137(Pt 7):1863–75.PubMedPubMed CentralView ArticleGoogle Scholar
  42. Arnold SE. Neurodevelopmental abnormalities in schizophrenia: insights from neuropathology. Dev Psychopathol. 1999;11(3):439–56.PubMedView ArticleGoogle Scholar
  43. Beneyto M, Lewis DA. Insights into the neurodevelopmental origin of schizophrenia from postmortem studies of prefrontal cortical circuitry. Int J Dev Neurosci. 2011;29(3):295–304.PubMedPubMed CentralView ArticleGoogle Scholar
  44. King S, Laplante D, Joober R. Understanding putative risk factors for schizophrenia: retrospective and prospective studies. J Psychiatry Neurosci. 2005;30(5):342–8.PubMedPubMed CentralGoogle Scholar
  45. Huttunen MO, Niskanen P. Prenatal loss of father and psychiatric disorders. Arch Gen Psychiatry. 1978;35(4):429–31.PubMedView ArticleGoogle Scholar
  46. van Os J, Selten JP. Prenatal exposure to maternal stress and subsequent schizophrenia. The May 1940 invasion of The Netherlands. Br J Psychiatry. 1998;172:324–6.PubMedView ArticleGoogle Scholar
  47. Betts KS, Williams GM, Najman JM, Scott J, Alati R. Exposure to stressful life events during pregnancy predicts psychotic experiences via behaviour problems in childhood. J Psychiatr Res. 2014;59:132–9.PubMedView ArticleGoogle Scholar
  48. Levine SZ, Levav I, Yoffe R, Pugachova I. The effects of pre-natal-, early-life- and indirectly-initiated exposures to maximum adversities on the course of schizophrenia. Schizophr Res. 2014;158(1–3):236–40.PubMedView ArticleGoogle Scholar
  49. Mennes M, Stiers P, Lagae L, Van den Bergh B. Long-term cognitive sequelae of antenatal maternal anxiety: involvement of the orbitofrontal cortex. Neurosci Biobehav Rev. 2006;30(8):1078–86.PubMedView ArticleGoogle Scholar
  50. Entringer S, Buss C, Kumsta R, Hellhammer DH, Wadhwa PD, Wust S. Prenatal psychosocial stress exposure is associated with subsequent working memory performance in young women. Behav Neurosci. 2009;123(4):886–93.PubMedPubMed CentralView ArticleGoogle Scholar
  51. Buss C, Davis EP, Hobel CJ, Sandman CA. Maternal pregnancy-specific anxiety is associated with child executive function at 6–9 years age. Stress. 2011;14(6):665–76.PubMedPubMed CentralView ArticleGoogle Scholar
  52. Schwabe K, Enkel T, Klein S, Schütte M, Koch M. Effects of neonatal lesions of the medial prefrontal cortex on adult rat behaviour. Behav Brain Res. 2004;153(1):21–34.PubMedView ArticleGoogle Scholar
  53. Uylings HBM, Groenewegen HJ, Kolb B. Do rats have a prefrontal cortex? Behav Brain Res. 2003;146(1–2):3–17.PubMedView ArticleGoogle Scholar
  54. Gue M, Bravard A, Meunier J, Veyrier R, Gaillet S, Recasens M, Maurice T. Sex differences in learning deficits induced by prenatal stress in juvenile rats. Behav Brain Res. 2004;150(1–2):149–57.PubMedView ArticleGoogle Scholar
  55. Negrón-Oyarzo I, Neira D, Espinosa N, Fuentealba P, Aboitiz F. Prenatal stress produces persistence of remote memory and disrupts functional connectivity in the hippocampal-prefrontal cortex axis. Cereb Cortex. 2015;25(9):3132–43.PubMedView ArticleGoogle Scholar
