Fig. 6

MX1-KD and AP-1 inhibition on DSACs. A Bright field and fluorescence images of DSACs transfected with MX1-KD and Blank lentivirus (scale bar = 100 μm). B Quantitative measurement of mRNA expression levels of key genes including MX1 and AP-1 in MX1-KD and Blank group (n = 4, ***p < 0.001, two-tailed Student’s t-test). C EdU staining and quantitative results in MX1-KD and Blank group (n = 3, **p < 0.01, two-tailed Student’s t-test). D Principal Components Analysis (PCA) plot. E Gene set enrichment analysis (GSEA) revealed altered pathways in T-5224 treatment versus non-treated DSACs. F EdU staining and quantitative results in T-5224 treatment versus non-treated DSACs (n = 3, *p < 0.05, two-tailed Student’s t-test)