Fig. 1

Down-regulation of miR-19a-3p exerted a neuroprotective role in focal cerebral ischemia/reperfusion rats. a Representative images of TTC staining in brain sections collected from rats in MCAO group receiving intracerebroventricular injection of miR-19a-3p inhibitor at 72 h after reperfusion (left panel). The relative infarct area percentage was evaluated by observing the unstained white infarcted tissue zone and the stained red normal tissue zone (right panel). b The Longa score (n = 6 per group) and c Bederson core (n = 6 per group) were applied to assess neurological function deficits. d The expression of miR-19a-3p in Sham rat brains and I/R rat brains treated with miR-19a-3p inhibitor was analyzed by RT-qPCR. The experiments were performed in triplicate and each value represented mean ± SD. ***p < 0.001, compared with Sham; ##p < 0.01, ###p < 0.001, compared with MCAO