  56. Bingham BC, Sheela Rani CS, Frazer A, Strong R, Morilak DA. Exogenous prenatal corticosterone exposure mimics the effects of prenatal stress on adult brain stress response systems and fear extinction behavior. Psychoneuroendocrinology. 2013;38(11):2746–57.PubMedView ArticleGoogle Scholar
  57. Weinstock M. The long-term behavioural consequences of prenatal stress. Neurosci Biobehav Rev. 2008;32(6):1073–86.PubMedView ArticleGoogle Scholar
  58. Richetto J, Riva MA. Prenatal maternal factors in the development of cognitive impairments in the offspring. J Reprod Immunol. 2014;104–105:20–5.PubMedView ArticleGoogle Scholar
  59. Moore H, Susser E. Relating the effects of prenatal stress in rodents to the pathogenesis of schizophrenia. Biol Psychiatry. 2011;70(10):906–7.PubMedPubMed CentralView ArticleGoogle Scholar
  60. Nieuwenhuis ILC, Takashima A. The role of the ventromedial prefrontal cortex in memory consolidation. Behav Brain Res. 2010;218(2):325–34.PubMedView ArticleGoogle Scholar
  61. Frankland PW, Bontempi B. The organization of recent and remote memories. Nat Rev Neurosci. 2005;6(2):119–30.PubMedView ArticleGoogle Scholar
  62. Muhammad A, Carroll C, Kolb B. Stress during development alters dendritic morphology in the nucleus accumbens and prefrontal cortex. Neuroscience. 2012;216:103–9.PubMedView ArticleGoogle Scholar
  63. Mychasiuk R, Gibb R, Kolb B. Prenatal stress alters dendritic morphology and synaptic connectivity in the prefrontal cortex and hippocampus of developing offspring. Synapse. 2012;66(4):308–14.PubMedView ArticleGoogle Scholar
  64. Markham JA, Mullins SE, Koenig JI. Periadolescent maturation of the prefrontal cortex is sex-specific and is disrupted by prenatal stress. J Comp Neurol. 2013;521(8):1828–43.PubMedPubMed CentralView ArticleGoogle Scholar
  65. Uchida T, Furukawa T, Iwata S, Yanagawa Y, Fukuda A. Selective loss of parvalbumin-positive GABAergic interneurons in the cerebral cortex of maternally stressed Gad1-heterozygous mouse offspring. Transl Psychiatry. 2014;4:e371.PubMedPubMed CentralView ArticleGoogle Scholar
  66. Farrell MS, Werge T, Sklar P, Owen MJ, Ophoff RA, O’Donovan MC, Corvin A, Cichon S, Sullivan PF. Evaluating historical candidate genes for schizophrenia. Mol Psychiatry 2015; 1–8.Google Scholar
  67. Chubb JE, Bradshaw NJ, Soares DC, Porteous DJ, Millar JK. The DISC locus in psychiatric illness. Mol Psychiatry. 2008;13(1):36–64.PubMedView ArticleGoogle Scholar
  68. Merelo V, Durand D, Lescallette AR, Vrana KE, Hong LE, Faghihi MA, Bellon A. Associating schizophrenia, long non-coding RNAs and neurostructural dynamics. Front Mol Neurosci. 2015;8:57.PubMedPubMed CentralView ArticleGoogle Scholar
  69. Ahmed AO, Mantini AM, Fridberg DJ, Buckley PF. Brain-derived neurotrophic factor (BDNF) and neurocognitive deficits in people with schizophrenia: a meta-analysis. Psychiatry Res. 2015;226(1):1–13.PubMedView ArticleGoogle Scholar
  70. DeSilva U, D’Arcangelo G, Braden VV, Chen J, Miao GG, Curran T, Green ED. The human reelin gene: isolation, sequencing, and mapping on chromosome 7. Genome Res. 1997;7(2):157–64.PubMedView ArticleGoogle Scholar
  71. Royaux I, Lambert de Rouvroit C, D’Arcangelo G, Demirov D, Goffinet AM. Genomic organization of the mouse reelin gene. Genomics. 1997;46(2):240–50.PubMedView ArticleGoogle Scholar
