Weinhaus AJ, Stout LE, Sorenson RL: Glucokinase, hexokinase, glucose transporter 2, and glucose metabolism in islets during pregnancy and prolactin-treated islets in vitro: mechanisms for long term up-regulation of islets.
Endocrinology 1996, 137:1640–1649.
CAS
PubMed
Google Scholar
Milanski M, Arantes VC, Ferreira F, de Barros Reis MA, Carneiro EM, Boschero AC, Collares-Buzato CB, Latorraca MQ: Low-protein diets reduce PKAalpha expression in islets from pregnant rats.
J Nutr 2005, 135:1873–1878.
CAS
PubMed
Google Scholar
de Mazancourt P, Carneiro EM, Atwater I, Boschero AC: Prolactin treatment increases GLUT2 but not the G protein subunit content in cell membranes from cultured neonatal rat islets.
FEBS Lett 1994, 343:137–140. 10.1016/0014-5793(94)80305-6
Article
CAS
PubMed
Google Scholar
Green IC, Perrin D, Howell SL: Insulin release in isolated islets of Langerhans of pregnant rats. Relationship between glucose metabolism and cyclic AMP.
Horm Metab Res 1978, 10:32–35. 10.1055/s-0028-1093476
Article
CAS
PubMed
Google Scholar
Brelje TC, Sorenson RL: Nutrient and hormonal regulation of the threshold of glucose-stimulated insulin secretion in isolated rat pancreases.
Endocrinology 1988, 123:1582–1590. 10.1210/endo-123-3-1582
Article
CAS
PubMed
Google Scholar
Van Assche FA: Quantitative morphologic and histoenzymatic study of the endocrine pancreas in nonpregnant and pregnant rats.
Am J Obstet Gynecol 1974, 118:39–41.
CAS
PubMed
Google Scholar
Bone AJ, Taylor KW: Metabolism adaptation to pregnancy shown by increased biosynthesis of insulin in islets of Langerhans isolated from pregnant rats.
Nature 1976, 262:501–502. 10.1038/262501a0
Article
CAS
PubMed
Google Scholar
Sheridan JD, Anaya PA, Parsons JA, Sorenson RL: Increased dye coupling in pancreatic islets from rats in late-term pregnancy.
Diabetes 1988, 37:908–911. 10.2337/diab.37.7.908
Article
CAS
PubMed
Google Scholar
Rao RH: Chronic undernutrition may accentuate the beta cell dysfunction of type 2 diabetes.
Diabetes Res Clin Pract 1990, 8:125–130. 10.1016/0168-8227(90)90022-L
Article
CAS
PubMed
Google Scholar
Rasschaert J, Reusens B, Dahri S, Sener A, Remacle C, Hoet JJ, Malaisse WJ: Impaired activity of rat pancreatic islet mitochondrial glycerophosphate dehydrogenase in protein malnutrition.
Endocrinology 1995, 136:2631–2634.
CAS
PubMed
Google Scholar
Boschero AC, Szpak-Glasman M, Carneiro EM, Bordin S, Paul I, Rojas E, Atwater I: Oxotremorine-m potentiation of glucose-induced insulin release from rat islets involves M3 muscarinic receptors.
Am J Physiol 1995, 268:E336–342.
CAS
PubMed
Google Scholar
Latorraca MQ, Carneiro EM, Mello MA, Boschero AC: Reduced insulin secretion in response to nutrients in islets from malnourished young rats is associated with a diminished calcium uptake.
J Nutr Biochem 1999, 10:37–43. 10.1016/S0955-2863(98)00080-1
Article
CAS
PubMed
Google Scholar
Ferreira F, Barbosa HC, Stoppiglia LF, Delghingaro-Augusto V, Pereira EA, Boschero AC, Carneiro EM: Decreased insulin secretion in islets from rats fed a low protein diet is associated with a reduced PKAalpha expression.
J Nutr 2004, 134:63–67.
