Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J, Forsgren L, French JA, Glynn M. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014;55:475–82.
Article
PubMed
Google Scholar
Lunardi MDS, Souza FPDSD, Xikota JC, Walz R, Lin K. Epilepsy perception amongst education professionals. J Epilepsy Clin Neurophysiol. 2012;18:79–84.
Article
Google Scholar
Patel AD. Variables associated with emergency department and/or unplanned hospital utilization for children with epilepsy. Epilepsy Behav. 2014;31:172–5.
Article
PubMed
Google Scholar
Chen WC, Chen EY, Gebre RZ, Johnson MR, Li N, Vitkovskiy P, Blumenfeld H. Epilepsy and driving: potential impact of transient impaired consciousness. Epilepsy Behav. 2014;30:50–7.
Article
PubMed
PubMed Central
Google Scholar
McPhee SJ, Lingappa VR, Ganong WF, Lange JD. Pathophysiology of disease: an introduction to clinical medicine. Lange Medical Books/McGraw–Hill; 2000.
Eid T, Thomas M, Spencer D, Runden-Pran E, Lai J, Malthankar G, Kim J, Danbolt N, Ottersen O, De Lanerolle N. Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy. Lancet. 2004;363:28–37.
Article
PubMed
CAS
Google Scholar
Turrin NP, Rivest S. Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy. Neurobiol Dis. 2004;16:321–34.
Article
PubMed
CAS
Google Scholar
Ravizza T, Gagliardi B, Noé F, Boer K, Aronica E, Vezzani A. Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. Neurobiol Dis. 2008;29:142–60.
Article
PubMed
CAS
Google Scholar
Lenburg ME, Liou LS, Gerry NP, Frampton GM, Cohen HT, Christman MF. Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data. BMC Cancer. 2003;3:31.
Article
PubMed
PubMed Central
Google Scholar
He K, Xiao W, Lv W. Comprehensive identification of essential pathways and transcription factors related to epilepsy by gene set enrichment analysis on microarray datasets. Int J Mol Med. 2014;34:715–24.
PubMed
CAS
PubMed Central
Google Scholar
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S. A human protein–protein interaction network: a resource for annotating the proteome. Cell. 2005;122:957–68.
Article
PubMed
CAS
Google Scholar
Fujita A, Sato JR, Rodrigues Lde O, Ferreira CE, Sogayar MC. Evaluating different methods of microarray data normalization. BMC Bioinform. 2006;7:469.
Article
Google Scholar
Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47.
Article
PubMed
PubMed Central
Google Scholar
Da Wei Huang BTS, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2008;4:44–57.
Article
Google Scholar
Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA. DAVID: database for annotation, visualization, and integrated discovery. Genome Biol. 2003;4:P3.
Article
PubMed
Google Scholar
da Huang W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4:44–57.
Article
CAS
Google Scholar
Yekutieli D, Benjamini Y. Resampling-based false discovery rate controlling multiple test procedures for correlated test statistics. J Stat Plan Inference. 1999;82:171–96.
Article
Google Scholar
Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering C. STRING v9. 1: protein–protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 2013;41:D808–15.
Article
PubMed
CAS
PubMed Central
Google Scholar
Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498–504.
Article
PubMed
CAS
PubMed Central
Google Scholar
Vezzani A, French J, Bartfai T, Baram TZ. The role of inflammation in epilepsy. Nat Rev Neurol. 2011;7:31–40.
Article
PubMed
CAS
PubMed Central
Google Scholar
Steinman L. Elaborate interactions between the immune and nervous systems. Nat Immunol. 2004;5:575–81.
Article
PubMed
CAS
Google Scholar
Rodgers KM, Hutchinson MR, Northcutt A, Maier SF, Watkins LR, Barth DS. The cortical innate immune response increases local neuronal excitability leading to seizures. Brain. 2009;132:2478–86.
Article
PubMed
PubMed Central
Google Scholar
Choi J, Nordli DR, Alden TD, DiPatri A, Laux L, Kelley K, Rosenow J, Schuele SU, Rajaram V, Koh S. Cellular injury and neuroinflammation in children with chronic intractable epilepsy. J Neuroinflammation. 2009;6:38.
Article
PubMed
PubMed Central
Google Scholar
Vezzani A. Innate immunity and inflammation in temporal lobe epilepsy: new emphasis on the role of complement activation. Epilepsy Curr. 2008;8:75–7.
Article
PubMed
PubMed Central
Google Scholar
Petry F, Hauptmann G, Goetz J, Grosshans E, Loos M. Molecular basis of a new type of C1q-deficiency associated with a non-functional low molecular weight (LMW) C1q: parallels and differences to other known genetic C1q-defects. Immunopharmacology. 1997;38:189–201.
Article
PubMed
CAS
Google Scholar
Niesen CE, Xu J, Fan X, Li X, Wheeler CJ, Mamelak AN, Wang C. Transcriptomic profiling of human peritumoral neocortex tissues revealed genes possibly involved in tumor-induced epilepsy. PLoS One. 2013;8:e56077.
Article
PubMed
CAS
PubMed Central
Google Scholar
Aronica E, Ravizza T, Zurolo E, Vezzani A. Astrocyte immune responses in epilepsy. Glia. 2012;60:1258–68.
Article
PubMed
Google Scholar
Corry B, Thomas M. Mechanism of ion permeation and selectivity in a voltage gated sodium channel. J Am Chem Soc. 2012;134:1840–6.
Article
PubMed
CAS
Google Scholar
Jung S, Bullis JB, Lau IH, Jones TD, Warner LN, Poolos NP. Downregulation of dendritic HCN channel gating in epilepsy is mediated by altered phosphorylation signaling. J Neurosci. 2010;30:6678–88.
Article
PubMed
CAS
PubMed Central
Google Scholar
Baek J-H, Rubinstein M, Scheuer T, Trimmer JS. Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures. J Biol Chem. 2014;289:15363–73.
Article
PubMed
CAS
PubMed Central
Google Scholar
Frank HY, Catterall WA. Overview of the voltage-gated sodium channel family. Genome Biol. 2003;4(10):1186.
Google Scholar
Engvall E, Ruoslahti E. Binding of soluble form of fibroblast surface protein, fibronectin, to collagen. Int J Cancer. 1977;20:1–5.
Article
PubMed
CAS
Google Scholar
de Rivero Vaccari JP, Dietrich WD, Keane RW. Activation and regulation of cellular inflammasomes: gaps in our knowledge for central nervous system injury. J Cereb Blood Flow Metab. 2014;34:369–75.
Article
PubMed
PubMed Central
Google Scholar
Müller N, Ackenheil M. Psychoneuroimmunology and the cytokine action in the CNS: implications for psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry. 1998;22:1–33.
Article
PubMed
Google Scholar
Coulter DA, Eid T. Astrocytic regulation of glutamate homeostasis in epilepsy. Glia. 2012;60:1215–26.
Article
PubMed
PubMed Central
Google Scholar