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Fig. 4 | Biological Research

Fig. 4

From: Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome

Fig. 4

Transcriptional regulation Networks analysis in DS. A Tissue distribution of the transcription factors targets for DEGs. B GO-BP analysis of the transcription factors targets for DEGs. C The top 20 transcription factors targets for DEGs from ENCODE ChIP-seq library. D The network of top 20 transcription factors targets for DEGs. E STRING protein network analysis of upregulated DEGs. F GO-BP analysis of the core regulatory network involving MX1 on chr21 and AP-1 TFs. G Quantitative measurement of mRNA expression levels of key genes including MX1 and AP-1 in Normal and DS group (n = 4, **p < 0.01, ***p < 0.001, two-tailed Student’s t-test)

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Biological Research

ISSN: 0717-6287

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