CAS
PubMed
Google Scholar
Ferreira F, Filiputti E, Arantes VC, Stoppiglia LF, Araujo EP, Delghingaro-Augusto V, Latorraca MQ, Toyama MH, Boschero AC, Carneiro EM: Decreased cholinergic stimulation of insulin secretion by islets from rats fed a low protein diet is associated with reduced protein kinase calpha expression.
J Nutr 2003, 133:695–699.
CAS
PubMed
Google Scholar
Meda P: The role of gap junction membrane channels in secretion and hormonal action.
J Bioenerg Biomembr 1996, 28:369–377. 10.1007/BF02110113
Article
CAS
PubMed
Google Scholar
Serre-Beinier V, Mas C, Calabrese A, Caton D, Bauquis J, Caille D, Charollais A, Cirulli V, Meda P: Connexins and secretion.
Biol Cell 2002, 94:477–492. 10.1016/S0248-4900(02)00024-2
Article
CAS
PubMed
Google Scholar
Le Gurun S, Martin D, Formenton A, Maechler P, Caille D, Waeber G, Meda P, Haefliger JA: Connexin-36 contributes to control function of insulin-producing cells.
J Biol Chem 2003, 278:37690–37697. 10.1074/jbc.M212382200
Article
CAS
PubMed
Google Scholar
Michon L, Nlend Nlend R, Bavamian S, Bischoff L, Boucard N, Caille D, Cancela J, Charollais A, Charpantier E, Klee P, et al.: Involvement of gap junctional communication in secretion.
Biochim Biophys Acta 2005, 1719:82–101. 10.1016/j.bbamem.2005.11.003
Article
CAS
PubMed
Google Scholar
Nlend RN, Michon L, Bavamian S, Boucard N, Caille D, Cancela J, Charollais A, Charpantier E, Klee P, Peyrou M, et al.: Connexin36 and pancreatic beta-cell functions.
Arch Physiol Biochem 2006, 112:74–81. 10.1080/13813450600712019
Article
CAS
PubMed
Google Scholar
Charpantier E, Cancela J, Meda P: Beta cells preferentially exchange cationic molecules via connexin 36 gap junction channels.
Diabetologia 2007, 50:2332–2341. 10.1007/s00125-007-0807-9
Article
CAS
PubMed
Google Scholar
Collares-Buzato CB, Leite AR, Boschero AC: Modulation of gap and adherens junctional proteins in cultured neonatal pancreatic islets.
Pancreas 2001, 23:177–185. 10.1097/00006676-200108000-00008
Article
CAS
PubMed
Google Scholar
Serre-Beinier V, Le Gurun S, Belluardo N, Trovato-Salinaro A, Charollais A, Haefliger JA, Condorelli DF, Meda P: Cx36 preferentially connects beta-cells within pancreatic islets.
Diabetes 2000, 49:727–734. 10.2337/diabetes.49.5.727
Article
CAS
PubMed
Google Scholar
Charollais A, Serre V, Mock C, Cogne F, Bosco D, Meda P: Loss of alpha 1 connexin does not alter the prenatal differentiation of pancreatic beta cells and leads to the identification of another islet cell connexin.
Dev Genet 1999, 24:13–26. 10.1002/(SICI)1520-6408(1999)24:1/2<13::AID-DVG3>3.0.CO;2-N
Article
CAS
PubMed
Google Scholar
Johnstone SR, Best AK, Wright CS, Isakson BE, Errington RJ, Martin PE: Enhanced connexin 43 expression delays intra-mitotic duration and cell cycle traverse independently of gap junction channel function.
J Cell Biochem 2010, 110:772–782. 10.1002/jcb.22590
Article
PubMed Central
CAS
PubMed
Google Scholar
Klee P, Lamprianou S, Charollais A, Caille D, Sarro R, Cederroth M, Haefliger JA, Meda P: Connexin implication in the control of the murine beta-cell mass.
Pediatr Res 2011, 70:142–147.
