Fig. 6

Transplantation of EGFP hiPSC-derived myogenic progenitors replenished the satellite cell compartment. a For intramuscular transplantation, immunofluorescence analysis showed PAX7-positive but GFP-negative cells (white arrowheads) in negative control mdx mice (upper panels), PAX7 and GFP double-positive cells (white arrows) in cell-transplanted left TA muscles (lower panel) and their counterparts that received PBS (middle panel). b For intravenous transplantation, immunofluorescence analysis showed PAX7-positive but GFP-negative cells (white arrowheads) in TA muscles of mdx mice received PBS (upper panels), whereas PAX7 and GFP double-positive cells (white arrows) in TA muscles of mdx mice received cells (upper panels). Scale bars = 400 μm