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Fig. 3 | Biological Research

Fig. 3

From: Effects of latroeggtoxin-VI on dopamine and α-synuclein in PC12 cells and the implications for Parkinson’s disease

Fig. 3

LETX-VI entered the nucleus of PC12 cells to promote tyrosine hydroxylase (TH) expression. A: LETX-VI increased TH abundance. B: LETX-VI up-regulated the level of phosphorylated TH at S31(p-TH). C: LETX-VI promoted transcription of TH confirmed by qPCR. *P < 0.05 vs. control. D: LETX-VI interacted with junction plakoglobin (Jup) and nuclear receptor related protein 1 (Nurr 1) verified with pulldown combined with western blot analysis. Input: PC12 cell lysate. Vector: showing that the nickel beads for fixing LETX-VI did not adsorb Jup and Nurr1. Pulldown: proteins pulled down from PC12 cell lysate by LETX-VI. E: LETX-VI had no obvious effect on the level of junction Jup. F: LETX-VI had no obvious effect on the level of Nurr 1. *P < 0.05. n ≥ 3

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Biological Research

ISSN: 0717-6287

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