Table 2 List of pathways in which the genes are included. In bold the genes resulting upregulated upon GSK0660 treatment
Parkin complex | PARK7 |
|---|---|
Parkin substrate | GPR37 |
Cell adhesion | NFASC |
Ubiquitination | FBXO9, LRRK2, PARK2, PINK1, UBA1, UCHL1 |
Inflammation | PRDX2 |
Apoptosis | MAPK9, BDNF, OPA1, PRDX2 |
Mitochondria | LRRK2, OPA1, PARK7, PINK1, SNCA, UCHL1, VDAC3 |
Synaptic vesicles | LRRK2 |
Signal transduction | Dopaminergic: NSG1, DDC, PARK2, PARK7, PINK1, SNCA MAP Kinase: MAPK9, PRDX2 |
Ion transport | ATP2B2, CXXC1, SNCA, VDAC3 |
Transporters | VDAC3 |
BDNF pathway | BDNF, NTRK2 (TrkB), CREB1 |
Others | NCOA1, RTN1 |