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Table 3 GO functional and KEGG pathway enrichment analysis on genes in co-expression modules

From: Identification of novel gene and pathway targets for human epilepsy treatment

ID

Term

Description

Count

p value

Up-co-expression

GOTERM_BP_FAT

GO:0016310 ~ phosphorylation

5

0.023081277

GOTERM_BP_FAT

GO:0006793 ~ phosphorus metabolic process

5

0.043264378

GOTERM_BP_FAT

GO:0006796 ~ phosphate metabolic process

5

0.043264378

GOTERM_BP_FAT

GO:0006915 ~ apoptosis

4

0.049975204

GOTERM_BP_FAT

GO:0006814 ~ sodium ion transport

3

0.014081453

GOTERM_CC_FAT

GO:0005886 ~ plasma membrane

11

0.02927495

GOTERM_CC_FAT

GO:0044459 ~ plasma membrane part

8

0.033090626

GOTERM_MF_FAT

GO:0030695 ~ GTPase regulator activity

4

0.020009788

GOTERM_MF_FAT

GO:0060589 ~ nucleoside-triphosphatase regulator activity

4

0.021203692

GOTERM_MF_FAT

GO:0008289 ~ lipid binding

4

0.02652355

GOTERM_MF_FAT

GO:0031402 ~ sodium ion binding

3

0.012457524

GOTERM_MF_FAT

GO:0005543 ~ phospholipid binding

3

0.027145214

Down-co-expression

GOTERM_BP_FAT

GO:0006955 ~ immune response

9

1.01E−07

GOTERM_BP_FAT

GO:0050778 ~ positive regulation of immune response

6

2.45E−07

GOTERM_BP_FAT

GO:0048584 ~ positive regulation of response to stimulus

6

2.73E−06

GOTERM_BP_FAT

GO:0002684 ~ positive regulation of immune system process

6

2.84E−06

GOTERM_BP_FAT

GO:0006952 ~ defense response

6

2.72E−04

GOTERM_MF_FAT

GO:0048154 ~ S100 beta binding

2

0.003999687

GOTERM_MF_FAT

GO:0048306 ~ calcium-dependent protein binding

2

0.031586688

GOTERM_MF_FAT

GO:0042803 ~ protein homodimerization activity

3

0.042687029

GOTERM_MF_FAT

GO:0004175 ~ endopeptidase activity

3

0.052602322

GOTERM_MF_FAT

GO:0005509 ~ calcium ion binding

4

0.05926993

GOTERM_CC_FAT

GO:0005576 ~ extracellular region

7

0.020898219

KEGG_PATHWAY

hsa04610:Complement and coagulation cascades

3

0.003647135

KEGG_PATHWAY

hsa04612:Antigen processing and presentation

3

0.005241774

KEGG_PATHWAY

hsa05322:Systemic lupus erythematosus

3

0.007393725

  1. Count represents the gene number