Table 2 Relative effect (%) of the single and combination treatments of Oxa and DNC on the oncogenic. properties of ovarian cancer cell lines
Properties | Cell lines | Treatments | ||
|---|---|---|---|---|
Oxa | DNC | Combination | ||
Colony formation | SKOV3 | 41 | 37.9 | 6.8 |
OVCAR3 | 46 | 42 | 9.2 | |
Cell motility | SKOV3 | 40 | 20 | 15 |
Cell adhesion | SKOV3 | 45 | 50 | 42 |
OVCAR3 | 30 | 42 | 40 | |
Matrigel invasion | SKOV3 | 72 | 80 | 60 |
OVCAR3 | 67 | 75 | 57 | |
Transwell migration | SKOV3 | 68 | 70 | 29 |
OVCAR3 | 50 | 56 | 27 | |
Cells in SubG0 | SKOV3 | 5 | 7 | 20 |
OVCAR3 | 10 | 10 | 20 | |
mRNA level: MMP-2 | SKOV3 | 40 | 25 | 8 |
OVCAR3 | 50 | 35 | 20 | |
mRNA level: MMP-9 | SKOV3 | 100 | 20 | 15 |
OVCAR3 | 85 | 25 | 32 | |
Protein level: MMP-2 | OVCAR3 | 15 | 20 | 15 |
Protein level: MMP-9 | OVCAR3 | 30 | 50 | 10 |