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Fig. 3 | Biological Research

Fig. 3

From: PELI3 mediates pro-tumor actions of down-regulated miR-365a-5p in non-small cell lung cancer

Fig. 3

Knockdown of PELI3 inhibits tumor growth and metastasis. a, b Knockdown efficiency of PELI3 in A549 cells stably transfected with PELI3 shRNA (sh-PELI3-1 and sh-PELI3-2) or empty vector (sh-CTR) was confirmed by qRT-PCR and western blot. c, d Tumor growth curve of A549-sh-CTR and A549-sh-PELI3 cells implanted into the flank of male nude mice. e, f H&E staining of the metastatic nodules in the lung of A549 cells which stably transfected with PELI3 shRNA (sh-PELI3-1 and sh-PELI3-2) or empty vector (sh-CTR) following tail vein injection into nude mice (200 × scale bars) and incidence of lung metastasis in mice following tail vein injection of the respective A549 cells. *P < 0.05; **P < 0.01; ***P < 0.001

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