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Fig. 5 | Biological Research

Fig. 5

From: Involvement of endothelial CK2 in the radiation induced perivascular resistant niche (PVRN) and the induction of radioresistance for non-small cell lung cancer (NSCLC) cells

Fig. 5

Schematic representation of a putative mechanism underlying the forming of perivascular resistance niche (PVRN) after exposure to IR. CK2 inhibition suppresses the phosphorylation of NF-κB, then reduces the increase of IL-8 and IL-6 in endothelial cells after exposure to IR, which destroyed the forming of PVRN and finally leads to radiosensitize lung cancer cells (→ indicates stimulation effect, ┫means inhibitory effect)

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