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Fig. 2 | Biological Research

Fig. 2

From: Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model

Fig. 2

Knockdown of Wnt5a using rAAV and validation of knockdown efficiency (A) shWnt5a or shC injected into the DG bilaterally. Coordinates of hippocampal DG area: from Bregma AP: − 2.00 mm, ML: ± 1.3 mm, DV: − 2.3 mm (B) Viral expression map of the DG. C Wnt5a mRNA levels were detected by qPCR after virus injection. (D, E) Western blot pictures and statistical results of Wnt5a expression levels in the hippocampus of mice in each group; (F, G) Western blot pictures and statistical results of FZD2 expression levels in the hippocampus of mice in each group. All data are presented as mean ± SD; N = 3 mice; ***P < 0.001 vs. WT group; #P < 0.05 vs. 5 × FAD group; &P < 0.05, &&&P < 0.001 vs EA group

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Biological Research

ISSN: 0717-6287

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