  72. Grayson DR, Chen Y, Costa E, Dong E, Guidotti A, Kundakovic M, Sharma RP. The human reelin gene: transcription factors (+), repressors (−) and the methylation switch (±) in schizophrenia. Pharmacol Ther. 2006;111(1):272–86.PubMedView ArticleGoogle Scholar
  73. Frotscher M. Role for Reelin in stabilizing cortical architecture. Trends Neurosci. 2010;33(9):407–14.PubMedView ArticleGoogle Scholar
  74. Lewis DA, Mirnics K. Transcriptome alterations in schizophrenia: disturbing the functional architecture of the dorsolateral prefrontal cortex. Prog Brain Res. 2006;158:141–52.PubMedView ArticleGoogle Scholar
  75. Costa E, Davis J, Grayson DR, Guidotti A, Pappas GD, Pesold C. Dendritic spine hypoplasticity and downregulation of reelin and GABAergic tone in schizophrenia vulnerability. Neurobiol Dis. 2001;8(5):723–42.PubMedView ArticleGoogle Scholar
  76. Fatemi SH, Earle JA, McMenomy T. Reduction in reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression. Mol. Psychiatry. 2000;5(6):571, 654–63.Google Scholar
  77. Fatemi SH. Reelin glycoprotein: structure, biology and roles in health and disease. Mol Psychiatry. 2005;10(3):251–7.PubMedView ArticleGoogle Scholar
  78. Folsom TD, Fatemi SH. The involvement of Reelin in neurodevelopmental disorders. Neuropharmacology. 2013;68:122–35.PubMedPubMed CentralView ArticleGoogle Scholar
  79. Alcantara S, Ruiz M, D’Arcangelo G, Ezan F, de Lecea L, Curran T, Sotelo C, Soriano E. Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse. J Neurosci. 1998;18(19):7779–99.PubMedGoogle Scholar
  80. Tissir F, Lambert de Rouvroit C, Goffinet AM. The role of reelin in the development and evolution of the cerebral cortex. Braz J Med Biol Res. 2002;35(12):1473–84.PubMedView ArticleGoogle Scholar
  81. Tissir F, Goffinet AM. Reelin and brain development. Nat Rev Neurosci. 2003;4(6):496–505.PubMedView ArticleGoogle Scholar
  82. Ringstedt T, Linnarsson S, Wagner J, Lendahl U, Kokaia Z, Arenas E, Ernfors P, Ibanez CF. BDNF regulates reelin expression and Cajal-Retzius cell development in the cerebral cortex. Neuron. 1998;21(2):305–15.PubMedView ArticleGoogle Scholar
  83. Ma J, Yao X-H, Fu Y, Yu Y-C. Development of layer 1 neurons in the mouse neocortex. Cereb Cortex. 2014;24(10):2604–18.PubMedView ArticleGoogle Scholar
  84. Pesold C, Impagnatiello F, Pisu MG, Uzunov DP, Costa E, Guidotti A, Caruncho HJ. Reelin is preferentially expressed in neurons synthesizing gamma-aminobutyric acid in cortex and hippocampus of adult rats. Proc Natl Acad Sci USA. 1998;95(6):3221–6.PubMedPubMed CentralView ArticleGoogle Scholar
  85. Fuentealba P, Klausberger T, Karayannis T, Suen WY, Huck J, Tomioka R, Rockland K, Capogna M, Studer M, Morales M, Somogyi P. Expression of COUP-TFII nuclear receptor in restricted GABAergic neuronal populations in the adult rat hippocampus. J Neurosci. 2010;30(5):1595–609.PubMedPubMed CentralView ArticleGoogle Scholar
  86. Lambert de Rouvroit C, Goffinet AM. A new view of early cortical development. Biochem Pharmacol. 1998;56(11):1403–9.PubMedView ArticleGoogle Scholar
