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Fig. 5 | Biological Research

Fig. 5

From: Knockdown of long non-coding RNA HOTAIR reverses cisplatin resistance of ovarian cancer cells through inhibiting miR-138-5p-regulated EZH2 and SIRT1

Fig. 5

Downregulation of miR-138-5p reversed silencing of HOTAIR mediated pro-apoptosis activity in DDP-treated SKOV3/DDP cells. a Cell viability in DDP-treated SKOV3/DDP cells with HOTAIR silencing or/and miR-138-5p silencing was determined by MTT assay. b Cell apoptosis was assessed by annexin V-FITC and PI staining with flow cytometry. c Expression levels of EZH2, SIRT1, Bcl2, Bax, Cl-caspase 3 and Cl-PARP were assessed by western blot assay. Data were presented as mean ± SD. * p < 0.05

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Biological Research

ISSN: 0717-6287

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