Fig. 4

S-Nitrosylation regulates lung metastasis in vivo. A Scheme of the treatments conducted in the murine syngeneic model of breast cancer. B Breast tumors were generated in BALB-C female mice by 4T1 cell injection in the fourth mammary pair. Representative image of the tumor formed after four weeks post-injection of 4T1 cells. Slices. C Bar graph showing the quantification of tumor weight. T-test; n.s = non-significant. D Bar graph showing the quantification of tumor volume. One-Way ANOVA and Bonferroni’s Multiple Comparison Test, * p < 0.05; n = 7. E Representative images of lungs post-euthanasia. Black arrows indicate surface metastases. F Graph showing the number of superficial metastases counted in each study group. One-Way ANOVA and Bonferroni’s Multiple Comparison Test, * p < 0.05; n = 7