Fig. 3

OFT and OLT performance of mice in each group after EA intervention and virus injections. A Representative plots of OFT trajectories in each group of mice after EA intervention and virus injections. There were no differences in total distance (B), the central area distance (C) and the central area time (D) among each group, indicating that the overall exploration ability and emotional state of the mice were normal. E Representative plots of OLT trajectories in each group of mice after virus injection and EA intervention. EA could improve the memory discrimination ability. Interference of Wnt5a expression aggravated the impairment of memory discrimination in AD mice, and the effect of EA was reduced (F). The motor ability of each mouse was consistent (G). All data are presented as mean ± SD; N = 10 mice; ^***P < 0.001 vs. WT group; ^#P < 0.05 vs. 5 × FAD group; ^&P < 0.05 vs EA group