Article
CAS
PubMed
Google Scholar
Jonkers FC, Jonas JC, Gilon P, Henquin JC: Influence of cell number on the characteristics and synchrony of Ca2+ oscillations in clusters of mouse pancreatic islet cells.
J Physiol 1999,520(Pt 3):839–849.
Article
PubMed Central
CAS
PubMed
Google Scholar
Collares-Buzato CB, Carvalho CP, Furtado AG, Boschero AC: Upregulation of the expression of tight and adherens junction-associated proteins during maturation of neonatal pancreatic islets in vitro.
J Mol Histol 2004, 35:811–822. 10.1007/s10735-004-1746-0
Article
CAS
PubMed
Google Scholar
Meyer RA, Laird DW, Revel JP, Johnson RG: Inhibition of gap junction and adherens junction assembly by connexin and A-CAM antibodies.
J Cell Biol 1992, 119:179–189. 10.1083/jcb.119.1.179
Article
CAS
PubMed
Google Scholar
Hauge-Evans AC, Squires PE, Persaud SJ, Jones PM: Pancreatic beta-cell-to-beta-cell interactions are required for integrated responses to nutrient stimuli: enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets.
Diabetes 1999, 48:1402–1408. 10.2337/diabetes.48.7.1402
Article
CAS
PubMed
Google Scholar
Bernard-Kargar C, Kassis N, Berthault MF, Pralong W, Ktorza A: Sialylated form of the neural cell adhesion molecule (NCAM): a new tool for the identification and sorting of beta-cell subpopulations with different functional activity.
Diabetes 2001,50(Suppl 1):S125–130.
Article
CAS
PubMed
Google Scholar
Lilla V, Webb G, Rickenbach K, Maturana A, Steiner DF, Halban PA, Irminger JC: Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines.
Endocrinology 2003, 144:1368–1379. 10.1210/en.2002-220916
Article
CAS
PubMed
Google Scholar
Geiger B, Yehuda-Levenberg S, Bershadsky AD: Molecular interactions in the submembrane plaque of cell-cell and cell-matrix adhesions.
Acta Anat (Basel) 1995, 154:46–62. 10.1159/000147751
Article
CAS
Google Scholar
Lerch MM, Lutz MP, Weidenbach H, Muller-Pillasch F, Gress TM, Leser J, Adler G: Dissociation and reassembly of adherens junctions during experimental acute pancreatitis.
Gastroenterology 1997, 113:1355–1366. 10.1053/gast.1997.v113.pm9322531
Article
CAS
PubMed
Google Scholar
Toyoda E, Doi R, Koizumi M, Kami K, Ito D, Mori T, Fujimoto K, Nakajima S, Wada M, Imamura M: Analysis of E-, N-cadherin, alpha-, beta-, and gamma-catenin expression in human pancreatic carcinoma cell lines.
Pancreas 2005, 30:168–173. 10.1097/01.mpa.0000148514.69873.85
Article
CAS
PubMed
Google Scholar
Rutland CS, Latunde-Dada AO, Thorpe A, Plant R, Langley-Evans S, Leach L: Effect of gestational nutrition on vascular integrity in the murine placenta.
Placenta 2007, 28:734–742. 10.1016/j.placenta.2006.07.001
Article
CAS
PubMed
Google Scholar
Ravier MA, Guldenagel M, Charollais A, Gjinovci A, Caille D, Sohl G, Wollheim CB, Willecke K, Henquin JC, Meda P: Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release.
Diabetes 2005, 54:1798–1807. 10.2337/diabetes.54.6.1798
Article
CAS
PubMed
Google Scholar
Benninger RK, Head WS, Zhang M, Satin LS, Piston DW: Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet.
