Fig. 3
From: Aβ promotes CD38 expression in senescent microglia in Alzheimer’s disease
CD38 knockout improves energy dysmetabolism and reduces the expression of inflammatory factors in Aβ1-40 injured BV2 cells. Scale bar: 50 μm. A Representative image of BV2 microglial cells exposed to Aβ1-40 (1 μM), and overexpressed or knockdown CD38 immunolabeled for CD38 (green). Nuclear staining (DAPI) is shown in blue. B CD38 protein expression level of BV2 cells. C NAD + level of BV2 cells. D NADH level of BV2 cells. E NAD + /NADH ratio of BV2 cells. F ATP level of BV2 cells. G ROS level of BV2 cells. H MMP level of BV2 cells. I IL-1β level of BV2 cells. J IL-6 level of BV2 cells. K TNF-α level of BV2 cells. All data are expressed as the mean ± standard error. **P < 0.01 vs. control group; ##P < 0.01 vs. Aβ1–40 group; △△P < 0.01