Fig. 1

Expression pattern of YME1L in kidneys from patients and mice with DKD. A Experiment schedule of the mouse model constructed in this study. B Representative immunohistochemical staining of YME1L in renal tissues from normal subjects (Normal), EDKD and LDKD patients and (C) the percentage of YME1L expression area was quantified (n = 6–11). Scale bar: 40 µm. D Representative immunohistochemical staining of YME1L in renal tissues from CON and HFD/STZ mice, and E the percentage of YME1L expression area was quantified (n = 4). Scale bar: 20 µm. F, G Western blotting and quantitative analysis of kidney YME1L expression in CON and HFD/STZ mice (n = 6). H RT-PCR analysis of kidney Yme1l mRNA expression in CON and HFD/STZ mice (n = 4). Data are shown as mean ± SD. **p < 0.01