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Fig. 1 | Biological Research

Fig. 1

From: Neuron-derived CCL2 contributes to microglia activation and neurological decline in hepatic encephalopathy

Fig. 1

CCL2 blockage alleviated TAA-induced neurological decline and liver damage. At 8 h following the last injection of thioacetamide (TAA), and every 4 h after, the encephalopathy grade of rats from different group was assessed (b). Blood, whole brains and liver tissue were collected at coma and CCL2 expression and concentration in cerebral cortex and serum were determined using qRT-PCR and Elisa (a). Liver function was determined through measuring the serum levels of ALT and total bilirubin using commercially available kits (c). Liver damage was evaluated using HE staining and the original magnification was ×100 (d). **P < 0.01, *P < 0.05, vs vehicle; ## P < 0.01, # P < 0.05, vs TAA

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