Fig. 9
UDCA increases the presence of mitophagosome-like structures in C2C12 myotubes. C2C12 myoblasts differentiated for 4–5 days were incubated with 200 μM UDCA for 72 h. a Representative transmission electron microscopy images of mitophagosome-like structures in myotubes. b Quantification of mitophagosome-like structures number by myotube area was performed. The values are shown as a percentage of presence and expressed as the mean ± SD of four independent experiments (no paired t-test, *p < 0.05 with respect to the control group). SD standard deviation, UDCA ursodeoxycholic acid