Fig. 8

The expression of CTRPs in Betahistine treated Slc26a4^loop/loop mutant mice. Slc26a4loop/loop mutant mice were subcutaneously injected with Betahistine (10 mg/Kg) for 15 days, twice a day. We performed auditory brainstem response (ABR) testing (A) and behavioral testing (B) in Slc26a4^loop/loop mutant and wild-type mice. Next, we evaluated the accuracy of air righting reflex (C), the time of contact righting reflex (D) and the scores of head tilt and swimming behavior in vertigo mice of vestibular dysfunction (E). The expression of CTRP1 (F), CTRP 3 (G), CTRP 6 (H), CTRP 9 (I) and CTRP 12 (J). In serum was detected by using ELISA. N = 7, Statistical differences were performed by using one-way ANOVA. *P < 0.05, **P < 0.01