Fig. 2

miRNAs regulating growth plate development. MiR-140 is expressed in the proliferating chondrocytes regulated by transcription factor Sox9. MiR-140 coordinately functions with let7, which is regulated by Lin28, to regulate chondrocyte proliferation in the growth plate. miR-1 is mainly expressed in the hypertrophic chondrocytes of growth plates in mice. miR-1 may regulate hedgehog signaling in hypertrophic chondrocytes