Fig. 5

Schematic representation of a putative mechanism underlying the forming of perivascular resistance niche (PVRN) after exposure to IR. CK2 inhibition suppresses the phosphorylation of NF-κB, then reduces the increase of IL-8 and IL-6 in endothelial cells after exposure to IR, which destroyed the forming of PVRN and finally leads to radiosensitize lung cancer cells (→ indicates stimulation effect, ┫means inhibitory effect)