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Table 4 Lipid parameters, enzymatic antioxydant activity/polymorphism and CHD severity

From: MnSOD and GPx1 polymorphism relationship with coronary heart disease risk and severity

Parameters

0-vessel (n = 13)

1-vessel (n = 42)

2-vessels (n = 35)

3-vessels (n = 16)

Total cholesterol (mmol/L)

4.11 ± 1.03

4.26 ± 1.07

4.59 ± 1.03

5.36 ± 1.41*

HDL-cholesterol (mmol/L)

0.86 ± 0.28

0.84 ± 0.26

0.81 ± 0.29

0.79 ± 0.23

LDL-cholesterol (mmol/L)

3.02 ± 0.93

3.15 ± 1.01

3.49 ± 1.04

4.19 ± 1.39*

Triglycerides (mmol/L)

1.14 ± 0.63

1.27 ± 0.65

1.34 ± 0.97

1.89 ± 1.00*

SOD activity, (U/gHb)

1246.9 ± 242.15

1112.4 ± 141.37

1065.6 ± 194.28

864.3 ± 229.08**, ‡

SOD genotypes, n (%), (CC/CT/TT)

4/6/3

10/21/11

7/18/10

3/7/6

(30.77/46.15/23.08)

(23.81/50.0/26.19)

(20.0/51.43/28.57)

(18.75/43.75/37.5)

GPx activity, (U/gHb)

38.90 ± 7.89

44.09 ± 11.32

42.94 ± 11.15

43.65 ± 12.64

GPx genotypes, n (%), (CC/CT/TT)

7/8/1

22/17/3

21/12/2

9/6/1

(53.85/38.46/7.69)

(52.38/40.47/7.14)

(60.0/34.29/5.71)

(56.26/37.5/6.25)

  1. * P < 0.05 compared with 0-vessel disease and P = 0.001 with 1-vessel disease
  2. ** P < 0.001 compared with 0-vessel disease and with 1-vessel disease and P = 0.002 with 2-vessels disease
  3. ‡ P < 0.001 compared with 0-vessel disease, 1-vessel disease and 2-vessels disease