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Table 1 GO and KEGG pathway enrichment anal ysis of DEGs in lung SCC

From: Integrated analyses of copy number variations and gene differential expression in lung squamous-cell carcinoma

Gene expression Category Term Count P value
Up-regulated GOTERM_BP_FAT GO:0006955, immune response 58 3.95E−33
GOTERM_BP_FAT GO:0006952, defense response 42 5.74E−20
GOTERM_BP_FAT GO:0009611, response to wounding 36 6.34E−17
GOTERM_BP_FAT GO:0006954, inflammatory response 28 1.41E−15
GOTERM_BP_FAT GO:0019882, antigen processing and presentation 13 2.68E−10
GOTERM_CC_FAT GO:0005576, extracellular region 70 8.37E−15
GOTERM_CC_FAT GO:0044421, extracellular region part 44 1.06E−12
GOTERM_CC_FAT GO:0005615, extracellular space 34 1.17E−10
GOTERM_CC_FAT GO:0042611, MHC protein complex 11 3.75E−09
GOTERM_CC_FAT GO:0042613, MHC class II protein complex 7 2.00E−06
GOTERM_MF_FAT GO:0008009, chemokine activity 10 2.21E−09
GOTERM_MF_FAT GO:0042379, chemokine receptor binding 10 3.99E−09
GOTERM_MF_FAT GO:0005125, cytokine activity 16 7.17E−09
GOTERM_MF_FAT GO:0032395, MHC class II receptor activity 6 1.97E−06
GOTERM_MF_FAT GO:0019865, immunoglobulin binding 4 6.21E−04
KEGG_PATHWAY hsa05330: allograft rejection 12 1.53E−11
KEGG_PATHWAY hsa05332: graft-versus-host disease 12 4.09E−11
KEGG_PATHWAY hsa04940: type I diabetes mellitus 12 1.00E−10
KEGG_PATHWAY hsa05320: autoimmune thyroid disease 12 9.74E−10
KEGG_PATHWAY hsa04514: cell adhesion molecules (CAMs) 17 1.01E−09
Down-regulated GOTERM_BP_FAT GO:0055088, lipid homeostasis 10 1.22E−08
GOTERM_BP_FAT GO:0042632, cholesterol homeostasis 9 1.87E−08
GOTERM_BP_FAT GO:0055092, sterol homeostasis 9 1.87E−08
GOTERM_BP_FAT GO:0065005, protein-lipid complex assembly 6 2.18E−07
GOTERM_BP_FAT GO:0034377, plasma lipoprotein particle assembly 6 2.18E−07
GOTERM_CC_FAT GO:0005615, extracellular space 35 4.43E−12
GOTERM_CC_FAT GO:0044421, extracellular region part 39 1.70E−10
GOTERM_CC_FAT GO:0005576, extracellular region 52 3.66E−07
GOTERM_CC_FAT GO:0034385, triglyceride-rich lipoprotein particle 6 4.09E−06
GOTERM_CC_FAT GO:0034361, very-low-density lipoprotein particle 6 4.09E−06
GOTERM_MF_FAT GO:0008289, lipid binding 19 6.35E−06
GOTERM_MF_FAT GO:0004866, endopeptidase inhibitor activity 11 8.62E−06
GOTERM_MF_FAT GO:0005496, steroid binding 8 1.02E−05
GOTERM_MF_FAT GO:0004867, serine-type endopeptidase inhibitor activity 9 1.31E−05
GOTERM_MF_FAT GO:0030414, peptidase inhibitor activity 11 1.38E−05
KEGG_PATHWAY hsa04610: complement and coagulation cascades 7 3.32E−04
KEGG_PATHWAY hsa00830: retinol metabolism 6 8.02E−04
KEGG_PATHWAY hsa00860: porphyrin and chlorophyll metabolism 5 9.97E−04
KEGG_PATHWAY hsa00053: ascorbate and aldarate metabolism 4 0.0015
KEGG_PATHWAY hsa00040: pentose and glucuronate interconversions 4 0.0018
  1. GO gene ontology, KEGG kyoto encyclopedia of genes and genomes, DEGs differentially expressed genes, SCC squamous-cell carcinoma, BP biological process, CC cellular component, MF molecular function