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Table 1 GO and KEGG pathway enrichment analysis for identified DEGs

From: Identification of novel gene and pathway targets for human epilepsy treatment

Category Term Count p value
Up-regulated genes
GOTERM_BP_FAT GO:0050877 ~ neurological system process 26 2.15E−04
GOTERM_BP_FAT GO:0019226 ~ transmission of nerve impulse 22 2.01E−11
GOTERM_BP_FAT GO:0006811 ~ ion transport 21 4.75E−05
GOTERM_BP_FAT GO:0007267 ~ cell–cell signaling 20 4.97E−06
GOTERM_BP_FAT GO:0007268 ~ synaptic transmission 19 5.63E−10
GOTERM_CC_FAT GO:0031224 ~ intrinsic to membrane 70 0.007687949
GOTERM_CC_FAT GO:0016021 ~ integral to membrane 65 0.030340215
GOTERM_CC_FAT GO:0005886 ~ plasma membrane 63 4.81E−06
GOTERM_CC_FAT GO:0044459 ~ plasma membrane part 48 9.49E−08
GOTERM_CC_FAT GO:0005887 ~ integral to plasma membrane 23 0.00337979
GOTERM_MF_FAT GO:0005216 ~ ion channel activity 15 1.16E−05
GOTERM_MF_FAT GO:0022838 ~ substrate specific channel activity 15 1.63E−05
GOTERM_MF_FAT GO:0015267 ~ channel activity 15 2.40E−05
GOTERM_MF_FAT GO:0022803 ~ passive transmembrane transporter activity 15 2.46E−05
GOTERM_MF_FAT GO:0022836 ~ gated channel activity 13 2.69E−05
KEGG_PATHWAY hsa04720:Long-term potentiation 7 1.89E−05
KEGG_PATHWAY hsa05014:Amyotrophic lateral sclerosis (ALS) 5 9.61E−04
KEGG_PATHWAY hsa04020:Calcium signaling pathway 7 0.003316868
KEGG_PATHWAY hsa04080:Neuroactive ligand-receptor interaction 8 0.005123351
KEGG_PATHWAY hsa04310:Wnt signaling pathway 5 0.037620947
Down-regulated genes
GOTERM_BP_FAT GO:0006955 ~ immune response 40 1.23E−16
GOTERM_BP_FAT GO:0006952 ~ defense response 30 1.65E−10
GOTERM_BP_FAT GO:0009611 ~ response to wounding 26 3.53E−09
GOTERM_BP_FAT GO:0007155 ~ cell adhesion 26 7.74E−07
GOTERM_BP_FAT GO:0022610 ~ biological adhesion 26 7.94E−07
GOTERM_MF_FAT GO:0005198 ~ structural molecule activity 20 4.49E−05
GOTERM_MF_FAT GO:0005509 ~ calcium ion binding 18 0.018905046
GOTERM_MF_FAT GO:0005201 ~ extracellular matrix structural constituent 13 1.09E−10
GOTERM_MF_FAT GO:0042802 ~ identical protein binding 13 0.041784269
GOTERM_MF_FAT GO:0004857 ~ enzyme inhibitor activity 12 1.53E−04
GOTERM_CC_FAT GO:0005576 ~ extracellular region 70 4.18E−15
GOTERM_CC_FAT GO:0005886 ~ plasma membrane 69 0.002166744
GOTERM_CC_FAT GO:0044421 ~ extracellular region part 50 4.52E−17
GOTERM_CC_FAT GO:0005615 ~ extracellular space 30 2.56E−08
GOTERM_CC_FAT GO:0005578 ~ proteinaceous extracellular matrix 28 1.34E−14
KEGG_PATHWAY hsa04510:Focal adhesion 16 4.33E−07
KEGG_PATHWAY hsa05322:Systemic lupus erythematosus 14 3.27E−09
KEGG_PATHWAY hsa04610:Complement and coagulation cascades 13 4.92E−10
KEGG_PATHWAY hsa04512:ECM-receptor interaction 13 5.21E−09
KEGG_PATHWAY hsa04060:Cytokine–cytokine receptor interaction 10 0.02253563
  1. Count represents the gene number