Fig. 8

Effects of Mdivi-1 on YME1L alleviating RTEC senescence. A, B Representative SA-β-Gal-staining micrographs of HK2 cells transfected with YME1L-plasmid in HG conditions and treated with DMSO or Mdivi-1 (5 µM) for 6 h (n = 4). Scale bar: 200 µm. C-E Western blotting and associated quantitative analysis of P16, and P21 in HK2 cells transfected with YME1L-plasmid in HG conditions and treated with DMSO or Mdivi-1 (5 µM) for 6 h (n = 4). Data are shown as mean ± SD. *p < 0.05, **p < 0.01. ns: no statistically significant difference