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Fig. 4 | Biological Research

Fig. 4

From: Linc-OIP5 in the breast cancer cells regulates angiogenesis of human umbilical vein endothelial cells through YAP1/Notch/NRP1 signaling circuit at a tumor microenvironment

Fig. 4

Linc-OIP5 knockdown in MDA-MB-231 cells affected angiogenesis capacity of HUVECs in vitro. a HUVECs capillary-like tube formation assay indicated that linc-OIP5 downregulation dramatically reduced the angiogenesis of co-cultured HUVECs. Magnification×40. b Tube formation assay analysis was quantified by the ImageJ software, plotted as the number of total junctions, the lenght of total branching, the area of total meshes, and the size of mean mesh. Fold changes were obtained by normalizing against control group. NS no statistical difference, ** P < 0.01, ***P < 0.001

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