Table 3 Expression of nine GC-associated proteins in GC and normal tissues detected by immunohistochemistry
Protein | GC (N = 121) No. (%) of patients | Normal gastric tissues (N = 30) No. (%) of patients | p value | ||||||
|---|---|---|---|---|---|---|---|---|---|
− | + | ++ | +++ | − | + | ++ | +++ | ||
p-PKCα | 4 (3.3) | 46 (38.0) | 59 (48.8) | 12 (9.9) | 10 (33.3) | 19 (63.3) | 1 (3.3) | 0 (0) | < 0.001 |
p-PKCα/β2 | 21 (17.4) | 59 (48.8) | 37 (30.6) | 4 (3.3) | 17 (56.7) | 13 (43.3) | 0 (0) | 0 (0) | <0.001 # |
Akt1 | 22 (18.2) | 73 (60.3) | 20 (16.5) | 6 (5.0) | 20 (66.7) | 10 (33.3) | 0 (0) | 0 (0) | < 0.001 |
CDK6 | 46 (38.0) | 68 (56.2) | 4 (3.3) | 3 (2.5) | 5 (17.7) | 25 (83.3 | 0 (0) | 0 (0) | 0.022 # |
Notch4 | 6 (5.0) | 64 (52.9) | 48 (39.7) | 3 (2.5) | 8 (26.7) | 22 (73.3) | 0 (0) | 0 (0) | < 0.001# |
β-Catenin | 4 (3.3) | 96 (79.3) | 21 (17.4) | 0 (0) | 2 (6.7) | 27 (90.0) | 1 (3.3) | 0 (0) | 0.119 |
CDK2 | 53 (43.8) | 55 (45.5) | 12 (9.9) | 1 (0.8) | 30 (100) | 0 (0) | 0 (0) | 0 (0) | < 0.001# |
PCNA | 3 (2.5) | 7 (5.8) | 57 (47.1) | 54 (44.6) | 8 (26.7) | 21 (70) | 1 (3.3) | 0 (0) | < 0.001 |
XIAP | 20 (16.5) | 63 (52.1) | 32 (26.4) | 6 (5.0) | 2 (6.1) | 26 (78.8) | 2 (6.1) | 0 (0) | 0.007 |