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Fig. 3 | Biological Research

Fig. 3

From: Alpha‐kinase1 promotes tubular injury and interstitial inflammation in diabetic nephropathy by canonical pyroptosis pathway

Fig. 3

A Kidney sections stained with HE in control (a) and DN mice (b). Loss of brush border (black arrow shows) and vacuolar degeneration (white arrow shows) were seen. IHC staining of ALPK1 (c, d), F4/80 (e, f), fibronectin (g, h) and α-SMA (i, j) in renal tissues (scale bar, 50 μm; magnification ×200). B Blood glucose levels. C Western blotting and densitometric analysis of ALPK1 (C1), NF-κB P65 (C2), phospho-NF-κB P65 (C3), GSDMD-FL (C4), GSDMD-NT (C5), cl-IL-1β (C6) and α-SMA (C7) expressions in kidney tissues of control and DN mice. D Serum IL-1β levels. E Urinary IL-1β levels. DN diabetic nephropathy. Experiments were performed in triplicate. Data were presented as mean ± SD (*P < 0.05, **P < 0.01)

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Biological Research

ISSN: 0717-6287

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