Table 2 Anti-inflammatory effects of compounds (1–4) on LPS-stimulated BMDCs
From: Anti-inflammatory components of the Vietnamese starfish Protoreaster nodosus
Compounds | IC 50 values (μM) a | ||
|---|---|---|---|
IL -12 p40 | IL -6 | TNF- α | |
(25S) 5α-Cholestane-3β,6α,8β,15α,16β,26-hexol (1) | 0.01 ± 0.00 | >100 | >100 |
(25S) 5α-Cholestane-3β,6α,7α,8β,15α,16β,26-heptol (2) | 1.02 ± 0.01 | >100 | >100 |
(25S) 5α-Cholestane-3β,4β,6α,7α,8β,15α,16β,26-octol (3) | 3.11 ± 0.08 | 1.35 ± 0.03 | >100 |
Nodososide (4) | 12.47 ± 0.38 | 23.18 ± 0.46 | >100 |
SB203580 b | 5.00 ± 0.16 | 3.50 ± 0.12 | 7.20 ± 0.13 |