  87. Gilmore EC, Herrup K. Cortical development: receiving reelin. Curr Biol. 2000;10(4):R162–6.PubMedView ArticleGoogle Scholar
  88. Gupta A, Tsai L-H, Wynshaw-Boris A. Life is a journey: a genetic look at neocortical development. Nat Rev Genet. 2002;3(5):342–55.PubMedView ArticleGoogle Scholar
  89. D’Arcangelo G, Miao GG, Curran T. Detection of the reelin breakpoint in reeler mice. Brain Res Mol Brain Res. 1996;39(1–2):234–6.PubMedView ArticleGoogle Scholar
  90. Hevner RF, Daza RAM, Englund C, Kohtz J, Fink A. Postnatal shifts of interneuron position in the neocortex of normal and reeler mice: evidence for inward radial migration. Neuroscience. 2004;124(3):605–18.PubMedView ArticleGoogle Scholar
  91. Hammond V, So E, Gunnersen J, Valcanis H, Kalloniatis M, Tan S-S. Layer positioning of late-born cortical interneurons is dependent on Reelin but not p35 signaling. J Neurosci. 2006;26(5):1646–55.PubMedView ArticleGoogle Scholar
  92. Curran T, D’Arcangelo G. Role of reelin in the control of brain development. Brain Res Brain Res Rev. 1998;26(2–3):285–94.PubMedView ArticleGoogle Scholar
  93. Costa E, Davis J, Pesold C, Tueting P, Guidotti A. The heterozygote reeler mouse as a model for the development of a new generation of antipsychotics. Curr Opin Pharmacol. 2002;2(1):56–62.PubMedView ArticleGoogle Scholar
  94. Badea A, Nicholls PJ, Johnson GA, Wetsel WC. Neuroanatomical phenotypes in the reeler mouse. Neuroimage. 2007;34(4):1363–74.PubMedPubMed CentralView ArticleGoogle Scholar
  95. Niu S, Yabut O, D’Arcangelo G. The Reelin signaling pathway promotes dendritic spine development in hippocampal neurons. J Neurosci. 2008;28(41):10339–48.PubMedPubMed CentralView ArticleGoogle Scholar
  96. Liu WS, Pesold C, Rodriguez MA, Carboni G, Auta J, Lacor P, Larson J, Condie BG, Guidotti A, Costa E. Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouse. Proc Natl Acad Sci USA. 2001;98(6):3477–82.PubMedPubMed CentralView ArticleGoogle Scholar
  97. Nullmeier S, Panther P, Dobrowolny H, Frotscher M, Zhao S, Schwegler H, Wolf R. Region-specific alteration of GABAergic markers in the brain of heterozygous reeler mice. Eur J Neurosci. 2011;33(4):689–98.PubMedView ArticleGoogle Scholar
  98. Carboni G, Tueting P, Tremolizzo L, Sugaya I, Davis J, Costa E, Guidotti A. Enhanced dizocilpine efficacy in heterozygous reeler mice relates to GABA turnover downregulation. Neuropharmacology. 2004;46(8):1070–81.PubMedView ArticleGoogle Scholar
  99. Borrell V, Del Rio JA, Alcantara S, Derer M, Martinez A, D’Arcangelo G, Nakajima K, Mikoshiba K, Derer P, Curran T, Soriano E. Reelin regulates the development and synaptogenesis of the layer-specific entorhino-hippocampal connections. J Neurosci. 1999;19(4):1345–58.PubMedGoogle Scholar
  100. Chen Y, Beffert U, Ertunc M, Tang T-S, Kavalali ET, Bezprozvanny I, Herz J. Reelin modulates NMDA receptor activity in cortical neurons. J Neurosci. 2005;25(36):8209–16.PubMedView ArticleGoogle Scholar
  101. Herz J, Chen Y. Reelin, lipoprotein receptors and synaptic plasticity. Nat Rev Neurosci. 2006;7(11):850–9.PubMedView ArticleGoogle Scholar
