Fig. 2

H&E-stained pancreas sections of A; Sham group showed closely packed pancreatic acini with basal basophilia and apical acidophilia and the acinar cells have basal open phase nuclei, B, C; NAFP group showed loss of pancreatic architecture, fat deposition among distorted acini (f), a congested and dilated blood vessel (↑), and fibrin clot with inflammatory cells margination and pavementation. The adjacent pancreatic acini were distorted, and some acinar cells showed vacuolated cytoplasm and pyknotic nuclei (▲) with edematous clear areas in-between the acini (*), D; R-10 group showed focal areas of loss of architecture and the acini in the affected areas showed variable structural changes. Some acini attained lightly stained cells with loss of basal basophilia and apical acidophilia and other acinar cells showed vacuolated cytoplasm and pyknotic nuclei (▲) with area of oedema and inflammatory cell infiltration (*), E; R-20 group showed the pancreatic lobules and the pancreatic acini are closely packed. Thin interlobular septa can be seen. There were focal areas of structural changes at the periphery of pancreatic lobules, where some acini attained pale vacuolated cytoplasm, (*), and F; R-30 group showed most of the pancreatic acini attained numerous and closely packed zymogen granules and the nuclei are basal and vesicular. [Magnification: 200x]