J Physiol 2011, 589:5453–5466. 10.1113/jphysiol.2011.218909
Article
PubMed Central
CAS
PubMed
Google Scholar
Pizarro-Delgado J, Fasciani I, Temperan A, Romero M, Gonzalez-Nieto D, Alonso-Magdalena P, Nualart-Marti A, Estil'les E, Paul DL, Martin-del-Rio R, et al.: Inhibition of connexin 36 hemichannels by glucose contributes to the stimulation of insulin secretion.
Am J Physiol Endocrinol Metab 2014, 306:E1354–1366. 10.1152/ajpendo.00358.2013
Article
CAS
PubMed
Google Scholar
Wellershaus K, Degen J, Deuchars J, Theis M, Charollais A, Caille D, Gauthier B, Janssen-Bienhold U, Sonntag S, Herrera P, et al.: A new conditional mouse mutant reveals specific expression and functions of connexin36 in neurons and pancreatic beta-cells.
Exp Cell Res 2008, 314:997–1012. 10.1016/j.yexcr.2007.12.024
Article
CAS
PubMed
Google Scholar
Souza Dde F, Ignacio-Souza LM, Reis SR, Reis MA, Stoppiglia LF, Carneiro EM, Boschero AC, Arantes VC, Latorraca MQ: A low-protein diet during pregnancy alters glucose metabolism and insulin secretion.
Cell Biochem Funct 2012, 30:114–121. 10.1002/cbf.1824
Article
PubMed
Google Scholar
Du F, Higginbotham DA, White BD: Food intake, energy balance and serum leptin concentrations in rats fed low-protein diets.
J Nutr 2000, 130:514–521.
CAS
PubMed
Google Scholar
Herrera E, Lasuncion MA, Palacin M, Zorzano A, Bonet B: Intermediary metabolism in pregnancy. First theme of the Freinkel era.
Diabetes 1991,40(Suppl 2):83–88.
Article
PubMed
Google Scholar
Frontera M, Pujol E, Rodriguez-Cuenca S, Catala-Niell A, Roca P, Garcia-Palmer FJ, Gianotti M: Rat brown adipose tissue thermogenic features are altered during mid-pregnancy.
Cell Physiol Biochem 2005, 15:203–210. 10.1159/000086407
Article
CAS
PubMed
Google Scholar
Macedo GS, Ferreira CL, Menegaz A, Arantes VC, Veloso RV, Carneiro EM, Boschero AC, Oller do Nascimento CM, Latorraca MQ, Gomes-da-Silva MH: Correlation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variables.
Braz J Med Biol Res 2008, 41:519–525. 10.1590/S0100-879X2008000600014
Article
CAS
PubMed
Google Scholar
Herrera E, Munoz C, Lopez-Luna P, Ramos P: Carbohydrate-lipid interactions during gestation and their control by insulin.
Braz J Med Biol Res 1994, 27:2499–2519.
CAS
PubMed
Google Scholar
Kargar C, Ktorza A: Anatomical versus functional beta-cell mass in experimental diabetes.
Diabetes Obes Metab 2008,10(Suppl 4):43–53.
Article
CAS
PubMed
Google Scholar
Genevay M, Pontes H, Meda P: Beta cell adaptation in pregnancy: a major difference between humans and rodents?
Diabetologia 2010, 53:2089–2092. 10.1007/s00125-010-1848-z
Article
CAS
PubMed
Google Scholar
Theis M, Mas C, Doring B, Degen J, Brink C, Caille D, Charollais A, Kruger O, Plum A, Nepote V, et al.: Replacement by a lacZ reporter gene assigns mouse connexin36, 45 and 43 to distinct cell types in pancreatic islets.
Exp Cell Res 2004, 294:18–29. 10.1016/j.yexcr.2003.09.031
Article
CAS
PubMed
Google Scholar
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF: Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
J Biol Chem 1998, 273:9188–9196. 10.1074/jbc.273.15.9188
Article
CAS
PubMed
Google Scholar
Lampe PD, TenBroek EM, Burt JM, Kurata WE, Johnson RG, Lau AF: Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication.
