Skip to main content

Table 1 Cytotoxicity (LC50 in µg/mL) and the selectivity index (SI) of three limonoids isolated from Trichilia welwitschii and reference compounds (doxorubicin and puromycin) against cancer cell lines

From: Cytotoxicity, nitric oxide and acetylcholinesterase inhibitory activity of three limonoids isolated from Trichilia welwitschii (Meliaceae)

Compounds Vero THP-1 RAW 264.7
LC50 SI LC50 SI
1 89.17 ± 5.00a 81.20 ± 6.38a 0.87 23.55 ± 5.77a 2.99
2 85.22 ± 6.31a 81.20 ± 4.04a 0.87 65.68 ± 3.64b 1.07
3 75.82 ± 1.85b 84.53 ± 5.81a 0.83 61.86 ± 4.14b 1.14
Doxorubicin 9.35 ± 0.66c nd nd 1.06 ± 0.65c 66.42
Puromycin 5.32 ± 0.90d 0.4 ± 0.02b 176.03 1.15 ± 0.17c 61.23
  1. Values with different letters are significantly different at p < 0.05
  2. nd not determined