Table 4 Pathway enrichment analysis for DE genes
No. | Pathway ID | Pathway | Number of DE genes | P-value |
|---|---|---|---|---|
HS/NC | ||||
 1 | ko04612 | Antigen processing and presentation | 18 | 1.45E−11 |
 2 | ko04141 | Protein processing in endoplasmic reticulum | 28 | 1.01E−07 |
 3 | ko03010 | Ribosome | 14 | 1.57E−06 |
 4 | ko00983 | Drug metabolism—other enzymes | 18 | 2.15E−05 |
 5 | ko01100 | Metabolic pathways | 88 | 6.79E−05 |
 6 | ko00140 | Steroid hormone biosynthesis | 13 | 0.000282 |
 7 | ko00830 | Retinol metabolism | 13 | 0.00053 |
 8 | ko00520 | Amino sugar and nucleotide sugar metabolism | 10 | 0.000747 |
 9 | ko04621 | NOD-like receptor signaling pathway | 7 | 0.001046 |
 10 | ko00190 | Oxidative phosphorylation | 11 | 0.002814 |
 11 | ko04080 | Neuroactive ligand-receptor interaction | 12 | 0.003165 |
 12 | ko00980 | Metabolism of xenobiotics by cytochrome P450 | 12 | 0.004002 |
 13 | ko00982 | Drug metabolism–cytochrome P450 | 12 | 0.004793 |
 14 | ko00062 | Fatty acid elongation in mitochondria | 3 | 0.006405 |
 15 | ko00860 | Porphyrin and chlorophyll metabolism | 9 | 0.007187 |
 16 | ko00981 | Insect hormone biosynthesis | 4 | 0.009516 |
 17 | ko00500 | Starch and sucrose metabolism | 10 | 0.011378 |
 18 | ko04260 | Cardiac muscle contraction | 11 | 0.015768 |
 19 | ko03320 | PPAR signaling pathway | 7 | 0.026265 |
 20 | ko04610 | Complement and coagulation cascades | 6 | 0.029497 |
 21 | ko00350 | Tyrosine metabolism | 7 | 0.032871 |
 22 | ko00071 | Fatty acid metabolism | 5 | 0.044768 |
CS/NC | ||||
 1 | ko00983 | Drug metabolism—other enzymes | 23 | 3.61E−10 |
 2 | ko01100 | Metabolic pathways | 91 | 5.30E−10 |
 3 | ko04142 | Lysosome | 26 | 7.61E−09 |
 4 | ko00980 | Metabolism of xenobiotics by cytochrome P450 | 19 | 2.03E−08 |
 5 | ko00982 | Drug metabolism—cytochrome P450 | 19 | 2.94E−08 |
 6 | ko04612 | Antigen processing and presentation | 13 | 5.57E−08 |
 7 | ko00500 | Starch and sucrose metabolism | 16 | 4.56E−07 |
 8 | ko00140 | Steroid hormone biosynthesis | 15 | 1.56E−06 |
 9 | ko00830 | Retinol metabolism | 15 | 3.55E−06 |
 10 | ko00520 | Amino sugar and nucleotide sugar metabolism | 12 | 5.03E−06 |
 11 | ko00053 | Ascorbate and aldarate metabolism | 10 | 7.59E−05 |
 12 | ko00511 | Other glycan degradation | 5 | 9.30E−05 |
 13 | ko00190 | Oxidative phosphorylation | 12 | 0.000137 |
 14 | ko04145 | Phagosome | 17 | 0.000231 |
 15 | ko00592 | Alpha-Linolenic acid metabolism | 9 | 0.000329 |
 16 | ko00860 | Porphyrin and chlorophyll metabolism | 10 | 0.000471 |
 17 | ko00040 | Pentose and glucuronate interconversions | 9 | 0.001679 |
 18 | ko00350 | Tyrosine metabolism | 8 | 0.003413 |
 19 | ko00591 | Linoleic acid metabolism | 7 | 0.003593 |
 20 | ko00561 | Glycerolipid metabolism | 9 | 0.004786 |
 21 | ko00071 | Fatty acid metabolism | 6 | 0.004981 |