Fig. 1

ATAC-seq results in DS derived amniocytes. A Principal Components Analysis (PCA) plot. B MA plot of DS-Normal contrast. Sites identified as significantly differentially bound shown in red. Red dots above and below the blue horizontal line means gain and loss binding affinity, respectively. C Enrichment of ATAC-seq signals around the 1.5 kb upper and lower reaches of transcriptional start site (TSS) with sample groups merged. D Chromosome distribution of differential peaks. E Location distribution of upregulated peaks on the genome. F Distribution ratio of upregulated peaks at the distance from TSS. G KEGG enrichment of upregulated peaks. H IGV shows peaks on chromosome 21 (chr21) in DS and Normal group. I Violin plot of log2FC distribution of differential peaks on chr21 and non-chr21 (***p < 0.001, two-tailed Student’s t-test)