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Table 2 Anti-inflammatory effects of compounds (1–4) on LPS-stimulated BMDCs

From: Anti-inflammatory components of the Vietnamese starfish Protoreaster nodosus

Compounds IC 50 values (μM) a
IL -12 p40 IL -6 TNF- α
(25S) 5α-Cholestane-3β,6α,8β,15α,16β,26-hexol (1) 0.01 ± 0.00 >100 >100
(25S) 5α-Cholestane-3β,6α,7α,8β,15α,16β,26-heptol (2) 1.02 ± 0.01 >100 >100
(25S) 5α-Cholestane-3β,4β,6α,7α,8β,15α,16β,26-octol (3) 3.11 ± 0.08 1.35 ± 0.03 >100
Nodososide (4) 12.47 ± 0.38 23.18 ± 0.46 >100
SB203580 b 5.00 ± 0.16 3.50 ± 0.12 7.20 ± 0.13
  1. aThe inhibitory effects are represented as giving 50% inhibition (IC50) relative to the vehicle control. These data represent the average values of three repeated experiments (mean ± SD). IC50 values for selected extracts are given in column IL-12 p40, IL-6 and TNF-α. Values <100 μM are considered to be active.
  2. bSB203580 was used as a positive control.