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Fig. 2 | Biological Research

Fig. 2

From: MicroRNA-107 is a novel tumor suppressor targeting POU3F2 in melanoma

Fig. 2

miR-107 inhibits melanoma cell proliferation, colony formation and induces apoptosis. a Cell proliferation study of SH-4 cells transfected with either miR-107 or the scramble control. The growth rate of cells was monitored using CCK-8 kit for 72 h. b Colony formation study of SH-4 cells transfected with either miR-107 or the scramble control. The colony formation ability of the transfected cells was accessed by counting the number of colonies (more than 50 cells) in the culturing plates. c Western blotting analysis of apoptotic pathway activities in transfected cells. The representative image from at least three independent experiments was shown. d The densitometric analysis of cleaved PARP1, cleaved Caspase 3 and Cytochrome C expression was shown. The data were presented as mean ± SD of at least three independent experiments (**p < 0.01, ***p < 0.001 as compared with control)

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