Table 3 The role of some ncRNAs in osteoarthritis and their mechanisms validated in the transgenic mice model

miRNA

miR-455-5p and − 3p

EPAS1; HIF-2α Mmp3 Mmp13

miR-455-/-

miR-455 KO developed cartilage degeneration

mimicking OA and elevated expression of cartilage degeneration-related genes

[183]

miRNA

miR-455-3p

PAK2; TGF-β signaling

miR-455-3p-/-

miR-455-3p inhibits cartilage degeneration

[184]

miRNA

miR-21-5p

Spry1; ERK-MAPK signaling

miR-21-5p-/-

Promoting the process of TMJOA

[188]

miRNA

miR-21-5p

FGF18

miR-21-5pfl/fl; Col2a1-CreER

The articular cartilage degradation of miR-21-5p conditional knockout mice was significantly alleviated in spontaneous destabilization of the medial meniscus models.

[187]

miRNA

miR-483-5p

Matn3 Timp2

pri-miR-483 TG mice

Intra-articular injection of lentivirus LV3-miR-483-5p or TG483 mice exhibited significant acceleration and increased severity of OA

[192]

miRNA

miR-483-5p

mTORC1-HDAC4‐miR‐483‐5p pathway

TSC1f/f; Col2a1-Cre pri-miR-483 TG mice

N.A

[193]

miRNA

miR-34a-5p

miR-34a-/-

miR-34a-KO mice exhibited protection against DMM-induced cartilage damage

[205]

miRNA

miR-204/211

Runx2; Akt signaling

miR-204 fl/fl; miR-211 fl/fl; Prx1-Cre or CMV-Cre

Maintaining healthy homeostasis of

mesenchymal joint cells to counteract OA pathogenesis

[157]

miRNA

miR-146a

Camk2d Ppp3r2

miR-146a-/-

miR-146a KO mice was alleviated in spontaneous and instability-induced OA models

[191]

miRNA

miR-140

Adamts-5

miR-140-/-

Loss of miR-140 contributes to the development of age-related OA-like changes

[98]

miRNA

miR-141/200c

SIRT1; IL-6/STAT3

miR-141/200cfl/fl; Col2a1-CreERT2

Increased retention of NPs inside joint space in cKO mice

[189]