Fig. 2
From: Aβ promotes CD38 expression in senescent microglia in Alzheimer’s disease
Aβ1-40 induced energy metabolism disorder and mitochondrial dysfunction in BV2 cells. Scale bar: 50 μm. A Morphological changes of BV2 cells treated with Aβ1-40 (1 μM). B SA-β-Gal positive stained area. C Representative images of BV2 cells immunolabeled for P16 (red) and P21 (red). Nuclear staining (DAPI) is shown in blue. D Cell viability of BV2 cells E ATP level of BV2 cells. F NAD + level of BV2 cells. G NADH level of BV2 cells. H NAD + /NADH ratio of BV2 cells. I ROS level of BV2 cells. J MMP level of BV2 cells. K CD38 enzymatic activity of BV2 cells. L P16, P21, and CD38 protein expression level of BV2 cells. All data are expressed as the mean ± standard error. **P < 0.01 vs. control group