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Fig. 5 | Biological Research

Fig. 5

From: Chemogenetic inhibition of NTS astrocytes normalizes cardiac autonomic control and ameliorate hypertension during chronic intermittent hypoxia

Fig. 5

Experimental design. (A) Adult male Sprague-Dawley rats were exposed to CIH for 21 days and monitored before CIH and pre/post-acute administration of clozapine N-Oxide (CNO). Animals were injected at 21d post CIH with AVV-GFAP-DREADDs(Gi)-mCherry bilaterally in commissural NTS (cNTS). (B) Representative immunostaining showing mCherry, GFAP and DAPI expression (left panel) at cNTS level, scale bar represent 170 μm (left panel) and 30 μm (middle panel). Arrowheads indicate co-localization of astrocytes and DREADDs in 2D and Z-plane. N = 4

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Biological Research

ISSN: 0717-6287

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