  102. Qiu S, Weeber EJ. Reelin signaling facilitates maturation of CA1 glutamatergic synapses. J Neurophysiol. 2007;97(3):2312–21.PubMedView ArticleGoogle Scholar
  103. Rogers JT, Rusiana I, Trotter J, Zhao L, Donaldson E, Pak DTS, Babus LW, Peters M, Banko JL, Chavis P, Rebeck GW, Hoe H-S, Weeber EJ. Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density. Learn Mem. 2011;18(9):558–64.PubMedPubMed CentralView ArticleGoogle Scholar
  104. Ventruti A, Kazdoba TM, Niu S, D’Arcangelo G. Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain. Neuroscience. 2011;189:32–42.PubMedView ArticleGoogle Scholar
  105. Hellwig S, Hack I, Kowalski J, Brunne B, Jarowyj J, Unger A, Bock HH, Junghans D, Frotscher M. Role for Reelin in neurotransmitter release. J Neurosci. 2011;31(7):2352–60.PubMedView ArticleGoogle Scholar
  106. Iafrati J, Orejarena MJ, Lassalle O, Bouamrane L, Gonzalez-Campo C, Chavis P. Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway. Mol Psychiatry. 2014;19(4):417–26.PubMedPubMed CentralView ArticleGoogle Scholar
  107. Impagnatiello F, Guidotti AR, Pesold C, Dwivedi Y, Caruncho H, Pisu MG, Uzunov DP, Smalheiser NR, Davis JM, Pandey GN, Pappas GD, Tueting P, Sharma RP, Costa E. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. Proc Natl Acad Sci USA. 1998;95(26):15718–23.PubMedPubMed CentralView ArticleGoogle Scholar
  108. Guidotti A, Auta J, Davis JM, Di-Giorgi-Gerevini V, Dwivedi Y, Grayson DR, Impagnatiello F, Pandey G, Pesold C, Sharma R, Uzunov D, Costa E. Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Arch Gen Psychiatry. 2000;57(11):1061–9.PubMedView ArticleGoogle Scholar
  109. Eastwood SL, Harrison PJ. Interstitial white matter neurons express less reelin and are abnormally distributed in schizophrenia: towards an integration of molecular and morphologic aspects of the neurodevelopmental hypothesis. Mol Psychiatry. 2003;8(9):769, 821–31.View ArticleGoogle Scholar
  110. Habl G, Schmitt A, Zink M, von Wilmsdorff M, Yeganeh-Doost P, Jatzko A, Schneider-Axmann T, Bauer M, Falkai P. Decreased reelin expression in the left prefrontal cortex (BA9) in chronic schizophrenia patients. Neuropsychobiology. 2012;66(1):57–62.PubMedView ArticleGoogle Scholar
  111. Klengel T, Pape J, Binder EB, Mehta D. The role of DNA methylation in stress-related psychiatric disorders. Neuropharmacology. 2014;80:115–32.PubMedView ArticleGoogle Scholar
  112. Schmitt A, Malchow B, Hasan A, Falkai P. The impact of environmental factors in severe psychiatric disorders. Front Neurosci. 2014;8:19.PubMedPubMed CentralView ArticleGoogle Scholar
  113. Provencal N, Binder EB. The effects of early life stress on the epigenome: from the womb to adulthood and even before. Exp Neurol. 2015;268:10–20.PubMedView ArticleGoogle Scholar
  114. Chen Y, Sharma RP, Costa RH, Costa E, Grayson DR. On the epigenetic regulation of the human reelin promoter. Nucleic Acids Res. 2002;30(13):2930–9.PubMedPubMed CentralView ArticleGoogle Scholar
  115. Abdolmaleky HM, Cheng K, Russo A, Smith CL, Faraone SV, Wilcox M, Shafa R, Glatt SJ, Nguyen G, Ponte JF, Thiagalingam S, Tsuang MT. Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report. Am J Med Genet B Neuropsychiatr Genet. 2005;134B(1):60–6.PubMedView ArticleGoogle Scholar
