Fig. 2

Prenatal stress decreases firing rate in the PFC and disrupts functional connectivity between the PFC and hippocampus. Control and PNS mice were subjected to in vivo local field potential recording under urethane anesthesia in the hippocampus and PFC, after either recent or remote memory testing in the Barnes maze. a Representative recordings for each group and condition displaying the hippocampal LFP filtered at 100–300 Hz (upper) and its correlative prefrontal LFP filtered at 300–5 Hz (lower). Asterisks indicate sharp wave ripples (SWR) cross-correlated with spikes from PFC cells. b Mean firing rate of spontaneously firing neurons in the PFC (**P < 0.01; Mann–Whitney U test). Data are shown as mean ± SEM. c Mean normalized cross-correlation between significantly correlated PFC single units to hippocampal SWRs. Note the significant difference of discharge in the PFC 200 ms after the ripple onset in remote memory in PNS group (*P < 0.05; Wilcoxon signed rank test). Data are presented as mean ± SEM. Adapted from [55]