Fig. 7

Effect of eMSC on inflammatory factors and the fertility restoration in the mouse endometrium. Relative gene expression of (A)Ifng, (B)Il-2, (C)Tnfa, (D)Il-10 and (E)Il-4 in the PBS group (blue bars) and the eMSC group (yellow bars) at different post-operative timepoints (n = 4). The injured uterine horn (L) was normalized against the control uterine horn (R) from the same animal. (F) Images showing the uterine horns with the number of implantation sites (blue arrow) in (I and II) non-injury group, (III and IV) injured endometrium with PBS transplantation and (V and VI) injured endometrium with eMSC-transplantation. (G) Number of implantation sites on the control side (blue bars) and injured side (yellow bars) of the uterine horn (n = 4). Results are presented as mean ± SD, *P < 0.05. Abbreviations: eMSC, endometrial mesenchymal stem-like cells; Ifn, interferon; Il, interleukin; IS, implantation sites; Tnf, tumor necrosis factor