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Table 2 Examples of the reciprocal effects observed following the variation of the cytosolic pool of glutathione and other thiols in the presence of oxyanions (selenite and/or tellurite) in different bacterial species

From: Tellurite and Selenite: how can these two oxyanions be chemically different yet so similar in the way they are transformed to their metal forms by bacteria?

Bacterial species Experimental procedures (metalloid) Results observed Refs.
Selenite
 Rsp. rubrum
R. capsulatus
*Inhibition of glutathione biosynthesis in cells grown in the presence of selenite Decrease of selenite reduction rate [75]
 Stenotrophomonas maltophilia *Inhibition of glutathione biosynthesis in cells grown in the presence of selenite Inhibition of selenite reduction as a function of the inhibitor* amount [152]
 Stenotrophomonas maltophilia Expression of genes involved in glutathione biosynthesis Induction of glutamate/cysteine ligase and glutathione synthetase [152]
 Streptomyces sp. ES2-5 *Inhibition of glutathione biosynthesis in cells grown in the presence of selenite Decrease of reduced thiols (RSH) following exposure to selenite [153]
 Achrobactrum sp. MPV1 *Inhibition of glutathione biosynthesis in cells grown in the presence of selenite Delay in selenite reduction to Se0 [87]
 Achrobactrum sp. MPV1 Determination of reduced thiols (RSH) in cells exposed to selenite Decrease of reduced thiols (RSH) following the exposure to selenite [87]
Tellurite
 E. coli Determination of reduced thiols (RSH) in cells lysates with DTNB as a reagent Decrease of RSH amount in cells grown in the presence of tellurite [2]
 E. coli HPLC-analysis of low MW compounds from cells grown in the presence of tellurite Glutathione is the major target of tellurite toxicity [135]
 Pseudomonas pseudoalcaligenes Determination of reduced thiols (RSH) in cell lysates Decrease of RSH amount in cells grown in the presence of tellurite [103]
 Geobacter stearothermophilus Expression of genes involved in cysteine metabolism (cysA, cysB, cysC, cysE, cysI, cysM,cysK) in the presence of tellurite Induction of the expression of cys genes in parallel with decrease of various reduced thiols [154]
  1. *Glutathione biosynthesis inhibitor, buthionine sulphoximine; DTNB, 5,5′-dithiobis(2-nitrobenzoic acid); HPLC, high-performance liquid chromatography; MW, molecular weight; RSH, reduced thiols; cys, cysteine gene. Bacterial species: E.coli, Escherichia coli; Rsp. rubrum, Rhodospirillum rubrum; R. capsulatus, Rhodobacter capsulatus