  116. Tamura Y, Kunugi H, Ohashi J, Hohjoh H. Epigenetic aberration of the human REELIN gene in psychiatric disorders. Mol Psychiatry. 2007;12(6):519, 593–600.Google Scholar
  117. Grayson DR, Jia X, Chen Y, Sharma RP, Mitchell CP, Guidotti A, Costa E. Reelin promoter hypermethylation in schizophrenia. Proc Natl Acad Sci USA. 2005;102(26):9341–6.PubMedPubMed CentralView ArticleGoogle Scholar
  118. Ruzicka WB, Zhubi A, Veldic M, Grayson DR, Costa E, Guidotti A. Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection. Mol Psychiatry. 2007;12(4):385–97.PubMedView ArticleGoogle Scholar
  119. Brigman JL, Padukiewicz KE, Sutherland ML, Rothblat LA. Executive functions in the heterozygous reeler mouse model of schizophrenia. Behav Neurosci. 2006;120(4):984–8.PubMedView ArticleGoogle Scholar
  120. Krueger DD, Howell JL, Hebert BF, Olausson P, Taylor JR, Nairn AC. Assessment of cognitive function in the heterozygous reeler mouse. Psychopharmacology. 2006;189(1):95–104.PubMedPubMed CentralView ArticleGoogle Scholar
  121. Ognibene E, Adriani W, Granstrem O, Pieretti S, Laviola G. Impulsivity-anxiety-related behavior and profiles of morphine-induced analgesia in heterozygous reeler mice. Brain Res. 2007;1131(1):173–80.PubMedView ArticleGoogle Scholar
  122. Teixeira CM, Martin ED, Sahun I, Masachs N, Pujadas L, Corvelo A, Bosch C, Rossi D, Martinez A, Maldonado R, Dierssen M, Soriano E. Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder. Neuropsychopharmacology. 2011;36(12):2395–405.PubMedPubMed CentralView ArticleGoogle Scholar
  123. Brosda J, Dietz F, Koch M. Impairment of cognitive performance after reelin knockdown in the medial prefrontal cortex of pubertal or adult rats. Neurobiol Dis. 2011;44(2):239–47.PubMedView ArticleGoogle Scholar
  124. Billack B, Serio R, Silva I, Kinsley CH. Epigenetic changes brought about by perinatal stressors: a brief review of the literature. J Pharmacol Toxicol Methods. 2012;66(3):221–31.PubMedView ArticleGoogle Scholar
  125. Palacios-Garcia I, Lara-Vasquez A, Montiel JF, Diaz-Veliz GF, Sepulveda H, Utreras E, Montecino M, Gonzalez-Billault C, Aboitiz F. Prenatal stress down-regulates Reelin expression by methylation of its promoter and induces adult behavioral impairments in rats. PLoS One. 2015;10(2):e0117680.PubMedPubMed CentralView ArticleGoogle Scholar
  126. Matrisciano F, Tueting P, Dalal I, Kadriu B, Grayson DR, Davis JM, Nicoletti F, Guidotti A. Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice. Neuropharmacology. 2013;68:184–94.PubMedPubMed CentralView ArticleGoogle Scholar
  127. Stevens HE, Su T, Yanagawa Y, Vaccarino FM. Prenatal stress delays inhibitory neuron progenitor migration in the developing neocortex. Psychoneuroendocrinology. 2013;38(4):509–21.PubMedPubMed CentralView ArticleGoogle Scholar
  128. Boersma GJ, Lee RS, Cordner ZA, Ewald ER, Purcell RH, Moghadam AA, Tamashiro KL. Prenatal stress decreases Bdnf expression and increases methylation of Bdnf exon IV in rats. Epigenetics. 2014;9(3):437–47.PubMedPubMed CentralView ArticleGoogle Scholar

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