J Cell Biol 2000, 149:1503–1512. 10.1083/jcb.149.7.1503
Article
PubMed Central
CAS
PubMed
Google Scholar
Laird DW: Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
Biochim Biophys Acta 2005, 1711:172–182. 10.1016/j.bbamem.2004.09.009
Article
CAS
PubMed
Google Scholar
Girao H, Pereira P: Phosphorylation of connexin 43 acts as a stimuli for proteasome-dependent degradation of the protein in lens epithelial cells.
Mol Vis 2003, 9:24–30.
CAS
PubMed
Google Scholar
Johnstone SR, Kroncke BM, Straub AC, Best AK, Dunn CA, Mitchell LA, Peskova Y, Nakamoto RK, Koval M, Lo CW, et al.: MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation.
Circ Res 2012, 111:201–211. 10.1161/CIRCRESAHA.112.272302
Article
PubMed Central
CAS
PubMed
Google Scholar
Dbouk HA, Mroue RM, El-Sabban ME, Talhouk RS: Connexins: a myriad of functions extending beyond assembly of gap junction channels.
Cell Commun Signal 2009, 7:4. 10.1186/1478-811X-7-4
Article
PubMed Central
PubMed
Google Scholar
Adams CL, Nelson WJ, Smith SJ: Quantitative analysis of cadherin-catenin-actin reorganization during development of cell-cell adhesion.
J Cell Biol 1996, 135:1899–1911. 10.1083/jcb.135.6.1899
Article
CAS
PubMed
Google Scholar
Hinck L, Nathke IS, Papkoff J, Nelson WJ: Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly.
J Cell Biol 1994, 125:1327–1340. 10.1083/jcb.125.6.1327
Article
CAS
PubMed
Google Scholar
Wakae-Takada N, Xuan S, Watanabe K, Meda P, Leibel RL: Molecular basis for the regulation of islet beta cell mass in mice: the role of E-cadherin.
Diabetologia 2013, 56:856–866. 10.1007/s00125-012-2824-6
Article
PubMed Central
CAS
PubMed
Google Scholar
Sorenson RL, Brelje TC: Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones.
Horm Metab Res 1997, 29:301–307. 10.1055/s-2007-979040
Article
CAS
PubMed
Google Scholar
Nadal A, Alonso-Magdalena P, Soriano S, Ropero AB, Quesada I: The role of oestrogens in the adaptation of islets to insulin resistance.
J Physiol 2009, 587:5031–5037. 10.1113/jphysiol.2009.177188
Article
PubMed Central
CAS
PubMed
Google Scholar
Scott AM, Atwater I, Rojas E: A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of Langerhans.
Diabetologia 1981, 21:470–475.
Article
CAS
PubMed
Google Scholar
Trinder P: Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen.
J Clin Pathol 1969, 22:158–161. 10.1136/jcp.22.2.158
Article
PubMed Central
CAS
PubMed
Google Scholar
Boschero AC, Szpak-Glasman M, Carneiro EM, Bordin S, Paul I, Rojas E, Atwater I: Oxotremorine-m potentiation of glucose-induced insulin release from rat islets involves M3 muscarinic receptors.
Am J Physiol 1995, 268:E336–342.
CAS
PubMed
Google Scholar
Kelley GG, Zawalich KC, Zawalich WS: Calcium and a mitochondrial signal interact to stimulate phosphoinositide hydrolysis and insulin secretion in rat islets.
Endocrinology 1994, 134:1648–1654.
CAS
PubMed
Google Scholar
Amaral ME, Ueno M, Carvalheira JB, Carneiro EM, Velloso LA, Saad MJ, Boschero AC: Prolactin-signal transduction in neonatal rat pancreatic islets and interaction with the insulin-signaling pathway.
Horm Metab Res 2003, 35:282–289.
Article
CAS
PubMed
Google Scholar
Sokal RR, Rohlf FJ: Biometry; the principles and practice of statistics in biological research. San Francisco: W. H. Freeman; 1969.
Google Scholar